NO20011778L - Derivater av isosorbid-mononitrat, og deres utnyttelse som vasodilaterende agens med redusert toleranse - Google Patents

Derivater av isosorbid-mononitrat, og deres utnyttelse som vasodilaterende agens med redusert toleranse

Info

Publication number: NO20011778L
Authority: NO; Norway
Prior art keywords: utilization; derivatives; isosorbide mononitrate; reduced tolerance; vasodilating agent
Prior art date: 1998-10-07

Application number

NO20011778A

Other languages

English (en)

Other versions

NO328584B1 (no

NO20011778D0 (no

Inventor

Jose Repolles Moliner

Francisco Pubill Coy

Lydia Cabeza Llorente

Marcelli Carbo Banus

Christina Negrie Rofes

Juan Antonio Cerda Riudavets

Alicia Ferrer Siso

Marek W Radomski

Eduardo Salas Perez-Rasilla

Juan Martinez Bonnin

Original Assignee

Lacer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-07

Filing date

2001-04-06

Publication date

2001-04-06

2001-04-06 Application filed by Lacer Sa filed Critical Lacer Sa

2001-04-06 Publication of NO20011778L publication Critical patent/NO20011778L/no

2001-04-06 Publication of NO20011778D0 publication Critical patent/NO20011778D0/no

2010-03-22 Publication of NO328584B1 publication Critical patent/NO328584B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Pharmacology & Pharmacy (AREA)
Cardiology (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Cosmetics (AREA)
Medicinal Preparation (AREA)

NO20011778A 1998-10-07 2001-04-06 Derivater av isosorbidmononitrat, farmasoytiske preparater som omfatter disse og deres anvendelse for fremstilling av medikamenter NO328584B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ES009802076A ES2142773B1 (es)	1998-10-07	1998-10-07	Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia desminuida.
PCT/ES1999/000316 WO2000020420A1 (es)	1998-10-07	1999-10-04	Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia disminuida

Publications (3)

Publication Number	Publication Date
NO20011778L true NO20011778L (no)	2001-04-06
NO20011778D0 NO20011778D0 (no)	2001-04-06
NO328584B1 NO328584B1 (no)	2010-03-22

Family

ID=8305360

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20011778A NO328584B1 (no)	1998-10-07	2001-04-06	Derivater av isosorbidmononitrat, farmasoytiske preparater som omfatter disse og deres anvendelse for fremstilling av medikamenter

Country Status (40)

Country	Link
US (2)	US20010051735A1 (no)
EP (1)	EP1120419B1 (no)
JP (1)	JP4659214B2 (no)
KR (1)	KR100641801B1 (no)
CN (1)	CN1096465C (no)
AP (1)	AP1555A (no)
AR (1)	AR020538A1 (no)
AT (1)	ATE323707T1 (no)
AU (1)	AU762724B2 (no)
BG (1)	BG65135B1 (no)
BR (1)	BR9914355B1 (no)
CA (1)	CA2346010C (no)
CO (1)	CO5180544A1 (no)
CU (1)	CU23162A3 (no)
CZ (1)	CZ294551B6 (no)
DE (2)	DE19983612T1 (no)
DK (1)	DK1120419T3 (no)
EA (1)	EA003360B1 (no)
EE (1)	EE04374B1 (no)
ES (2)	ES2142773B1 (no)
GB (1)	GB2359810B (no)
GE (1)	GEP20043162B (no)
GT (1)	GT199900173A (no)
HR (1)	HRP20010256B1 (no)
HU (1)	HUP0103937A3 (no)
ID (1)	ID29946A (no)
IL (2)	IL142391A0 (no)
IS (1)	IS2312B (no)
NO (1)	NO328584B1 (no)
NZ (1)	NZ510855A (no)
OA (1)	OA11661A (no)
PA (1)	PA8483901A1 (no)
PE (1)	PE20001083A1 (no)
PL (1)	PL200028B1 (no)
PT (1)	PT1120419E (no)
RS (1)	RS50112B (no)
TR (1)	TR200100961T2 (no)
WO (1)	WO2000020420A1 (no)
YU (1)	YU25201A (no)
ZA (1)	ZA200102836B (no)

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ES2258365B1 (es)	2003-10-03	2007-12-01	Lacer, S.A.	Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos.
EP1941876A1 (en) *	2006-12-28	2008-07-09	Lacer, S.A.	Isosorbide mononitrate derivatives for the treatment of Inflammation and ocular hypertension
ES2332565B1 (es) *	2007-01-23	2010-10-21	Lacer, S.A.	Uso de derivados de mononitrato de dianhidrohexita como agentes antiinflamatorios.
IE20070934A1 (en)	2007-12-21	2009-06-24	Trinity College Dublin	Efficient aspirin prodrugs
EP2240491B1 (en)	2008-01-09	2015-07-15	Amura Therapeutics Limited	TETRAHYDROFURO(2,3-b)PYRROL-3-ONE DERIVATIVES AS INHIBITORS OF CYSTEINE PROTEINASES
CA2706082C (en) *	2008-02-07	2017-10-03	Nicox S.A.	Nitric oxide donor compounds
EP2149577B1 (en)	2008-07-22	2011-04-27	Lacer, S.A.	New stereospecific method for the preparation of dioxa-bicyclooctane compounds
EP2149576A1 (en) *	2008-07-22	2010-02-03	Lacer, S.A.	Isosorbide Nitrates having vasodilating activity
EP2177216A1 (en) *	2008-10-13	2010-04-21	Lacer, S.A.	Use of dianhydrohexite mononitrate derivatives as healing agents
WO2010055138A1 (en) *	2008-11-14	2010-05-20	Lacer, S.A.	New stereospecific method for the preparation of dioxa-bicyclooctane compounds
EP2199294A1 (en) *	2008-12-19	2010-06-23	Lacer, S.A.	New stereospecific method for the preparation of dioxa bicyclooctane nitrate compounds
EP2301941B1 (en) *	2009-09-10	2013-06-19	Cognis IP Management GmbH	Isosorbide glyceryl ether derivatives and their use in household applications
EP2515899B1 (en) *	2009-12-23	2016-05-25	ARCA biopharma, Inc.	Methods and compositions for cardiovascular diseases and conditions
CN102241687A (zh) *	2011-05-23	2011-11-16	中国人民解放军第四军医大学	抗缺血/再灌注损伤的药物
CN103739499B (zh)	2011-10-24	2016-09-07	尼科斯科学爱尔兰公司	醌基一氧化氮供体化合物
BR112015021072A2 (pt) *	2013-03-05	2017-07-18	Archer Daniels Midland Co	processo de preparação de um monotriflato de isohexídeo, composto químico, processo para fabricação de um composto derivado de um monotriflato de isohexídeo, e, composto derivado
WO2014169976A1 (en)	2013-04-18	2014-10-23	Nicox Science Ireland	Quinone based nitric oxide donating compounds
CN104650108B (zh) *	2013-11-18	2017-05-24	富力	连翘脂素硫酸酯及其衍生物、制备方法及其应用
CN105461731B (zh) *	2014-08-07	2017-05-24	富力	连翘脂素布洛芬酯、其制备及其应用

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FR1356374A (fr)	1963-02-12	1964-03-27		Machine à fonctions multiples pour le travail du bois
AU465217B2 (en)	1971-04-29	1975-09-18	American Home Products Corporation	Mononitrte esters of 1,4:3, 6-dianhydro-d-glucitol
US3886196A (en)	1973-02-07	1975-05-27	Phillips Petroleum Co	Magnesium-aluminum-silicate-phosphate catalysts for ammonialytic cleavage of lactams to form omega-aminonitriles
DE3028289C2 (de)	1980-07-25	1986-11-27	Dr. Willmar Schwabe GmbH & Co, 7500 Karlsruhe	2-O- und 5-O-substituierte 1.4;3.6-Dianhydro-hexit-mononitrate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
DE3248548A1 (de)	1982-12-29	1984-07-05	Heinrich Mack Nachf., 7918 Illertissen	Acylderivate von 1,4:3,6-dianhydro-hexiten, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3421072A1 (de)	1984-06-06	1985-12-12	Heinrich Mack Nachf., 7918 Illertissen	1,4:3,6-dianhydro-hexit-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3602067A1 (de)	1986-01-24	1987-07-30	Mack Chem Pharm	2,6-dioxabicyclo(3.3.0)octan-derivate, ihre herstellung und verwendung als arzneimittel
DE3606634A1 (de)	1986-02-28	1987-09-03	Mack Chem Pharm	Isohexid-nucleoside, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
IT1204571B (it) *	1987-05-08	1989-03-10	Chiesi Farma Spa	Esteri di 1,4:3,6-dianidrosorbitolo-2-mononitrato e 5-mononitrato,loro procedimento di preparazione e loro composizioni farmaceutiche
DE3741005A1 (de)	1987-12-03	1989-06-15	Mack Chem Pharm	Aminopropanol-derivate von 1,4:3,6-dianhydro-hexit-nitraten, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JP2628756B2 (ja) *	1988-09-15	1997-07-09	シュバルツファルマアクチェンゲゼルシャフト	新規有機ニトレート及びそれらの製造方法
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CA2014520C (en)	1989-04-17	1996-07-16	Fumio Suzuki	Hexitol derivatives
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FR2680173A1 (fr) *	1991-08-07	1993-02-12	Hoechst Lab	Nitrates organiques, leurs procedes de preparation et leur utilisation dans le traitement de maladies cardiovasculaires .
EP0656881B1 (en) *	1992-07-30	1998-10-14	Cal International Limited	Ester and combinations of an organic nitrate and a salicylate
IL120531A (en)	1997-03-26	2006-12-31	Yissum Res Dev Co	Nitric oxide donors and pharmaceutical compositions containing them

1998
- 1998-10-07 ES ES009802076A patent/ES2142773B1/es not_active Expired - Fee Related
1999
- 1999-09-30 AR ARP990104928A patent/AR020538A1/es active IP Right Grant
- 1999-10-04 KR KR1020017004374A patent/KR100641801B1/ko not_active Expired - Fee Related
- 1999-10-04 RS YUP-252/01A patent/RS50112B/sr unknown
- 1999-10-04 CZ CZ20011257A patent/CZ294551B6/cs not_active IP Right Cessation
- 1999-10-04 DE DE19983612T patent/DE19983612T1/de not_active Ceased
- 1999-10-04 ES ES99949015T patent/ES2257871T3/es not_active Expired - Lifetime
- 1999-10-04 TR TR2001/00961T patent/TR200100961T2/xx unknown
- 1999-10-04 GB GB0111172A patent/GB2359810B/en not_active Expired - Fee Related
- 1999-10-04 DK DK99949015T patent/DK1120419T3/da active
- 1999-10-04 EE EEP200100207A patent/EE04374B1/xx not_active IP Right Cessation
- 1999-10-04 AT AT99949015T patent/ATE323707T1/de not_active IP Right Cessation
- 1999-10-04 NZ NZ510855A patent/NZ510855A/xx not_active IP Right Cessation
- 1999-10-04 PL PL347030A patent/PL200028B1/pl not_active IP Right Cessation
- 1999-10-04 DE DE69930949T patent/DE69930949T2/de not_active Expired - Lifetime
- 1999-10-04 HU HU0103937A patent/HUP0103937A3/hu unknown
- 1999-10-04 PE PE1999001005A patent/PE20001083A1/es not_active Application Discontinuation
- 1999-10-04 JP JP2000574532A patent/JP4659214B2/ja not_active Expired - Fee Related
- 1999-10-04 IL IL14239199A patent/IL142391A0/xx active IP Right Grant
- 1999-10-04 EA EA200100422A patent/EA003360B1/ru not_active IP Right Cessation
- 1999-10-04 WO PCT/ES1999/000316 patent/WO2000020420A1/es not_active Ceased
- 1999-10-04 EP EP99949015A patent/EP1120419B1/en not_active Expired - Lifetime
- 1999-10-04 PT PT99949015T patent/PT1120419E/pt unknown
- 1999-10-04 BR BRPI9914355-0A patent/BR9914355B1/pt not_active IP Right Cessation
- 1999-10-04 CA CA002346010A patent/CA2346010C/en not_active Expired - Fee Related
- 1999-10-04 GE GEAP19995886A patent/GEP20043162B/en unknown
- 1999-10-04 ID IDW00200101008A patent/ID29946A/id unknown
- 1999-10-04 YU YU25201A patent/YU25201A/sh unknown
- 1999-10-04 HR HR20010256A patent/HRP20010256B1/xx not_active IP Right Cessation
- 1999-10-04 CN CN99811802A patent/CN1096465C/zh not_active Expired - Fee Related
- 1999-10-04 AU AU62041/99A patent/AU762724B2/en not_active Ceased
- 1999-10-04 AP APAP/P/2001/002128A patent/AP1555A/en active
- 1999-10-04 OA OA1200100085A patent/OA11661A/en unknown
- 1999-10-06 CO CO99063420A patent/CO5180544A1/es not_active Application Discontinuation
- 1999-10-07 GT GT199900173A patent/GT199900173A/es unknown
- 1999-10-07 PA PA19998483901A patent/PA8483901A1/es unknown
2001
- 2001-03-29 IS IS5910A patent/IS2312B/is unknown
- 2001-04-03 IL IL142391A patent/IL142391A/en not_active IP Right Cessation
- 2001-04-04 CU CU83A patent/CU23162A3/es not_active IP Right Cessation
- 2001-04-05 ZA ZA200102836A patent/ZA200102836B/xx unknown
- 2001-04-06 BG BG105417A patent/BG65135B1/bg unknown
- 2001-04-06 US US09/827,868 patent/US20010051735A1/en not_active Abandoned
- 2001-04-06 NO NO20011778A patent/NO328584B1/no not_active IP Right Cessation
2003
- 2003-04-28 US US10/424,828 patent/US6858632B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PT1120419E (pt)	2006-07-31
BR9914355A (pt)	2001-06-26
IS5910A (is)	2001-03-29
GEP20043162B (en)	2004-01-26
ES2257871T3 (es)	2006-08-01
PE20001083A1 (es)	2000-11-28
EE04374B1 (et)	2004-10-15
ATE323707T1 (de)	2006-05-15
CN1096465C (zh)	2002-12-18
PL347030A1 (en)	2002-03-11
EE200100207A (et)	2002-06-17
IL142391A0 (en)	2002-03-10
CA2346010A1 (en)	2000-04-13
EP1120419A1 (en)	2001-08-01
HRP20010256B1 (hr)	2009-08-31
GB2359810A (en)	2001-09-05
EA003360B1 (ru)	2003-04-24
YU25201A (sh)	2003-04-30
DE69930949D1 (de)	2006-05-24
TR200100961T2 (tr)	2003-02-21
US20010051735A1 (en)	2001-12-13
KR100641801B1 (ko)	2006-11-02
DE69930949T2 (de)	2006-12-28
WO2000020420A1 (es)	2000-04-13
ID29946A (id)	2001-10-25
CA2346010C (en)	2010-01-12
BG105417A (en)	2001-12-29
HUP0103937A3 (en)	2003-11-28
AP1555A (en)	2006-01-18
HRP20010256A2 (en)	2002-04-30
KR20010088848A (ko)	2001-09-28
US6858632B2 (en)	2005-02-22
BG65135B1 (bg)	2007-03-30
IS2312B (is)	2007-11-15
JP4659214B2 (ja)	2011-03-30
ES2142773A1 (es)	2000-04-16
CO5180544A1 (es)	2002-07-30
EA200100422A1 (ru)	2001-10-22
NO328584B1 (no)	2010-03-22
DK1120419T3 (da)	2006-07-03
DE19983612T1 (de)	2001-09-27
ES2142773B1 (es)	2001-01-01
RS50112B (sr)	2009-03-25
GB0111172D0 (en)	2001-06-27
AU6204199A (en)	2000-04-26
PL200028B1 (pl)	2008-11-28
CU23162A3 (es)	2006-07-18
OA11661A (en)	2004-12-08
AP2001002128A0 (en)	2001-06-30
PA8483901A1 (es)	2000-09-29
IL142391A (en)	2007-07-24
BR9914355B1 (pt)	2014-10-21
EP1120419B1 (en)	2006-04-19
ZA200102836B (en)	2002-09-25
US20030225134A1 (en)	2003-12-04
AU762724B2 (en)	2003-07-03
JP2002526544A (ja)	2002-08-20
CZ294551B6 (cs)	2005-01-12
NZ510855A (en)	2004-02-27
AR020538A1 (es)	2002-05-15
NO20011778D0 (no)	2001-04-06
GB2359810B (en)	2003-12-03
CZ20011257A3 (cs)	2001-08-15
HUP0103937A2 (hu)	2002-02-28
GT199900173A (es)	2001-03-30
CN1322205A (zh)	2001-11-14

Publication	Publication Date	Title
NO20011778L (no)	2001-04-06	Derivater av isosorbid-mononitrat, og deres utnyttelse som vasodilaterende agens med redusert toleranse
DK1204649T3 (da)	2007-12-03	Arylmethylcarbonylaminothiazolderivater og deres anvendelse som antitumormidler
DK1198454T3 (da)	2006-06-12	Multilinderivater og deres anvendelse som antibakterielle midler
NO20021408L (no)	2002-05-14	Oksa- og tiadiazol-derivater anvendelige som antidiabetiske og antiovervektsmidler
NO20021253L (no)	2002-04-24	Kinolylpropylpiperidinderivater og deres anvendelse som antibakterielle midler
NO20015156L (no)	2001-12-18	5-pyridyl-1,3-azolforbindelser, deres fremstilling og anvendelse
NO20012058L (no)	2001-06-28	2-ureido-tiazolderivater, fremgangsmåte for deres fremstilling og anvendelse som antitumormidler
NO20011956L (no)	2001-04-20	Substituerte fenylderivater, deres fremstilling og anvendelse
NO20001079L (no)	2000-09-04	Kopolymerer og deres anvendelse som borehjelpemiddel
NO20020684D0 (no)	2002-02-11	Aminopyrazolderivater, fremgangsmåte for deres fremstilling og deres anvendelse som antitumormidler
NO20014603D0 (no)	2001-09-21	Tienopyrimidinforbindelser, deres fremstilling og anvendelse
NO20000294D0 (no)	2000-01-20	Derivater av acylpiperazinylpyrimidiner, deres fremstilling og anvendelse som legemidler
NO20025150L (no)	2002-12-16	2-acylindolderivater og deres anvendelse som antitumormidler
NO20014270L (no)	2001-11-05	Pyridopyranoazepinderivater, deres fremstilling og terapeutisk anvendelse
HUP0202578A3 (en)	2005-02-28	Novel derivatives of flavones, xanthones and coumarins
NO991131D0 (no)	1999-03-09	Benzamidinderivater og deres anvendelse som legemiddel med LTB4-antagonistisk virkning
DK1043307T3 (da)	2003-09-22	3-amino-3-arylpropan-1-ol-derivater, deres fremstilling og anvendelse
NO20023146L (no)	2002-06-28	Substituerte fenyl-piperazinderivater, deres fremstilling og anvendelse
NO985307D0 (no)	1998-11-13	Distamycinderivater, fremgangsmÕte for deres fremstilling, og deres anvendelse som antitumor- og antivirale midler
DK1259515T3 (da)	2005-01-31	Thienopyridinderivater og deres anvendelse som antiinflammatoriske midler
NO20015652D0 (no)	2001-11-20	1-trifluorometyl-4-hydroksy-7-piperidinyl- aminometylkromanderivater
NO20012802L (no)	2001-08-07	Benzofuranderivater, deres fremstilling og anvendelse
NO20001782L (no)	2000-10-09	3-amino-3-arylpropan-1-ol-derivater, deres fremstilling og anvendelse
NO20005549L (no)	2001-01-05	Substituerte sulfonylcyanamider, deres fremstilling og anvendelse som medikament
NO20020404D0 (no)	2002-01-25	Streptograminderivater, deres produksjon og forbindelser derav

Legal Events

Date	Code	Title	Description
2011-05-30	MM1K	Lapsed by not paying the annual fees