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EA200701815A1 - 6-гетероарил-1,2,3,4,4а,10в-гексагидрофенантридины в качестве pde-4 ингибиторов для лечения воспалительных заболеваний - Google Patents

6-гетероарил-1,2,3,4,4а,10в-гексагидрофенантридины в качестве pde-4 ингибиторов для лечения воспалительных заболеваний

Info

Publication number
EA200701815A1
EA200701815A1 EA200701815A EA200701815A EA200701815A1 EA 200701815 A1 EA200701815 A1 EA 200701815A1 EA 200701815 A EA200701815 A EA 200701815A EA 200701815 A EA200701815 A EA 200701815A EA 200701815 A1 EA200701815 A1 EA 200701815A1
Authority
EA
Eurasian Patent Office
Prior art keywords
inhibitors
hexagidrophenanthridine
heteroaril
pde
treatment
Prior art date
Application number
EA200701815A
Other languages
English (en)
Inventor
Ульрих Каутц
Беате Шмидт
Дитер Флокерци
Мария Виттория Кеса
Армин Хатцельманн
Кристоф Цитт
Андреа Вользен
Дегенхард Маркс
Ханс-Петер Клей
Original Assignee
Никомед Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Никомед Гмбх filed Critical Никомед Гмбх
Publication of EA200701815A1 publication Critical patent/EA200701815A1/ru

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/02—Nasal agents, e.g. decongestants
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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Otolaryngology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
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  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
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Abstract

Предложены соединения формулы I, в которой R1, R2, R3, R31, R4, R5, R51 и Har имеют значения, указанные в описании, являющиеся новыми эффективными PDE4 ингибиторами.
EA200701815A 2005-03-02 2006-03-01 6-гетероарил-1,2,3,4,4а,10в-гексагидрофенантридины в качестве pde-4 ингибиторов для лечения воспалительных заболеваний EA200701815A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05101589 2005-03-02
PCT/EP2006/060370 WO2006092417A1 (en) 2005-03-02 2006-03-01 6 -heteroaryl-1, 2, 3,4,4a, 1ob-hexahydro-phenanthridines as pde-4 inhibitors for the treatment of inflammatory disorders

Publications (1)

Publication Number Publication Date
EA200701815A1 true EA200701815A1 (ru) 2008-02-28

Family

ID=34938858

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200701815A EA200701815A1 (ru) 2005-03-02 2006-03-01 6-гетероарил-1,2,3,4,4а,10в-гексагидрофенантридины в качестве pde-4 ингибиторов для лечения воспалительных заболеваний

Country Status (7)

Country Link
US (1) US20080167316A1 (ru)
EP (1) EP1856092A1 (ru)
JP (1) JP2008531654A (ru)
AU (1) AU2006219862A1 (ru)
CA (1) CA2598858A1 (ru)
EA (1) EA200701815A1 (ru)
WO (1) WO2006092417A1 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
WO2005087745A1 (en) * 2004-03-10 2005-09-22 Altana Pharma Ag Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors
EP3763367A1 (en) 2012-12-06 2021-01-13 Celgene Quanticel Research, Inc. Pyridine-pyrazole derivatives as histone demethylase inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59708265D1 (de) * 1996-03-26 2002-10-24 Altana Pharma Ag Neue in 6-position substituierte phenanthridine
AU2289400A (en) * 1999-01-15 2000-08-01 Byk Gulden Lomberg Chemische Fabrik Gmbh 6-arylphenanthridines with pde-iv inhibiting activity
AU2001283935B2 (en) * 2000-07-14 2006-07-13 Altana Pharma Ag Novel 6-heteroarylphenanthridines
BRPI0508321B1 (pt) * 2004-03-03 2018-02-06 Takeda Gmbh Hidróxi-6-heteroarilfenantridinas, seu uso e composições farmacêuticas que as compreende

Also Published As

Publication number Publication date
CA2598858A1 (en) 2006-09-08
JP2008531654A (ja) 2008-08-14
WO2006092417A1 (en) 2006-09-08
US20080167316A1 (en) 2008-07-10
EP1856092A1 (en) 2007-11-21
AU2006219862A1 (en) 2006-09-08

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