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NO20070201L - Seksleddede heterocykler anvendelige som serinproteaseinhibitorer - Google Patents

Seksleddede heterocykler anvendelige som serinproteaseinhibitorer

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Publication number
NO20070201L
NO20070201L NO20070201A NO20070201A NO20070201L NO 20070201 L NO20070201 L NO 20070201L NO 20070201 A NO20070201 A NO 20070201A NO 20070201 A NO20070201 A NO 20070201A NO 20070201 L NO20070201 L NO 20070201L
Authority
NO
Norway
Prior art keywords
sup
factor
compounds
serine protease
protease inhibitors
Prior art date
Application number
NO20070201A
Other languages
English (en)
Inventor
Jon J Hangeland
James R Corte
Mimi L Quan
Joanne M Smallheer
Tianan Fang
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35276485&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20070201(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO20070201L publication Critical patent/NO20070201L/no

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
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Abstract

Foreliggende oppfinnelse tilveiebringer forbindelser med formel (I). eller en stereoisomer eller et farmasøytisk akseptabelt salt eller solvat derav, hvor. variablene A, L, Z, X, X,,og Xer som definert her. Forbindelsene med formel (I) er anvendelige som selektive hemmere av serinprotease-enzymer i koaguleringskaskade- og/eller kontakt-aktiveirngssystemet; for eksempel trombin, faktor Xa, faktor Xla, faktor lXa, faktor VI la og/eller plasma-kallikrein. Særlig vedrører den forbindelser som er selektive faktor Xla-hemmere.Denne oppfinnelsen vedrører også farmasøytiske preparater inneholdende disse forbindelser, og metoder for behandling av tromboemboliske og/eller infiammatoriske lidelser ved anvendelse av samme.
NO20070201A 2004-06-15 2007-01-11 Seksleddede heterocykler anvendelige som serinproteaseinhibitorer NO20070201L (no)

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US11/151,627 US7429604B2 (en) 2004-06-15 2005-06-13 Six-membered heterocycles useful as serine protease inhibitors
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