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WO2008109856A3 - Methods of using diazepinone compounds in treating sodium channel-mediated diseases or conditions - Google Patents

Methods of using diazepinone compounds in treating sodium channel-mediated diseases or conditions Download PDF

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Publication number
WO2008109856A3
WO2008109856A3 PCT/US2008/056285 US2008056285W WO2008109856A3 WO 2008109856 A3 WO2008109856 A3 WO 2008109856A3 US 2008056285 W US2008056285 W US 2008056285W WO 2008109856 A3 WO2008109856 A3 WO 2008109856A3
Authority
WO
WIPO (PCT)
Prior art keywords
conditions
sodium channel
mediated diseases
methods
treating sodium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/056285
Other languages
French (fr)
Other versions
WO2008109856A2 (en
Inventor
Robert Fraser
Jianmin Fu
Rajender Kamboj
Shaoyi Sun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xenon Pharmaceuticals Inc
Original Assignee
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc filed Critical Xenon Pharmaceuticals Inc
Publication of WO2008109856A2 publication Critical patent/WO2008109856A2/en
Publication of WO2008109856A3 publication Critical patent/WO2008109856A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

This invention is directed to compounds of formula (I): wherein n,, R1, R2, R3, R4 and R5 are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, and their use for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
PCT/US2008/056285 2007-03-07 2008-03-07 Methods of using diazepinone compounds in treating sodium channel-mediated diseases or conditions Ceased WO2008109856A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89360107P 2007-03-07 2007-03-07
US60/893,601 2007-03-07

Publications (2)

Publication Number Publication Date
WO2008109856A2 WO2008109856A2 (en) 2008-09-12
WO2008109856A3 true WO2008109856A3 (en) 2009-02-19

Family

ID=39620215

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/056285 Ceased WO2008109856A2 (en) 2007-03-07 2008-03-07 Methods of using diazepinone compounds in treating sodium channel-mediated diseases or conditions

Country Status (1)

Country Link
WO (1) WO2008109856A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012075456A1 (en) 2010-12-02 2012-06-07 Constellation Pharmaceuticals Bromodomain inhibitors and uses thereof
AR084070A1 (en) 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc BROMODOMINIUM INHIBITORS AND USES OF THE SAME
EP2705039B1 (en) 2011-05-04 2017-07-26 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
EP2721031B1 (en) 2011-06-17 2016-01-20 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
EP2864336B1 (en) 2012-06-06 2016-11-23 Constellation Pharmaceuticals, Inc. Benzo[b]isoxazoloazepine bromodomain inhibitors and uses thereof
TWI602820B (en) 2012-06-06 2017-10-21 星宿藥物公司 Bromodomain inhibitors and uses thereof
CA2878804A1 (en) * 2012-09-12 2014-03-20 F. Hoffmann-La Roche Ag Non-annulated thiophenylamides as inhibitors of fatty acid binding protein(fabp) 4 and/or 5
US9969747B2 (en) 2014-06-20 2018-05-15 Constellation Pharmaceuticals, Inc. Crystalline forms of 2-((4S)-6-(4-chlorophenyl)-1-methyl-4H-benzo[C]isoxazolo[4,5-e]azepin-4-yl)acetamide

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1311220A (en) * 1970-12-07 1973-03-28 Yoshitomi Pharmaceutical Thieno 2,3-e 1,4 diazepine derivatives their production and pharma ceutical compositions containing them
JPS4849786A (en) * 1971-10-23 1973-07-13
JPS4914490A (en) * 1972-06-09 1974-02-07
FR2222090A1 (en) * 1973-03-20 1974-10-18 Yoshitomi Pharmaceutical
JPS51118785A (en) * 1975-04-09 1976-10-18 Yoshitomi Pharmaceut Ind Ltd Method for preparing novel thienodiazepine derivatives
WO1994005673A1 (en) * 1992-08-28 1994-03-17 Merck Sharp & Dohme Limited Thienodiazepine derivatives as cholecystokinin and gastrin antagonists

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1311220A (en) * 1970-12-07 1973-03-28 Yoshitomi Pharmaceutical Thieno 2,3-e 1,4 diazepine derivatives their production and pharma ceutical compositions containing them
JPS4849786A (en) * 1971-10-23 1973-07-13
JPS4914490A (en) * 1972-06-09 1974-02-07
FR2222090A1 (en) * 1973-03-20 1974-10-18 Yoshitomi Pharmaceutical
JPS51118785A (en) * 1975-04-09 1976-10-18 Yoshitomi Pharmaceut Ind Ltd Method for preparing novel thienodiazepine derivatives
WO1994005673A1 (en) * 1992-08-28 1994-03-17 Merck Sharp & Dohme Limited Thienodiazepine derivatives as cholecystokinin and gastrin antagonists

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BACKUS K H ET AL: "Action of diazepam on the voltage-dependent Na+ current. Comparison with the effects of phenytoin, carbamazepine, lidocaine and flumazenil.", BRAIN RESEARCH 10 MAY 1991, vol. 548, no. 1-2, 10 May 1991 (1991-05-10), pages 41 - 49, XP002489675, ISSN: 0006-8993 *
BRITISH JOURNAL OF ANAESTHESIA, vol. 53, no. 8, 1981, pages 831 - 836, ISSN: 0007-0912 *
COURTNEY K R ET AL: "Modulated anticonvulsant block of sodium channels in nerve and muscle.", EUROPEAN JOURNAL OF PHARMACOLOGY 18 MAR 1983, vol. 88, no. 1, 18 March 1983 (1983-03-18), pages 1 - 9, XP002489676, ISSN: 0014-2999 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1981, SINGH P N ET AL: "CLINICAL EVALUATION OF DIAZEPAM FOR RELIEF OF POST OPERATIVE PAIN", XP002489703, Database accession no. PREV198273049225 *
DATABASE WPI Week 197342, Derwent World Patents Index; AN 1973-62575U, XP002489679 *
DATABASE WPI Week 197412, Derwent World Patents Index; AN 1974-21919V, XP002489678 *
DATABASE WPI Week 197649, Derwent World Patents Index; AN 1976-91177X, XP002489680 *
SWENSON R P JR: "Flurazepam interaction with sodium and potassium channels in squid giant axon.", BRAIN RESEARCH 10 JUN 1982, vol. 241, no. 2, 10 June 1982 (1982-06-10), pages 317 - 322, XP002489677, ISSN: 0006-8993 *

Also Published As

Publication number Publication date
WO2008109856A2 (en) 2008-09-12

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