NO20072486L - N-[(3S)-pyrrolidin-2-yl]-benzamid-derivater som monoamin reopptaksinhibitorer - Google Patents
N-[(3S)-pyrrolidin-2-yl]-benzamid-derivater som monoamin reopptaksinhibitorerInfo
- Publication number
- NO20072486L NO20072486L NO20072486A NO20072486A NO20072486L NO 20072486 L NO20072486 L NO 20072486L NO 20072486 A NO20072486 A NO 20072486A NO 20072486 A NO20072486 A NO 20072486A NO 20072486 L NO20072486 L NO 20072486L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- alkoxy
- reuptake inhibitors
- pyrrolidin
- ocf3
- Prior art date
Links
- KXDAEFPNCMNJSK-UHFFFAOYSA-N benzene carboxamide Natural products NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000000407 monoamine reuptake Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 125000001054 5 membered carbocyclic group Chemical group 0.000 abstract 1
- 125000004008 6 membered carbocyclic group Chemical group 0.000 abstract 1
- 206010046543 Urinary incontinence Diseases 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 239000002767 noradrenalin uptake inhibitor Substances 0.000 abstract 1
- 229940076279 serotonin Drugs 0.000 abstract 1
- 239000003772 serotonin uptake inhibitor Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Reproductive Health (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Gynecology & Obstetrics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Det beskrives en forbindelse av formel (I) og farmasøytisk og/eller veterinærisk akseptable derivater derav, hvor: R1, R2, R3 og R20 er hver uavhengig H, Cl, Br, F, I, CF3, OCF3, Me eller Et; R4 er het eller C3-7 sykloalkyl valgfritt substituert med C1.4 alkyl, C1-4 alkoksy, alkoksyalkyl inneholdende 2 til 4 karbonatomer eller -S-(C1-4 alkyl); a er 0 eller 1; og het er en ikke-aromatisk 4-, 5- eller6-leddet heteroring som inneholder minst en N, O eller S heteroatom, valgfritt fusjonert til en 5- eller 6-leddet karbosyklisk gruppe eller en andre 4-, 5- eller 6-leddet heteroring som inneholder minst et N, O eller S heteroatom, hvor het-gruppen er valgfritt substituert med minst én substituent uavhengig valgt blant C1-8alkyl, C-1-8alkoksy, OH, halo, CF3, OCF3, SCF3, hydroksy-C1-6alkyl, C1-4alkoksy-C1-6alkyl og C1-4alkyl-S-C-1-4alkyl; gitt at minst én av R1, R2 og R3 er forskjellig fra H. Forbindelsene ifølge oppfinnelsen oppviser aktivitet som både serotonin og noradrenalin reopptaksinhibitorer og har derfor nytte i en rekke terapeutiske områder, for eksempel urinveisinkontinens.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0425766.3A GB0425766D0 (en) | 2004-11-23 | 2004-11-23 | Novel compounds |
| PCT/IB2005/003643 WO2006056884A1 (en) | 2004-11-23 | 2005-11-18 | N- [ (3s)- pyrrolidin-3-yl]- benzamide derivatives as monoamine re-uptake inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20072486L true NO20072486L (no) | 2007-06-20 |
Family
ID=33548739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20072486A NO20072486L (no) | 2004-11-23 | 2007-05-15 | N-[(3S)-pyrrolidin-2-yl]-benzamid-derivater som monoamin reopptaksinhibitorer |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP1817281A1 (no) |
| JP (1) | JP4233596B2 (no) |
| KR (1) | KR100886294B1 (no) |
| CN (1) | CN101065355A (no) |
| AP (1) | AP2007004003A0 (no) |
| AR (1) | AR052243A1 (no) |
| AU (1) | AU2005308534A1 (no) |
| BR (1) | BRPI0518486A2 (no) |
| CA (1) | CA2589258A1 (no) |
| CR (1) | CR9171A (no) |
| EA (1) | EA011217B1 (no) |
| GB (1) | GB0425766D0 (no) |
| GT (1) | GT200500337A (no) |
| IL (1) | IL183191A0 (no) |
| MA (1) | MA29038B1 (no) |
| MX (1) | MX2007006138A (no) |
| NL (2) | NL1030485C2 (no) |
| NO (1) | NO20072486L (no) |
| PA (1) | PA8653501A1 (no) |
| PE (1) | PE20061056A1 (no) |
| SV (1) | SV2006002311A (no) |
| TN (1) | TNSN07201A1 (no) |
| TW (1) | TWI300776B (no) |
| UY (1) | UY29224A1 (no) |
| WO (1) | WO2006056884A1 (no) |
| ZA (1) | ZA200703910B (no) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH628885A5 (en) * | 1978-01-01 | 1982-03-31 | Anphar Sa | Piperidine derivative |
| SI1638933T1 (sl) * | 2003-06-17 | 2008-10-31 | Pfizer | Derivati N-pirolidin-3-il-amida kot inhibitorji ponovnega privzema serotonina in noradrenalina |
| GB0314054D0 (en) * | 2003-06-17 | 2003-07-23 | Pfizer Ltd | Amide derivatives as selective serotonin re-uptake inhibitors |
-
2004
- 2004-11-23 GB GBGB0425766.3A patent/GB0425766D0/en not_active Ceased
-
2005
- 2005-11-18 AP AP2007004003A patent/AP2007004003A0/xx unknown
- 2005-11-18 WO PCT/IB2005/003643 patent/WO2006056884A1/en not_active Ceased
- 2005-11-18 BR BRPI0518486-0A patent/BRPI0518486A2/pt not_active IP Right Cessation
- 2005-11-18 EP EP05808510A patent/EP1817281A1/en not_active Withdrawn
- 2005-11-18 JP JP2007542360A patent/JP4233596B2/ja not_active Expired - Fee Related
- 2005-11-18 AU AU2005308534A patent/AU2005308534A1/en not_active Abandoned
- 2005-11-18 CN CNA2005800401025A patent/CN101065355A/zh active Pending
- 2005-11-18 KR KR1020077014351A patent/KR100886294B1/ko not_active Expired - Fee Related
- 2005-11-18 EA EA200700920A patent/EA011217B1/ru not_active IP Right Cessation
- 2005-11-18 MX MX2007006138A patent/MX2007006138A/es active IP Right Grant
- 2005-11-18 CA CA002589258A patent/CA2589258A1/en not_active Abandoned
- 2005-11-21 AR ARP050104866A patent/AR052243A1/es not_active Application Discontinuation
- 2005-11-21 PE PE2005001362A patent/PE20061056A1/es not_active Application Discontinuation
- 2005-11-22 NL NL1030485A patent/NL1030485C2/nl not_active IP Right Cessation
- 2005-11-22 GT GT200500337A patent/GT200500337A/es unknown
- 2005-11-22 TW TW094140922A patent/TWI300776B/zh active
- 2005-11-22 UY UY29224A patent/UY29224A1/es not_active Application Discontinuation
- 2005-11-23 SV SV2005002311A patent/SV2006002311A/es unknown
- 2005-11-23 PA PA20058653501A patent/PA8653501A1/es unknown
-
2006
- 2006-10-27 NL NL1032760A patent/NL1032760C2/nl not_active IP Right Cessation
-
2007
- 2007-05-14 IL IL183191A patent/IL183191A0/en unknown
- 2007-05-15 NO NO20072486A patent/NO20072486L/no not_active Application Discontinuation
- 2007-05-15 ZA ZA200703910A patent/ZA200703910B/xx unknown
- 2007-05-22 TN TNP2007000201A patent/TNSN07201A1/fr unknown
- 2007-05-23 MA MA29935A patent/MA29038B1/fr unknown
- 2007-06-07 CR CR9171A patent/CR9171A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| GB0425766D0 (en) | 2004-12-22 |
| NL1030485C2 (nl) | 2006-11-07 |
| ZA200703910B (en) | 2008-09-25 |
| GT200500337A (es) | 2006-06-13 |
| JP4233596B2 (ja) | 2009-03-04 |
| NL1032760A1 (nl) | 2006-12-13 |
| PE20061056A1 (es) | 2006-11-08 |
| AU2005308534A1 (en) | 2006-06-01 |
| EA011217B1 (ru) | 2009-02-27 |
| JP2008520646A (ja) | 2008-06-19 |
| IL183191A0 (en) | 2007-08-19 |
| PA8653501A1 (es) | 2006-06-02 |
| MX2007006138A (es) | 2007-07-19 |
| CA2589258A1 (en) | 2006-06-01 |
| TNSN07201A1 (fr) | 2008-11-21 |
| AP2007004003A0 (en) | 2007-06-30 |
| NL1030485A1 (nl) | 2006-05-24 |
| SV2006002311A (es) | 2006-09-14 |
| CN101065355A (zh) | 2007-10-31 |
| EP1817281A1 (en) | 2007-08-15 |
| BRPI0518486A2 (pt) | 2008-11-18 |
| KR100886294B1 (ko) | 2009-03-04 |
| KR20070086599A (ko) | 2007-08-27 |
| TW200626543A (en) | 2006-08-01 |
| NL1032760C2 (nl) | 2007-04-17 |
| CR9171A (es) | 2007-07-04 |
| EA200700920A1 (ru) | 2007-12-28 |
| WO2006056884A1 (en) | 2006-06-01 |
| UY29224A1 (es) | 2006-06-30 |
| AR052243A1 (es) | 2007-03-07 |
| MA29038B1 (fr) | 2007-11-01 |
| TWI300776B (en) | 2008-09-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |