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AR035065A1 - Derivados de quinolina y quinolinona, uso de dichos compuestos en la fabricacion de medicamentos, composiciones farmaceuticas que comprenden dichos compuestos, proceso para preparar dichas composiciones y procedimiento para la preparacion de dichos compuestos - Google Patents

Derivados de quinolina y quinolinona, uso de dichos compuestos en la fabricacion de medicamentos, composiciones farmaceuticas que comprenden dichos compuestos, proceso para preparar dichas composiciones y procedimiento para la preparacion de dichos compuestos

Info

Publication number
AR035065A1
AR035065A1 ARP010104629A ARP010104629A AR035065A1 AR 035065 A1 AR035065 A1 AR 035065A1 AR P010104629 A ARP010104629 A AR P010104629A AR P010104629 A ARP010104629 A AR P010104629A AR 035065 A1 AR035065 A1 AR 035065A1
Authority
AR
Argentina
Prior art keywords
alkyl
amino
mono
alkyloxy
alkyloxycarbonyl
Prior art date
Application number
ARP010104629A
Other languages
English (en)
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of AR035065A1 publication Critical patent/AR035065A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07—ORGANIC CHEMISTRY
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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
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Abstract

Derivados de quinolina y quinolinona que tienen las fórmulas (1-A) o (1B) respectivamente, formas N-óxido, sales de adición farmacéuticamente aceptables, aminas cuaternarias y formas estereoquímicamente isoméricas de los mismos, en donde: X representa O, C(R6)2 donde R6 es hidrógeno, arilo o alquilo C1-6, opcionalmente sustituido con amino o mono- o di(alquilo C1-6) amino, S o N-R7 donde R7 es amino o hidroxi; R1 representa alquilo C1-6, arilo, tienilo, quinolinilo, cicloalquilo C3-12 o (ciclo C3-12 alquilo) alquilo C1-6, donde la porción cicloalquilo C3-12 puede contener opcionalmente n doble enlace o donde un átomo de carbono en la porción cicloalquilo C3-12 puede estar reemplazada por un átomo de hidrógeno o una porción NR8, donde R8 es hidrógeno, bencilo o alquiloxicarbonilo C1-6; donde uno o más átomos de hidrógeno en una porción alquilo C1-6 o en una porción cicloalquilo C3-12 pueden estar opcionalmente reemplazados con alquilo C1-6, hidroxialquilo C1-6, haloalquilo C1-6, aminoalquilo C1-6, hidroxi, alquiloxi C1-6, arilalquiloxi C1-6, halo, alquiloxicarbonilo C1-6, arilo, amino, mono- o di(alquilo C1-6) amino, alquiloxicarbonilamino C1-6, halo, piperazinilo, piridinilo, morfolinilo, tienilo o un radical bivalente de fórmula -O-, -O-CH2-O o -O-CH2-CH2-O-; o un radical de fórmula (2) en la cual: Z1 es un enlace covalente simple, O, NH o CH2; Z2 es un enlace covalente simple, O, NH o CH2; n es un número entero de 0, 1, 2 o 3; y donde cada átomo de hidrógeno en el anillo fenilo puede estar independientemente reemplazado con halo, hidroxi, alquilo C1-6, alquiloxi C1-6 o hidroxialquilo C1-6; o X o R1 pueden tomarse conjuntamente con el átomo de carbono al cual X y R1 están unidos para formar un radical de fórmula (3), (4) o (5); R2 representa hidrógeno, halo, ciano, alquilo C1-6, alquiloxi C1-6, alquiltio C1-6, alquilcarbonilo, alquiloxicarbonilo C1-6, alquilcarboniloxi C1-6 alquilo C1-6, alquenilo C2-6, hidroxialquenilo C2-6, alquinilo C2-6, hidroxialquinilo C2-6, tri(alquilo C1-6) silanoalquinilo C2-6, mono- o di-(alquilo C1-6) amino, mono- o di(alquiloxi C1-6) alquilo C1-6 amino, mono- o di-(alquiltio C1-6 alquilo C1-6) amino, arilo, arilalquilo C1-6, arilalquinilo C2-6, alquiloxi C1-6, alquilamino C1-6 alquilo C1-6, aminocarbonilo opcionalmente sustituido con alquilo C1-6, alquiloxi C1-6 alquilo C1-6, alquiloxicarbonilo C1-6 alquilo C1-6 o piridinilo C1-6 alquilo, un heterociclo seleccionado entre tienilo, furanilo, pirrolilo, tiazolilo, oxazolilo, imidazolilo, isotiazolilo, isoxazolilo, pirazolilo, piridilo, pirazinilo, piridazinilo, pirimidinilo, piperidinilo y piperazinilo, opcionalmente N-sustituidos con alquiloxi C1-6 alquilo C1-6, morfolinilo, tiomorfolinilo, dioxanilo o ditianilo, un radical -NH-C(=O)R9 en el cual R9 representa alquilo C1-6 opcionalmente sustituido con cicloalquilo C3-12, alquiloxi C1-6, alquiloxicarbonilo C1-6, arilo, ariloxi, tienilo, piridinilo, mono- o di- (alquilo C1-6), amino, alquiltio C1-6, benciltio, piridiniltio o pirimidiniltio, cicloalquilo C3-12, ciclohexenilo, amino, arilcicloalquilamino C3-12, mono- o di (alquilo C1-6) di (alquilo C1-6), amino, mono- o di-alquiloxicarbonilo C1-6 (alquilo C1-6) amino, mono- o di (alquiloxicarbonilo C1-6) amino, mono- o di (alquenilo C2-6) amino, mono- o di (ariloalquilo C1-6) amino, mono- o di-arilamino, arilalquenilo C2-6, furanilalquenilo C2-6, piperidinilo, piperazinilo, indolilo, furilo, benzofurilo, tetrahidrofurilo, indonilo, adamantilo, piridinilo, piperazinilo, arilo, arilalquiltio C1-6 o un radical de fórmula (2), una sulfonamida -NH-SO2-R10 en la cual R10 representa alquilo C1-6, mono- o poli- haloalquilo C1-6, arilalquilo C1-6, arilalquenilo C2-6, arilo, quinolinilo, isoxazolil o di(alquilo C1-6) amino; R3 y R4 representan cada uno independientemente hidrógeno, halo, hidroxi, ciano, alquilo C1-6, alquiloxi C1-6, alquiloxi C1-6 alquilo C1-6, alquilcarbonilo C1-6, alquiloxicarbonilo C1-6, alquenilo C2-6, hidroxi alquenilo C2-6, alquinilo C2-6, hidroxi alquinilo C2-6, tri (alquilo C1-6) silano alquinilo C2-6, amino, mono- o di (alquilo C1-6) amino, mono- o di-(alquiloxi C1-6) alquilo C1-6, mono- o di (alquiltio C1-6 alquilo C1-6) amino, arilo, morfolinilalquilo C1-6 o piperidinilalquilo C1-6; o R2 y R3 pueden tomarse conjuntamente para formar -R2-R3-, que representa un enlace divalente de la fórmula -(CH2)3-, -(CH2)4-, -(CH2)5-, -(CH2)6-, -CH=CH-CH=CH-, -Z4-CH=CH-, -CH=CH-Z4-, -Z4-CH2-CH2-CH2-, -CH2-Z4-CH2-CH2-, CH2-CH2-Z4-CH2-, -CH2-CH2-CH2-Z4-, -Z4-CH2-CH2-, -CH2-Z4-CH2- o -CH2-CH2-Z4-, con Z4 siendo O, S, SO2 o NR11 donde R11 es hidrógeno, alquilo C1-6, bencilo o alquiloxicarbonilo C1-6, y donde cada radical divalente está opcionalmente sustituido con alquilo C1-6; o R3 y R4 pueden tomarse conjuntamente para formar un radical divalente de fórmula -CH=CH-CH=CH-o -CH2-CH2-CH2-CH2-; R5 representa hidrógeno, cicloalquilo C3-12, piperinilo, oxa-tienilo, tetrahidrotienilo, arilalquilo C1-6, alquiloxi C1-6 alquilo C1-6, alquiloxicarbonil C1-6 alquilo C1-6 o alquilo C1-6 opcionalmente sustituido con un radical C(=O)NRxRy, en el cual Rx y Ry, cada uno independientemente son hidrógeno, cicloalquilo C3-12, alquinilo C2-6, alquilo C1-6 opcionalmente sustituido con ciano, alquiloxi C1-6, alquiloxicarbonilo C1-6, furanilo, pirrolidinilo, benciltio, piridinilo pirrolilo y tienilo, Y representa O o S; o Y y R5 pueden tomarse conjuntamente para forma =Y-R5- que presenta un radical de fórmula: -CH=N-N= (c-1); -N=N-N= (c-2); o -N-CH=CH- (c-3); arilo representa fenilo o naftilo opcionalmente sustituido con uno o más sustituyentes seleccionados entre halo, hidroxi, alquilo C1-6, alquiloxi C1-6, feniloxi, nitro, amino, tio, alquiltio C1-6, haloalquilo C1-6, polihaloalquilo C1-6, polihaloalquiloxi C1-6, hidroxialquilo C1-6, alquiloxialquilo C1-6, aminoalquilo C1-6, mono o di (alquilo C1-6) amino, mono- o di(alquilo C1-6) amino alquilo C1-6, ciano, -CO-R12, -CO-OR13, -NR13SO2R12, -SO2R13R14, -NR13C(O)R12, -C(O)NR13R14, -SOR12, -SO2R12, donde cada R12, R13 y R14 independientemente representan alquilo C1-6, cicloalquilo C3-6, fenilo, fenilo sustituido con halo, hidroxi, alquilo C1-6, alquiloxi C1-6, haloalquilo C1-6, polihaloalquilo, furanilo, tienilo, pirrolilo, imidazolilo, tiazolilo u oxazolilo; y cuando la porción R1-C(=X) está ligado a otra posición distinta de la posición 7 u 8 entonces dicha posición 7 y 8 puede estar sustituida con R15 y R16 donde cualquiera o ambos de R15 y R16 representan alquilo C1-6, alquiloxi C1-6, o R15 y R16 tomados conjuntamente pueden formar un radical divalente de fórmula -CH=CH-CH=CH. Tales Derivados de quinolina y quinolina exhiben actividad antagonista del receptor metabotrópico de glutamato, y por lo tanto son útiles para tratar o prevenir enfermedades del sistema nervioso central inducidas por glutamato. También se dan a conocer: el uso de dichos compuestos en la fabricación de medicamentos, composiciones farmacéuticas que comprenden dichos compuestos, un proceso para preparar dichas composiciones y un procedimiento para la preparación de dichos compuestos.
ARP010104629A 2000-10-02 2001-10-01 Derivados de quinolina y quinolinona, uso de dichos compuestos en la fabricacion de medicamentos, composiciones farmaceuticas que comprenden dichos compuestos, proceso para preparar dichas composiciones y procedimiento para la preparacion de dichos compuestos AR035065A1 (es)

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Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA007464B1 (ru) * 2000-10-02 2006-10-27 Янссен Фармацевтика Н.В. Антагонисты метаботропных рецепторов глутамата
US7084156B2 (en) * 2001-11-27 2006-08-01 Merck & Co., Inc. 2-Aminoquinoline compounds
AR037641A1 (es) 2001-12-05 2004-11-17 Tularik Inc Moduladores de inflamacion
ATE398108T1 (de) 2002-03-27 2008-07-15 Glaxo Group Ltd Chinolinderivate und deren verwendung als 5-ht6 liganden
PL218788B1 (pl) 2002-03-29 2015-01-30 Janssen Pharmaceutica Nv Znakowane radioaktywnie pochodne chinoliny i jej zastosowanie
SE0201943D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab New use
US7964609B2 (en) 2002-06-20 2011-06-21 Astrazeneca Ab Use of mGluR5 antagonists for the treatment of gerd
US7153889B2 (en) 2002-11-12 2006-12-26 Abbott Laboratories Bicyclic-substituted amines as histamine-3 receptor ligands
CA2765093A1 (en) * 2002-11-12 2004-05-27 Abbott Laboratories Bicyclic-substituted amines as histamine-3 receptor ligands
US7332508B2 (en) 2002-12-18 2008-02-19 Novo Nordisk A/S Substituted homopiperidine, piperidine or pyrrolidine derivatives
HRP20060100T3 (en) 2003-07-22 2007-03-31 Arena Pharmaceuticals Inc Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of disorders related thereto
CA2540021A1 (en) 2003-09-26 2005-04-07 Rigel Pharmaceuticals, Inc. Hcv inhibitors and methods of using them
SG150534A1 (en) * 2003-11-20 2009-03-30 Janssen Pharmaceutica Nv 7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp- ribose) polymerase inhibitors
JP4864718B2 (ja) * 2003-11-20 2012-02-01 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ポリ（ａｄｐ−リボース）ポリメラーゼ阻害剤としての６−アルケニルおよび６−フェニルアルキル置換２−キノリノンおよび２−キノキサリノン
US7855207B2 (en) 2003-11-20 2010-12-21 Janssen Pharmaceutica, Nv 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adpribose) polymerase inhibitors
UA89618C2 (ru) * 2003-12-05 2010-02-25 Янссен Фармацевтика Н.В. 6-замещенные 2-хинолиноны и 2-хиноксалиноны как ингибиторы поли(адф-рибоза)полимеразы
EA010592B1 (ru) * 2003-12-10 2008-10-30 Янссен Фармацевтика Н.В. 6-замещённые циклогексилалкил 2-замещённые хинолиноны и 2-хиноксалиноны в качестве ингибиторов поли(adp-рибоза)полимеразы
WO2005070924A1 (en) * 2004-01-23 2005-08-04 Janssen Pharmaceutica N.V. Substituted quinolines and their use as mycobacterial inhibitors
TWI301760B (en) 2004-02-27 2008-10-11 Merz Pharma Gmbh & Co Kgaa Tetrahydroquinolinones and their use as antagonists of metabotropic glutamate receptors
US7550482B2 (en) 2004-02-27 2009-06-23 Merz Pharma Gmbh & Co. Kgaa Tetrahydroquinolones and their use as modulators of metabotropic glutamate receptors
US20060004001A1 (en) * 2004-02-27 2006-01-05 Merz Pharma Gmbh & Co., Kgaa Tetrahydroquinolones and their use as modulators of metabotropic glutamate receptors
US7569580B2 (en) * 2004-06-03 2009-08-04 Rigel Pharmaceuticals, Inc. Heterotricyclic compounds for use as HCV inhibitors
WO2006003147A1 (en) * 2004-06-30 2006-01-12 Janssen Pharmaceutica N.V. Phthalazine derivatives as parp inhibitors
CA2569826C (en) 2004-06-30 2013-07-16 Janssen Pharmaceutica N.V. Substituted 2-alkyl quinazolinone derivatives as parp inhibitors
SG154432A1 (en) 2004-06-30 2009-08-28 Janssen Pharmaceutica Nv Quinazolinedione derivatives as parp inhibitors
GB0420722D0 (en) * 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
GB0420970D0 (en) * 2004-09-21 2004-10-20 Smithkline Beecham Corp Novel triazoloquinoline compounds
BRPI0517549A (pt) * 2004-10-05 2008-10-14 Merz Pharma Gmbh & Co Kgaa novas propenonas cìclicas e acìclicas para o tratamento de distúrbios do snc
US7608643B2 (en) 2005-03-09 2009-10-27 Schering Corporation Compounds for inhibiting KSP kinesin activity
US20060281778A1 (en) * 2005-03-09 2006-12-14 Schering Corporation Compounds for inhibiting KSP Kinesin activity
WO2007023242A1 (en) * 2005-08-24 2007-03-01 Merz Pharma Gmbh & Co. Kgaa Tetrahydroquinolinones and their use as modulators of metabotropic glutamate receptors
WO2007023245A1 (en) * 2005-08-25 2007-03-01 Merz Pharma Gmbh & Co. Kgaa Tetrahydroquinolinones and their use as modulators of metabotropic glutamate receptors
CA2620333A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258357A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
CA2624413A1 (en) * 2005-10-05 2007-04-12 F. Hoffmann-La Roche Ag Naphthyridin derivatives
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20090270371A1 (en) * 2005-12-20 2009-10-29 Gyorgy Keseru Quinoline derivatives useful in the treatment of mglur5 receptor-mediated disorders
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
TWI417095B (zh) 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
EP2382975A3 (en) 2006-05-09 2012-02-29 Braincells, Inc. Neurogenesis by modulating angiotensin
CA2651862A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
US7956064B2 (en) * 2006-09-01 2011-06-07 Cylene Pharmaceuticals, Inc. Fused tricyclic compounds as serine-threonine protein kinase and PARP modulators
JP2010502722A (ja) 2006-09-08 2010-01-28 ブレインセルス，インコーポレイティド ４−アシルアミノピリジン誘導体を含む組み合わせ
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
PL2085387T3 (pl) * 2006-11-14 2013-09-30 Ayumi Pharmaceutical Corp Nowe pochodne 1,2-dihydrochinoliny zawierające jako podstawniki fenylochalkogeno-podstawioną niższą grupę alkilową oraz wprowadzoną przez ester grupę fenylową
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
ES2381446T3 (es) 2007-03-08 2012-05-28 Janssen Pharmaceutica, N.V. Derivado de quinolinona como inhibidores de PARP y TANK
CA2690079C (en) * 2007-06-18 2016-01-26 Richter Gedeon Nyrt. Sulfonyl-quinoline derivatives
EP2203439B1 (en) 2007-09-14 2011-01-26 Ortho-McNeil-Janssen Pharmaceuticals, Inc. 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-ý1, 4'¨bipyridinyl-2'-ones
CN101848893B (zh) 2007-09-14 2012-06-06 奥梅-杨森制药有限公司 1,3-二取代的4-(芳基-x-苯基)-1h-吡啶-2-酮
EP2215075B1 (en) 2007-10-26 2013-12-11 Janssen Pharmaceutica, N.V. Quinolinone derivatives as parp inhibitors
US9084742B2 (en) 2007-12-12 2015-07-21 Axovant Sciences Ltd. Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-Quinoline
HRP20150139T1 (hr) 2008-03-27 2015-05-22 Janssen Pharmaceutica N.V. Tetrahidrofenanthridinoni i tetrahidrociklopentakinolinoni kao inhibitori parp i polimerizacije tubulina
AU2009228945B2 (en) * 2008-03-27 2013-05-02 Janssen Pharmaceutica Nv Quinazolinone derivatives as tubulin polymerization inhibitors
WO2009123714A2 (en) 2008-04-02 2009-10-08 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
MX2011002042A (es) 2008-09-02 2011-06-20 Ortho Mcneil Janssen Pharm Derivados de 3-azabiciclo[3.1.o]hexilo como moduladores de los receptores del glutamato metabotropico.
WO2010062321A1 (en) 2008-10-28 2010-06-03 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto
WO2010060589A1 (en) 2008-11-28 2010-06-03 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP2430022B1 (en) 2009-05-12 2013-11-20 Janssen Pharmaceuticals, Inc. 1,2,4-Triazolo[4,3-a]pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
JP5707390B2 (ja) 2009-05-12 2015-04-30 ジャンセン ファーマシューティカルズ， インコーポレイテッド １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体の正のアロステリック調節因子としてのその使用
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
EP2661435B1 (en) 2010-11-08 2015-08-19 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
WO2012062750A1 (en) 2010-11-08 2012-05-18 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
CA2814998C (en) 2010-11-08 2019-10-29 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
SG11201500339XA (en) * 2012-07-27 2015-02-27 Biogen Ma Inc Atx modulating agents
PE20151203A1 (es) 2012-10-16 2015-08-31 Janssen Pharmaceutica Nv MODULADORES DE QUINOLINILO UNIDOS A FENILO DE ROR-GAMMA-t
PE20150778A1 (es) 2012-10-16 2015-05-23 Janssen Pharmaceutica Nv Moduladores de quinolinilo unidos a metileno de ror-gamma-t
KR20150070348A (ko) 2012-10-16 2015-06-24 얀센 파마슈티카 엔.브이. RoRγt의 헤테로아릴 결합 퀴놀리닐 조절제
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
US9403816B2 (en) 2013-10-15 2016-08-02 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
US9346782B2 (en) 2013-10-15 2016-05-24 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat
US9284308B2 (en) 2013-10-15 2016-03-15 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
US9624225B2 (en) 2013-10-15 2017-04-18 Janssen Pharmaceutica Nv Quinolinyl modulators of RORγt
ME03518B (me) 2014-01-21 2020-04-20 Janssen Pharmaceutica Nv Kombinacije koje obuhvataju pozitivne alosterične modulatore ili ortosterične agoniste metabotropnog glutamatergičnog receptora podtipa 2 i njihova primjena
AU2015208233B2 (en) 2014-01-21 2019-08-29 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
JP2018516992A (ja) 2015-06-12 2018-06-28 アクソファント サイエンシーズ ゲーエムベーハーＡｘｏｖａｎｔ Ｓｃｉｅｎｃｅｓ Ｇｍｂｈ レム睡眠行動障害の予防および処置のために有用なジアリールおよびアリールヘテロアリール尿素誘導体
WO2017011767A2 (en) 2015-07-15 2017-01-19 Axovant Sciences Ltd. Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of hallucinations associated with a neurodegenerative disease
KR20180026774A (ko) * 2015-07-17 2018-03-13 후지필름 가부시키가이샤 질소-함유 헤테로시클릭 화합물
AU2017385292B2 (en) 2016-12-27 2020-05-14 Fujifilm Corporation Antitumor agent and bromodomain inhibitor

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2526232A (en) * 1946-10-21 1950-10-17 Parke Davis & Co Substituted hydantoins and methods for obtaining the same
GB1013224A (en) * 1962-06-21 1965-12-15 Ici Ltd Heterocyclic aminoethanols
JPS5566560A (en) * 1978-11-14 1980-05-20 Yoshitomi Pharmaceut Ind Ltd Quinolone derivative
US4348398A (en) * 1980-12-23 1982-09-07 Merck Sharp & Dohme (I.A.) Corp. Quinolinyl ethanolamines
DE3276432D1 (en) * 1981-03-24 1987-07-02 Ciba Geigy Ag Acyl quinolinone derivatives, processes for their preparation, pharmaceutical compositions containing them and their use
US4473132A (en) * 1981-11-25 1984-09-25 Schwing Robert F Fire escape mechanism
GB8307831D0 (en) * 1983-03-22 1983-04-27 Fujisawa Pharmaceutical Co Triazine derivatives
JPS6019767A (ja) * 1983-07-11 1985-01-31 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体を有効成分とする抗潰瘍剤
US4845100A (en) * 1985-04-12 1989-07-04 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof, processes for preparing the same and cardiotonic composition containing the same
JPH0696555B2 (ja) * 1986-07-31 1994-11-30 大塚製薬株式会社 カルボスチリル誘導体
JPH0776838B2 (ja) * 1988-10-05 1995-08-16 富士ゼロックス株式会社 電子写真感光体及び画像形成方法
DK1130017T3 (da) * 1990-11-30 2005-10-10 Otsuka Pharma Co Ltd Azolderivater og deres anvendelse som superoxidradikalinhibitorer
PH31245A (en) * 1991-10-30 1998-06-18 Janssen Pharmaceutica Nv 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
JPH06239858A (ja) * 1993-02-16 1994-08-30 Otsuka Pharmaceut Co Ltd 末梢血管拡張剤
US5475007A (en) * 1993-05-28 1995-12-12 The Regents Of The University Of California 1,2,3,4-tetrahydroquinoline-2,3,4-trione-3 or 4-oximes and the use thereof
JPH0733743A (ja) * 1993-07-22 1995-02-03 Kyorin Pharmaceut Co Ltd ２−アリール−４−キノリノール誘導体
JPH08295690A (ja) * 1995-04-26 1996-11-12 Tokuyama Corp クロメン化合物
JP2000511532A (ja) * 1996-05-20 2000-09-05 メルク エンド カンパニー インコーポレーテッド 性腺刺激ホルモン放出ホルモンのアンタゴニスト
WO1999003822A1 (en) 1997-07-18 1999-01-28 Georgetown University Bicyclic metabotropic glutamate receptor ligands
EP1037878A2 (en) 1997-11-21 2000-09-27 Nps Pharmaceuticals, Inc. Metabotropic glutamate receptor antagonists for treating central nervous system diseases
BR9913315A (pt) * 1998-08-27 2001-05-22 Pfizer Prod Inc Derivados de quinolin-2-ona úteis como agentes anticâncer
JP2000169450A (ja) 1998-09-30 2000-06-20 Kyorin Pharmaceut Co Ltd ６―アリ―ルキノリンカルボン酸誘導体とその付加塩及びそれらの製造方法
HU229404B1 (en) * 1998-12-23 2013-12-30 Janssen Pharmaceutica Nv 1,2-annelated quinoline derivatives
DE19859750A1 (de) 1998-12-23 2000-06-29 Henkel Kgaa Mittel zum Färben von keratinhaltigen Fasern
ID29584A (id) * 1999-02-11 2001-09-06 Pfizer Prod Inc Turunan-turunan kuinolin-2-on tersubstitusi heteroaril yang bermanfaat sebagai zat-zat anti kanker
CA2402096A1 (en) 2000-03-07 2001-09-13 Takeda Chemical Industries, Ltd. Vasoactive agents
EA007464B1 (ru) * 2000-10-02 2006-10-27 Янссен Фармацевтика Н.В. Антагонисты метаботропных рецепторов глутамата

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