[go: up one dir, main page]

UY29224A1 - Derivados sustituidos de n-((3s)-pirrolidin-3il)benzamida, composiciones que los contienen, procedimientos de preparación y aplicaciones - Google Patents

Derivados sustituidos de n-((3s)-pirrolidin-3il)benzamida, composiciones que los contienen, procedimientos de preparación y aplicaciones

Info

Publication number
UY29224A1
UY29224A1 UY29224A UY29224A UY29224A1 UY 29224 A1 UY29224 A1 UY 29224A1 UY 29224 A UY29224 A UY 29224A UY 29224 A UY29224 A UY 29224A UY 29224 A1 UY29224 A1 UY 29224A1
Authority
UY
Uruguay
Prior art keywords
applications
compositions containing
preparation procedures
benzamida
pirrolidin
Prior art date
Application number
UY29224A
Other languages
English (en)
Inventor
Thomas Ryckmans
Paul Vincent Fish
Alan Stobie
Florian Wakenhut
Gavin Alistair Whitlock
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of UY29224A1 publication Critical patent/UY29224A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Reproductive Health (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compuestos de la Fórmula (I): y sus derivados farmacéutica y/o veterinariamente aceptables, en la que R1,R2, R3, R4 y R20 son como se definieron en la memoria y reivindicaciones; composiciones farmacéuticas que los contienen, procedimientos de preparación y aplicaciones. Los compuestos de la invención exhiben actividad como inhibidores de la recaptación tanto de serotonina como de noradrenalina y por lo tanto tienen utilidad en varias áreas terapéuticas, por ejemplo, incontinencia urinaria.
UY29224A 2004-11-23 2005-11-22 Derivados sustituidos de n-((3s)-pirrolidin-3il)benzamida, composiciones que los contienen, procedimientos de preparación y aplicaciones UY29224A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0425766.3A GB0425766D0 (en) 2004-11-23 2004-11-23 Novel compounds

Publications (1)

Publication Number Publication Date
UY29224A1 true UY29224A1 (es) 2006-06-30

Family

ID=33548739

Family Applications (1)

Application Number Title Priority Date Filing Date
UY29224A UY29224A1 (es) 2004-11-23 2005-11-22 Derivados sustituidos de n-((3s)-pirrolidin-3il)benzamida, composiciones que los contienen, procedimientos de preparación y aplicaciones

Country Status (26)

Country Link
EP (1) EP1817281A1 (es)
JP (1) JP4233596B2 (es)
KR (1) KR100886294B1 (es)
CN (1) CN101065355A (es)
AP (1) AP2007004003A0 (es)
AR (1) AR052243A1 (es)
AU (1) AU2005308534A1 (es)
BR (1) BRPI0518486A2 (es)
CA (1) CA2589258A1 (es)
CR (1) CR9171A (es)
EA (1) EA011217B1 (es)
GB (1) GB0425766D0 (es)
GT (1) GT200500337A (es)
IL (1) IL183191A0 (es)
MA (1) MA29038B1 (es)
MX (1) MX2007006138A (es)
NL (2) NL1030485C2 (es)
NO (1) NO20072486L (es)
PA (1) PA8653501A1 (es)
PE (1) PE20061056A1 (es)
SV (1) SV2006002311A (es)
TN (1) TNSN07201A1 (es)
TW (1) TWI300776B (es)
UY (1) UY29224A1 (es)
WO (1) WO2006056884A1 (es)
ZA (1) ZA200703910B (es)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH628885A5 (en) * 1978-01-01 1982-03-31 Anphar Sa Piperidine derivative
GB0314054D0 (en) * 2003-06-17 2003-07-23 Pfizer Ltd Amide derivatives as selective serotonin re-uptake inhibitors
AU2004247487B2 (en) * 2003-06-17 2010-05-20 Pfizer Inc. N-pyrrolidin-3-YL-amide derivatives as serotonin and noradrenaline re-uptake inhibitors

Also Published As

Publication number Publication date
NL1030485C2 (nl) 2006-11-07
CA2589258A1 (en) 2006-06-01
GB0425766D0 (en) 2004-12-22
MX2007006138A (es) 2007-07-19
NL1032760C2 (nl) 2007-04-17
MA29038B1 (fr) 2007-11-01
TWI300776B (en) 2008-09-11
ZA200703910B (en) 2008-09-25
TW200626543A (en) 2006-08-01
CN101065355A (zh) 2007-10-31
NL1032760A1 (nl) 2006-12-13
BRPI0518486A2 (pt) 2008-11-18
AR052243A1 (es) 2007-03-07
PA8653501A1 (es) 2006-06-02
EA200700920A1 (ru) 2007-12-28
JP2008520646A (ja) 2008-06-19
SV2006002311A (es) 2006-09-14
CR9171A (es) 2007-07-04
GT200500337A (es) 2006-06-13
KR20070086599A (ko) 2007-08-27
AU2005308534A1 (en) 2006-06-01
EP1817281A1 (en) 2007-08-15
IL183191A0 (en) 2007-08-19
PE20061056A1 (es) 2006-11-08
TNSN07201A1 (fr) 2008-11-21
WO2006056884A1 (en) 2006-06-01
NL1030485A1 (nl) 2006-05-24
AP2007004003A0 (en) 2007-06-30
EA011217B1 (ru) 2009-02-27
NO20072486L (no) 2007-06-20
JP4233596B2 (ja) 2009-03-04
KR100886294B1 (ko) 2009-03-04

Similar Documents

Publication Publication Date Title
ECSP20027480A (es) Indolil alquil amino derivados sustituidos como nuevos inhibidores de la histona desacetilasa
SE0401971D0 (sv) Piperidne derivatives
UY30316A1 (es) Derivados sustituidos de benzamidas, nicotinamidas, propanamidas, acetamidas y carboxamidas n-(2-(piperidin-1-ilmetil)ciclohexil)sustituidas, procesos de preparacion, composiciones conteniéndolos y aplicaciones
UA88012C2 (uk) Похідні хіназоліндіону як інгібітори parp
SE0402735D0 (sv) Novel compounds
ATE433447T1 (de) Pyrimiidinverbindungen
EA200970156A1 (ru) Пиридизиноновые производные
UY28936A1 (es) Grupo de compuestos benzoil-amino-heterociclilo y composiciones farmaceuticas que los comprenden, utiles para tratamiento de enfermedades mediadas por glucoquinasa (gq)
UY28572A1 (es) Compuestos novedosos
SV2002000245A (es) Oxazolidinonas substituidas y su uso ref. lea 34122-sv
EA200970585A1 (ru) Бензамидные производные как агонисты ер-рецепторов
TW200801003A (en) Novel compounds
UY30195A1 (es) Derivados de fenetanolamina, procedimiento de preparacion, composiciones que los contienen y aplicaciones
UY28360A1 (es) Nuevos compuestos
SE0401762D0 (sv) Novel compounds
SE0401970D0 (sv) Novel compounds
DK1506185T3 (da) Forbindelser og deres anvendelse som 5-HT-inhibitorer
SE0302139D0 (sv) Novel compounds
UY30393A1 (es) Derivados sustituidos de la 1-piperidin-1-il-1,3-dihidro-2h-benzimidazol-2-ona, composiciones farmacéuticas conteniéndolos, procesos de preparación y aplicaciones
SE0302546D0 (sv) New compounds
UY29234A1 (es) Derivados de adamantano, composiciones farmacéuticas que los contienen, procedimientos de preparación de ambos y aplicaciones.
UY30363A1 (es) Derivados sustituidos de la n-(3-oxo-2,3-dihidro-1h-isoindol-4-il)-1-naftamida, procesos de preparacion, composiciones farmacéuticas y aplicaciones
SE0301701D0 (sv) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
UY29370A1 (es) Derivados de tiazol, composiciones que lo contienen, procedimientos de preparación y aplicaciones
SE0301699D0 (sv) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof

Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20160601