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MEP51208A - Postupak za pripremanje skopin estara - Google Patents

Postupak za pripremanje skopin estara

Info

Publication number
MEP51208A
MEP51208A MEP-512/08A MEP51208A MEP51208A ME P51208 A MEP51208 A ME P51208A ME P51208 A MEP51208 A ME P51208A ME P51208 A MEP51208 A ME P51208A
Authority
ME
Montenegro
Prior art keywords
estar
preparing
procedure
groups
scopin
Prior art date
Application number
MEP-512/08A
Other languages
Bosnian (bs)
English (en)
Croatian (hr)
Inventor
Joerg Brandenburg
Waldemar Pfrengle
Werner Rall
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of MEP51208A publication Critical patent/MEP51208A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Polyethers (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
MEP-512/08A 2002-01-12 2002-12-24 Postupak za pripremanje skopin estara MEP51208A (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10200943A DE10200943A1 (de) 2002-01-12 2002-01-12 Verfahren zur Herstellung von Scopinestern
PCT/EP2002/014756 WO2003057694A1 (de) 2002-01-12 2002-12-24 Verfahren zur herstellung von scopinestern
YUP-594/04A RS50771B (sr) 2002-01-12 2002-12-24 Postupak za pripremanje skopin estara

Publications (1)

Publication Number Publication Date
MEP51208A true MEP51208A (hr) 2011-05-10

Family

ID=7711974

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-512/08A MEP51208A (hr) 2002-01-12 2002-12-24 Postupak za pripremanje skopin estara

Country Status (30)

Country Link
US (1) US6747154B2 (xx)
EP (2) EP1972626A3 (xx)
JP (1) JP5134756B2 (xx)
KR (1) KR100929503B1 (xx)
CN (1) CN100406456C (xx)
AT (1) ATE404557T1 (xx)
AU (1) AU2002361218B2 (xx)
BR (1) BR0215493A (xx)
CA (1) CA2471755C (xx)
CO (1) CO5601006A2 (xx)
CY (1) CY1108471T1 (xx)
DE (2) DE10200943A1 (xx)
DK (1) DK1467993T3 (xx)
EA (1) EA007230B1 (xx)
EC (1) ECSP045182A (xx)
ES (1) ES2312655T3 (xx)
HR (1) HRP20040623B1 (xx)
HU (1) HU226665B1 (xx)
IL (2) IL162416A0 (xx)
ME (1) MEP51208A (xx)
MX (1) MXPA04006677A (xx)
NO (1) NO328825B1 (xx)
NZ (1) NZ534339A (xx)
PL (1) PL208132B1 (xx)
PT (1) PT1467993E (xx)
RS (1) RS50771B (xx)
SI (1) SI1467993T1 (xx)
UA (1) UA78753C2 (xx)
WO (1) WO2003057694A1 (xx)
ZA (1) ZA200403852B (xx)

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DE10141377A1 (de) 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Aufstreuverfahren zur Herstellung von Pulverformulierungen
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US7417051B2 (en) * 2002-04-12 2008-08-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising betamimetics and a novel anticholinergic
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US20040048886A1 (en) * 2002-07-09 2004-03-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on new anticholinergics and NK1 receptor antagonists
US20040044020A1 (en) * 2002-07-09 2004-03-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on novel anticholinergics and p38 kinase inhibitors
US20040058950A1 (en) * 2002-07-09 2004-03-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on anticholinergics and PDE-IV inhibitors
US20040048887A1 (en) * 2002-07-09 2004-03-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on anticholinergics and EGFR kinase inhibitors
US20040166065A1 (en) * 2002-08-14 2004-08-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosol formulation for inhalation comprising an anticholinergic
JP4602767B2 (ja) * 2002-08-14 2010-12-22 ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト 抗コリン作用薬を含有する吸入用エアロゾル製剤
US7244742B2 (en) * 2002-08-17 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co Kg Pharmaceutical compositions for inhalation containing an anticholinergic, corticosteroid and betamimetic
US7056916B2 (en) * 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
US7332175B2 (en) * 2003-05-27 2008-02-19 Boehringer Ingelheim International Gmbh Long-acting drug combinations for the treatment of respiratory complaints
US7273603B2 (en) * 2003-07-11 2007-09-25 Boehringer Ingelheim International Gmbh HFC solution formulations containing an anticholinergic
ATE526967T1 (de) * 2003-07-31 2011-10-15 Boehringer Ingelheim Int Medikamente für inhalationen enthaltend ein anticholinergikum und ein betamimetikum
US20050025718A1 (en) * 2003-07-31 2005-02-03 Boehringer Ingelheim International Gmbh Medicaments for inhalation comprising an anticholinergic and a betamimetic
ATE478071T1 (de) * 2003-11-03 2010-09-15 Boehringer Ingelheim Int Verfahren zur herstellung neuer tiotropiumsalze
HRP20100149T1 (hr) * 2003-11-03 2010-04-30 Boehringer Ingelheim International Gmbh Postupak priprave tiotropijevih soli
US20050272726A1 (en) * 2004-04-22 2005-12-08 Boehringer Ingelheim International Gmbh Novel medicaments for the treatment of respiratory diseases
US20050256115A1 (en) * 2004-05-14 2005-11-17 Boehringer Ingelheim International Gmbh Aerosol formulation for the inhalation of beta-agonists
US20050255050A1 (en) * 2004-05-14 2005-11-17 Boehringer Ingelheim International Gmbh Powder formulations for inhalation, comprising enantiomerically pure beta agonists
US7220742B2 (en) 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
DE102004041253A1 (de) * 2004-08-26 2006-03-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen
SI1881980T1 (sl) * 2005-05-02 2012-12-31 Boehringer Ingelheim International Gmbh Nove kristalinične oblike tiotropijevega bromida
CN101227905A (zh) * 2005-06-15 2008-07-23 贝林格尔·英格海姆国际有限公司 制备噻托铵盐的方法、噻托铵盐及其药物组合物
DE102005035112A1 (de) * 2005-07-27 2007-02-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
BRPI0614410A2 (pt) * 2005-08-15 2011-03-29 Boehringer Ingelheim Int processo para preparação de betamiméticos
WO2008089852A1 (de) * 2007-01-26 2008-07-31 Boehringer Ingelheim Pharma Gmbh & Co.Kg Neues verfahren zur herstellung von tiotropiumsalzen
EP1953156A1 (de) * 2007-01-29 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Scopiniumsalzen
EP1997819A1 (de) * 2007-05-25 2008-12-03 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Scopinestern
JP6087492B2 (ja) * 2008-01-10 2017-03-01 ジェネリクス・［ユーケー］・リミテッド スコピンエステルを調製するための新規プロセス
US8263623B2 (en) 2008-07-11 2012-09-11 Pfizer Inc. Triazol derivatives useful for the treatment of diseases
WO2011015884A1 (en) * 2009-08-07 2011-02-10 Generics [Uk] Limited Process to prepare scopine esters
EP2462140A2 (en) 2009-08-07 2012-06-13 Generics [UK] Limited Anhydrate of triotropium bromide
TR201005222A2 (tr) * 2010-04-01 2011-10-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür sentez yöntemi
TR201002520A2 (tr) * 2010-04-01 2010-05-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür imalat metodu.
TR201005221A2 (tr) * 2010-04-01 2012-01-23 Bi̇lgi̇ç Mahmut Geliştirilmiş sentez metodu.
US8957209B2 (en) 2010-04-01 2015-02-17 Mahmut Bilgic Methods for the synthesis of tiotropium bromide
ITRM20110508A1 (it) 2011-09-27 2013-03-28 Lusochimica Spa Processo per la preparazione degli esteri della scopina.
PT106142B (pt) 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A Processo para a preparação de brometo de tiotrópio
CZ304808B6 (cs) 2012-03-16 2014-11-05 Zentiva, K.S. Způsob přípravy skopinesteru kyseliny di(2-thienyl)glykolové, intermediátu v syntéze tiotropium bromidu a jeho nová forma
CZ305012B6 (cs) 2012-03-30 2015-03-25 Zentiva, K.S. Způsob přípravy skopinesteru kyseliny di(2-thienyl)glykolové, intermediátu v syntéze tiotropium bromidu

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Also Published As

Publication number Publication date
CN1610680A (zh) 2005-04-27
ZA200403852B (en) 2005-06-22
AU2002361218B2 (en) 2008-04-24
UA78753C2 (en) 2007-04-25
CA2471755A1 (en) 2003-07-17
HRP20040623B1 (en) 2012-09-30
EA007230B1 (ru) 2006-08-25
WO2003057694A1 (de) 2003-07-17
HUP0402604A2 (hu) 2005-04-28
NO20043341L (no) 2004-08-11
PL208132B1 (pl) 2011-03-31
ATE404557T1 (de) 2008-08-15
ES2312655T3 (es) 2009-03-01
HRP20040623A2 (en) 2005-04-30
CN100406456C (zh) 2008-07-30
EP1972626A2 (de) 2008-09-24
EA200400875A1 (ru) 2004-12-30
US20030232993A1 (en) 2003-12-18
HU226665B1 (en) 2009-06-29
PL369126A1 (en) 2005-04-18
RS50771B (sr) 2010-08-31
BR0215493A (pt) 2004-12-28
DE50212650D1 (de) 2008-09-25
KR20040072715A (ko) 2004-08-18
CA2471755C (en) 2011-02-08
PT1467993E (pt) 2008-09-03
EP1467993B1 (de) 2008-08-13
EP1972626A3 (de) 2008-10-01
MXPA04006677A (es) 2004-10-04
CY1108471T1 (el) 2014-04-09
AU2002361218A1 (en) 2003-07-24
SI1467993T1 (sl) 2009-02-28
HK1073847A1 (zh) 2005-10-21
RS59404A (sr) 2007-04-10
DE10200943A1 (de) 2003-07-24
US6747154B2 (en) 2004-06-08
CO5601006A2 (es) 2006-01-31
HUP0402604A3 (en) 2008-05-28
JP5134756B2 (ja) 2013-01-30
DK1467993T3 (da) 2008-11-10
IL162416A0 (en) 2005-11-20
JP2005519890A (ja) 2005-07-07
ECSP045182A (es) 2004-08-27
IL162416A (en) 2010-06-30
KR100929503B1 (ko) 2009-12-03
EP1467993A1 (de) 2004-10-20
NZ534339A (en) 2005-04-29
NO328825B1 (no) 2010-05-25

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