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NO20074620L - Spiroheterocykliske forbindelser og deres anvendelse som medikamenter - Google Patents

Spiroheterocykliske forbindelser og deres anvendelse som medikamenter

Info

Publication number
NO20074620L
NO20074620L NO20074620A NO20074620A NO20074620L NO 20074620 L NO20074620 L NO 20074620L NO 20074620 A NO20074620 A NO 20074620A NO 20074620 A NO20074620 A NO 20074620A NO 20074620 L NO20074620 L NO 20074620L
Authority
NO
Norway
Prior art keywords
heterocyclic compounds
spiro heterocyclic
drugs
compounds
tautomer
Prior art date
Application number
NO20074620A
Other languages
English (en)
Inventor
Serguei Sviridov
Rajender Kamboj
Shifeng Liu
Sultan Chowdhury
Mikhail Chafeev
Robert Fraser
Jianmin Fu
Mehran Seid Bagherzadeh
Jianyu Sun
Original Assignee
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc filed Critical Xenon Pharmaceuticals Inc
Publication of NO20074620L publication Critical patent/NO20074620L/no

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Diabetes (AREA)
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  • Urology & Nephrology (AREA)
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Abstract

Foreliggende oppfinnelse angår spiro-heterocykliske forbindelser med formel (I) : hvor , k, j, p, Q, R1, R3a, R3b, R3c og R3d er som definert her, som en stereoisomer, enantiomer, tautomer derav eller blandinger derav; eller et farmasøytisk akseptabelt salt, solvat eller prodrug derav, som er anvendelige for behandling og/eller forebygging av natriumkanal-medierte sykdommer eller tilstander, så som smerte. Farmasøytiske preparater som omfatter forbindelsene, samt metoder for anvendelse av forbindelsene, er også beskrevet.
NO20074620A 2005-04-11 2007-09-12 Spiroheterocykliske forbindelser og deres anvendelse som medikamenter NO20074620L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67096205P 2005-04-11 2005-04-11
PCT/US2006/013318 WO2006110654A1 (en) 2005-04-11 2006-04-11 Spiroheterocyclic compounds and their uses as therapeutic agents

Publications (1)

Publication Number Publication Date
NO20074620L true NO20074620L (no) 2007-11-07

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ID=36694990

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NO20074620A NO20074620L (no) 2005-04-11 2007-09-12 Spiroheterocykliske forbindelser og deres anvendelse som medikamenter

Country Status (27)

Country Link
US (2) US7799798B2 (no)
EP (1) EP1888592B1 (no)
JP (1) JP2008535916A (no)
KR (1) KR20080007250A (no)
CN (2) CN101967150A (no)
AR (1) AR053710A1 (no)
AT (1) ATE504587T1 (no)
AU (1) AU2006235329B2 (no)
BR (1) BRPI0608995A2 (no)
CA (1) CA2604010A1 (no)
DE (1) DE602006021169D1 (no)
EC (1) ECSP077848A (no)
ES (1) ES2362908T3 (no)
HR (1) HRP20070499A2 (no)
IL (1) IL186615A0 (no)
MA (1) MA29685B1 (no)
MX (1) MX2007012637A (no)
MY (1) MY145694A (no)
NO (1) NO20074620L (no)
NZ (1) NZ561204A (no)
PL (1) PL1888592T3 (no)
RU (1) RU2428424C2 (no)
SG (1) SG161264A1 (no)
TN (1) TNSN07384A1 (no)
TW (1) TW200720278A (no)
WO (1) WO2006110654A1 (no)
ZA (1) ZA200709004B (no)

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MY144968A (en) * 2005-04-11 2011-11-30 Xenon Pharmaceuticals Inc Spiro-oxindole compounds and their uses as therapeutic agents
AR053713A1 (es) * 2005-04-20 2007-05-16 Xenon Pharmaceuticals Inc Compuestos heterociclicos y sus usos como agentes terapeuticos
ATE545416T1 (de) * 2006-10-12 2012-03-15 Xenon Pharmaceuticals Inc Verwendung von spiro-oxindol-verbindungen als therapeutika
AU2007307635A1 (en) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Tricyclic spiro-oxindole derivatives and their uses as therapeutic agents
WO2008046087A2 (en) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Spiro compounds and their uses as therapeutic agents
WO2008046065A1 (en) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Spiroheterocyclic compounds and their uses as therapeutic agents
AR063278A1 (es) * 2006-10-12 2009-01-14 Xenon Pharmaceuticals Inc Compuestos de espiro-oxindol, una composicion farmaceutica que los comprende y su uso para el tratamiento de enfermedades o condiciones mediadas por los canales de sodio.
WO2008046082A2 (en) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Use of heterocyclic compounds as therapeutic agents
CN101641090B (zh) * 2006-12-19 2012-12-05 亚勒斯有限公司 莫达非尼在制备治疗多动腿综合征的药物中的应用
US7795228B2 (en) * 2006-12-28 2010-09-14 Theracos, Inc. Spiroheterocyclic glycosides and methods of use
AU2008254270B2 (en) * 2007-05-16 2013-06-06 Merck Sharp & Dohme Corp. Spiroindalones
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WO2009045381A1 (en) 2007-10-04 2009-04-09 Merck & Co., Inc. N-substituted oxindoline derivatives as calcium channel blockers
UA101004C2 (en) 2007-12-13 2013-02-25 Теракос, Инк. Derivatives of benzylphenylcyclohexane and use thereof
EA019601B1 (ru) 2008-04-29 2014-04-30 Новартис Аг Производные спироиндола, предназначенные для лечения паразитарных заболеваний
EP2324002B1 (en) 2008-08-22 2016-10-05 Theracos Sub, LLC Processes for the preparation of sglt2 inhibitors
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