[go: up one dir, main page]

NO20005215L - Dihydropyrimidiner - Google Patents

Dihydropyrimidiner

Info

Publication number
NO20005215L
NO20005215L NO20005215A NO20005215A NO20005215L NO 20005215 L NO20005215 L NO 20005215L NO 20005215 A NO20005215 A NO 20005215A NO 20005215 A NO20005215 A NO 20005215A NO 20005215 L NO20005215 L NO 20005215L
Authority
NO
Norway
Prior art keywords
dihydropyrimidine
Prior art date
Application number
NO20005215A
Other languages
English (en)
Other versions
NO20005215D0 (no
NO321985B1 (no
Inventor
Juergen Stoltefuss
Siegfried Goldmann
Thomas Kraemer
Karl-Heinz Schlemmer
Ulrich Niewoehner
Arnold Paessens
Erwin Graef
Stefan Lottmann
Kark Deres
Olaf Weber
Joern Stoelting
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of NO20005215D0 publication Critical patent/NO20005215D0/no
Publication of NO20005215L publication Critical patent/NO20005215L/no
Publication of NO321985B1 publication Critical patent/NO321985B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84Nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
NO20005215A 1998-04-18 2000-10-17 Dihydropyrimidinforbindelser, fremgangsmater for fremstilling av slike, samt fremgangsmate for fremstilling av farmasoytiske preparater og anvendelse av forbindelsene i farmasoytiske preparater for behandling av virussykdommer, saerlig hepatitt B NO321985B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19817264A DE19817264A1 (de) 1998-04-18 1998-04-18 Neue Dihydropyrimidine
PCT/EP1999/002344 WO1999054326A1 (de) 1998-04-18 1999-04-07 Dihydropyrimidine

Publications (3)

Publication Number Publication Date
NO20005215D0 NO20005215D0 (no) 2000-10-17
NO20005215L true NO20005215L (no) 2000-12-13
NO321985B1 NO321985B1 (no) 2006-07-31

Family

ID=7864972

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20005215A NO321985B1 (no) 1998-04-18 2000-10-17 Dihydropyrimidinforbindelser, fremgangsmater for fremstilling av slike, samt fremgangsmate for fremstilling av farmasoytiske preparater og anvendelse av forbindelsene i farmasoytiske preparater for behandling av virussykdommer, saerlig hepatitt B
NO20045259A NO329020B1 (no) 1998-04-18 2004-12-01 Difluorpyridiner

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20045259A NO329020B1 (no) 1998-04-18 2004-12-01 Difluorpyridiner

Country Status (36)

Country Link
US (3) US6696451B1 (no)
EP (1) EP1080086B1 (no)
JP (2) JP4590097B2 (no)
KR (1) KR100636771B1 (no)
CN (1) CN1159311C (no)
AR (1) AR018187A1 (no)
AT (1) ATE223401T1 (no)
AU (1) AU740318B2 (no)
BG (1) BG64649B1 (no)
BR (2) BRPI9917862B8 (no)
CA (1) CA2328780C (no)
CO (1) CO5021127A1 (no)
CU (1) CU23049A3 (no)
CZ (1) CZ293482B6 (no)
DE (2) DE19817264A1 (no)
DK (1) DK1080086T3 (no)
ES (1) ES2183548T3 (no)
GT (1) GT199900056A (no)
HU (1) HUP0102372A3 (no)
ID (1) ID27263A (no)
IL (2) IL138584A0 (no)
MY (1) MY126527A (no)
NO (2) NO321985B1 (no)
NZ (1) NZ507569A (no)
PE (1) PE20000427A1 (no)
PL (1) PL193898B1 (no)
PT (1) PT1080086E (no)
RU (1) RU2245881C9 (no)
SI (1) SI1080086T1 (no)
SK (1) SK286407B6 (no)
SV (1) SV1999000047A (no)
TR (1) TR200003011T2 (no)
TW (1) TW548274B (no)
UA (1) UA63998C2 (no)
WO (1) WO1999054326A1 (no)
ZA (1) ZA200005136B (no)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000058302A1 (de) * 1999-03-25 2000-10-05 Bayer Aktiengesellschaft Dihydropyrimidine und ihre verwendung zur behandlung von hepatitis b
EP1193259A4 (en) 1999-06-23 2003-01-29 Ajinomoto Kk dihydropyrimidine
AU3009801A (en) * 1999-12-22 2001-07-03 Bayer Aktiengesellschaft Combinations of medicaments for treating viral diseases
DE10012823A1 (de) 2000-03-16 2001-09-20 Bayer Ag Arzneimittel gegen virale Erkrankungen
DE10013125A1 (de) * 2000-03-17 2001-09-20 Bayer Ag Arzneimittel gegen virale Erkrankungen
DE10013126A1 (de) * 2000-03-17 2001-09-20 Bayer Ag Arzneimittel gegen virale Erkrankungen
DE10125131A1 (de) 2001-05-23 2002-12-05 Bayer Ag Verfahren zur Spaltung des Methyl 4-(2-chlor-4-fluorphenyl)-2-(3,5-difluor-2-pyridinyl)-6-methyl-1,4-dihydro-5-pyrmidincarboxylat-Racemats
US20040092735A1 (en) * 2002-11-08 2004-05-13 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of cefuroxime sodium
CN101104604B (zh) 2006-07-10 2011-03-02 北京摩力克科技有限公司 光学纯二氢嘧啶类化合物及其用于制备治疗和预防病毒性疾病的药物的用途
CN101104617B (zh) * 2006-07-10 2010-06-23 北京摩力克科技有限公司 二氢嘧啶类化合物及其用于制备治疗和预防病毒性疾病的药物的用途
RU2452733C2 (ru) * 2007-04-27 2012-06-10 Пэдью Фарма Л.П. Антагонисты trpv1 и их применение
BRPI0813237B8 (pt) 2007-06-18 2021-05-25 Sunshine Lake Pharma Co Ltd composto, método para preparar o composto, medicamento, e, uso do composto
BRPI0815562A2 (pt) 2007-07-12 2015-02-18 Novartis Ag Soluções farmacêuticas orais contendo telbivudina.
US20130267517A1 (en) 2012-03-31 2013-10-10 Hoffmann-La Roche Inc. Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
RU2655914C9 (ru) 2012-08-24 2018-07-24 Саншайн Лейк Фарма Ко., Лтд. Соединения дигидропиримидина и их применение в фармацевтических препаратах
KR20150054795A (ko) 2012-09-10 2015-05-20 에프. 호프만-라 로슈 아게 B형 간염 바이러스 감염의 치료 및 예방을 위한 6-아미노산 헤테로아릴다이하이드로피리미딘
CN103664899B (zh) * 2012-09-11 2017-06-16 广东东阳光药业有限公司 杂芳基取代的二氢嘧啶类化合物及其在药物中的应用
US20150292045A1 (en) * 2012-11-09 2015-10-15 Indiana University Research And Technology Corporation Alternative uses for hbv assembly effectors
TW201609652A (zh) * 2013-11-12 2016-03-16 陶氏農業科學公司 用於氟化化合物之過程(三)
RU2678990C1 (ru) 2013-11-19 2019-02-05 Саншайн Лейк Фарма Ко., Лтд. Соединения дигидропиримидина и их применение в фармацевтических препаратах
AU2014356986B2 (en) 2013-11-27 2018-01-04 Sunshine Lake Pharma Co., Ltd. Processes for preparing dihydropyrimidine derivatives and intermediates thereof
WO2015144093A1 (en) 2014-03-28 2015-10-01 Sunshine Lake Pharma Co., Ltd. Dihydropyrimidine compounds and their application in pharmaceuticals
CN105153164B (zh) * 2014-05-30 2018-10-30 齐鲁制药有限公司 作为hbv抑制剂的二氢嘧啶并环衍生物
WO2015180631A1 (zh) * 2014-05-30 2015-12-03 南京明德新药研发股份有限公司 作为hbv抑制剂的二氢嘧啶并环衍生物
CN105859708B (zh) 2015-02-07 2020-01-21 广东东阳光药业有限公司 二氢嘧啶衍生物的盐及其在药物中的应用
EP3645516A4 (en) * 2017-06-27 2021-07-07 Janssen Pharmaceutica NV HETEROARYLDIHYDROPYRIMIDE DERIVATIVES AND METHODS OF TREATMENT OF HEPATITIS B INFECTIONS
US10759774B2 (en) 2017-09-28 2020-09-01 The Curators Of The University Of Missouri Inhibitors of hepatitis B virus targeting capsid assembly
JP2021501768A (ja) 2017-11-02 2021-01-21 アイクリス ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト B型肝炎ウイルス(hbv)に対し活性を有する新規の高活性なピラゾロ−ピペリジン置換インドール−2−カルボキサミド
MA50524A (fr) 2017-11-02 2020-09-09 Aicuris Gmbh & Co Kg Nouveaux indole-2-carboxamides à substitution amino-thiazole hautement actifs agissant contre le virus de l'hépatite b (vhb)
CA3097784A1 (en) * 2018-05-08 2019-11-14 Janssen Sciences Ireland Unlimited Company Dihydropyrimidine derivatives and uses thereof in the treatment of hbv infection or of hbv-induced diseases
US11053235B2 (en) 2018-08-09 2021-07-06 Janssen Sciences Ireland Unlimited Company Substituted 1,4-dihydropyrimidines for the treatment of HBV infection or HBV-induced diseases
AR116948A1 (es) 2018-11-02 2021-06-30 Aicuris Gmbh & Co Kg Derivados de urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (vhb)
AR117189A1 (es) 2018-11-02 2021-07-21 Aicuris Gmbh & Co Kg Derivados de 6,7-dihidro-4h-pirazolo[1,5-a]pirazin indol-2-carboxamidas activos contra el virus de la hepatitis b (vhb)
AR116946A1 (es) 2018-11-02 2021-06-30 Aicuris Gmbh & Co Kg Derivados de urea 6,7-dihidro-4h-pirazolo[4,3-c]piridinas activas contra el virus de la hepatitis b (vhb)
JP2022506351A (ja) * 2018-11-02 2022-01-17 アイクリス ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト B型肝炎ウイルス(hbv)に対して活性を有する新規ウレア6,7-ジヒドロ-4h-チアゾロ[5,4-c]ピリジン
AR116947A1 (es) 2018-11-02 2021-06-30 Aicuris Gmbh & Co Kg Derivados de urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas-indol-2-carboxamidas activas contra el virus de la hepatitis b (vhb)
UY38437A (es) 2018-11-02 2020-05-29 Aicuris Gmbh & Co Kg Nuevas urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (hbv)
MA54560A (fr) 2018-12-20 2021-10-27 Janssen Pharmaceutica Nv Dérivés d'hétéroaryldihydropyrimidine et procédés de traitement d'infections par le virus de l'hépatite b
WO2020221824A1 (en) 2019-04-30 2020-11-05 Aicuris Gmbh & Co. Kg Novel indolizine-2-carboxamides active against the hepatitis b virus (hbv)
US20220306647A1 (en) 2019-04-30 2022-09-29 Aicuris Gmbh & Co. Kg Novel indole-2-carboxamides active against the hepatitus b virus (hbv)
WO2020221811A1 (en) 2019-04-30 2020-11-05 Aicuris Gmbh & Co. Kg Novel oxalyl piperazines active against the hepatitis b virus (hbv)
US20220227785A1 (en) 2019-04-30 2022-07-21 Aicuris Gmbh & Co. Kg Novel phenyl and pyridyl ureas active against the hepatitis b virus (hbv)
WO2020255016A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL130304C (no) * 1964-02-12
CH550189A (de) 1971-01-08 1974-06-14 Ciba Geigy Ag Verfahren zur herstellung von neuen dibenzo (b,f) thiepincarbonsaeuren.
CH569043A5 (no) 1973-01-23 1975-11-14 Ciba Geigy Ag
US4371537A (en) * 1981-08-13 1983-02-01 The Dow Chemical Company Sulfur-substituted phenoxypyridines having antiviral activity
DE3234684A1 (de) 1982-09-18 1984-03-22 Bayer Ag, 5090 Leverkusen Neue dihydropyrimidine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
JPS60185764A (ja) * 1984-03-05 1985-09-21 Wako Pure Chem Ind Ltd ピリジン誘導体の新規な製造法
US4698340A (en) 1984-07-19 1987-10-06 Fujisawa Pharmaceutical Co., Ltd. Pyrimidine derivatives, processes for preparation thereof and composition containing the same
US4727073A (en) 1984-10-01 1988-02-23 Fujisawa Pharmaceutical Co., Ltd. Pyrimidine derivatives and composition of the same
GB8906168D0 (en) * 1989-03-17 1989-05-04 Pfizer Ltd Therapeutic agents
EP0941222A2 (en) * 1996-11-12 1999-09-15 Novartis AG Pyrazole derivatives useful as herbicides
SE9702564D0 (sv) 1997-07-02 1997-07-02 Astra Ab New compounds

Also Published As

Publication number Publication date
BR9909730A (pt) 2000-12-19
HK1039119A1 (en) 2002-04-12
SK15652000A3 (sk) 2001-04-09
US20070117812A1 (en) 2007-05-24
SI1080086T1 (en) 2003-02-28
DE59902573D1 (en) 2002-10-10
NO20005215D0 (no) 2000-10-17
US6696451B1 (en) 2004-02-24
BR9909730B1 (pt) 2012-09-04
PL343481A1 (en) 2001-08-27
JP5237332B2 (ja) 2013-07-17
KR100636771B1 (ko) 2006-10-23
GT199900056A (es) 2000-10-07
RU2245881C2 (ru) 2005-02-10
WO1999054326A8 (de) 1999-12-29
HUP0102372A3 (en) 2003-01-28
DE19817264A1 (de) 1999-10-21
PL193898B1 (pl) 2007-03-30
NO321985B1 (no) 2006-07-31
TW548274B (en) 2003-08-21
BRPI9917862B8 (pt) 2021-05-25
CZ20003871A3 (cs) 2001-01-17
CO5021127A1 (es) 2001-03-27
BG104812A (en) 2001-06-29
BG64649B1 (bg) 2005-10-31
CU23049A3 (es) 2005-06-24
US20040167135A1 (en) 2004-08-26
PE20000427A1 (es) 2000-06-25
AU740318B2 (en) 2001-11-01
RU2245881C9 (ru) 2006-02-10
HUP0102372A2 (hu) 2001-12-28
IL138584A (en) 2006-09-05
CN1305471A (zh) 2001-07-25
DK1080086T3 (da) 2002-12-23
NO329020B1 (no) 2010-07-26
EP1080086A1 (de) 2001-03-07
JP2002512243A (ja) 2002-04-23
ZA200005136B (en) 2001-03-02
UA63998C2 (uk) 2004-02-16
NZ507569A (en) 2002-04-26
EP1080086B1 (de) 2002-09-04
SV1999000047A (es) 2000-06-23
JP4590097B2 (ja) 2010-12-01
AR018187A1 (es) 2001-10-31
PT1080086E (pt) 2002-12-31
BRPI9917862A2 (no) 2010-12-07
US7514565B2 (en) 2009-04-07
CZ293482B6 (cs) 2004-05-12
IL138584A0 (en) 2001-10-31
WO1999054326A1 (de) 1999-10-28
CA2328780A1 (en) 1999-10-28
KR20010042788A (ko) 2001-05-25
TR200003011T2 (tr) 2001-01-22
ID27263A (id) 2001-03-22
ATE223401T1 (de) 2002-09-15
CN1159311C (zh) 2004-07-28
CA2328780C (en) 2008-09-23
AU3813399A (en) 1999-11-08
NO20045259L (no) 2000-12-13
MY126527A (en) 2006-10-31
BRPI9917862B1 (pt) 2013-05-07
SK286407B6 (sk) 2008-09-05
ES2183548T3 (es) 2003-03-16
JP2010241837A (ja) 2010-10-28

Similar Documents

Publication Publication Date Title
NO20005215D0 (no) Dihydropyrimidiner
DK1115721T3 (da) Pyrimidonderivater
DE69829040D1 (de) Elektroplattierungschemie
DE59914158D1 (de) Metallocenmonohalogenide
ATE341990T1 (de) Sigmidoskop
DE59911453D1 (de) Aktivkohlefilter
DE69808145D1 (de) Tintenbehälternachfüllsystem
DE59912371D1 (de) Gleitschalungsfertiger
DE69812868D1 (de) Flanschreformierungsanlage
DE59907306D1 (de) Fadenchangierung
ID23458A (id) Bentuk sediaan nefazodon
DE59906931D1 (de) Exzenterzahnradgetriebe
DE59911683D1 (de) Fahrzeugschliessanlage
DE69811890D1 (de) Einzellenkalorimeter
ATE262513T1 (de) Benzoylpyridazine
DE59903966D1 (de) Exzenterzahnradgetriebe
DE59913393D1 (de) Fadenchangierung
DE59908769D1 (de) N-arylsulfonyl-aminosäure-omega-amide
DE69827358D1 (de) Weglenkungsverfahren
DE69820261D1 (de) Steuerventilanordnnung
DE59908057D1 (de) Underdruckhandhabungseinrichung
DE69809804D1 (de) Notlaufgeländereifen
DE59901046D1 (de) Methylcyclotetradec-5-en-1-one
NO20006616D0 (no) Propionibacteriumvektor
DE59808995D1 (de) Endomikroskopsystem

Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: BAYER INTELLECTUAL PROPERTY GMBH, DE

MK1K Patent expired