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NO20020217L - Nitrogenholdige heterobisykler som faktor Xa-inhibitorer - Google Patents

Nitrogenholdige heterobisykler som faktor Xa-inhibitorer

Info

Publication number
NO20020217L
NO20020217L NO20020217A NO20020217A NO20020217L NO 20020217 L NO20020217 L NO 20020217L NO 20020217 A NO20020217 A NO 20020217A NO 20020217 A NO20020217 A NO 20020217A NO 20020217 L NO20020217 L NO 20020217L
Authority
NO
Norway
Prior art keywords
inhibitors
factor
nitrogen
heterobicycles
same
Prior art date
Application number
NO20020217A
Other languages
English (en)
Norwegian (no)
Other versions
NO20020217D0 (no
Inventor
Irina Cipora Jacobson
Mimi Lifen Quan
Original Assignee
Bristol Myers Squibb Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co
Publication of NO20020217D0 publication Critical patent/NO20020217D0/no
Publication of NO20020217L publication Critical patent/NO20020217L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20020217A 1999-07-16 2002-01-15 Nitrogenholdige heterobisykler som faktor Xa-inhibitorer NO20020217L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14434499P 1999-07-16 1999-07-16
PCT/US2000/018903 WO2001005784A1 (fr) 1999-07-16 2000-07-12 Composes heterobicycliques contenant de l'azote et utilises en tant qu'inhibiteurs du facteur xa

Publications (2)

Publication Number Publication Date
NO20020217D0 NO20020217D0 (no) 2002-01-15
NO20020217L true NO20020217L (no) 2002-03-15

Family

ID=22508178

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20020217A NO20020217L (no) 1999-07-16 2002-01-15 Nitrogenholdige heterobisykler som faktor Xa-inhibitorer

Country Status (18)

Country Link
US (2) US6429205B1 (fr)
EP (1) EP1196412B1 (fr)
JP (1) JP2004507439A (fr)
KR (1) KR20030011268A (fr)
CN (1) CN1454211A (fr)
AT (1) ATE268766T1 (fr)
AU (1) AU2481501A (fr)
BR (1) BR0013200A (fr)
CA (1) CA2380727A1 (fr)
DE (1) DE60011430T2 (fr)
ES (1) ES2222257T3 (fr)
HK (1) HK1045502B (fr)
IL (1) IL147317A0 (fr)
MX (1) MXPA02000537A (fr)
NO (1) NO20020217L (fr)
PL (1) PL357108A1 (fr)
WO (1) WO2001005784A1 (fr)
ZA (1) ZA200200094B (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6339099B1 (en) * 1997-06-20 2002-01-15 Dupont Pharmaceuticals Company Guanidine mimics as factor Xa inhibitors
CA2375920A1 (fr) 1999-06-14 2000-12-21 Eli Lilly And Company Composes
AU2001234690A1 (en) 2000-02-01 2001-08-14 Cor Therapeutics, Inc. 2-(1h)-quinolone and 2-(1h)-quinoxalone inhibitors of factor xa
EP1255743A1 (fr) * 2000-02-01 2002-11-13 Millenium Pharmaceuticals, Inc. 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINES UTILISEES COMME INHIBITEURS DU FACTEUR Xa
AU2001256733A1 (en) * 2000-05-16 2001-11-26 Takeda Chemical Industries Ltd. Melanin-concentrating hormone antagonist
CA2409762A1 (fr) 2000-06-23 2002-01-03 Donald J.P. Pinto Inhibiteurs du facteur xa a substitution heteroaryl-phenyle
WO2002000655A1 (fr) 2000-06-23 2002-01-03 Bristol-Myers Squibb Pharma Company Derives de pyrazole condenses par 1 - (heteroaryl-phenyl) utilises comme inhibiteurs du facteur xa
TWI331526B (en) 2001-09-21 2010-10-11 Bristol Myers Squibb Pharma Co Lactam-containing compounds and derivatives thereof as factor xa inhibitors
SI1427415T1 (sl) 2001-09-21 2009-12-31 Bristol Myers Squibb Co Sestavine, ki vsebujejo laktame in njihovi derivati kot inhibitorji faktorja xa
WO2003048081A2 (fr) 2001-12-04 2003-06-12 Bristol-Myers Squibb Company Glycinamides en tant qu'inhibiteurs du facteur xa
TW200302225A (en) 2001-12-04 2003-08-01 Bristol Myers Squibb Co Substituted amino methyl factor Xa inhibitors
EP1569912B1 (fr) 2002-12-03 2015-04-29 Pharmacyclics, Inc. Derives de 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine utilises en tant qu'inhibiteurs du facteur viia
EP1467988B1 (fr) * 2002-01-22 2013-07-17 E.I. Du Pont De Nemours And Company Quinazoline(di)ones utilisées comme agents de lutte contre les nuisibles invertébrés
DE60318188T2 (de) 2002-03-26 2008-12-11 Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield Glucocorticoid-mimetika, deren herstellung, pharmazeutische zusammensetzungen und verwendung
US7312214B2 (en) 2002-05-10 2007-12-25 Bristol-Myers Squibb Company 1, 1-disubstituted cycloalkyl derivatives as factor Xa inhibitors
WO2004018429A2 (fr) * 2002-08-21 2004-03-04 Boehringer Ingelheim Pharmaceuticals, Inc. Composes mimetiques de glucocorticoide, leurs procedes de fabrication, compositions pharmaceutiques, et leurs utilisations
JP4585448B2 (ja) * 2002-12-23 2010-11-24 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 第Ｘａ因子阻害剤としてのピラゾール−誘導体
US7429581B2 (en) 2002-12-23 2008-09-30 Sanofi-Aventis Deutschland Gmbh Pyrazole-derivatives as factor Xa inhibitors
EP1479678A1 (fr) * 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Derivés du pyrazole en tant qu'inhibiteurs du facteur Xa
US7122557B2 (en) 2003-03-18 2006-10-17 Bristol-Myers Squibb Company Sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds as factor Xa inhibitors
US7129264B2 (en) * 2003-04-16 2006-10-31 Bristol-Myers Squibb Company Biarylmethyl indolines and indoles as antithromboembolic agents
UY28526A1 (es) 2003-09-24 2005-04-29 Boehringer Ingelheim Pharma Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos
US20050124664A1 (en) * 2003-10-30 2005-06-09 Eric Sartori Urea thiadiazole inhibitors of plasminogen activator inhibior-1
US7795272B2 (en) 2004-03-13 2010-09-14 Boehringer Ingelheim Pharmaceutical, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
AU2005299693B2 (en) * 2004-10-26 2012-07-05 Janssen Pharmaceutica, N.V. Factor Xa compounds
ES2326907T3 (es) 2004-12-27 2009-10-21 Boehringer Ingelheim Pharmaceuticals Inc. Mimeticos de glucocorticoides, metodos para su preparacion, composiciones farmaceuticas y su uso.
GT200600042A (es) * 2005-02-10 2006-09-27 Aventis Pharma Inc Compuestos de bis arilo y heteroarilo sustituido como antagonistas selectivos de 5ht2a
DE102005038947A1 (de) 2005-05-18 2006-11-30 Grünenthal GmbH Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
BRPI0720131A2 (pt) 2006-12-06 2014-02-04 Boehringer Ingelheim Int Glicocorticoides miméticos, métodos para fazê-los, composições farmacêuticas e usos dos mesmos.
EP2146722A4 (fr) * 2007-05-10 2011-08-03 Amr Technology Inc Tétrahydrobenzo-l,4-diazépines substituées par un aryle ou un hétéroaryle et utilisation desdites dans le blocage de la réassimilation de la norépinéphrine, de la dopamine et de la sérotonine
KR20110020902A (ko) 2008-06-06 2011-03-03 베링거 인겔하임 인터내셔날 게엠베하 글루코코르티코이드 유사체, 이의 제조방법, 약제학적 조성물 및 이의 용도
CN104395298A (zh) * 2012-06-22 2015-03-04 住友化学株式会社 稠合杂环化合物
MX385138B (es) * 2016-05-23 2025-03-14 Univ Rockefeller Inmunomoduladores de aminoacilindazol para el tratamiento de enfermedades autoinmunes.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001502655A (ja) 1995-12-21 2001-02-27 デュポン ファーマシューティカルズ カンパニー Ｘａ因子阻害薬であるイソオキサゾリン、イソチアゾリンおよびピラゾリン
EP0946508B1 (fr) * 1996-12-23 2009-09-23 Bristol-Myers Squibb Pharma Company COMPOSES HETEROAROMATIQUES CONTENANT DE L'AZOTE, UTILISES EN TANT QU'INHIBITEURS DU FACTEUR Xa
DE69720773T2 (de) 1996-12-23 2004-01-29 Bristol Myers Squibb Pharma Co SAUERSTOFF ODER SCHWEFEL ENTHALTENDE 5-GLIEDRIGE HETEROAROMATISHE DERIVATIVE ALS FACTOR Xa HEMMER
PT991625E (pt) 1997-06-19 2005-10-31 Bristol Myers Squibb Pharma Co Inibidores de factor xa com um grupo de especificidade p1 neutro
ZA985247B (en) * 1997-06-19 1999-12-17 Du Pont Merck Pharma Guanidine mimics as factor Xa inhibitors.
JP2001526268A (ja) 1997-12-22 2001-12-18 デュポン ファーマシューティカルズ カンパニー Ｘａ因子阻害剤としての、オルト−置換Ｐ１を有する、窒素含有複素環式芳香族化合物

Also Published As

Publication number Publication date
IL147317A0 (en) 2002-08-14
US6429205B1 (en) 2002-08-06
ES2222257T3 (es) 2005-02-01
EP1196412B1 (fr) 2004-06-09
ATE268766T1 (de) 2004-06-15
CN1454211A (zh) 2003-11-05
DE60011430D1 (de) 2004-07-15
NO20020217D0 (no) 2002-01-15
HK1045502B (en) 2004-12-10
CA2380727A1 (fr) 2001-01-25
JP2004507439A (ja) 2004-03-11
EP1196412A1 (fr) 2002-04-17
US6716841B2 (en) 2004-04-06
AU2481501A (en) 2001-02-05
PL357108A1 (en) 2004-07-12
KR20030011268A (ko) 2003-02-07
ZA200200094B (en) 2003-04-30
US20030096820A1 (en) 2003-05-22
DE60011430T2 (de) 2005-07-07
WO2001005784A1 (fr) 2001-01-25
MXPA02000537A (es) 2004-09-10
HK1045502A1 (en) 2002-11-29
BR0013200A (pt) 2002-05-07

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