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NO20082594L - Pyrimidinylbenzotiofenforbindelser - Google Patents

Pyrimidinylbenzotiofenforbindelser

Info

Publication number
NO20082594L
NO20082594L NO20082594A NO20082594A NO20082594L NO 20082594 L NO20082594 L NO 20082594L NO 20082594 A NO20082594 A NO 20082594A NO 20082594 A NO20082594 A NO 20082594A NO 20082594 L NO20082594 L NO 20082594L
Authority
NO
Norway
Prior art keywords
pyrimidinylbenzotiofenforbindelser
cancer
useful
formula
treatment
Prior art date
Application number
NO20082594A
Other languages
English (en)
Norwegian (no)
Inventor
Chuan Shih
Ho-Shen Lin
Michael Enrico Richett
Karl Robert Dahnke
Q May Wang
Bo Zhang
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO20082594L publication Critical patent/NO20082594L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO20082594A 2005-11-18 2008-06-10 Pyrimidinylbenzotiofenforbindelser NO20082594L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73809705P 2005-11-18 2005-11-18
PCT/US2006/060911 WO2007092095A2 (fr) 2005-11-18 2006-11-15 Composes de pyrimidinyl benzothiophene

Publications (1)

Publication Number Publication Date
NO20082594L true NO20082594L (no) 2008-06-10

Family

ID=38345605

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20082594A NO20082594L (no) 2005-11-18 2008-06-10 Pyrimidinylbenzotiofenforbindelser

Country Status (27)

Country Link
US (1) US7547691B2 (fr)
EP (1) EP1989200B1 (fr)
JP (1) JP2009516697A (fr)
KR (1) KR100990771B1 (fr)
CN (1) CN101309918B (fr)
AR (1) AR057911A1 (fr)
AT (1) ATE437873T1 (fr)
AU (1) AU2006337626B2 (fr)
BR (1) BRPI0618245A2 (fr)
CA (1) CA2629336A1 (fr)
CR (1) CR9947A (fr)
DE (1) DE602006008187D1 (fr)
DK (1) DK1989200T3 (fr)
EA (1) EA014426B1 (fr)
EC (1) ECSP088456A (fr)
ES (1) ES2329085T3 (fr)
IL (1) IL190489A0 (fr)
MA (1) MA30053B1 (fr)
NO (1) NO20082594L (fr)
PE (1) PE20070833A1 (fr)
PL (1) PL1989200T3 (fr)
PT (1) PT1989200E (fr)
SI (1) SI1989200T1 (fr)
TN (1) TNSN08227A1 (fr)
TW (1) TW200800201A (fr)
WO (1) WO2007092095A2 (fr)
ZA (1) ZA200803940B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2007752E (pt) 2006-03-31 2010-10-18 Janssen Pharmaceutica Nv Benzoimidazol-2-il pirimidinas e pirazinas como moduladores do receptor de histamina h4
US20080021026A1 (en) * 2006-07-20 2008-01-24 Mehmet Kahraman Benzothiophene inhibitors of rho kinase
HRP20100641T1 (hr) * 2006-12-21 2010-12-31 Eli Lilly And Company Imidazolidinonilaminopirimidinski spojevi za liječenje raka
EP2125793B1 (fr) * 2006-12-21 2010-09-01 Eli Lilly & Company Composés imidazolidinonyl aminopyrimidine pour le traitement du cancer
CN101679395B (zh) 2007-05-16 2012-06-13 伊莱利利公司 三唑基氨基嘧啶化合物
CA2687474A1 (fr) 2007-05-16 2008-11-27 Eli Lilly And Company Composes triazolyl aminopyrimidine
US9371311B2 (en) 2008-06-30 2016-06-21 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine derivatives
PE20110163A1 (es) 2008-06-30 2011-03-28 Janssen Pharmaceutica Nv Proceso para la preparacion de derivados de pirimidina sustituidos
KR101123178B1 (ko) * 2009-04-09 2012-06-13 (주)에스메디 2-아릴벤조싸이오펜 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 퇴행성 뇌질환의 진단 또는 치료용 약학적 조성물
KR20120059558A (ko) 2009-08-19 2012-06-08 암비트 바이오사이언시즈 코포레이션 바이아릴 화합물 및 이의 사용 방법
BR112012027542A2 (pt) 2010-04-27 2019-09-24 Hutchison Medipharma Ltd compostos de indol de pirimidinil indol
US20140194383A1 (en) 2011-04-07 2014-07-10 Cornell University Monomers capable of dimerizing in an aqueous solution, and methods of using same
US9245773B2 (en) 2011-09-02 2016-01-26 Taiwan Semiconductor Manufacturing Company, Ltd. Semiconductor device packaging methods and structures thereof
CN103159742B (zh) * 2011-12-16 2015-08-12 北京韩美药品有限公司 5-氯嘧啶类化合物及其作为egfr酪氨酸激酶抑制剂的应用
AU2013216935C1 (en) 2012-02-08 2017-12-14 John Emmerson Campbell Heteroaryl compounds and methods of use thereof
UY35464A (es) 2013-03-15 2014-10-31 Araxes Pharma Llc Inhibidores covalentes de kras g12c.
JO3805B1 (ar) 2013-10-10 2021-01-31 Araxes Pharma Llc مثبطات كراس جي12سي
CN105085434B (zh) * 2014-05-09 2018-02-09 上海特化医药科技有限公司 硫乙拉嗪或其中间体的制备方法
US9796699B2 (en) 2015-11-03 2017-10-24 Janssen Pharmaceutica Nv Substituted 2-[3-(1-methyl-piperidin-4-yl)-propylamino]-pyrimidine-5-carboxylic acids and amides and methods of making the same
HUE070203T2 (hu) 2016-07-29 2025-05-28 Sumitomo Pharma America Inc Vegyületek és készítmények és alkalmazásaik
AU2017301767A1 (en) 2016-07-29 2019-02-14 Pgi Drug Discovery Llc Compounds and compositions and uses thereof
WO2018140512A1 (fr) 2017-01-26 2018-08-02 Araxes Pharma Llc Composés benzohétéroaromatiques bicycliques fusionnés et leurs procédés d'utilisation
EP3573970A1 (fr) 2017-01-26 2019-12-04 Araxes Pharma LLC Dérivés de 1-(6-(3-hydroxynaphtalen-1-yl)quinazolin-2-yl)azétidin-1-yl)prop-2-en-1-one et composés similaires utilisés en tant qu'inhibiteurs de kras g12c pour le traitement du cancer
EP3573964A1 (fr) * 2017-01-26 2019-12-04 Araxes Pharma LLC Composés à base de benzothiophène et de benzothiazole et leurs procédés d'utilisation
US11279689B2 (en) 2017-01-26 2022-03-22 Araxes Pharma Llc 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1 yl)prop-2-en-1-one derivatives and similar compounds as KRAS G12C modulators for treating cancer
MX2019013954A (es) 2017-05-25 2020-08-31 Araxes Pharma Llc Inhibidores covalentes de kras.
JP2020521740A (ja) 2017-05-25 2020-07-27 アラクセス ファーマ エルエルシー 変異体ｋｒａｓ、ｈｒａｓまたはｎｒａｓの調節因子としてのキナゾリン誘導体
AU2018312559B2 (en) 2017-08-02 2022-06-02 Pgi Drug Discovery Llc Isochroman compounds and uses thereof
KR20210045998A (ko) 2018-08-01 2021-04-27 아락세스 파마 엘엘씨 헤테로사이클릭 스피로 화합물 및 암 치료를 위한 그의 사용 방법
KR20210139376A (ko) 2019-03-14 2021-11-22 선오비온 파마슈티컬스 인코포레이티드 이소크로마닐 화합물의 염, 및 이의 결정성 형태, 제조방법, 치료 용도 및 약제학적 조성물

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3752589A (en) * 1988-05-16 1989-12-12 Georgia State University Research Foundation, Inc. Nucleic acid interacting unfused heteropolycyclic compounds
GB0308466D0 (en) * 2003-04-11 2003-05-21 Novartis Ag Organic compounds
CA2590939C (fr) * 2004-12-17 2011-10-18 Amgen Inc. Composes d'aminopyrimidine et procedes d'utilisation correspondants

Also Published As

Publication number Publication date
DE602006008187D1 (de) 2009-09-10
JP2009516697A (ja) 2009-04-23
US7547691B2 (en) 2009-06-16
AU2006337626A8 (en) 2008-06-19
SI1989200T1 (sl) 2009-12-31
WO2007092095A2 (fr) 2007-08-16
AU2006337626A1 (en) 2007-08-16
CA2629336A1 (fr) 2007-08-16
EP1989200A2 (fr) 2008-11-12
WO2007092095A3 (fr) 2007-11-08
ZA200803940B (en) 2009-09-30
US20080306082A1 (en) 2008-12-11
EP1989200B1 (fr) 2009-07-29
MA30053B1 (fr) 2008-12-01
EA014426B1 (ru) 2010-12-30
PL1989200T3 (pl) 2009-12-31
ECSP088456A (es) 2008-06-30
CN101309918B (zh) 2010-12-29
TW200800201A (en) 2008-01-01
KR100990771B1 (ko) 2010-10-29
AU2006337626B2 (en) 2012-03-22
AR057911A1 (es) 2007-12-26
BRPI0618245A2 (pt) 2011-08-23
CR9947A (es) 2008-11-28
ATE437873T1 (de) 2009-08-15
PE20070833A1 (es) 2007-08-27
TNSN08227A1 (en) 2009-10-30
DK1989200T3 (da) 2009-11-09
KR20080059451A (ko) 2008-06-27
ES2329085T3 (es) 2009-11-20
IL190489A0 (en) 2008-11-03
CN101309918A (zh) 2008-11-19
EA200801362A1 (ru) 2009-02-27
PT1989200E (pt) 2009-10-12

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Legal Events

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