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NO20054195L - Isoksazolforbindelser som inhibitorer for varmesjokkproteiner - Google Patents

Isoksazolforbindelser som inhibitorer for varmesjokkproteiner

Info

Publication number
NO20054195L
NO20054195L NO20054195A NO20054195A NO20054195L NO 20054195 L NO20054195 L NO 20054195L NO 20054195 A NO20054195 A NO 20054195A NO 20054195 A NO20054195 A NO 20054195A NO 20054195 L NO20054195 L NO 20054195L
Authority
NO
Norway
Prior art keywords
formula
optionally substituted
inhibitors
alk1
nra
Prior art date
Application number
NO20054195A
Other languages
English (en)
Other versions
NO335001B1 (no
NO20054195D0 (no
Inventor
Martin James Drysdale
Brian William Dymock
Harry Finch
Paul Webb
Edward Mcdonald
Karen Elizabeth James
Kwai Ming Cheung
Thomas Peter Mathews
Original Assignee
Vernalis R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0303105A external-priority patent/GB0303105D0/en
Priority claimed from GBGB0306560.4A external-priority patent/GB0306560D0/en
Priority claimed from GB0313751A external-priority patent/GB0313751D0/en
Application filed by Vernalis R&D Ltd filed Critical Vernalis R&D Ltd
Publication of NO20054195D0 publication Critical patent/NO20054195D0/no
Publication of NO20054195L publication Critical patent/NO20054195L/no
Publication of NO335001B1 publication Critical patent/NO335001B1/no

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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Abstract

Isoksazoler med formel (A) eller (B) er inhibitorer for HSP90-aktivitet og anvendbare til behandling av f.eks. kreft, hvor Rx er en gruppe med formel (IA): -Ar1-(Alk1)p- (Z)r- (Alk2)s-Q, hvor i hvilken som helst kompatibel kombinasjon Ar1 er et eventuelt substituert aryl- eller heteroarylradikal, Alk1 og Alk2 er eventuelt substituerte to-verdige Ci-C6-alkylen eller C2-C6-alken-ylenradikaler, p, r og s er uavhengig av hverandre 0 eller 1, Z er -0-, -S-, -(C=0)-f -(C=S)-, -S02-, -C(=0)0-, -C-(=O)NRA-, -C(=S)NRA-, -SO2NRA-, -NRAC-(=0)-, -NRASO2- eller -NRA-, hvor RA er hydrogen eller d-C6-alkyl, og Q er hydrogen eller et eventuelt substituert karbosyklisk eller heterosyklisk radikal; R2 er (i) en gruppe med formel (IA) ovenfor, eller (ii) et karboks-amidradikal, eller (iii) en ikke-aromatisk, karbosyklisk eller heterosyklisk ring hvor et ringkarbon eventuelt er substituert, og/eller hvor et ringnitrogen eventuelt er substituert med en gruppe med formel - (Alk1)p-(Z) r-
NO20054195A 2003-02-11 2005-09-09 Isoksazolforbindelser, og farmasøytisk preparat som omfatter forbindelsene, som inhibitorer for varmesjokkproteiner NO335001B1 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0303105A GB0303105D0 (en) 2003-02-11 2003-02-11 Isoxazole compounds
GBGB0306560.4A GB0306560D0 (en) 2003-03-21 2003-03-21 Isoxazole compounds
GB0313751A GB0313751D0 (en) 2003-06-13 2003-06-13 Isoxazole compounds
PCT/GB2004/000506 WO2004072051A1 (en) 2003-02-11 2004-02-09 Isoxazole compounds as inhibitors of heat shock proteins

Publications (3)

Publication Number Publication Date
NO20054195D0 NO20054195D0 (no) 2005-09-09
NO20054195L true NO20054195L (no) 2005-11-09
NO335001B1 NO335001B1 (no) 2014-08-18

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NO20054195A NO335001B1 (no) 2003-02-11 2005-09-09 Isoksazolforbindelser, og farmasøytisk preparat som omfatter forbindelsene, som inhibitorer for varmesjokkproteiner

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US (6) US7705027B2 (no)
EP (1) EP1611112B1 (no)
JP (1) JP4921162B2 (no)
KR (1) KR101166749B1 (no)
CN (1) CN1771235B (no)
AU (1) AU2004210779B2 (no)
BR (1) BRPI0407403B1 (no)
CA (1) CA2515726C (no)
CY (1) CY1113761T1 (no)
DK (1) DK1611112T3 (no)
EA (1) EA009919B1 (no)
ES (1) ES2393483T3 (no)
MX (1) MXPA05008335A (no)
NO (1) NO335001B1 (no)
NZ (1) NZ541479A (no)
PT (1) PT1611112E (no)
SI (1) SI1611112T1 (no)
WO (1) WO2004072051A1 (no)

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DK1611112T3 (da) 2003-02-11 2012-11-19 Cancer Res Inst Isoxazolforbindelser som hæmmere af varmechokproteiner
GB0315111D0 (en) * 2003-06-27 2003-07-30 Cancer Rec Tech Ltd Substituted 5-membered ring compounds and their use
WO2005063222A1 (ja) * 2003-12-26 2005-07-14 Kyowa Hakko Kogyo Co., Ltd. Hsp90ファミリー蛋白質阻害剤
MXPA06013705A (es) 2004-05-28 2007-02-13 Unigen Pharmaceuticals Inc Diarilalcanos como potentes inhibidores de enzimas binucleares.
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NZ552159A (en) 2004-06-23 2009-12-24 Synta Pharmaceuticals Corp Bis(thio-hydrazide amide) salts for treatment of cancers
RU2375384C2 (ru) 2004-09-22 2009-12-10 Ниппон Каяку Кабусики Кайся Новый блок-сополимер, мицеллярный препарат и противораковое средство, включающее мицеллярный препарат в качестве активного ингредиента
WO2006051808A1 (ja) * 2004-11-09 2006-05-18 Kyowa Hakko Kogyo Co., Ltd. Hsp90ファミリー蛋白質阻害剤
ME01498B (me) 2004-11-18 2014-04-20 Synta Pharmaceuticals Corp Jedinjenja triazola koja modulišu aktivnost hsp90
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