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NO20074619L - Spiro-oksindolforbindelser og deres anvendelse som medikamenter - Google Patents

Spiro-oksindolforbindelser og deres anvendelse som medikamenter

Info

Publication number
NO20074619L
NO20074619L NO20074619A NO20074619A NO20074619L NO 20074619 L NO20074619 L NO 20074619L NO 20074619 A NO20074619 A NO 20074619A NO 20074619 A NO20074619 A NO 20074619A NO 20074619 L NO20074619 L NO 20074619L
Authority
NO
Norway
Prior art keywords
compounds
spiro
drugs
oxindole compounds
tautomer
Prior art date
Application number
NO20074619A
Other languages
English (en)
Inventor
Serguei Sviridov
Rajender Kamboj
Shifeng Liu
Sultan Chowdhury
Mikhail Chafeev
Robert Fraser
Jianmin Fu
Duanjie Hou
Mehran Seid Bagherzadeh
Shaoyi Sun
Jianyu Sun
Nagasree Chakka
Tom Hsieh
Vandna Raina
Original Assignee
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc filed Critical Xenon Pharmaceuticals Inc
Publication of NO20074619L publication Critical patent/NO20074619L/no

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Foreliggende oppfinnelse angår spiro-oksindol-forbindelser med formel (I): hvor k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c og R3d er som definert her, som en stereoisomer, enantiomer, tautomer derav eller blandinger derav; eller et farmasøytisk akseptabelt salt, solvat eller prodrug derav, som er anvendelige for behandling og/eller forebygging av natriumkanal-medierte sykdommer eller tilstander, så som smerte. Farmasøytiske preparater som omfatter forbindelsene, samt metoder for fremstilling og anvendelse av forbindelsene, er også beskrevet.
NO20074619A 2005-04-11 2007-09-12 Spiro-oksindolforbindelser og deres anvendelse som medikamenter NO20074619L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67089605P 2005-04-11 2005-04-11
PCT/US2006/014352 WO2006110917A2 (en) 2005-04-11 2006-04-11 Spiro-oxindole compounds and their uses as therapeutic agents

Publications (1)

Publication Number Publication Date
NO20074619L true NO20074619L (no) 2007-10-31

Family

ID=36952847

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20074619A NO20074619L (no) 2005-04-11 2007-09-12 Spiro-oksindolforbindelser og deres anvendelse som medikamenter

Country Status (30)

Country Link
US (4) US7700641B2 (no)
EP (4) EP1888595B1 (no)
JP (4) JP5118627B2 (no)
KR (5) KR20150091542A (no)
CN (2) CN102153562B (no)
AR (1) AR056968A1 (no)
AT (1) ATE543825T1 (no)
AU (1) AU2006235593B2 (no)
BR (1) BRPI0607926A2 (no)
CA (3) CA2853635C (no)
DK (1) DK1888595T3 (no)
EC (1) ECSP077852A (no)
ES (2) ES2488618T3 (no)
HK (1) HK1199874A1 (no)
HR (1) HRP20070505B1 (no)
IL (1) IL186616A (no)
MA (1) MA29684B1 (no)
MX (1) MX2007012636A (no)
MY (2) MY144968A (no)
NO (1) NO20074619L (no)
NZ (1) NZ561210A (no)
PL (1) PL1888595T3 (no)
PT (1) PT1888595E (no)
RS (1) RS52295B (no)
RU (1) RU2415143C2 (no)
SG (1) SG161262A1 (no)
SI (1) SI1888595T1 (no)
TN (1) TNSN07382A1 (no)
TW (1) TWI374141B (no)
WO (1) WO2006110917A2 (no)

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CN103554121B (zh) * 2013-10-16 2015-06-24 华东师范大学 3,3-螺(2-四氢呋喃)氧化吲哚多环状化合物及其应用
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