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NO20070343L - N-(1 -(1 -benzyl-4-fenyl-1 H-imidazol-2-yl)-2,2-dimetylpropyl)benzamid derivater og relaterte forbindelser som kinesin spindelprotein (KSP) inhibitorer for behandling av kreft - Google Patents

N-(1 -(1 -benzyl-4-fenyl-1 H-imidazol-2-yl)-2,2-dimetylpropyl)benzamid derivater og relaterte forbindelser som kinesin spindelprotein (KSP) inhibitorer for behandling av kreft

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Publication number
NO20070343L
NO20070343L NO20070343A NO20070343A NO20070343L NO 20070343 L NO20070343 L NO 20070343L NO 20070343 A NO20070343 A NO 20070343A NO 20070343 A NO20070343 A NO 20070343A NO 20070343 L NO20070343 L NO 20070343L
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Norway
Prior art keywords
group
optionally substituted
substituted
hydrogen
aryl
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NO20070343A
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English (en)
Inventor
Weibo Wang
Paul A Barsanti
Yi Xi
Rustum S Boyce
Sabina Pecchi
Nathan Brammeier
Megan Phillips
Kris Mendenhall
Kelly Wayman
Liana Marie Lagniton
Ryan Constantine
Hong Yang
Elizabeth Mieuli
Savithri Murthy
Elisa Jazan
Anu Sharma
Jain Rama
Sharadha Sabramanian
Paul Renhowe
Kenneth Walter Bair
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Uswalter Annette
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Application filed by Uswalter Annette filed Critical Uswalter Annette
Publication of NO20070343L publication Critical patent/NO20070343L/no

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Abstract

Foreliggende oppfinnelse angår substituerte imidazolforbindelser som modulerer aktiviteten til KSP og er anvendlige for behandling av kreft og er representert ved formel (I) hvori: R1 er valgt fra gruppen som består av aminoacyl, acylamino, karboksyl, karboksylester, aryl og alkyl eventuelt substituert med hydroksy eller halo; R2 er valgt fra gruppen som består av hydrogen, alkyl og aryl; R3 er valgt fra gruppen som består av hydrogen og X-A; hvori X er valgt fra gruppen som består av -C(O)-, -C(S), S(O)2- og -S(O)2-N(R)-hvor R er hydrogen eller alkyl; og A er valgt fra gruppen som består av hydrogen, eventuelt substituert alkyl, eventuelt substituert alkoksy, eventuelt substituert aryl, karboksyl, karboksylester, aminoacyl, eventuelt substituert heteroaryl, eventuelt substituert heterocyklisk og eventuelt substituert cykloalkyl, hvori de eventuelt substituerte gruppene er substituerte med 1 til 4 substituenter; R5 er valgt fra gruppen som består av L-A1, hvori L er valgt fra gruppen som består av -S(O)q- hvor q er 1 eller 2, og Ci til C5 alkylen eventuelt substituert med hydroksy, halo, eller acylamino; og A1 er valgt fra gruppen som består av aryl, substituert aryl, heteroaryl, substituert heteroaryl, heterocyklisk, substituert heterocyklisk, cykloalkyl og substituert alkyl; og en av enten R6 eller R7 er valgt fra gruppen som består av heterocyklisk, aryl og heteroaryl, hvor alle eventuelt kan være substituert med -(R8)m hvor R8 er som defienrt heri og m er et heltall på fra 1 til 3 og den andre av R6 og R7 er valgt fra gruppen som består av hydrogen, halo og alkyl; eller R6 og R7 begge er hydrogen; og de andre substituentene er som definert i kravene.
NO20070343A 2004-06-18 2007-01-18 N-(1 -(1 -benzyl-4-fenyl-1 H-imidazol-2-yl)-2,2-dimetylpropyl)benzamid derivater og relaterte forbindelser som kinesin spindelprotein (KSP) inhibitorer for behandling av kreft NO20070343L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58092704P 2004-06-18 2004-06-18
PCT/US2005/022062 WO2006002236A1 (en) 2004-06-18 2005-06-20 N- (1- (1-benzyl -4-phenyl-1h-imidazol-2-yl) -2,2-dymethylpropyl) benzamide derivatives and related compounds as kinesin spindle protein (ksp) inhibitors for the treatment of cancer

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NO20070343L true NO20070343L (no) 2007-03-05

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US (3) US7576221B2 (no)
EP (1) EP1765789B1 (no)
JP (2) JP4836280B2 (no)
KR (1) KR101170925B1 (no)
CN (1) CN1993331A (no)
AU (1) AU2005258135B2 (no)
BR (1) BRPI0510929A (no)
CA (1) CA2571002A1 (no)
EC (1) ECSP077183A (no)
ES (1) ES2409345T3 (no)
IL (1) IL180147A0 (no)
MA (1) MA28739B1 (no)
MX (1) MXPA06014909A (no)
NO (1) NO20070343L (no)
NZ (1) NZ552510A (no)
RU (1) RU2427572C2 (no)
SG (1) SG153851A1 (no)
TN (1) TNSN06419A1 (no)
TW (1) TW200612958A (no)
WO (1) WO2006002236A1 (no)
ZA (1) ZA200700481B (no)

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CA2571002A1 (en) 2006-01-05
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IL180147A0 (en) 2007-06-03
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US7576221B2 (en) 2009-08-18
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AU2005258135A1 (en) 2006-01-05
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