[go: up one dir, main page]

NO20035731L - Forbedret farmakokinetisk profil av hydrofobe substanser - Google Patents

Forbedret farmakokinetisk profil av hydrofobe substanser

Info

Publication number
NO20035731L
NO20035731L NO20035731A NO20035731A NO20035731L NO 20035731 L NO20035731 L NO 20035731L NO 20035731 A NO20035731 A NO 20035731A NO 20035731 A NO20035731 A NO 20035731A NO 20035731 L NO20035731 L NO 20035731L
Authority
NO
Norway
Prior art keywords
pharmacokinetic profile
improved pharmacokinetic
hydrophobic substances
mammal
substance
Prior art date
Application number
NO20035731A
Other languages
English (en)
Other versions
NO20035731D0 (no
Inventor
Thomas Pinkerton
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of NO20035731D0 publication Critical patent/NO20035731D0/no
Publication of NO20035731L publication Critical patent/NO20035731L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G23/00—Compounds of titanium
    • C01G23/04—Oxides; Hydroxides
    • C01G23/047—Titanium dioxide
    • C01G23/053—Producing by wet processes, e.g. hydrolysing titanium salts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
    • C04B35/46—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on titanium oxides or titanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ceramic Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Environmental & Geological Engineering (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • Geology (AREA)
  • Inorganic Chemistry (AREA)
  • Structural Engineering (AREA)
  • Materials Engineering (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Metode for systemisk administrering av en hydrofob substans til et pattedyr beskrives. Metoden omfatter avlevering av den hydrofobe substansen til dermis hos pattedyret hvormed en forbedret systemisk absorpsjon oppnås sammenlignet med den absorpsjon som oppnås ved av levering av substansen subkutant ved bolusadministrering.
NO20035731A 2001-06-29 2003-12-19 Forbedret farmakokinetisk profil av hydrofobe substanser NO20035731L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/897,801 US20030073609A1 (en) 2001-06-29 2001-06-29 Enhanced pharmacokinetic profile of intradermally delivered substances
PCT/US2002/020080 WO2003002094A2 (en) 2001-06-29 2002-06-24 Enhanced pharmacokinetic profile of hydrophobic substances

Publications (2)

Publication Number Publication Date
NO20035731D0 NO20035731D0 (no) 2003-12-19
NO20035731L true NO20035731L (no) 2004-02-27

Family

ID=25408438

Family Applications (3)

Application Number Title Priority Date Filing Date
NO20035580A NO20035580D0 (no) 2001-06-29 2003-12-15 Forsterket systemisk absorpsjon av intradermalt avleverte substanser
NO20035731A NO20035731L (no) 2001-06-29 2003-12-19 Forbedret farmakokinetisk profil av hydrofobe substanser
NO20035782A NO20035782L (no) 2001-06-29 2003-12-22 Forbedret farmakokinetisk profil for hydrofobe dopaminagonister

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20035580A NO20035580D0 (no) 2001-06-29 2003-12-15 Forsterket systemisk absorpsjon av intradermalt avleverte substanser

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20035782A NO20035782L (no) 2001-06-29 2003-12-22 Forbedret farmakokinetisk profil for hydrofobe dopaminagonister

Country Status (17)

Country Link
US (4) US20030073609A1 (no)
EP (3) EP1399205A2 (no)
JP (3) JP2004537540A (no)
KR (3) KR20040022438A (no)
CN (3) CN1610567A (no)
AU (1) AU2002345813B2 (no)
BR (2) BR0210688A (no)
CA (3) CA2450354A1 (no)
CO (2) CO5640074A2 (no)
CZ (3) CZ20033059A3 (no)
EA (3) EA006922B1 (no)
IL (3) IL158651A0 (no)
MX (3) MXPA03011931A (no)
NO (3) NO20035580D0 (no)
PL (3) PL365667A1 (no)
WO (3) WO2003002175A2 (no)
ZA (3) ZA200308385B (no)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69926053T2 (de) 1999-04-27 2006-04-27 Transgene S.A. Verfahren zur Herstellung von Säugetier-Zellinien
US8465468B1 (en) 2000-06-29 2013-06-18 Becton, Dickinson And Company Intradermal delivery of substances
US20020156453A1 (en) * 1999-10-14 2002-10-24 Pettis Ronald J. Method and device for reducing therapeutic dosage
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US20040175360A1 (en) * 2000-06-29 2004-09-09 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US20050008683A1 (en) * 2000-06-29 2005-01-13 Becton Dickinson And Company Method for delivering interferons to the intradermal compartment
DE10043321B4 (de) * 2000-08-24 2005-07-28 Neurobiotec Gmbh Verwendung eines transdermalen therapeutischen Systems zur Behandlung der Parkinsonschen Krankheit, zur Behandlung und Prävention des prämenstruellen Syndroms und zur Lactationshemmung
DE10053397A1 (de) 2000-10-20 2002-05-02 Schering Ag Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen
DE10064453A1 (de) * 2000-12-16 2002-07-04 Schering Ag Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen
MXPA03009371A (es) * 2001-04-13 2004-11-12 Becton Dickinson Co Metodos y dispositivos para administrar sustancias en la capa intradermica de la piel para absorcion sistemica.
WO2003002069A2 (en) * 2001-06-29 2003-01-09 Becton, Dickinson And Company Intradermal delivery of vaccines and gene therapeutic agents via microcannula
US20050010193A1 (en) * 2002-05-06 2005-01-13 Laurent Philippe E. Novel methods for administration of drugs and devices useful thereof
US20030073609A1 (en) * 2001-06-29 2003-04-17 Pinkerton Thomas C. Enhanced pharmacokinetic profile of intradermally delivered substances
US20040120964A1 (en) * 2001-10-29 2004-06-24 Mikszta John A. Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses
US20060264886A9 (en) * 2002-05-06 2006-11-23 Pettis Ronald J Method for altering insulin pharmacokinetics
JP4764626B2 (ja) 2002-05-06 2011-09-07 ベクトン・ディキンソン・アンド・カンパニー 薬剤の薬物動力学を制御する方法およびデバイス
CA2497086A1 (en) * 2002-08-30 2004-03-11 Becton, Dickinson And Company Method of controlling pharmacokinetics of immunomodulatory compounds
DK1575656T3 (da) * 2002-10-11 2009-09-14 Becton Dickinson Co Insulinafgivesystem med sensor
EP1635876A4 (en) * 2003-06-13 2009-05-06 Becton Dickinson Co IMPROVED INTRADERMAL ADMINISTRATION OF BIOACTIVE AGENTS
BR0318454A (pt) 2003-08-08 2006-09-12 Abgenix Inc anticorpos dirigidos a hormÈnio da paratireóide (pth) e seus usos
US7318925B2 (en) 2003-08-08 2008-01-15 Amgen Fremont, Inc. Methods of use for antibodies against parathyroid hormone
BR122020015610B8 (pt) 2003-08-12 2023-11-14 Becton Dickinson Co Dispositivo para distribuir um medicamento para dentro do corpo de um paciente por injeção
BRPI0414014A (pt) * 2003-08-26 2006-10-24 Becton Dickinson Co métodos para distribuição intradérmica de agentes terapêuticos
US20050256499A1 (en) * 2004-03-03 2005-11-17 Pettis Ronald J Methods and devices for improving delivery of a substance to skin
US20050256182A1 (en) * 2004-05-11 2005-11-17 Sutter Diane E Formulations of anti-pain agents and methods of using the same
US7806854B2 (en) * 2005-05-13 2010-10-05 Trustees Of Boston University Fully automated control system for type 1 diabetes
US20070202186A1 (en) 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
US8197435B2 (en) * 2006-05-02 2012-06-12 Emory University Methods and devices for drug delivery to ocular tissue using microneedle
US8025634B1 (en) * 2006-09-18 2011-09-27 Baxter International Inc. Method and system for controlled infusion of therapeutic substances
CA2681398A1 (en) * 2007-03-19 2008-09-25 Insuline Medical Ltd. Drug delivery device
US9220837B2 (en) 2007-03-19 2015-12-29 Insuline Medical Ltd. Method and device for drug delivery
WO2009081262A1 (en) 2007-12-18 2009-07-02 Insuline Medical Ltd. Drug delivery device with sensor for closed-loop operation
US8622991B2 (en) 2007-03-19 2014-01-07 Insuline Medical Ltd. Method and device for drug delivery
US20100286467A1 (en) * 2007-03-19 2010-11-11 Benny Pesach Device for drug delivery and associated connections thereto
WO2008115586A1 (en) * 2007-03-21 2008-09-25 Alza Corporation Apparatus and method for transdermal delivery of a triptan agonist
US8642062B2 (en) 2007-10-31 2014-02-04 Abbott Cardiovascular Systems Inc. Implantable device having a slow dissolving polymer
ATE542521T1 (de) * 2007-11-29 2012-02-15 Alltranz Inc Verfahren und zusammensetzungen zur verstärkung der lebensfähigkeit von mikronadelporen
AU2009312474B2 (en) 2008-11-07 2014-12-04 Insuline Medical Ltd. Device and method for drug delivery
US7828996B1 (en) 2009-03-27 2010-11-09 Abbott Cardiovascular Systems Inc. Method for the manufacture of stable, nano-sized particles
US9199034B2 (en) * 2009-11-09 2015-12-01 Becton, Dickinson And Company Drug delivery devices, systems, and methods
KR100967900B1 (ko) * 2010-04-12 2010-07-06 대전광역시 교차로 정보제공 시스템
EP3520749A1 (en) 2010-10-15 2019-08-07 Clearside Biomedical, Inc. Device for ocular access
WO2012058694A2 (en) 2010-10-31 2012-05-03 Trustees Of Boston University Blood glucose control system
KR20210133321A (ko) 2012-11-08 2021-11-05 클리어사이드 바이오메디컬, 인코포레이드 인간 대상체에서 안구 질병을 치료하기 위한 방법 및 장치
KR102282973B1 (ko) 2013-05-03 2021-07-27 클리어사이드 바이오메디컬, 인코포레이드 안구용 주사를 위한 장치 및 방법
WO2014197317A1 (en) 2013-06-03 2014-12-11 Clearside Biomedical, Inc. Apparatus and methods for drug delivery using multiple reservoirs
DK3089667T3 (da) 2014-01-31 2022-05-09 Univ Boston Offline-glucosestyring baseret på forudgående tidsrum
JP2017524419A (ja) 2014-06-20 2017-08-31 クリアサイド バイオメディカル，インコーポレイテッド 薬剤送達のための挿入深さを制御するための可変径カニューレ及び方法
US9572819B2 (en) * 2015-05-28 2017-02-21 Dr. Reddy's Laboratories, Ltd. Oral composition of celecoxib for treatment of pain
CA2993830A1 (en) 2015-08-07 2017-02-16 Trustees Of Boston University Glucose control system with automatic adaptation of glucose target
US10390901B2 (en) 2016-02-10 2019-08-27 Clearside Biomedical, Inc. Ocular injection kit, packaging, and methods of use
EP3452165A1 (en) 2016-05-02 2019-03-13 Clearside Biomedical, Inc. Systems and methods for ocular drug delivery
IL305537B2 (en) 2016-08-12 2025-02-01 Clearside Biomedical Inc Devices and methods for adjusting the insertion depth of a needle for administering a drug
US12090294B2 (en) 2017-05-02 2024-09-17 Georgia Tech Research Corporation Targeted drug delivery methods using a microneedle
WO2021011738A1 (en) 2019-07-16 2021-01-21 Beta Bionics, Inc. Blood glucose control system
AU2020314752A1 (en) 2019-07-16 2022-02-24 Beta Bionics, Inc. Blood glucose control system
US11957876B2 (en) 2019-07-16 2024-04-16 Beta Bionics, Inc. Glucose control system with automated backup therapy protocol generation
EP4267132A1 (en) 2020-12-28 2023-11-01 Dr. Reddy's Laboratories Ltd. Celecoxib for treating pain
US12465686B2 (en) 2021-03-25 2025-11-11 Beta Bionics, Inc. Emergency medicament dose control

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2619962A (en) * 1948-02-19 1952-12-02 Res Foundation Vaccination appliance
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
BE795384A (fr) * 1972-02-14 1973-08-13 Ici Ltd Pansements
US4270537A (en) * 1979-11-19 1981-06-02 Romaine Richard A Automatic hypodermic syringe
IE53703B1 (en) * 1982-12-13 1989-01-18 Elan Corp Plc Drug delivery device
US4826689A (en) 1984-05-21 1989-05-02 University Of Rochester Method for making uniformly sized particles from water-insoluble organic compounds
CA1283827C (en) * 1986-12-18 1991-05-07 Giorgio Cirelli Appliance for injection of liquid formulations
US6056716A (en) * 1987-06-08 2000-05-02 D'antonio Consultants International Inc. Hypodermic fluid dispenser
AU614092B2 (en) * 1987-09-11 1991-08-22 Paul Max Grinwald Improved method and apparatus for enhanced drug permeation of skin
IT1227626B (it) 1988-11-28 1991-04-23 Vectorpharma Int Farmaci supportati aventi velocita' di dissoluzione aumentata e procedimento per la loro preparazione
US5273975A (en) 1989-06-09 1993-12-28 The Upjohn Company Heterocyclic amines having central nervous system activity
US5098389A (en) * 1990-06-28 1992-03-24 Becton, Dickinson And Company Hypodermic needle assembly
US5279544A (en) * 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
TW279133B (no) * 1990-12-13 1996-06-21 Elan Med Tech
US5156591A (en) * 1990-12-13 1992-10-20 S. I. Scientific Innovations Ltd. Skin electrode construction and transdermal drug delivery device utilizing same
US5527288A (en) * 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
SE9102652D0 (sv) * 1991-09-13 1991-09-13 Kabi Pharmacia Ab Injection needle arrangement
US5346702A (en) 1992-12-04 1994-09-13 Sterling Winthrop Inc. Use of non-ionic cloud point modifiers to minimize nanoparticle aggregation during sterilization
US5298262A (en) 1992-12-04 1994-03-29 Sterling Winthrop Inc. Use of ionic cloud point modifiers to prevent particle aggregation during sterilization
US5336507A (en) 1992-12-11 1994-08-09 Sterling Winthrop Inc. Use of charged phospholipids to reduce nanoparticle aggregation
US5279552A (en) * 1993-01-11 1994-01-18 Anton Magnet Intradermal injection device
CA2132277C (en) * 1993-10-22 2005-05-10 Giorgio Cirelli Injection device
US5997501A (en) * 1993-11-18 1999-12-07 Elan Corporation, Plc Intradermal drug delivery device
US5591139A (en) * 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
US5582591A (en) * 1994-09-02 1996-12-10 Delab Delivery of solid drug compositions
IE72524B1 (en) * 1994-11-04 1997-04-23 Elan Med Tech Analyte-controlled liquid delivery device and analyte monitor
US5983130A (en) * 1995-06-07 1999-11-09 Alza Corporation Electrotransport agent delivery method and apparatus
US5801057A (en) * 1996-03-22 1998-09-01 Smart; Wilson H. Microsampling device and method of construction
US6576636B2 (en) * 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
EP0910420B1 (en) * 1996-06-10 2003-02-05 ELAN CORPORATION, Plc Needle for subcutaneous delivery of fluids
US5871158A (en) * 1997-01-27 1999-02-16 The University Of Utah Research Foundation Methods for preparing devices having metallic hollow microchannels on planar substrate surfaces
US5783705A (en) * 1997-04-28 1998-07-21 Texas Biotechnology Corporation Process of preparing alkali metal salys of hydrophobic sulfonamides
US5928207A (en) * 1997-06-30 1999-07-27 The Regents Of The University Of California Microneedle with isotropically etched tip, and method of fabricating such a device
IE970782A1 (en) * 1997-10-22 1999-05-05 Elan Corp An improved automatic syringe
US5957895A (en) * 1998-02-20 1999-09-28 Becton Dickinson And Company Low-profile automatic injection device with self-emptying reservoir
AU3973599A (en) * 1998-05-08 1999-11-29 Genetronics, Inc. Electrically induced vessel vasodilation
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
JP2002517300A (ja) * 1998-06-10 2002-06-18 ジョージア テック リサーチ コーポレイション 微小針デバイスおよび製造方法ならびにそれらの使用
US6589987B2 (en) * 1998-09-08 2003-07-08 Charlotte-Mecklenburg Hospital Authority Method of treating cancer using tetraethyl thiuram disulfide
US6455564B1 (en) 1999-01-06 2002-09-24 Pharmacia & Upjohn Company Method of treating sexual disturbances
CA2376128C (en) * 1999-06-04 2009-01-06 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
DE19938823A1 (de) * 1999-08-19 2001-02-22 Boehringer Ingelheim Pharma Medikamentöse Behandlung des Restless Leg Syndroms
US6319224B1 (en) * 1999-08-20 2001-11-20 Bioject Medical Technologies Inc. Intradermal injection system for injecting DNA-based injectables into humans
US7113821B1 (en) * 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
US6776776B2 (en) * 1999-10-14 2004-08-17 Becton, Dickinson And Company Prefillable intradermal delivery device
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US6569143B2 (en) * 1999-10-14 2003-05-27 Becton, Dickinson And Company Method of intradermally injecting substances
US6843781B2 (en) * 1999-10-14 2005-01-18 Becton, Dickinson And Company Intradermal needle
AU3440601A (en) * 1999-11-24 2001-06-04 Elan Pharmaceuticals, Inc. Method and composition for protecting against radio-contrast medium-induced renal dysfunction
DE10001785A1 (de) * 2000-01-18 2001-07-19 Boehringer Ingelheim Pharma NK¶1¶-Rezeptor-Antagonisten zur Behandlung des Restless Legs Syndroms
US20030073609A1 (en) * 2001-06-29 2003-04-17 Pinkerton Thomas C. Enhanced pharmacokinetic profile of intradermally delivered substances
WO2003002069A2 (en) * 2001-06-29 2003-01-09 Becton, Dickinson And Company Intradermal delivery of vaccines and gene therapeutic agents via microcannula

Also Published As

Publication number Publication date
EA200301308A1 (ru) 2004-08-26
PL366635A1 (en) 2005-02-07
KR20040029327A (ko) 2004-04-06
US20040028707A1 (en) 2004-02-12
US20040175401A1 (en) 2004-09-09
EP1399205A2 (en) 2004-03-24
IL158651A0 (en) 2004-05-12
WO2003002103A3 (en) 2003-04-10
MXPA03011710A (es) 2004-12-06
CN1723052A (zh) 2006-01-18
CZ20033059A3 (cs) 2004-04-14
WO2003002175A8 (en) 2003-07-10
ZA200309125B (en) 2004-11-24
ZA200309151B (en) 2004-11-25
CN1522139A (zh) 2004-08-18
MXPA03011794A (es) 2005-03-07
WO2003002175A2 (en) 2003-01-09
AU2002345813B2 (en) 2006-10-26
EA006961B1 (ru) 2006-06-30
US20040170654A1 (en) 2004-09-02
IL159025A0 (en) 2004-05-12
PL365667A1 (en) 2005-01-10
CA2452321A1 (en) 2003-01-09
CA2452393A1 (en) 2003-01-09
JP2005503359A (ja) 2005-02-03
KR20040022438A (ko) 2004-03-12
NO20035782L (no) 2004-02-24
PL366370A1 (en) 2005-01-24
CZ20033364A3 (cs) 2004-08-18
NO20035580D0 (no) 2003-12-15
BR0210688A (pt) 2004-09-21
CA2450354A1 (en) 2003-01-09
CO5540369A2 (es) 2005-07-29
CZ20033363A3 (cs) 2004-09-15
EA200301307A1 (ru) 2004-06-24
EP1399206A2 (en) 2004-03-24
CO5640074A2 (es) 2006-05-31
ZA200308385B (en) 2004-10-28
WO2003002175A3 (en) 2003-03-20
BR0210665A (pt) 2004-10-05
US20030073609A1 (en) 2003-04-17
MXPA03011931A (es) 2005-03-07
CN1610567A (zh) 2005-04-27
EA200301309A1 (ru) 2004-12-30
EA006578B1 (ru) 2006-02-24
KR20040019024A (ko) 2004-03-04
JP2004537540A (ja) 2004-12-16
EP1416915A1 (en) 2004-05-12
NO20035731D0 (no) 2003-12-19
IL159024A0 (en) 2004-05-12
WO2003002103A2 (en) 2003-01-09
WO2003002094A8 (en) 2005-10-20
WO2003002094A2 (en) 2003-01-09
EA006922B1 (ru) 2006-04-28
JP2005502613A (ja) 2005-01-27

Similar Documents

Publication Publication Date Title
NO20035731L (no) Forbedret farmakokinetisk profil av hydrofobe substanser
CY1110547T1 (el) Συμπυκνωμενα πρωτεϊνικα σκευασματα μειωμενου ιξωδους
NO20054555D0 (no) Farmasoytiske preparater som omfatter syrestabilisert insulin
AR029139A1 (es) Interleuquina 2 estabilizada
BR0106103A (pt) Bomba de infusão, motor de bomba papa mover fluido através de uma câmara de fluido de um corpo cilìndrico de seringa, método para infusão de um fluido em um paciente, e, bomba de infusão ambulatorial
IS6719A (is) Aðferð til verkjadeyfingar
DE602007005755D1 (de) Spritzenfassung für eine medizinische Flüssigkeitsinjektionsvorrichtung
DK1151004T3 (da) Fremgangsmåde til fremstilling af IL-1RA, et terapeutisk protein, ud fra legemsvæsker
WO2005025646A3 (en) System and method for providing servo-controlled resuscitation
WO2006020255A3 (en) Apparatus and methods for treating tissue using passive injection systems
IN266817B (no)
IS8060A (is) Truflanaþolið skammtaform til íkomu um húð sem inniheldur virkan efnisþátt og andstæðan efnisþátt við fjarhlið virka efnislagsins
EP1460261A4 (en) METHOD FOR DRIVEING A FUEL INJECTION PUMP
WO2006054280A3 (en) System and method for delivering fluid into flexible biological barrier
PA8621201A1 (es) Composicion farmaceutica apta la comprension directa para la administracion oral de cci-779
PE20011223A1 (es) Composicion farmaceutica que comprende pemetrexed y un antioxidante como monotioglicerol, l-cisteina y acido tioglicolico
EP1483966A4 (en) METHOD FOR CONTROLLING MITES
EA200600402A1 (ru) Клеточные стенки дрожжей для лечения или профилактики гипергликемии или для стабилизации уровня сахара в крови
DK2359854T3 (da) Farmaceutiske sammensætninger og fremgangsmåder egnet til modulering af angiogenese
WO2006138236A3 (en) Method and apparatus for bubble injection of agent into exhaust gas for use with emission abatement device
ITTO20001111A0 (it) Buretta con valvola di fondo per apparecchiature medicali di infusione.
DE50308873D1 (de) Kanüle zum Applizieren von medizinischen Stoffen
FR2787517B1 (fr) Pompe haute pression
FR2794811B1 (fr) Pompe a haute pression a etancheite perfectionnee
WO2001093921A3 (en) Administration of an anti-endotoxin drug by bolus or intermittent intravenous infusion

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application