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NO20043341L - Fremgangsmate for fremstilling av scopinestere - Google Patents

Fremgangsmate for fremstilling av scopinestere

Info

Publication number
NO20043341L
NO20043341L NO20043341A NO20043341A NO20043341L NO 20043341 L NO20043341 L NO 20043341L NO 20043341 A NO20043341 A NO 20043341A NO 20043341 A NO20043341 A NO 20043341A NO 20043341 L NO20043341 L NO 20043341L
Authority
NO
Norway
Prior art keywords
esters
scopin
making
rog
residues
Prior art date
Application number
NO20043341A
Other languages
English (en)
Other versions
NO328825B1 (no
Inventor
Jorg Brandenburg
Werner Rall
Waldemar Pfrengle
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of NO20043341L publication Critical patent/NO20043341L/no
Publication of NO328825B1 publication Critical patent/NO328825B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Polyethers (AREA)

Abstract

Oppfinnelsen vedrører en ny fremgangsmåte for fremstilling av Scopinestere med den generelle formel 1 hvori X" og restene Rog Ar kan ha de i kravene og i beskrivelsen nevnte betydninger.
NO20043341A 2002-01-12 2004-08-11 Fremgangsmate for fremstilling av scopinestere NO328825B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10200943A DE10200943A1 (de) 2002-01-12 2002-01-12 Verfahren zur Herstellung von Scopinestern
PCT/EP2002/014756 WO2003057694A1 (de) 2002-01-12 2002-12-24 Verfahren zur herstellung von scopinestern

Publications (2)

Publication Number Publication Date
NO20043341L true NO20043341L (no) 2004-08-11
NO328825B1 NO328825B1 (no) 2010-05-25

Family

ID=7711974

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20043341A NO328825B1 (no) 2002-01-12 2004-08-11 Fremgangsmate for fremstilling av scopinestere

Country Status (30)

Country Link
US (1) US6747154B2 (no)
EP (2) EP1467993B1 (no)
JP (1) JP5134756B2 (no)
KR (1) KR100929503B1 (no)
CN (1) CN100406456C (no)
AT (1) ATE404557T1 (no)
AU (1) AU2002361218B2 (no)
BR (1) BR0215493A (no)
CA (1) CA2471755C (no)
CO (1) CO5601006A2 (no)
CY (1) CY1108471T1 (no)
DE (2) DE10200943A1 (no)
DK (1) DK1467993T3 (no)
EA (1) EA007230B1 (no)
EC (1) ECSP045182A (no)
ES (1) ES2312655T3 (no)
HR (1) HRP20040623B1 (no)
HU (1) HU226665B1 (no)
IL (2) IL162416A0 (no)
ME (1) MEP51208A (no)
MX (1) MXPA04006677A (no)
NO (1) NO328825B1 (no)
NZ (1) NZ534339A (no)
PL (1) PL208132B1 (no)
PT (1) PT1467993E (no)
RS (1) RS50771B (no)
SI (1) SI1467993T1 (no)
UA (1) UA78753C2 (no)
WO (1) WO2003057694A1 (no)
ZA (1) ZA200403852B (no)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
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DE10141377A1 (de) 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Aufstreuverfahren zur Herstellung von Pulverformulierungen
DE10216427A1 (de) * 2002-04-12 2003-10-23 Boehringer Ingelheim Pharma Arzneimittelkompositionen enthaltend heterocyclische Verbindungen und ein neues Anticholinergikum
US7084153B2 (en) * 2002-04-12 2006-08-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising steroids and a novel anticholinergic
US7417051B2 (en) * 2002-04-12 2008-08-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising betamimetics and a novel anticholinergic
US20040044020A1 (en) * 2002-07-09 2004-03-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on novel anticholinergics and p38 kinase inhibitors
US20040058950A1 (en) * 2002-07-09 2004-03-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on anticholinergics and PDE-IV inhibitors
US20040048887A1 (en) * 2002-07-09 2004-03-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on anticholinergics and EGFR kinase inhibitors
US20040048886A1 (en) * 2002-07-09 2004-03-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on new anticholinergics and NK1 receptor antagonists
HRP20050132A2 (en) * 2002-08-14 2006-05-31 Boehringer Ingelheim Pharma Gmbh & Co.Kg. Aerosol formulation for inhalation containing an anticholinergic agent
US20040166065A1 (en) 2002-08-14 2004-08-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosol formulation for inhalation comprising an anticholinergic
US7244742B2 (en) * 2002-08-17 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co Kg Pharmaceutical compositions for inhalation containing an anticholinergic, corticosteroid and betamimetic
US7056916B2 (en) * 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
US7332175B2 (en) * 2003-05-27 2008-02-19 Boehringer Ingelheim International Gmbh Long-acting drug combinations for the treatment of respiratory complaints
US7273603B2 (en) * 2003-07-11 2007-09-25 Boehringer Ingelheim International Gmbh HFC solution formulations containing an anticholinergic
ATE526967T1 (de) * 2003-07-31 2011-10-15 Boehringer Ingelheim Int Medikamente für inhalationen enthaltend ein anticholinergikum und ein betamimetikum
US20050025718A1 (en) * 2003-07-31 2005-02-03 Boehringer Ingelheim International Gmbh Medicaments for inhalation comprising an anticholinergic and a betamimetic
EP2067779B9 (de) * 2003-11-03 2013-10-16 Boehringer Ingelheim International GmbH Tiotropiumsalze, Verfahren zu deren Herstellung und Arzneimittelformulierungen diese enthaltend
CA2544357A1 (en) * 2003-11-03 2005-05-12 Boehringer Ingelheim International Gmbh Tiotropium salts, methods for the production thereof, and pharmaceutical formulations containing the same
US20050272726A1 (en) * 2004-04-22 2005-12-08 Boehringer Ingelheim International Gmbh Novel medicaments for the treatment of respiratory diseases
US20050255050A1 (en) * 2004-05-14 2005-11-17 Boehringer Ingelheim International Gmbh Powder formulations for inhalation, comprising enantiomerically pure beta agonists
US20050256115A1 (en) * 2004-05-14 2005-11-17 Boehringer Ingelheim International Gmbh Aerosol formulation for the inhalation of beta-agonists
US7220742B2 (en) 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
DE102004041253A1 (de) * 2004-08-26 2006-03-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen
EP1881980B1 (en) * 2005-05-02 2012-08-22 Boehringer Ingelheim International GmbH Novel crystalline forms of tiotropium bromide
MX2007015997A (es) * 2005-06-15 2008-03-07 Boehringer Ingelheim Int Procedimiento para preparar nuevas sales de tiotropio, nuevas sales de tiotropio como tales y composiciones farmaceuticas de las mismas.
DE102005035112A1 (de) * 2005-07-27 2007-02-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
JP5270343B2 (ja) * 2005-08-15 2013-08-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ベータミメティックスの製造方法
WO2008089852A1 (de) * 2007-01-26 2008-07-31 Boehringer Ingelheim Pharma Gmbh & Co.Kg Neues verfahren zur herstellung von tiotropiumsalzen
EP1953156A1 (de) * 2007-01-29 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Scopiniumsalzen
EP1997819A1 (de) * 2007-05-25 2008-12-03 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Scopinestern
US20110028508A1 (en) * 2008-01-10 2011-02-03 Gemerocs [UK] Limited Novel process for the preparation of scopine esters
US8263623B2 (en) 2008-07-11 2012-09-11 Pfizer Inc. Triazol derivatives useful for the treatment of diseases
CN102639531B (zh) 2009-08-07 2016-01-20 基因里克斯(英国)有限公司 噻托溴铵的无水合物
WO2011015884A1 (en) * 2009-08-07 2011-02-10 Generics [Uk] Limited Process to prepare scopine esters
US8957209B2 (en) 2010-04-01 2015-02-17 Mahmut Bilgic Methods for the synthesis of tiotropium bromide
TR201005221A2 (tr) * 2010-04-01 2012-01-23 Bi̇lgi̇ç Mahmut Geliştirilmiş sentez metodu.
TR201002520A2 (tr) * 2010-04-01 2010-05-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür imalat metodu.
TR201005222A2 (tr) * 2010-04-01 2011-10-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür sentez yöntemi
ITRM20110508A1 (it) 2011-09-27 2013-03-28 Lusochimica Spa Processo per la preparazione degli esteri della scopina.
PT106142B (pt) 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A Processo para a preparação de brometo de tiotrópio
CZ304808B6 (cs) 2012-03-16 2014-11-05 Zentiva, K.S. Způsob přípravy skopinesteru kyseliny di(2-thienyl)glykolové, intermediátu v syntéze tiotropium bromidu a jeho nová forma
CZ305012B6 (cs) 2012-03-30 2015-03-25 Zentiva, K.S. Způsob přípravy skopinesteru kyseliny di(2-thienyl)glykolové, intermediátu v syntéze tiotropium bromidu

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Also Published As

Publication number Publication date
IL162416A0 (en) 2005-11-20
RS50771B (sr) 2010-08-31
HUP0402604A3 (en) 2008-05-28
HRP20040623B1 (en) 2012-09-30
ATE404557T1 (de) 2008-08-15
HK1073847A1 (zh) 2005-10-21
DE10200943A1 (de) 2003-07-24
HU226665B1 (en) 2009-06-29
AU2002361218A1 (en) 2003-07-24
RS59404A (sr) 2007-04-10
NZ534339A (en) 2005-04-29
PL208132B1 (pl) 2011-03-31
IL162416A (en) 2010-06-30
EP1972626A2 (de) 2008-09-24
UA78753C2 (en) 2007-04-25
ES2312655T3 (es) 2009-03-01
EP1972626A3 (de) 2008-10-01
US6747154B2 (en) 2004-06-08
HRP20040623A2 (en) 2005-04-30
NO328825B1 (no) 2010-05-25
JP2005519890A (ja) 2005-07-07
MXPA04006677A (es) 2004-10-04
CA2471755C (en) 2011-02-08
BR0215493A (pt) 2004-12-28
CN100406456C (zh) 2008-07-30
ECSP045182A (es) 2004-08-27
CA2471755A1 (en) 2003-07-17
JP5134756B2 (ja) 2013-01-30
HUP0402604A2 (hu) 2005-04-28
DE50212650D1 (de) 2008-09-25
PT1467993E (pt) 2008-09-03
CY1108471T1 (el) 2014-04-09
EP1467993B1 (de) 2008-08-13
EA007230B1 (ru) 2006-08-25
US20030232993A1 (en) 2003-12-18
SI1467993T1 (sl) 2009-02-28
WO2003057694A1 (de) 2003-07-17
DK1467993T3 (da) 2008-11-10
PL369126A1 (en) 2005-04-18
EA200400875A1 (ru) 2004-12-30
CN1610680A (zh) 2005-04-27
AU2002361218B2 (en) 2008-04-24
CO5601006A2 (es) 2006-01-31
EP1467993A1 (de) 2004-10-20
KR100929503B1 (ko) 2009-12-03
ZA200403852B (en) 2005-06-22
MEP51208A (hr) 2011-05-10
KR20040072715A (ko) 2004-08-18

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