NO312161B1 - 1,3,8-Triaza-spiro(4,5)dekan-4-on-derivater, fremgangsmåter ved fremstilling derav, anvendelse derav og medikamenterinneholdende disse derivater - Google Patents

1,3,8-Triaza-spiro(4,5)dekan-4-on-derivater, fremgangsmåter ved fremstilling derav, anvendelse derav og medikamenterinneholdende disse derivater Download PDF

Info

Publication number: NO312161B1
Authority: NO; Norway
Prior art keywords: phenyl; spiro; triaza; decan; lower alkyl
Prior art date: 1997-12-05

Application number

NO19985684A

Other languages

English (en)

Norwegian (no)

Other versions

NO985684L (no

NO985684D0 (no

Inventor

Geo Adam

Andrea Cesura

Guido Galley

Francois Jenck

Stephan Roever

Juergen Wichmann

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-05

Filing date

1998-12-04

Publication date

2002-04-02

1998-12-04 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1998-12-04 Publication of NO985684D0 publication Critical patent/NO985684D0/no

1999-06-07 Publication of NO985684L publication Critical patent/NO985684L/no

2002-04-02 Publication of NO312161B1 publication Critical patent/NO312161B1/no

Links

238000000034 method Methods 0.000 title claims description 99
238000002360 preparation method Methods 0.000 title claims description 7
239000003814 drug Substances 0.000 title claims description 6
229940079593 drug Drugs 0.000 title claims description 6
JRKPNHLSQGAUDY-UHFFFAOYSA-N 1,3,8-triazaspiro[4.5]decan-4-one Chemical class O=C1NCNC11CCNCC1 JRKPNHLSQGAUDY-UHFFFAOYSA-N 0.000 title description 2
150000001875 compounds Chemical class 0.000 claims description 168
239000000203 mixture Substances 0.000 claims description 81
239000001257 hydrogen Substances 0.000 claims description 35
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125000000217 alkyl group Chemical group 0.000 claims description 27
-1 cyanomethyl Chemical group 0.000 claims description 21
150000003839 salts Chemical class 0.000 claims description 18
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UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 14
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125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 13
PULGYDLMFSFVBL-SMFNREODSA-N nociceptin Chemical compound C([C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O)[C@@H](C)O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 PULGYDLMFSFVBL-SMFNREODSA-N 0.000 claims description 13
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125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 10
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208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
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GHRFRJDKSJJJFQ-UHFFFAOYSA-N 8-(1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalen-2-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Chemical compound C1CN(C2CC3CCCCC3CC2)CCC11C(=O)NCN1C1=CC=CC=C1 GHRFRJDKSJJJFQ-UHFFFAOYSA-N 0.000 claims description 5
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230000029936 alkylation Effects 0.000 claims description 2
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NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 claims description 2
BNRNAKTVFSZAFA-UHFFFAOYSA-N hydrindane Chemical group C1CCCC2CCCC21 BNRNAKTVFSZAFA-UHFFFAOYSA-N 0.000 claims description 2
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LVKCSZQWLOVUGB-UHFFFAOYSA-M magnesium;propane;bromide Chemical compound [Mg+2].[Br-].C[CH-]C LVKCSZQWLOVUGB-UHFFFAOYSA-M 0.000 description 1
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150000004681 metal hydrides Chemical class 0.000 description 1
AFVFQIVMOAPDHO-UHFFFAOYSA-M methanesulfonate group Chemical class CS(=O)(=O)[O-] AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 description 1
ZFRIZGKGVHDLOM-UHFFFAOYSA-N methyl 2-(8-cyclodecyl-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)acetate;hydrochloride Chemical compound Cl.C1CN(C2CCCCCCCCC2)CCC21C(=O)N(CC(=O)OC)CN2C1=CC=CC=C1 ZFRIZGKGVHDLOM-UHFFFAOYSA-N 0.000 description 1
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QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
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238000002731 protein assay Methods 0.000 description 1
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FEYUTRZPSFLEST-UHFFFAOYSA-N spiro[5.5]undecan-4-one Chemical compound C1C(=O)CCCC11CCCCC1 FEYUTRZPSFLEST-UHFFFAOYSA-N 0.000 description 1
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Classifications

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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- A61P25/08—Antiepileptics; Anticonvulsants
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Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
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Hospice & Palliative Care (AREA)
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Child & Adolescent Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
Color Printing (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

NO19985684A 1997-12-05 1998-12-04 1,3,8-Triaza-spiro(4,5)dekan-4-on-derivater, fremgangsmåter ved fremstilling derav, anvendelse derav og medikamenterinneholdende disse derivater NO312161B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP97121427		1997-12-05

Publications (3)

Publication Number	Publication Date
NO985684D0 NO985684D0 (no)	1998-12-04
NO985684L NO985684L (no)	1999-06-07
NO312161B1 true NO312161B1 (no)	2002-04-02

Family

ID=8227753

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19985684A NO312161B1 (no)	1997-12-05	1998-12-04	1,3,8-Triaza-spiro(4,5)dekan-4-on-derivater, fremgangsmåter ved fremstilling derav, anvendelse derav og medikamenterinneholdende disse derivater

Country Status (29)

Country	Link
US (1)	US6043366A (cs)
JP (1)	JP3366868B2 (cs)
KR (1)	KR19990062800A (cs)
CN (1)	CN1118467C (cs)
AR (1)	AR016428A1 (cs)
AT (1)	ATE212635T1 (cs)
AU (1)	AU744338B2 (cs)
BR (1)	BR9805297B1 (cs)
CA (1)	CA2255171C (cs)
CO (1)	CO4990965A1 (cs)
CZ (1)	CZ399698A3 (cs)
DE (1)	DE69803653T2 (cs)
DK (1)	DK0921125T3 (cs)
ES (1)	ES2170446T3 (cs)
HR (1)	HRP980613A2 (cs)
HU (1)	HUP9802807A3 (cs)
ID (1)	ID21413A (cs)
IL (1)	IL127399A0 (cs)
MA (1)	MA26573A1 (cs)
NO (1)	NO312161B1 (cs)
NZ (1)	NZ333159A (cs)
PE (1)	PE135299A1 (cs)
PL (1)	PL330062A1 (cs)
PT (1)	PT921125E (cs)
SG (1)	SG71173A1 (cs)
TR (1)	TR199802520A2 (cs)
TW (1)	TW408123B (cs)
YU (1)	YU55198A (cs)
ZA (1)	ZA9811128B (cs)

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ES2237047T3 (es) *	1998-10-23	2005-07-16	Pfizer Inc.	Compuestos de 1,3,8-triazaespiro(4,5)decanona como agonistas del receptor orl1.
AU1948601A (en) *	1999-12-06	2001-06-12	Euro-Celtique S.A.	Triazospiro compounds having nociceptin receptor affinity
JP4356453B2 (ja) *	2001-07-23	2009-11-04	萬有製薬株式会社	４−オキソイミダゾリジン−２−スピロピペリジン誘導体
DK1491212T3 (da)	2002-03-29	2012-10-29	Mitsubishi Tanabe Pharma Corp	Middel til behandling af søvnforstyrrelser
WO2004022558A2 (en) *	2002-09-09	2004-03-18	Janssen Pharmaceutica, N.V.	Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of orl-1 receptor mediated disorders
WO2004058727A1 (en) *	2002-12-20	2004-07-15	Bayer Pharmaceuticals Corporation	Substituted 3,5-dihydro-4h-imidazol-4-ones for the treatment of obesity
ZA200510329B (en) *	2003-05-23	2007-04-25	Zealand Pharma As	Triaza-spiro compounds as nociceptin analogues and uses thereof
BRPI0415833A (pt) *	2003-10-23	2007-01-02	Hoffmann La Roche	derivados de triaza-espiropiperidina para uso como inibidores de glyt-1 no tratamento de distúrbios neurológicos e neuropsiquiátricos
US20060178390A1 (en) *	2004-08-02	2006-08-10	Alfonzo Jordan	1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
AU2006226447B2 (en) *	2005-03-22	2009-07-16	F. Hoffmann-La Roche Ag	New salt and polymorphs of a DPP-IV inhibitor
WO2007149873A2 (en) *	2006-06-20	2007-12-27	Wyeth	Kv1.5 potassium channel inhibitors
CA2670858C (en) *	2006-11-28	2015-01-13	Janssen Pharmaceutica N.V.	Salts of 3-(3-amino-2-(r)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one
MX2009009355A (es)	2007-03-01	2009-09-11	Mitsubishi Tanabe Pharma Corp	Compuesto de bencimidazol y uso farmaceutico del mismo.
CN101679430B (zh) *	2007-04-09	2013-12-25	詹森药业有限公司	用于治疗焦虑和抑郁症的作为orl-1受体的配体的1,3,8-三取代-1,3,8-三氮杂-螺[4.5]癸-4-酮衍生物
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1998
- 1998-11-27 DE DE69803653T patent/DE69803653T2/de not_active Expired - Lifetime
- 1998-11-27 PT PT98122511T patent/PT921125E/pt unknown
- 1998-11-27 AT AT98122511T patent/ATE212635T1/de active
- 1998-11-27 DK DK98122511T patent/DK0921125T3/da active
- 1998-11-27 ES ES98122511T patent/ES2170446T3/es not_active Expired - Lifetime
- 1998-12-03 ID IDP981576A patent/ID21413A/id unknown
- 1998-12-03 CA CA002255171A patent/CA2255171C/en not_active Expired - Fee Related
- 1998-12-03 YU YU55198A patent/YU55198A/sh unknown
- 1998-12-03 NZ NZ333159A patent/NZ333159A/en unknown
- 1998-12-03 SG SG1998005141A patent/SG71173A1/en unknown
- 1998-12-03 AR ARP980106141A patent/AR016428A1/es active IP Right Grant
- 1998-12-03 US US09/204,184 patent/US6043366A/en not_active Expired - Fee Related
- 1998-12-03 PL PL98330062A patent/PL330062A1/xx unknown
- 1998-12-03 PE PE1998001176A patent/PE135299A1/es not_active Application Discontinuation
- 1998-12-04 TW TW087120132A patent/TW408123B/zh not_active IP Right Cessation
- 1998-12-04 HR HR97121427.5A patent/HRP980613A2/hr not_active Application Discontinuation
- 1998-12-04 CN CN98122759A patent/CN1118467C/zh not_active Expired - Fee Related
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- 1998-12-04 JP JP34527898A patent/JP3366868B2/ja not_active Expired - Fee Related
- 1998-12-04 CZ CZ983996A patent/CZ399698A3/cs unknown
- 1998-12-04 KR KR1019980053080A patent/KR19990062800A/ko not_active Ceased
- 1998-12-04 MA MA25369A patent/MA26573A1/fr unknown
- 1998-12-04 HU HU9802807A patent/HUP9802807A3/hu unknown
- 1998-12-04 NO NO19985684A patent/NO312161B1/no not_active IP Right Cessation
- 1998-12-04 CO CO98072457A patent/CO4990965A1/es unknown
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Also Published As

Publication number	Publication date
ES2170446T3 (es)	2002-08-01
BR9805297A (pt)	2000-02-01
HRP980613A2 (en)	1999-08-31
ATE212635T1 (de)	2002-02-15
MA26573A1 (fr)	2004-12-20
NZ333159A (en)	2000-06-23
SG71173A1 (en)	2000-03-21
CN1118467C (zh)	2003-08-20
BR9805297B1 (pt)	2010-07-13
PE135299A1 (es)	2000-01-18
TR199802520A3 (tr)	1999-06-21
NO985684L (no)	1999-06-07
AR016428A1 (es)	2001-07-04
CA2255171A1 (en)	1999-06-05
KR19990062800A (ko)	1999-07-26
DE69803653T2 (de)	2002-08-29
TR199802520A2 (xx)	1999-06-21
CO4990965A1 (es)	2000-12-26
ZA9811128B (en)	1999-06-07
DE69803653D1 (de)	2002-03-14
CA2255171C (en)	2009-09-29
ID21413A (id)	1999-06-10
HUP9802807A3 (en)	2000-01-28
TW408123B (en)	2000-10-11
HUP9802807A2 (hu)	1999-08-30
AU744338B2 (en)	2002-02-21
DK0921125T3 (da)	2002-05-13
CN1222521A (zh)	1999-07-14
PL330062A1 (en)	1999-06-07
US6043366A (en)	2000-03-28
JPH11228575A (ja)	1999-08-24
NO985684D0 (no)	1998-12-04
JP3366868B2 (ja)	2003-01-14
IL127399A0 (en)	1999-10-28
YU55198A (sh)	2001-12-26
CZ399698A3 (cs)	1999-06-16
HU9802807D0 (en)	1999-02-01
AU9608798A (en)	1999-06-24
PT921125E (pt)	2002-06-28

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EP0921125B1 (en)	2002-01-30	1,3,8-Triazaspiro[4,5]decan-4-on derivatives
NO312161B1 (no)	2002-04-02	1,3,8-Triaza-spiro(4,5)dekan-4-on-derivater, fremgangsmåter ved fremstilling derav, anvendelse derav og medikamenterinneholdende disse derivater
AU730147B2 (en)	2001-03-01	8-substituted-1,3,8-triaza-spiro(4.5)decan-4-on derivatives
TW201414735A (zh)	2014-04-16	三環喹啉及喹噁啉衍生物
AU743983B2 (en)	2002-02-14	Diaza-spiro (3,5)nonane derivatives
EP0963985B1 (en)	2003-03-12	Di-or triaza-spiro(4,5)decane derivatives
CA2274204C (en)	2009-09-15	Spiro[piperidine-4,1'-pyrrolo[3,4-c]pyrrole]
MXPA98010263A (en)	1999-09-20	Derivatives of 1,3,8-triaza-espiro [4,5] decan-4-
JP2010536919A (ja)	2010-12-02	ノルエピネフリン、セロトニンまたはドーパミン再取り込み阻害剤として有用な３−アザビシクロ（４．１．０）ヘプタン誘導体
NZ561905A (en)	2009-01-31	Tetracyclic compounds, a process for their preparation and pharmaceutical compositions containing them

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