NO20081893L - 4-(3-aminopyrazol)pyrimidinderivater til anvendelse som tyrosin-kinaseinhibitorer i behandling av kreft - Google Patents
4-(3-aminopyrazol)pyrimidinderivater til anvendelse som tyrosin-kinaseinhibitorer i behandling av kreftInfo
- Publication number
- NO20081893L NO20081893L NO20081893A NO20081893A NO20081893L NO 20081893 L NO20081893 L NO 20081893L NO 20081893 A NO20081893 A NO 20081893A NO 20081893 A NO20081893 A NO 20081893A NO 20081893 L NO20081893 L NO 20081893L
- Authority
- NO
- Norway
- Prior art keywords
- cancer
- treatment
- aminopyrazole
- tyrosine kinase
- kinase inhibitors
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 title 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73129905P | 2005-10-28 | 2005-10-28 | |
| US80306106P | 2006-05-24 | 2006-05-24 | |
| PCT/GB2006/003978 WO2007049041A1 (fr) | 2005-10-28 | 2006-10-26 | Derives 4-(3-aminopyrazole)pyrimidine et leur utilisation en tant qu’inhibiteurs de tyrosine kinases dans le cadre d’un traitement anticancereux |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20081893L true NO20081893L (no) | 2008-05-20 |
Family
ID=37575154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20081893A NO20081893L (no) | 2005-10-28 | 2008-04-22 | 4-(3-aminopyrazol)pyrimidinderivater til anvendelse som tyrosin-kinaseinhibitorer i behandling av kreft |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US20080287475A1 (fr) |
| EP (2) | EP1945631B8 (fr) |
| JP (1) | JP2009513615A (fr) |
| KR (1) | KR20080063846A (fr) |
| AR (1) | AR056210A1 (fr) |
| AU (1) | AU2006307657B2 (fr) |
| BR (1) | BRPI0618011A2 (fr) |
| CA (1) | CA2626375A1 (fr) |
| DK (1) | DK1945631T3 (fr) |
| EC (1) | ECSP088450A (fr) |
| ES (1) | ES2391783T3 (fr) |
| HR (1) | HRP20120824T1 (fr) |
| IL (1) | IL190935A0 (fr) |
| MX (1) | MX2008005398A (fr) |
| NO (1) | NO20081893L (fr) |
| NZ (1) | NZ567584A (fr) |
| PL (1) | PL1945631T3 (fr) |
| PT (1) | PT1945631E (fr) |
| RU (1) | RU2463302C2 (fr) |
| TW (1) | TW200800963A (fr) |
| UY (1) | UY29886A1 (fr) |
| WO (1) | WO2007049041A1 (fr) |
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| PT2383268E (pt) * | 2005-02-04 | 2015-12-21 | Astrazeneca Ab | Derivados de pirazolilaminopiridina úteis como inibidores de quinase |
| US8129403B2 (en) | 2005-02-16 | 2012-03-06 | Astrazeneca Ab | Chemical compounds |
| US20080287437A1 (en) * | 2005-05-16 | 2008-11-20 | Astrazeneca Ab | Pyrazolylaminopyrimidine Derivatives Useful as Tyrosine Kinase Inhibitors |
| HRP20120824T1 (hr) * | 2005-10-28 | 2012-11-30 | Astrazeneca Ab | Derivati 4-(3-aminopirazol) pirimidina za uporabu kao inhibitori tirozin kinaze u lijeäśenju karcinoma |
| SI2426129T1 (sl) | 2005-12-13 | 2017-02-28 | Incyte Holdings Corporation | Heteroarilno substituirani pirolo(2,3-b)piridini in pirolo(2,3-b)pirimidini kot zaviralci janusove kinaze |
| EP2057140B1 (fr) | 2006-08-24 | 2012-08-08 | AstraZeneca AB | Dérivés de la morpholino pyrimidine utiles dans le traitement de maladies prolifératives |
| WO2008061370A1 (fr) * | 2006-11-24 | 2008-05-29 | Mcmaster University | Procédé de diagnostic permettant de détecter l'endométriose |
| WO2008129255A1 (fr) * | 2007-04-18 | 2008-10-30 | Astrazeneca Ab | Dérivés de 5-aminopyrazol-3-yl-3h-imidazo[4,5-b]pyridine et leur utilisation pour le traitement du cancer |
| CN101687863B (zh) * | 2007-05-04 | 2012-09-12 | 阿斯利康(瑞典)有限公司 | 氨基-噻唑基-嘧啶衍生物及其治疗癌症的用途 |
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| MX342814B (es) | 2007-06-13 | 2016-10-13 | Incyte Holdings Corp | Sales de inhibidor de janus cinasa (r)-3-(4-7h-pirrolo[2,3-d]pirim idin-4-il)-1h-pirazol-1-il)-3-ciclopentilpropanitrilo. |
| AU2008273891B2 (en) | 2007-07-09 | 2012-01-12 | Astrazeneca Ab | Morpholino pyrimidine derivatives used in diseases linked to mTOR kinase and/or PI3K |
| WO2009007753A2 (fr) * | 2007-07-11 | 2009-01-15 | Astrazeneca Ab | Composés chimiques 916-1 |
| WO2009013545A2 (fr) * | 2007-07-26 | 2009-01-29 | Astrazeneca Ab | Composés chimiques |
| TW200906818A (en) * | 2007-07-31 | 2009-02-16 | Astrazeneca Ab | Chemical compounds |
| AU2008321046B2 (en) | 2007-11-16 | 2013-10-24 | Incyte Holdings Corporation | 4-pyrazolyl-N-arylpyrimidin-2-amines and 4-pyrazolyl-N-heteroarylpyrimidin-2-amines as janus kinase inhibitors |
| WO2009095712A2 (fr) * | 2008-01-29 | 2009-08-06 | Astrazeneca Ab | Composés chimiques |
| WO2009150462A1 (fr) * | 2008-06-11 | 2009-12-17 | Astrazeneca Ab | Dérivés tricycliques de 2,4-diamino-l,3,5-triazine utiles pour le traitement du cancer et de troubles myéloprolifératifs |
| UY32055A (es) * | 2008-08-19 | 2010-03-26 | Astrazeneca Ab | Derivados sustituidos de la 5-Halo-N2-[sustituido](1-metil-1H-imidazol-4-il)pirimidin-2,-diamina y sus sales farmacéuticamente aceptables, procesos de preparación, composiciones y aplicaciones. |
| MX2011003447A (es) * | 2008-09-30 | 2011-07-29 | Astrazeneca Ab | Inhibidores heterociclicos de jak quinasa. |
| CN102458581B (zh) | 2009-05-22 | 2016-03-30 | 因塞特控股公司 | 作为JANUS激酶抑制剂的吡唑-4-基-吡咯并[2，3-d]嘧啶和吡咯-3-基-吡咯并[2，3-d]嘧啶的N-(杂)芳基-吡咯烷衍生物 |
| HUE046493T2 (hu) | 2009-05-22 | 2020-03-30 | Incyte Holdings Corp | 3-[4-(7H-Pirrolo[2,3-d]pirimidin-4-il)-lH-pirazol-l-il]oktán- vagy heptán-nitril JAK inhibitorokként |
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| EP2464633A1 (fr) | 2009-08-14 | 2012-06-20 | Boehringer Ingelheim International GmbH | Préparation régiosélective de dérivés de 2-amino-5-trifluorométhylpyrimidine |
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| RS57219B1 (sr) | 2010-03-10 | 2018-07-31 | Incyte Holdings Corp | Piperidin-4-il azetidin derivati kao inhibitori jak1 |
| EP3087972A1 (fr) | 2010-05-21 | 2016-11-02 | Incyte Holdings Corporation | Formulation topique pour un inhibiteur jak |
| SA111320519B1 (ar) | 2010-06-11 | 2014-07-02 | Astrazeneca Ab | مركبات بيريميدينيل للاستخدام كمثبطات atr |
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| EP1347971B1 (fr) | 2000-12-21 | 2006-03-01 | Bristol-Myers Squibb Company | Inhibiteurs thiazolyl des tyrosine kinases de la famille tec |
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| TW200826937A (en) * | 2006-11-01 | 2008-07-01 | Astrazeneca Ab | New use |
-
2006
- 2006-10-26 HR HRP20120824TT patent/HRP20120824T1/hr unknown
- 2006-10-26 EP EP06794902A patent/EP1945631B8/fr active Active
- 2006-10-26 CA CA002626375A patent/CA2626375A1/fr not_active Abandoned
- 2006-10-26 JP JP2008537190A patent/JP2009513615A/ja active Pending
- 2006-10-26 PT PT06794902T patent/PT1945631E/pt unknown
- 2006-10-26 KR KR1020087011816A patent/KR20080063846A/ko not_active Ceased
- 2006-10-26 ES ES06794902T patent/ES2391783T3/es active Active
- 2006-10-26 AU AU2006307657A patent/AU2006307657B2/en not_active Ceased
- 2006-10-26 RU RU2008120848/04A patent/RU2463302C2/ru not_active IP Right Cessation
- 2006-10-26 DK DK06794902.4T patent/DK1945631T3/da active
- 2006-10-26 EP EP11177767A patent/EP2388259A1/fr not_active Withdrawn
- 2006-10-26 PL PL06794902T patent/PL1945631T3/pl unknown
- 2006-10-26 WO PCT/GB2006/003978 patent/WO2007049041A1/fr not_active Ceased
- 2006-10-26 MX MX2008005398A patent/MX2008005398A/es not_active Application Discontinuation
- 2006-10-26 NZ NZ567584A patent/NZ567584A/en not_active IP Right Cessation
- 2006-10-26 US US12/091,382 patent/US20080287475A1/en not_active Abandoned
- 2006-10-26 TW TW095139565A patent/TW200800963A/zh unknown
- 2006-10-26 BR BRPI0618011-6A patent/BRPI0618011A2/pt not_active IP Right Cessation
- 2006-10-27 AR ARP060104713A patent/AR056210A1/es not_active Application Discontinuation
- 2006-10-27 UY UY29886A patent/UY29886A1/es not_active Application Discontinuation
-
2008
- 2008-04-17 IL IL190935A patent/IL190935A0/en unknown
- 2008-04-22 NO NO20081893A patent/NO20081893L/no not_active Application Discontinuation
- 2008-05-14 EC EC2008008450A patent/ECSP088450A/es unknown
-
2010
- 2010-02-26 US US12/713,695 patent/US8088784B2/en not_active Expired - Fee Related
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- 2011-12-01 US US13/308,584 patent/US20120071480A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| RU2008120848A (ru) | 2009-12-10 |
| RU2463302C2 (ru) | 2012-10-10 |
| ES2391783T3 (es) | 2012-11-29 |
| US20100160325A1 (en) | 2010-06-24 |
| BRPI0618011A2 (pt) | 2011-08-16 |
| EP1945631B8 (fr) | 2013-01-02 |
| EP1945631A1 (fr) | 2008-07-23 |
| WO2007049041A8 (fr) | 2012-11-01 |
| WO2007049041A1 (fr) | 2007-05-03 |
| AU2006307657A1 (en) | 2007-05-03 |
| HRP20120824T1 (hr) | 2012-11-30 |
| US20080287475A1 (en) | 2008-11-20 |
| ECSP088450A (es) | 2008-06-30 |
| MX2008005398A (es) | 2008-09-24 |
| US8088784B2 (en) | 2012-01-03 |
| JP2009513615A (ja) | 2009-04-02 |
| IL190935A0 (en) | 2009-09-22 |
| TW200800963A (en) | 2008-01-01 |
| AU2006307657B2 (en) | 2010-10-28 |
| DK1945631T3 (da) | 2012-10-22 |
| EP1945631B1 (fr) | 2012-08-08 |
| UY29886A1 (es) | 2007-05-31 |
| CA2626375A1 (fr) | 2007-05-03 |
| PL1945631T3 (pl) | 2012-12-31 |
| KR20080063846A (ko) | 2008-07-07 |
| US20120071480A1 (en) | 2012-03-22 |
| NZ567584A (en) | 2011-08-26 |
| AR056210A1 (es) | 2007-09-26 |
| EP2388259A1 (fr) | 2011-11-23 |
| PT1945631E (pt) | 2012-10-15 |
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