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NO20082330L - Nye krystallinske polymorfe former av lerkanidipinhydroklorid og fremgangsmate for fremstilling derav - Google Patents

Nye krystallinske polymorfe former av lerkanidipinhydroklorid og fremgangsmate for fremstilling derav

Info

Publication number
NO20082330L
NO20082330L NO20082330A NO20082330A NO20082330L NO 20082330 L NO20082330 L NO 20082330L NO 20082330 A NO20082330 A NO 20082330A NO 20082330 A NO20082330 A NO 20082330A NO 20082330 L NO20082330 L NO 20082330L
Authority
NO
Norway
Prior art keywords
canidipine
clay
hydrochloride
processes
preparation
Prior art date
Application number
NO20082330A
Other languages
English (en)
Other versions
NO335651B1 (no
Inventor
Fausto Bonifacio
Gianluca De Iasi
Amedeo Leonardi
Francesco Campana
Original Assignee
Recordati Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11448245&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20082330(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Publication of NO20082330L publication Critical patent/NO20082330L/no
Application filed by Recordati Ireland Ltd filed Critical Recordati Ireland Ltd
Publication of NO335651B1 publication Critical patent/NO335651B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

Oppfinnelsen beskriver nye ubearbeidede lerkanidipinformer (A) og (B), nye lerkanidipinhydroklorid krystallinske former (I) og (II) oppnådd fra nevnte ubearbeidede former, farmasøytiske, antihypertensive sammensetninger som inneholder som aktivt middel minst en av lerkanidipinhydroklorid krystallinske former (I) og (II) og fremgangsmåter for anvendelse derav.
NO20082330A 2001-08-06 2008-05-22 Nye krystallinske polymorfe former av lerkanidipinhydroklorid og fremgangsmåte for fremstilling derav NO335651B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2001MI001726A ITMI20011726A1 (it) 2001-08-06 2001-08-06 Forme polimorfe della lercanidipina cloridrato
PCT/EP2002/008699 WO2003014084A1 (en) 2001-08-06 2002-08-05 Novel crystalline polymorphic forms of lercanidipine hydrochloride and process for their preparation

Publications (2)

Publication Number Publication Date
NO20082330L true NO20082330L (no) 2004-03-24
NO335651B1 NO335651B1 (no) 2015-01-19

Family

ID=11448245

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20040266A NO325541B1 (no) 2001-08-06 2004-01-20 Nye krystallinske polymorfe former av lerkanidipinhydroklorid og fremgangsmate for fremstilling derav
NO20082330A NO335651B1 (no) 2001-08-06 2008-05-22 Nye krystallinske polymorfe former av lerkanidipinhydroklorid og fremgangsmåte for fremstilling derav

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20040266A NO325541B1 (no) 2001-08-06 2004-01-20 Nye krystallinske polymorfe former av lerkanidipinhydroklorid og fremgangsmate for fremstilling derav

Country Status (35)

Country Link
EP (4) EP1600441B1 (no)
JP (1) JP2005504045A (no)
KR (3) KR100667687B1 (no)
CN (2) CN100448847C (no)
AP (1) AP1766A (no)
AR (1) AR037139A1 (no)
AT (2) ATE453624T1 (no)
AU (1) AU2002327924C1 (no)
BR (1) BR0211739A (no)
CY (2) CY1109711T1 (no)
DE (2) DE60206787T2 (no)
DK (3) DK2157083T3 (no)
EA (1) EA005673B1 (no)
EC (1) ECSP044973A (no)
ES (3) ES2212759T3 (no)
HR (1) HRP20040156B1 (no)
HU (1) HU229563B1 (no)
IL (3) IL164648A0 (no)
IT (1) ITMI20011726A1 (no)
MA (1) MA27133A1 (no)
ME (2) MEP2908A (no)
MX (1) MXPA04001069A (no)
NO (2) NO325541B1 (no)
NZ (2) NZ531558A (no)
OA (1) OA12648A (no)
PE (1) PE20030328A1 (no)
PL (1) PL216066B1 (no)
PT (2) PT1600441E (no)
RS (1) RS52161B (no)
SI (3) SI2157083T1 (no)
TN (1) TNSN04024A1 (no)
UA (1) UA82988C2 (no)
UY (1) UY27410A1 (no)
WO (1) WO2003014084A1 (no)
ZA (1) ZA200401806B (no)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20011726A1 (it) 2001-08-06 2003-02-06 Recordati Ind Chimica E Farma Forme polimorfe della lercanidipina cloridrato
AR043395A1 (es) * 2003-02-28 2005-07-27 Recordati Ireland Ltd Terapia de combinacion para la hipertension utilizando lercanidipina y un bloqueante de los receptores de angiotensina ii
CA2547657A1 (en) * 2003-12-01 2005-06-16 Lifecycle Pharma A/S Pharmaceutical compositions comprising lercanidipine
AR052918A1 (es) 2005-02-25 2007-04-11 Recordati Ireland Ltd Clorhidrato de lercanidipina amorfo
EP1940790B1 (en) 2005-09-16 2015-09-02 Glenmark Pharmaceuticals Limited Polymorphic form of lercanidipine hydrochloride and process for the preparation thereof
KR100821165B1 (ko) * 2006-03-10 2008-04-14 동우신테크 주식회사 레르카니디핀 염산염의 제조 방법
EP2114883A4 (en) * 2006-12-29 2010-09-08 Dongwoo Syntech Co Ltd PROCESS FOR THE PREPARATION OF LERCANIDIPINE HYDROCHLORIDE
WO2008107797A2 (en) * 2007-03-05 2008-09-12 Actavis Group Ptc Ehf Lercanidipine hydrochloride polymorphs and an improved process for preparation of 1,1,n-trimethyl-n-(3,3-diphenylpropyl)-2-aminoethyl acetoacetate
SI2585051T2 (sl) 2010-06-23 2020-07-31 Krka, D.D., Novo Mesto Farmacevtske oralne odmerne oblike,ki obsegajo lerkanidipin in enalapril in njune farmacevtsko sprejemljive soli
EP2444394A1 (en) 2010-10-21 2012-04-25 Alembic Pharmaceuticals Limited Process for the preparation of amorphous form of lercanidipine HCI
EA023996B1 (ru) 2010-12-24 2016-08-31 КРКА, д.д., НОВО МЕСТО Гомогенные фармацевтические пероральные лекарственные формы, содержащие лерканидипин и эналаприл или их фармацевтически приемлемые соли совместно с органической кислотой
US20140031557A1 (en) * 2011-04-18 2014-01-30 Hefeibeinie Medical Technology Company, Ltd. Method for purification of calcium channel blockers of dihydorpyridine type and preparation of nanoparticles thereof
CN102531999B (zh) * 2011-12-16 2014-02-26 华润赛科药业有限责任公司 无定形盐酸乐卡地平及其制备方法
CN102558032B (zh) * 2011-12-16 2014-02-26 华润赛科药业有限责任公司 一种无定形盐酸乐卡地平及其制备方法
CN102584682A (zh) * 2011-12-31 2012-07-18 苏州二叶制药有限公司 盐酸乐卡地平的制备方法
CN103497075B (zh) * 2013-09-25 2016-03-23 山西北化关铝化工有限公司 水悬浮延期药造型粉
CN109232389B (zh) * 2018-05-15 2021-10-08 迪嘉药业集团有限公司 一种小粒度硝苯地平的结晶制备方法
CN115353485B (zh) * 2022-07-26 2024-04-19 山西双雁药业有限公司 从硝苯地平母液中回收硝苯地平的方法及应用
CN115671066B (zh) * 2022-11-21 2024-07-02 安徽宏业药业有限公司 一种盐酸乐卡地平片及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US596139A (en) * 1897-12-28 Process of generating acetylene gas
GB8403866D0 (en) 1984-02-14 1984-03-21 Recordati Chem Pharm Diphenylalkylaminoalkyl esters
IT1275532B (it) * 1995-07-14 1997-08-07 Recordati Chem Pharm Uso di derivati 1,4-diidropiridinici per la prevenzione e la terapia della degenerazione aterosclerotica della parete arteriosa
IT1274480B (it) * 1995-05-12 1997-07-17 Recordati Chem Pharm Procedimento migliorato per la preparazione della lercanidipina cloridrato
US5696139A (en) * 1995-05-12 1997-12-09 Recordati S.A., Chemical And Pharmaceutical Company Use of S-enantiomers of 1,4-dihydropyridine derivatives for treating heart failure
US5912351A (en) 1995-05-12 1999-06-15 Recordati, S.A. Chemical And Pharmaceutical Company Anhydrous 1,4-Dihydropyridines and salts thereof
NZ520484A (en) 2000-02-16 2005-03-24 Neurogen Corp Substituted arylpyrazines that are modulators of CRF (corticotropin releasing factor) receptor and methods of treatment using them
ITMI20011726A1 (it) 2001-08-06 2003-02-06 Recordati Ind Chimica E Farma Forme polimorfe della lercanidipina cloridrato
US20040198789A1 (en) 2003-02-28 2004-10-07 Recordati Ireland Limited Lercanidipine/ARB/diuretic therapeutic combinations

Also Published As

Publication number Publication date
HK1086263A1 (en) 2006-09-15
RS52161B (sr) 2012-08-31
AU2002327924B2 (en) 2008-04-24
ES2212759T3 (es) 2006-04-16
AP1766A (en) 2007-08-10
CN100448847C (zh) 2009-01-07
CN101475524A (zh) 2009-07-08
IL153917A (en) 2005-11-20
NZ531558A (en) 2005-12-23
KR100626819B1 (ko) 2006-09-20
ES2212759T1 (es) 2004-08-01
EA200400280A1 (ru) 2004-08-26
ES2555213T3 (es) 2015-12-29
NZ541341A (en) 2007-02-23
EP1432683A1 (en) 2004-06-30
SI2157083T1 (sl) 2016-01-29
EP1600441A2 (en) 2005-11-30
PT1600441E (pt) 2010-01-20
KR20050043992A (ko) 2005-05-11
NO325541B1 (no) 2008-06-16
SI1432683T1 (sl) 2006-04-30
DK2157083T3 (en) 2015-11-02
KR100667687B1 (ko) 2007-01-12
PE20030328A1 (es) 2003-05-09
AU2002327924C1 (en) 2009-12-10
HK1140487A1 (en) 2010-10-15
KR20040030903A (ko) 2004-04-09
ZA200401806B (en) 2005-06-29
PL216066B1 (pl) 2014-02-28
HU229563B1 (en) 2014-02-28
EP2157083A3 (en) 2010-03-24
CN1538957A (zh) 2004-10-20
ATE453624T1 (de) 2010-01-15
ITMI20011726A1 (it) 2003-02-06
CN101475524B (zh) 2012-08-29
NO20040266L (no) 2004-03-24
ES2334678T3 (es) 2010-03-15
HUP0401163A2 (hu) 2004-09-28
IL153917A0 (en) 2003-07-31
MA27133A1 (fr) 2005-01-03
RS11304A (sr) 2007-02-05
JP2005504045A (ja) 2005-02-10
EP1600441A3 (en) 2005-12-07
HRP20040156B1 (en) 2012-03-31
CY1117051T1 (el) 2017-04-05
MEP2908A (en) 2010-10-10
HK1067123A1 (en) 2005-04-01
UY27410A1 (es) 2003-03-31
DE60234961D1 (de) 2010-02-11
EA005673B1 (ru) 2005-04-28
SI1600441T1 (sl) 2010-02-26
ATE307114T1 (de) 2005-11-15
DK1600441T3 (da) 2010-02-08
WO2003014084A1 (en) 2003-02-20
HRP20040156A2 (en) 2004-08-31
TNSN04024A1 (en) 2006-06-01
EP2157083B1 (en) 2015-09-30
ECSP044973A (es) 2004-06-28
EP2157083A2 (en) 2010-02-24
BR0211739A (pt) 2004-09-28
EP1432683B1 (en) 2005-10-19
DK1432683T3 (da) 2006-03-06
DE60206787T2 (de) 2006-07-13
EP2036890A1 (en) 2009-03-18
AP2004002989A0 (en) 2004-03-31
DE60206787D1 (de) 2006-03-02
IL164648A (en) 2007-02-11
EP1432683B9 (en) 2006-01-18
AR037139A1 (es) 2004-10-27
UA82988C2 (uk) 2008-06-10
NO335651B1 (no) 2015-01-19
PT2157083E (pt) 2016-01-22
KR20050111799A (ko) 2005-11-28
MXPA04001069A (es) 2005-02-17
IL164648A0 (en) 2005-12-18
HUP0401163A3 (en) 2009-04-28
CY1109711T1 (el) 2014-08-13
PL369522A1 (en) 2005-05-02
EP1600441B1 (en) 2009-12-30
ITMI20011726A0 (it) 2001-08-06
OA12648A (en) 2006-06-16
ME01525B (me) 2011-02-10

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