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NO20062884L - AKT-proteinkinaseinhibitorer - Google Patents

AKT-proteinkinaseinhibitorer

Info

Publication number
NO20062884L
NO20062884L NO20062884A NO20062884A NO20062884L NO 20062884 L NO20062884 L NO 20062884L NO 20062884 A NO20062884 A NO 20062884A NO 20062884 A NO20062884 A NO 20062884A NO 20062884 L NO20062884 L NO 20062884L
Authority
NO
Norway
Prior art keywords
protein kinase
kinase inhibitors
akt protein
compounds
diastereomers
Prior art date
Application number
NO20062884A
Other languages
English (en)
Inventor
Dengming Xiao
Mark Munson
Guy Vigers
John Anthony Josey
Peter Stengel
Ian S Mitchell
Keith L Spencer
Yongxin Han
Nicholas Kallan
James Blake
Anthony Piscopio
Scott Miller
Riu Xu
Chang Rao
Bin Wang
April L Bernacki
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of NO20062884L publication Critical patent/NO20062884L/no

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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Theoretical Computer Science (AREA)
  • Geometry (AREA)
  • General Physics & Mathematics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Quinoline Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Foreliggende oppfinnelse tilveiebringer forbindelser, inkludert utledede enantiomerer, diastereomerer, solvater og farmasøytisk akseptable salter derav, som omfatter Formelen: A-L-CR der CR er en syklisk kjernegruppe, L er en linkergruppe og A er som definert her. Også tilveiebrakt er fremgangsmåter for å benytte forbindelsene ifølge denne oppfinnelsen som AKT-proteinkinaseinhibitorer og til behandlingen av hyperproliferative sykdommer slik som kreft.
NO20062884A 2003-11-21 2006-06-20 AKT-proteinkinaseinhibitorer NO20062884L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52400303P 2003-11-21 2003-11-21
PCT/US2004/039094 WO2005051304A2 (en) 2003-11-21 2004-11-19 Akt protein kinase inhibitors

Publications (1)

Publication Number Publication Date
NO20062884L true NO20062884L (no) 2006-08-18

Family

ID=34632854

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20062884A NO20062884L (no) 2003-11-21 2006-06-20 AKT-proteinkinaseinhibitorer

Country Status (15)

Country Link
US (3) US20050130954A1 (no)
EP (1) EP1684694A2 (no)
JP (1) JP2007512364A (no)
KR (2) KR20110137838A (no)
CN (2) CN102786482A (no)
AU (1) AU2004293026B2 (no)
BR (1) BRPI0416852A (no)
CA (1) CA2546754A1 (no)
IL (2) IL175221A (no)
NO (1) NO20062884L (no)
NZ (2) NZ547327A (no)
PH (1) PH12012501891A1 (no)
RU (1) RU2006121990A (no)
WO (1) WO2005051304A2 (no)
ZA (1) ZA200604069B (no)

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US7402652B2 (en) * 2004-09-14 2008-07-22 Miller Landon C G Baclofen conjugate and a pharmaceutical composition for treatment of neuronal disorders
MY179032A (en) * 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
KR20130006516A (ko) * 2004-12-02 2013-01-16 다이이찌 산쿄 가부시키가이샤 7원환 화합물 및 그 제조법 및 의약 용도
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MX2007010572A (es) * 2005-03-01 2007-10-04 Wyeth Corp Compuestos de cinolina y su uso como moduladores de receptor x de higado.
EP1702916A1 (en) * 2005-03-18 2006-09-20 Santhera Pharmaceuticals (Schweiz) GmbH DPP-IV inhibitors
US8921376B2 (en) * 2005-05-20 2014-12-30 Vertex Pharmaceuticals Incorporated Pyrrolopyridines useful as inhibitors of protein kinase
US8071768B2 (en) 2005-06-10 2011-12-06 Janssen Pharmaceutica, N.V. Alkylquinoline and alkylquinazoline kinase modulators
US7825244B2 (en) 2005-06-10 2010-11-02 Janssen Pharmaceutica Nv Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
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