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NO20084411L - Tetrahydro-pyrimidoazepiner som modulatorer av TRPVI - Google Patents

Tetrahydro-pyrimidoazepiner som modulatorer av TRPVI

Info

Publication number
NO20084411L
NO20084411L NO20084411A NO20084411A NO20084411L NO 20084411 L NO20084411 L NO 20084411L NO 20084411 A NO20084411 A NO 20084411A NO 20084411 A NO20084411 A NO 20084411A NO 20084411 L NO20084411 L NO 20084411L
Authority
NO
Norway
Prior art keywords
trpvi
modulators
compounds
tetrahydro
pyrimidoazepines
Prior art date
Application number
NO20084411A
Other languages
English (en)
Other versions
NO341676B1 (no
Inventor
Michael D Hack
Brett D Allison
Bryan James Branstetter
James Guy Breitenbucher
Natalie A Hawryluk
Alec D Lebsack
Kelly J Mcclure
Jeffrey E Merit
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO20084411L publication Critical patent/NO20084411L/no
Publication of NO341676B1 publication Critical patent/NO341676B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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  • Heart & Thoracic Surgery (AREA)
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Abstract

Visse tetrahydro-pyrimidoazepinforbindelser er beskrevet, som er anvendelig som. TRPVI -modulatorer. Slike forbindelser kan anvendes i farmasøytiske sammensetninger og fremgangsmåter for behandling av sykdomstilstander, forstyrrelser og tilstander mediert av TRPVI. Således kan forbindelsene administreres for å behandle for eksempel smerte, kløe, hoste, astma eller infiammatorisk tarmsykdom.
NO20084411A 2006-03-21 2008-10-21 Tetrahydro-pyrimidoazepiner som modulatorer av TRPVI NO341676B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78541506P 2006-03-21 2006-03-21
PCT/US2007/007166 WO2007109355A2 (en) 2006-03-21 2007-03-21 6,7,8, 9 -tetrahydro- 5h- pyrimido [4, 5-d] azepin-4-yl] -amine derivatives as modulators of trpvl for the treatment of pain

Publications (2)

Publication Number Publication Date
NO20084411L true NO20084411L (no) 2008-11-03
NO341676B1 NO341676B1 (no) 2017-12-18

Family

ID=38353855

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20084411A NO341676B1 (no) 2006-03-21 2008-10-21 Tetrahydro-pyrimidoazepiner som modulatorer av TRPVI

Country Status (30)

Country Link
US (3) US8673895B2 (no)
EP (1) EP2024368B1 (no)
JP (1) JP5232768B2 (no)
KR (1) KR101461376B1 (no)
CN (1) CN101448835B (no)
AR (1) AR059985A1 (no)
AU (1) AU2007227203B2 (no)
BR (1) BRPI0709034B1 (no)
CA (1) CA2646977C (no)
CR (1) CR10387A (no)
DK (1) DK2024368T3 (no)
EA (1) EA017069B1 (no)
EC (1) ECSP088807A (no)
ES (1) ES2474152T3 (no)
HR (1) HRP20140664T1 (no)
MX (1) MX2008012163A (no)
NI (1) NI200800253A (no)
NO (1) NO341676B1 (no)
NZ (1) NZ571343A (no)
PE (1) PE20080145A1 (no)
PL (1) PL2024368T3 (no)
PT (1) PT2024368E (no)
RS (1) RS53436B (no)
SG (1) SG177176A1 (no)
SI (1) SI2024368T1 (no)
TW (1) TWI440639B (no)
UA (1) UA92636C2 (no)
UY (1) UY30229A1 (no)
WO (1) WO2007109355A2 (no)
ZA (1) ZA200808975B (no)

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KR101447789B1 (ko) * 2009-11-12 2014-10-06 에프. 호프만-라 로슈 아게 Ｎ-7 치환된 퓨린 및 피라졸로피리미딘 화합물, 조성물 및 사용 방법
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CN102154494B (zh) * 2011-03-14 2013-01-02 中国人民解放军军事医学科学院基础医学研究所 一种用于儿童哮喘检测的标志物
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CN103641762A (zh) * 2013-12-18 2014-03-19 中国药科大学 一类trpv1/cox-2双重抑制剂、其制备方法及其制备镇痛药物的用途
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