IL127399A0 - 1,3,8-Triaza-spiro (4,5) decan-4-on derivatives - Google Patents

1,3,8-Triaza-spiro (4,5) decan-4-on derivatives

Info

Publication number: IL127399A0
Authority: IL; Israel
Prior art keywords: triaza; decan; spiro; derivatives
Prior art date: 1997-12-05

Application number

IL12739998A

Other languages

English (en)

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-05

Filing date

1998-12-04

Publication date

1999-10-28

1998-12-04 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1999-10-28 Publication of IL127399A0 publication Critical patent/IL127399A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Anesthesiology (AREA)
Addiction (AREA)
Child & Adolescent Psychology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
Color Printing (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

IL12739998A 1997-12-05 1998-12-04 1,3,8-Triaza-spiro (4,5) decan-4-on derivatives IL127399A0 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP97121427		1997-12-05

Publications (1)

Publication Number	Publication Date
IL127399A0 true IL127399A0 (en)	1999-10-28

Family

ID=8227753

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12739998A IL127399A0 (en)	1997-12-05	1998-12-04	1,3,8-Triaza-spiro (4,5) decan-4-on derivatives

Country Status (29)

Country	Link
US (1)	US6043366A (cs)
JP (1)	JP3366868B2 (cs)
KR (1)	KR19990062800A (cs)
CN (1)	CN1118467C (cs)
AR (1)	AR016428A1 (cs)
AT (1)	ATE212635T1 (cs)
AU (1)	AU744338B2 (cs)
BR (1)	BR9805297B1 (cs)
CA (1)	CA2255171C (cs)
CO (1)	CO4990965A1 (cs)
CZ (1)	CZ399698A3 (cs)
DE (1)	DE69803653T2 (cs)
DK (1)	DK0921125T3 (cs)
ES (1)	ES2170446T3 (cs)
HR (1)	HRP980613A2 (cs)
HU (1)	HUP9802807A3 (cs)
ID (1)	ID21413A (cs)
IL (1)	IL127399A0 (cs)
MA (1)	MA26573A1 (cs)
NO (1)	NO312161B1 (cs)
NZ (1)	NZ333159A (cs)
PE (1)	PE135299A1 (cs)
PL (1)	PL330062A1 (cs)
PT (1)	PT921125E (cs)
SG (1)	SG71173A1 (cs)
TR (1)	TR199802520A3 (cs)
TW (1)	TW408123B (cs)
YU (1)	YU55198A (cs)
ZA (1)	ZA9811128B (cs)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69923744T2 (de) *	1998-10-23	2006-02-23	Pfizer Inc.	1,3,8-Triazaspiro[4,5] decanon Verbindungen als orl1-receptor Agonisten
AU1948601A (en) *	1999-12-06	2001-06-12	Euro-Celtique S.A.	Triazospiro compounds having nociceptin receptor affinity
JP4356453B2 (ja) *	2001-07-23	2009-11-04	萬有製薬株式会社	４−オキソイミダゾリジン−２−スピロピペリジン誘導体
US7566728B2 (en) *	2002-03-29	2009-07-28	Mitsubishi Tanabe Pharma Corporation	Remedy for sleep disturbance
EA009369B1 (ru) *	2002-09-09	2007-12-28	Янссен Фармацевтика, Н.В.	Производные гидроксизамещенного 1,3,8-триазинспиро[4,5]декан-4-она, полезные для лечения расстройств, опосредованных orl-рецептором
AU2003299791A1 (en) *	2002-12-20	2004-07-22	Bayer Pharmaceuticals Corporation	Substituted 3,5-dihydro-4h-imidazol-4-ones for the treatment of obesity
US20080287478A1 (en) *	2003-05-23	2008-11-20	Lars Bo Laurenborg Hansen	Nociceptin Analogues and Uses Thereof
WO2005040166A1 (en) *	2003-10-23	2005-05-06	F.Hoffmann-La Roche Ag	Triaza-spiropiperidine derivatives for use as glyt-1 inhibitors in the treatment of neurological and neuropsychiatric disorders
US20060178390A1 (en) *	2004-08-02	2006-08-10	Alfonzo Jordan	1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
WO2006100181A2 (en) *	2005-03-22	2006-09-28	F. Hoffmann-La Roche Ag	New salt and polymorphs of a dpp-iv inhibitor
AU2007260984A1 (en) *	2006-06-20	2007-12-27	Wyeth	Kv1.5 potassium channel inhibitors
MX2009005641A (es) *	2006-11-28	2009-06-05	Janssen Pharmaceutica Nv	Sales de 3-(3-amino-2-(r)-hidroxi-propil)-1-(4-fluoro-fenil)-8-(8- metil-naftalen-1-ilmetil)-1,3,8-triaza-espiro[4,5]deca n-4-ona.
US8877779B2 (en) *	2007-03-01	2014-11-04	Mitsubishi Tanabe Pharma Corporation	Benzimidazole compound and pharmaceutical use thereof
CN101679430B (zh) *	2007-04-09	2013-12-25	詹森药业有限公司	用于治疗焦虑和抑郁症的作为orl-1受体的配体的1,3,8-三取代-1,3,8-三氮杂-螺[4.5]癸-4-酮衍生物
PA8801401A1 (es) *	2007-10-25	2009-05-15	Janssen Pharmaceutica Nv	Arilindenopirimidinas y su uso como adenosina a2a
TW201016675A (en) *	2008-09-16	2010-05-01	Mitsubishi Tanabe Pharma Corp	Crystalline benzoimidazole compound and salt thereof
US20100076003A1 (en) *	2008-09-19	2010-03-25	Kathleen Battista	5-oxazolidin-2-one substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful as orl-1 receptor modulators
WO2010037081A1 (en) *	2008-09-29	2010-04-01	Palatin Technologies, Inc.	Melanocortin receptor-specific spiro-piperidine compounds
AU2010260381B2 (en)	2009-06-16	2013-10-24	Merck Sharp & Dohme Corp.	Substituted -1,3,8-triazaspiro[4.5]decane-2,4-diones
WO2017005583A1 (en) *	2015-07-03	2017-01-12	F. Hoffmann-La Roche Ag	Triaza-spirodecanones as ddr1 inhibitors
WO2023198181A1 (en) *	2022-04-15	2023-10-19	The Chinese University Of Hong Kong	Carbobicyclic nucleosides for treatment of viral infection

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3155670A (en) *	1962-06-22	1964-11-03	Res Lab Dr C Janssen N V	1-oxo-2, 4, 8, triaza-spiro (4, 5) decanes
US3161644A (en) *	1962-06-22	1964-12-15	Res Lab Dr C Janssen N V	1-benzyl-4-substituted piperidines
US3155669A (en) *	1962-06-22	1964-11-03	Res Lab Dr C Janssen N V	2, 4, 8-triaza-spiro (4, 5) dec-2-enes
US3238216A (en) *	1963-06-20	1966-03-01	Res Lab Dr C Janssen N V	Substituted 1, 3, 8-triaza-spiro (4, 5) decanes
GB1486546A (en) *	1975-02-28	1977-09-21	Yoshitomo Pharma Ind Ltd	4,4-diphenyl-cyclohexylpiperidine compounds and analogues thereof
JPS51100084A (cs) *	1975-02-28	1976-09-03	Yoshitomi Pharmaceutical
JPS5212171A (en) *	1975-07-17	1977-01-29	Yoshitomi Pharmaceut Ind Ltd	Process for preparation of cyclohexane derivatives
JPS5934713B2 (ja) *	1976-01-05	1984-08-24	ウェルファイド株式会社	脂環式誘導体
US4076821A (en) *	1976-02-27	1978-02-28	Yoshitomi Pharmaceutical Industries, Ltd.	4,4-Diphenylcycloalkylpiperidines and psychotropic compositions thereof
GR73633B (cs) *	1980-03-10	1984-03-26	Janssen Pharmaceutica Nv
MA19091A1 (fr) *	1980-03-10	1981-10-01	Janssen Pharmaceutica Nv	Nouveaux derives de i-(4-aryl-cyclohexyl)piperidine .
US4329353A (en) *	1980-10-22	1982-05-11	Janssen Pharmaceutica, N.V.	1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof
EP0114787B1 (de) *	1983-01-25	1991-09-25	Ciba-Geigy Ag	Neue Peptidderivate
JPS6012357B2 (ja) *	1984-01-23	1985-04-01	吉富製薬株式会社	脂環式誘導体
CA2226058C (en) *	1997-01-30	2008-01-29	F. Hoffmann-La Roche Ag	8-substituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives

1998
- 1998-11-27 PT PT98122511T patent/PT921125E/pt unknown
- 1998-11-27 DE DE69803653T patent/DE69803653T2/de not_active Expired - Lifetime
- 1998-11-27 DK DK98122511T patent/DK0921125T3/da active
- 1998-11-27 AT AT98122511T patent/ATE212635T1/de active
- 1998-11-27 ES ES98122511T patent/ES2170446T3/es not_active Expired - Lifetime
- 1998-12-03 ID IDP981576A patent/ID21413A/id unknown
- 1998-12-03 US US09/204,184 patent/US6043366A/en not_active Expired - Fee Related
- 1998-12-03 NZ NZ333159A patent/NZ333159A/en unknown
- 1998-12-03 PE PE1998001176A patent/PE135299A1/es not_active Application Discontinuation
- 1998-12-03 YU YU55198A patent/YU55198A/sh unknown
- 1998-12-03 SG SG1998005141A patent/SG71173A1/en unknown
- 1998-12-03 AR ARP980106141A patent/AR016428A1/es active IP Right Grant
- 1998-12-03 PL PL98330062A patent/PL330062A1/xx unknown
- 1998-12-03 CA CA002255171A patent/CA2255171C/en not_active Expired - Fee Related
- 1998-12-04 CO CO98072457A patent/CO4990965A1/es unknown
- 1998-12-04 TR TR1998/02520A patent/TR199802520A3/tr unknown
- 1998-12-04 JP JP34527898A patent/JP3366868B2/ja not_active Expired - Fee Related
- 1998-12-04 BR BRPI9805297-7A patent/BR9805297B1/pt not_active IP Right Cessation
- 1998-12-04 TW TW087120132A patent/TW408123B/zh not_active IP Right Cessation
- 1998-12-04 HU HU9802807A patent/HUP9802807A3/hu unknown
- 1998-12-04 AU AU96087/98A patent/AU744338B2/en not_active Ceased
- 1998-12-04 CZ CZ983996A patent/CZ399698A3/cs unknown
- 1998-12-04 KR KR1019980053080A patent/KR19990062800A/ko not_active Ceased
- 1998-12-04 HR HR97121427.5A patent/HRP980613A2/hr not_active Application Discontinuation
- 1998-12-04 ZA ZA9811128A patent/ZA9811128B/xx unknown
- 1998-12-04 IL IL12739998A patent/IL127399A0/xx unknown
- 1998-12-04 MA MA25369A patent/MA26573A1/fr unknown
- 1998-12-04 NO NO19985684A patent/NO312161B1/no not_active IP Right Cessation
- 1998-12-04 CN CN98122759A patent/CN1118467C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES2170446T3 (es)	2002-08-01
DE69803653D1 (de)	2002-03-14
US6043366A (en)	2000-03-28
ATE212635T1 (de)	2002-02-15
JPH11228575A (ja)	1999-08-24
TR199802520A2 (xx)	1999-06-21
CA2255171A1 (en)	1999-06-05
HRP980613A2 (en)	1999-08-31
DK0921125T3 (da)	2002-05-13
TW408123B (en)	2000-10-11
BR9805297A (pt)	2000-02-01
SG71173A1 (en)	2000-03-21
AU744338B2 (en)	2002-02-21
PE135299A1 (es)	2000-01-18
YU55198A (sh)	2001-12-26
HUP9802807A2 (hu)	1999-08-30
HU9802807D0 (en)	1999-02-01
HUP9802807A3 (en)	2000-01-28
MA26573A1 (fr)	2004-12-20
CA2255171C (en)	2009-09-29
ID21413A (id)	1999-06-10
PT921125E (pt)	2002-06-28
AR016428A1 (es)	2001-07-04
KR19990062800A (ko)	1999-07-26
CO4990965A1 (es)	2000-12-26
AU9608798A (en)	1999-06-24
NZ333159A (en)	2000-06-23
PL330062A1 (en)	1999-06-07
DE69803653T2 (de)	2002-08-29
CZ399698A3 (cs)	1999-06-16
NO985684D0 (no)	1998-12-04
ZA9811128B (en)	1999-06-07
CN1222521A (zh)	1999-07-14
BR9805297B1 (pt)	2010-07-13
NO312161B1 (no)	2002-04-02
TR199802520A3 (tr)	1999-06-21
CN1118467C (zh)	2003-08-20
JP3366868B2 (ja)	2003-01-14
NO985684L (no)	1999-06-07

Publication	Publication Date	Title
HU9800138D0 (en)	1998-03-30	8-substituted-1,3,8-triaza-spiro [4,5]-decan-4-on derivatives
EG24081A (en)	2008-05-11	4-Substituted-9-deoxo-9a-aza-9a-homerythromycin derivatives
SI0921125T1 (en)	2002-04-30	1,3,8-Triazaspiro(4,5)decan-4-on derivatives
HUP0003642A3 (en)	2001-11-28	N-alkanoylphenylalanine derivatives
GB9702194D0 (en)	1997-03-26	Sulphonide derivatives
ZA987602B (en)	1999-05-04	N-alkanoylphenylalanine derivatives
PL334847A1 (en)	2000-03-27	Substituted 3-heterocyclyl-benzoyl derivatives
SI0891978T1 (en)	2002-06-30	5H-Thiazolo (3,2-a) pyrimidine derivatives
IL125226A0 (en)	1999-03-12	Heterocycle-condensed morphinoid derivatives (II)
IL127399A0 (en)	1999-10-28	1,3,8-Triaza-spiro (4,5) decan-4-on derivatives
HUP9801168A3 (en)	1999-11-29	Triazinylaminostilbene derivatives
AP9901650A0 (en)	1999-09-30	1,2, ,4-tetrahydro-benzofuro (3,2-c)pyridine derivatives
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IL132982A0 (en)	2001-03-19	Cis-disubstituted aminocycloalkyl-pyrrolidine derivatives
ZA982436B (en)	1999-09-23	Thiazolimine derivatives.
GB9715821D0 (en)	1997-10-01	Amidino-camptothecin derivatives
GB9725541D0 (en)	1998-02-04	Amino-benzothiazole derivatives
ZA98611B (en)	1998-08-17	Imino-aza-anthracyclinone derivatives
ZA983116B (en)	1998-10-21	Arylsecocholadiene derivatives
HRP970162A2 (en)	1998-04-30	1,25-dihydroxy-16,22,23-trisdehydro-cholecalciferol derivatives
ZA983168B (en)	1998-10-20	New naphthylpiperazine derivatives
IL131159A0 (en)	2001-01-28	4-Aminoethoxyindazole derivatives
GB9706753D0 (en)	1997-05-21	Aralkoxy-morphinan derivatives
SI1005445T1 (en)	2004-12-31	N-alkanoylphenylalanine derivatives
ZA983700B (en)	1998-11-24	1-galactose derivatives