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NO20081008L - Antibakterielle kinolinderivater - Google Patents

Antibakterielle kinolinderivater

Info

Publication number
NO20081008L
NO20081008L NO20081008A NO20081008A NO20081008L NO 20081008 L NO20081008 L NO 20081008L NO 20081008 A NO20081008 A NO 20081008A NO 20081008 A NO20081008 A NO 20081008A NO 20081008 L NO20081008 L NO 20081008L
Authority
NO
Norway
Prior art keywords
compounds
required compounds
pharmaceutically acceptable
quinoline derivatives
forms
Prior art date
Application number
NO20081008A
Other languages
English (en)
Other versions
NO341795B1 (no
Inventor
Jerome Emile George Guillemont
David Francis Alain Lancois
Koenraad Jozef Lodewij Andries
Anil Koul
Elisabeth Therese Jea Pasquier
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO20081008L publication Critical patent/NO20081008L/no
Publication of NO341795B1 publication Critical patent/NO341795B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

Foreliggende oppfinnelse vedrører nye substituerte kinolinderivater ifølge den generelle formel (Ia) eller formel (Ib): eller: de farmasøytisk akseptable syre- og baseaddisjonssalter derav, de kvaternære aminer derav, de stereokjemiske isomere former derav, de tautomere former derav og N-oksidformene derav. De krevede forbindelser er nyttige for behandling av en bakteriell sykdom iberegnet en mykobakteriell sykdom, spesielt sykdommer forårsaket av patogene mykobakterier så som Mycobacterium tuberkulosis, M. bovis, M. avium og M. marinum. Også krevet er en sammensetning omfattende en farmasøytisk akseptabel bærer og, som aktiv ingrediens, en terapeutisk effektiv mengde av de krevede forbindelser, anvendelsen av de krevede forbindelser eller sammensetninger for fremstilling av et medikament for behandling av bakterielle sykdommer og en fremgangsmåte for å fremstille de krevede forbindelser.
NO20081008A 2005-07-28 2008-02-27 Antibakterielle kinolinderivater NO341795B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05106962 2005-07-28
PCT/EP2006/064656 WO2007014885A1 (en) 2005-07-28 2006-07-26 Antibacterial quinoline derivatives

Publications (2)

Publication Number Publication Date
NO20081008L true NO20081008L (no) 2008-02-27
NO341795B1 NO341795B1 (no) 2018-01-22

Family

ID=35610159

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20081008A NO341795B1 (no) 2005-07-28 2008-02-27 Antibakterielle kinolinderivater

Country Status (30)

Country Link
US (1) US7915292B2 (no)
EP (1) EP1912948B1 (no)
JP (1) JP5100647B2 (no)
KR (1) KR101334719B1 (no)
CN (1) CN101273016B (no)
AP (1) AP2322A (no)
AR (1) AR054587A1 (no)
AU (1) AU2006274918B2 (no)
BR (1) BRPI0614122B8 (no)
CA (1) CA2614981C (no)
CY (1) CY1117247T1 (no)
DK (1) DK1912948T3 (no)
EA (1) EA015617B1 (no)
ES (1) ES2554924T3 (no)
HR (1) HRP20151308T1 (no)
HU (1) HUE026259T2 (no)
IL (1) IL188987A0 (no)
JO (1) JO3077B1 (no)
MX (1) MX2008001219A (no)
MY (1) MY148219A (no)
NO (1) NO341795B1 (no)
NZ (1) NZ565946A (no)
PL (1) PL1912948T3 (no)
PT (1) PT1912948E (no)
RS (1) RS54382B1 (no)
SI (1) SI1912948T1 (no)
TW (1) TWI427065B (no)
UA (1) UA94051C2 (no)
WO (1) WO2007014885A1 (no)
ZA (1) ZA200800783B (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008005368A2 (en) * 2006-06-30 2008-01-10 Abbott Laboratories Piperazines as p2x7 antagonists
EP2571851A1 (en) * 2010-05-21 2013-03-27 Syngenta Participations AG Novel amides as fungicides
JP6153603B2 (ja) 2012-04-27 2017-06-28 ヤンセン ファーマシューティカ エヌ．ベー． 抗菌性キノリン誘導体
EP2841425B1 (en) 2012-04-27 2016-03-23 Janssen Pharmaceutica, N.V. Antibacterial quinoline derivatives
JP6258937B2 (ja) * 2012-08-24 2018-01-10 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 新規二環式ピリジン誘導体
CN104650054B (zh) * 2013-11-25 2019-09-13 重庆医药工业研究院有限责任公司 一种抗结核菌的喹啉噻吩芳氧乙胺衍生物
CN105175329B (zh) * 2014-06-10 2017-09-19 重庆圣华曦药业股份有限公司 一种贝达喹啉消旋体的合成路线及方法
US20190321324A1 (en) * 2016-12-30 2019-10-24 Board Of Regents, The University Of Texas System Quaternary amine antibiotic therapeutics
CN110804016B (zh) * 2019-12-05 2022-11-04 福建省微生物研究所 抗结核分枝杆菌的二芳基喹啉衍生物
WO2023278222A1 (en) * 2021-06-28 2023-01-05 Merck Sharp & Dohme Llc Il4i1 inhibitors and methods of use
CN119666810A (zh) * 2025-02-19 2025-03-21 吉林国际旅行卫生保健中心(长春海关口岸门诊部) 基于图像处理的舌拭子样本荧光检测结核分歧杆菌的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1041035A3 (ru) * 1982-02-25 1983-09-07 Киорин Сейяку Кабусики Кайся (Фирма) Способ получени производных хинолинкарбоновой кислоты,их гидратов или солей
JPS6463518A (en) * 1987-09-02 1989-03-09 Otsuka Pharma Co Ltd Antiarrhythmic agent
US5235054A (en) * 1992-07-15 1993-08-10 Pfizer Inc. 3-carboxaldehyde substituted quinolines and naphthyridines
BR9507672A (pt) * 1994-05-24 1997-08-19 Hoffmann La Roche Derivados tricíclicos de dicarbonila
CA2330564A1 (en) * 1998-04-29 1999-11-04 John Stephen Elder Quinolones used as mrs inhibitors and bactericides
BRPI0312927B8 (pt) * 2002-07-25 2021-05-25 Janssen Pharmaceutica Nv "compostos, derivados de quinolina, composição, seu uso como inibidores micobacteriais, bem como processo para preparação dos referidos derivados".

Also Published As

Publication number Publication date
PL1912948T3 (pl) 2016-02-29
MY148219A (en) 2013-03-29
TWI427065B (zh) 2014-02-21
DK1912948T3 (en) 2016-01-18
IL188987A0 (en) 2008-08-07
CY1117247T1 (el) 2017-04-05
EP1912948A1 (en) 2008-04-23
MX2008001219A (es) 2008-03-24
JO3077B1 (ar) 2017-03-15
SI1912948T1 (sl) 2016-01-29
KR20080031973A (ko) 2008-04-11
US7915292B2 (en) 2011-03-29
EP1912948B1 (en) 2015-09-09
HK1122804A1 (en) 2009-05-29
JP5100647B2 (ja) 2012-12-19
HUE026259T2 (en) 2016-06-28
NZ565946A (en) 2010-11-26
CA2614981C (en) 2014-06-03
CN101273016B (zh) 2013-01-02
EA200800455A1 (ru) 2008-10-30
WO2007014885A1 (en) 2007-02-08
TW200800901A (en) 2008-01-01
PT1912948E (pt) 2015-12-21
RS54382B1 (sr) 2016-04-28
BRPI0614122A2 (pt) 2011-03-09
ZA200800783B (en) 2009-06-24
KR101334719B1 (ko) 2013-11-29
EA015617B1 (ru) 2011-10-31
JP2009502869A (ja) 2009-01-29
CN101273016A (zh) 2008-09-24
UA94051C2 (ru) 2011-04-11
BRPI0614122B8 (pt) 2023-01-10
US20080182855A1 (en) 2008-07-31
AP2322A (en) 2011-11-18
CA2614981A1 (en) 2007-02-08
AR054587A1 (es) 2007-06-27
AU2006274918B2 (en) 2011-09-22
BRPI0614122A8 (pt) 2019-01-29
HRP20151308T1 (hr) 2016-01-01
BRPI0614122B1 (pt) 2020-09-24
NO341795B1 (no) 2018-01-22
AU2006274918A1 (en) 2007-02-08
ES2554924T3 (es) 2015-12-28

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