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NO20080963L - Piperidinyl-substiuerte isokinolinderivater som Rho-kinaseinhibitorer - Google Patents

Piperidinyl-substiuerte isokinolinderivater som Rho-kinaseinhibitorer

Info

Publication number
NO20080963L
NO20080963L NO20080963A NO20080963A NO20080963L NO 20080963 L NO20080963 L NO 20080963L NO 20080963 A NO20080963 A NO 20080963A NO 20080963 A NO20080963 A NO 20080963A NO 20080963 L NO20080963 L NO 20080963L
Authority
NO
Norway
Prior art keywords
piperidinyl
kinase inhibitors
isoquinoline derivatives
rho kinase
substituted isoquinoline
Prior art date
Application number
NO20080963A
Other languages
English (en)
Other versions
NO341888B1 (no
Inventor
Dieter Kadereit
Armin Hofmeister
Oliver Plettenburg
Joachim Brendel
Matthias Loehn
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of NO20080963L publication Critical patent/NO20080963L/no
Publication of NO341888B1 publication Critical patent/NO341888B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Cardiology (AREA)
  • Neurosurgery (AREA)
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Abstract

Foreliggende oppfinnelse angår 6-piperidinylsubstituerte isoquinolonderivater med formel (I) eller isoquinolinderivater med formel (I') anvendelige for behandling og/eller hindring av sykdommer assosiert med Rho-kinase og/eller Rho-kinasemediert fosforylering av myosinlettkjedefosfatase, og sammensetninger som inneholder slike forbindelser.
NO20080963A 2005-07-26 2008-02-22 Piperidinylsubstiuerte isoquinolonderivater som Rho-kinaseinhibitorer NO341888B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05016154 2005-07-26
PCT/EP2006/007139 WO2007012421A1 (en) 2005-07-26 2006-07-20 Piperidinyl-substituted isoquinolone derivatives as rho-kinase inhibitors

Publications (2)

Publication Number Publication Date
NO20080963L true NO20080963L (no) 2008-04-02
NO341888B1 NO341888B1 (no) 2018-02-12

Family

ID=34979095

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20080963A NO341888B1 (no) 2005-07-26 2008-02-22 Piperidinylsubstiuerte isoquinolonderivater som Rho-kinaseinhibitorer

Country Status (31)

Country Link
US (1) US8188117B2 (no)
EP (2) EP2385047B1 (no)
JP (1) JP5060478B2 (no)
KR (1) KR101373535B1 (no)
CN (1) CN101228149B (no)
AR (1) AR054868A1 (no)
AU (1) AU2006274245B2 (no)
BR (1) BRPI0613861B8 (no)
CA (1) CA2615577C (no)
CR (1) CR9603A (no)
DK (1) DK1910333T3 (no)
DO (1) DOP2006000178A (no)
EC (1) ECSP088135A (no)
ES (1) ES2423006T3 (no)
GT (1) GT200600328A (no)
IL (1) IL188702A (no)
MA (1) MA29636B1 (no)
MX (1) MX2008001053A (no)
MY (1) MY148479A (no)
NI (1) NI200800025A (no)
NO (1) NO341888B1 (no)
NZ (1) NZ565668A (no)
PE (1) PE20070217A1 (no)
PT (1) PT1910333E (no)
RU (1) RU2414467C2 (no)
TN (1) TNSN08039A1 (no)
TW (1) TWI383979B (no)
UA (1) UA93882C2 (no)
UY (1) UY29697A1 (no)
WO (1) WO2007012421A1 (no)
ZA (1) ZA200710951B (no)

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WO2008077552A1 (en) 2006-12-27 2008-07-03 Sanofi-Aventis Substituted isoquinoline and isoquinolinone derivatives
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KR101545533B1 (ko) 2006-12-27 2015-08-19 사노피 치환된 이소퀴놀린 및 Ｒｈｏ-키나아제 억제제로서의 이의 용도
MY150746A (en) 2006-12-27 2014-02-28 Sanofi Aventis Substituted isoquinoline and isoquinolinone derivatives as inhibitors of rho-kinase
JP5405316B2 (ja) 2006-12-27 2014-02-05 サノフイ シクロアルキルアミン置換イソキノリン誘導体
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