PE20030328A1 - Formas novedosas, crudas y cristalinas de clorhidrato de lercanidipina - Google Patents
Formas novedosas, crudas y cristalinas de clorhidrato de lercanidipinaInfo
- Publication number
- PE20030328A1 PE20030328A1 PE2002000715A PE2002000715A PE20030328A1 PE 20030328 A1 PE20030328 A1 PE 20030328A1 PE 2002000715 A PE2002000715 A PE 2002000715A PE 2002000715 A PE2002000715 A PE 2002000715A PE 20030328 A1 PE20030328 A1 PE 20030328A1
- Authority
- PE
- Peru
- Prior art keywords
- dimethyl
- refers
- compound
- melting point
- lercanidipine hydrochloride
- Prior art date
Links
- WMFYOYKPJLRMJI-UHFFFAOYSA-N Lercanidipine hydrochloride Chemical compound Cl.COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)CN(C)CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 WMFYOYKPJLRMJI-UHFFFAOYSA-N 0.000 title abstract 3
- 229960002162 lercanidipine hydrochloride Drugs 0.000 title abstract 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 4
- 238000002844 melting Methods 0.000 abstract 3
- 230000008018 melting Effects 0.000 abstract 3
- SSXYKBHZZRYLLY-UHFFFAOYSA-N 2-chloro-1,3-oxazole Chemical compound ClC1=NC=CO1 SSXYKBHZZRYLLY-UHFFFAOYSA-N 0.000 abstract 1
- -1 3,3-DIPHENYLPROPYL Chemical class 0.000 abstract 1
- JPXPPUOCSLMCHK-UHFFFAOYSA-N 5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid Chemical compound COC(=O)C1=C(C)NC(C)=C(C(O)=O)C1C1=CC=CC([N+]([O-])=O)=C1 JPXPPUOCSLMCHK-UHFFFAOYSA-N 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-PWCQTSIFSA-N Tritiated water Chemical compound [3H]O[3H] XLYOFNOQVPJJNP-PWCQTSIFSA-N 0.000 abstract 1
- 238000002441 X-ray diffraction Methods 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
SE REFIERE A CLORHIDRATO DE LERCANIDIPINA, (METIL 1,1-N-TRIMETIL-N-(3,3-DIFENILPROPIL)-2-AMINOETIL 1,4-DIHIDRO-2,6-DIMETIL-4-(3-NITROFENIL)PIRIDIN-3,5-DICARBOXILATO) CRUDO O SOLIDO DE: i)FORMA A CON PUNTO DE FUSION ENTRE 150°C Y 152°C, CON 3% Y 4% DE ACETATO DE ETILO; ii)FORMA B CON PUNTO DE FUSION ENTRE 131°C Y 135 °C, CON 0,3% Y 0,7% DE ACETATO DE ETILO. TAMBIEN SE REFIERE A METODOS PARA PRODUCIR FORMA A, ENTRE OTROS QUE COMPRENDE: a)REACCIONAR ACIDO 2,6-DIMETIL-5-METOXICARBONIL-4-(3-NITROFENIL)-1,4-DIHIDROPIRIDIN-3-CARBOXILICO CON CLORURO DE TIONILO Y CLORURO DE OXAZOLILO EN UN SOLVENTE DIPOLAR APROTICO Y SOLVENTE POLAR APROTICO PARA PRODUCIR CLORURO DE CARBONILO CORRESPONDIENTE; b)REACCIONAR IN SITU CLORURO DEL PRODUCTO CON ALCOHOL, 2-N-DIMETIL-N-(3,3-DIFENILPROPIL)-1-AMINO-2-PROPILICO PARA FORMAR EL COMPUESTO CRUDO A UNA TEMPERATURA DE -5°C Y 5°C; c)AISLAR, LAVAR CON AGUA, RECUPERAR EL COMPUESTO CRUDO DE FORMA A; ENTRE OTROS; iii)CLORHIDRATO DE LERCANIDIPINA CRISTALINO FORMA I CON UN PATRON DE RAYOS X. TAMBIEN SE REFIERE A FORMAS DE DOSIFICACION DE LIBERACION INMEDIATA O SOSTENIDA CON 0,1mg A 400 mg DEL COMPUESTO FORMA I CON PUNTO DE FUSION 197°C A 201°C, FORMA II CON PUNTO DE FUSION 207°C Y 211°C, SIENDO LA RELACION ENTRE FORMAS I Y II DE 1:9 Y 9:1. EL COMPUESTO ES ANTAGONISTA CALCICO DIHIDROPIRIDINICO LIPOFILICO CON ACTIVIDAD ANTIHIPERTENSIVA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001MI001726A ITMI20011726A1 (it) | 2001-08-06 | 2001-08-06 | Forme polimorfe della lercanidipina cloridrato |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030328A1 true PE20030328A1 (es) | 2003-05-09 |
Family
ID=11448245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000715A PE20030328A1 (es) | 2001-08-06 | 2002-08-06 | Formas novedosas, crudas y cristalinas de clorhidrato de lercanidipina |
Country Status (35)
| Country | Link |
|---|---|
| EP (4) | EP1432683B9 (es) |
| JP (1) | JP2005504045A (es) |
| KR (3) | KR100626819B1 (es) |
| CN (2) | CN101475524B (es) |
| AP (1) | AP1766A (es) |
| AR (1) | AR037139A1 (es) |
| AT (2) | ATE453624T1 (es) |
| AU (1) | AU2002327924C1 (es) |
| BR (1) | BR0211739A (es) |
| CY (2) | CY1109711T1 (es) |
| DE (2) | DE60206787T2 (es) |
| DK (3) | DK2157083T3 (es) |
| EA (1) | EA005673B1 (es) |
| EC (1) | ECSP044973A (es) |
| ES (3) | ES2334678T3 (es) |
| HR (1) | HRP20040156B1 (es) |
| HU (1) | HU229563B1 (es) |
| IL (3) | IL164648A0 (es) |
| IT (1) | ITMI20011726A1 (es) |
| MA (1) | MA27133A1 (es) |
| ME (2) | MEP2908A (es) |
| MX (1) | MXPA04001069A (es) |
| NO (2) | NO325541B1 (es) |
| NZ (2) | NZ541341A (es) |
| OA (1) | OA12648A (es) |
| PE (1) | PE20030328A1 (es) |
| PL (1) | PL216066B1 (es) |
| PT (2) | PT1600441E (es) |
| RS (1) | RS52161B (es) |
| SI (3) | SI1432683T1 (es) |
| TN (1) | TNSN04024A1 (es) |
| UA (1) | UA82988C2 (es) |
| UY (1) | UY27410A1 (es) |
| WO (1) | WO2003014084A1 (es) |
| ZA (1) | ZA200401806B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20011726A1 (it) | 2001-08-06 | 2003-02-06 | Recordati Ind Chimica E Farma | Forme polimorfe della lercanidipina cloridrato |
| AR043395A1 (es) * | 2003-02-28 | 2005-07-27 | Recordati Ireland Ltd | Terapia de combinacion para la hipertension utilizando lercanidipina y un bloqueante de los receptores de angiotensina ii |
| AU2004294674B2 (en) * | 2003-12-01 | 2009-02-26 | Recordati Ireland Limited | Pharmaceutical compositions comprising lercanidipine |
| AR052918A1 (es) | 2005-02-25 | 2007-04-11 | Recordati Ireland Ltd | Clorhidrato de lercanidipina amorfo |
| US8097729B2 (en) | 2005-09-16 | 2012-01-17 | Glenmark Generics Ltd. | Polymorphic form of lercanidipine hydrochloride and process for the preparation thereof |
| KR100821165B1 (ko) * | 2006-03-10 | 2008-04-14 | 동우신테크 주식회사 | 레르카니디핀 염산염의 제조 방법 |
| EP2114883A4 (en) * | 2006-12-29 | 2010-09-08 | Dongwoo Syntech Co Ltd | PROCESS FOR THE PREPARATION OF LERCANIDIPINE HYDROCHLORIDE |
| EP2121575A2 (en) * | 2007-03-05 | 2009-11-25 | Actavis Group PTC EHF | Lercanidipine hydrochloride polymorphs and an improved process for preparation of 1,1,n-trimethyl-n-(3,3-diphenylpropyl)-2-aminoethyl acetoacetate |
| WO2011161223A2 (en) | 2010-06-23 | 2011-12-29 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Pharmaceutical oral dosage forms comprising lercanidipine and enalapril and their pharmaceutically acceptable salts |
| EP2444394A1 (en) | 2010-10-21 | 2012-04-25 | Alembic Pharmaceuticals Limited | Process for the preparation of amorphous form of lercanidipine HCI |
| EA023996B1 (ru) | 2010-12-24 | 2016-08-31 | КРКА, д.д., НОВО МЕСТО | Гомогенные фармацевтические пероральные лекарственные формы, содержащие лерканидипин и эналаприл или их фармацевтически приемлемые соли совместно с органической кислотой |
| EP2700632A4 (en) * | 2011-04-18 | 2014-09-03 | Hefei Beini Medical Technology Company Ltd | METHOD FOR CLEANING DIHYDROPYRIDINE CALCIUM CHANNEL BLOCKERS AND PRODUCING NANOPARTICLES THEREFOR |
| CN102531999B (zh) * | 2011-12-16 | 2014-02-26 | 华润赛科药业有限责任公司 | 无定形盐酸乐卡地平及其制备方法 |
| CN102558032B (zh) * | 2011-12-16 | 2014-02-26 | 华润赛科药业有限责任公司 | 一种无定形盐酸乐卡地平及其制备方法 |
| CN102584682A (zh) * | 2011-12-31 | 2012-07-18 | 苏州二叶制药有限公司 | 盐酸乐卡地平的制备方法 |
| CN103497075B (zh) * | 2013-09-25 | 2016-03-23 | 山西北化关铝化工有限公司 | 水悬浮延期药造型粉 |
| CN109232389B (zh) * | 2018-05-15 | 2021-10-08 | 迪嘉药业集团有限公司 | 一种小粒度硝苯地平的结晶制备方法 |
| CN115353485B (zh) * | 2022-07-26 | 2024-04-19 | 山西双雁药业有限公司 | 从硝苯地平母液中回收硝苯地平的方法及应用 |
| CN115671066B (zh) * | 2022-11-21 | 2024-07-02 | 安徽宏业药业有限公司 | 一种盐酸乐卡地平片及其制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US596139A (en) * | 1897-12-28 | Process of generating acetylene gas | ||
| GB8403866D0 (en) | 1984-02-14 | 1984-03-21 | Recordati Chem Pharm | Diphenylalkylaminoalkyl esters |
| US5696139A (en) * | 1995-05-12 | 1997-12-09 | Recordati S.A., Chemical And Pharmaceutical Company | Use of S-enantiomers of 1,4-dihydropyridine derivatives for treating heart failure |
| IT1275532B (it) * | 1995-07-14 | 1997-08-07 | Recordati Chem Pharm | Uso di derivati 1,4-diidropiridinici per la prevenzione e la terapia della degenerazione aterosclerotica della parete arteriosa |
| IT1274480B (it) * | 1995-05-12 | 1997-07-17 | Recordati Chem Pharm | Procedimento migliorato per la preparazione della lercanidipina cloridrato |
| US5912351A (en) | 1995-05-12 | 1999-06-15 | Recordati, S.A. Chemical And Pharmaceutical Company | Anhydrous 1,4-Dihydropyridines and salts thereof |
| KR20030031886A (ko) | 2000-02-16 | 2003-04-23 | 뉴로젠 코포레이션 | 치환된 아릴피라진 |
| ITMI20011726A1 (it) | 2001-08-06 | 2003-02-06 | Recordati Ind Chimica E Farma | Forme polimorfe della lercanidipina cloridrato |
| US20040198789A1 (en) | 2003-02-28 | 2004-10-07 | Recordati Ireland Limited | Lercanidipine/ARB/diuretic therapeutic combinations |
-
2001
- 2001-08-06 IT IT2001MI001726A patent/ITMI20011726A1/it unknown
-
2002
- 2002-05-08 UA UA2004031657A patent/UA82988C2/uk unknown
- 2002-08-02 AR ARP020102958A patent/AR037139A1/es unknown
- 2002-08-05 CN CN2008101812364A patent/CN101475524B/zh not_active Expired - Lifetime
- 2002-08-05 KR KR1020057021508A patent/KR100626819B1/ko not_active Expired - Fee Related
- 2002-08-05 HR HR20040156A patent/HRP20040156B1/xx not_active IP Right Cessation
- 2002-08-05 ES ES05106264T patent/ES2334678T3/es not_active Expired - Lifetime
- 2002-08-05 AU AU2002327924A patent/AU2002327924C1/en not_active Expired
- 2002-08-05 ES ES02762428T patent/ES2212759T3/es not_active Expired - Lifetime
- 2002-08-05 ME MEP-29/08A patent/MEP2908A/xx unknown
- 2002-08-05 DK DK09174609.9T patent/DK2157083T3/en active
- 2002-08-05 IL IL16464802A patent/IL164648A0/xx active IP Right Grant
- 2002-08-05 CN CNB028154134A patent/CN100448847C/zh not_active Expired - Lifetime
- 2002-08-05 JP JP2003519034A patent/JP2005504045A/ja active Pending
- 2002-08-05 RS YU11304A patent/RS52161B/sr unknown
- 2002-08-05 PT PT05106264T patent/PT1600441E/pt unknown
- 2002-08-05 AT AT05106264T patent/ATE453624T1/de active
- 2002-08-05 PL PL369522A patent/PL216066B1/pl unknown
- 2002-08-05 SI SI200230250T patent/SI1432683T1/sl unknown
- 2002-08-05 WO PCT/EP2002/008699 patent/WO2003014084A1/en not_active Ceased
- 2002-08-05 SI SI200231065T patent/SI2157083T1/sl unknown
- 2002-08-05 BR BR0211739-8A patent/BR0211739A/pt not_active Application Discontinuation
- 2002-08-05 AT AT02762428T patent/ATE307114T1/de active
- 2002-08-05 PT PT91746099T patent/PT2157083E/pt unknown
- 2002-08-05 ME MEP-2008-29A patent/ME01525B/me unknown
- 2002-08-05 EP EP02762428A patent/EP1432683B9/en not_active Expired - Lifetime
- 2002-08-05 EP EP08019093A patent/EP2036890A1/en not_active Withdrawn
- 2002-08-05 DK DK02762428T patent/DK1432683T3/da active
- 2002-08-05 KR KR1020057006786A patent/KR20050043992A/ko not_active Ceased
- 2002-08-05 EP EP09174609.9A patent/EP2157083B1/en not_active Expired - Lifetime
- 2002-08-05 HU HU0401163A patent/HU229563B1/hu unknown
- 2002-08-05 EP EP05106264A patent/EP1600441B1/en not_active Expired - Lifetime
- 2002-08-05 KR KR1020047001558A patent/KR100667687B1/ko not_active Expired - Fee Related
- 2002-08-05 NZ NZ541341A patent/NZ541341A/en not_active IP Right Cessation
- 2002-08-05 DE DE60206787T patent/DE60206787T2/de not_active Expired - Lifetime
- 2002-08-05 EA EA200400280A patent/EA005673B1/ru unknown
- 2002-08-05 AP APAP/P/2004/002989A patent/AP1766A/en active
- 2002-08-05 DE DE60234961T patent/DE60234961D1/de not_active Expired - Lifetime
- 2002-08-05 SI SI200230871T patent/SI1600441T1/sl unknown
- 2002-08-05 OA OA1200400033A patent/OA12648A/en unknown
- 2002-08-05 IL IL15391702A patent/IL153917A/xx active IP Right Grant
- 2002-08-05 DK DK05106264.4T patent/DK1600441T3/da active
- 2002-08-05 ES ES09174609.9T patent/ES2555213T3/es not_active Expired - Lifetime
- 2002-08-05 NZ NZ531558A patent/NZ531558A/en not_active IP Right Cessation
- 2002-08-05 MX MXPA04001069A patent/MXPA04001069A/es active IP Right Grant
- 2002-08-06 UY UY27410A patent/UY27410A1/es unknown
- 2002-08-06 PE PE2002000715A patent/PE20030328A1/es not_active Application Discontinuation
-
2004
- 2004-01-20 NO NO20040266A patent/NO325541B1/no not_active IP Right Cessation
- 2004-02-05 TN TNP2004000024A patent/TNSN04024A1/en unknown
- 2004-02-06 EC EC2004004973A patent/ECSP044973A/es unknown
- 2004-02-06 MA MA27517A patent/MA27133A1/fr unknown
- 2004-03-04 ZA ZA2004/01806A patent/ZA200401806B/en unknown
- 2004-10-17 IL IL164648A patent/IL164648A/en not_active IP Right Cessation
-
2008
- 2008-05-22 NO NO20082330A patent/NO335651B1/no not_active IP Right Cessation
-
2010
- 2010-01-05 CY CY20101100011T patent/CY1109711T1/el unknown
-
2015
- 2015-12-10 CY CY20151101129T patent/CY1117051T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |