AR117189A1 - Derivados de 6,7-dihidro-4h-pirazolo[1,5-a]pirazin indol-2-carboxamidas activos contra el virus de la hepatitis b (vhb) - Google Patents
Derivados de 6,7-dihidro-4h-pirazolo[1,5-a]pirazin indol-2-carboxamidas activos contra el virus de la hepatitis b (vhb)Info
- Publication number
- AR117189A1 AR117189A1 ARP190103182A ARP190103182A AR117189A1 AR 117189 A1 AR117189 A1 AR 117189A1 AR P190103182 A ARP190103182 A AR P190103182A AR P190103182 A ARP190103182 A AR P190103182A AR 117189 A1 AR117189 A1 AR 117189A1
- Authority
- AR
- Argentina
- Prior art keywords
- carboxamidas
- pirazin
- pirazolo
- dihidro
- hbv
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title 1
- 208000006454 hepatitis Diseases 0.000 title 1
- 231100000283 hepatitis Toxicity 0.000 title 1
- -1 CH (CH3) OH Chemical compound 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- VUWZPRWSIVNGKG-UHFFFAOYSA-N fluoromethane Chemical compound F[CH2] VUWZPRWSIVNGKG-UHFFFAOYSA-N 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Reivindicación 1: Compuesto de fórmula (1) en la que R¹, R², R³ y R⁴ se seleccionan, para cada posición, independientemente del grupo que comprende H, CF₂H, CF₃, CF₂CH₃, F, Cl, Br, CH₃, Et, i-Pr, c-Pr, D, CH₂OH, CH(CH₃)OH, CH₂F, CH(F)CH₃, I, C=C, C&
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18000878 | 2018-11-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR117189A1 true AR117189A1 (es) | 2021-07-21 |
Family
ID=64426622
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP190103182A AR117189A1 (es) | 2018-11-02 | 2019-10-31 | Derivados de 6,7-dihidro-4h-pirazolo[1,5-a]pirazin indol-2-carboxamidas activos contra el virus de la hepatitis b (vhb) |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20220081444A1 (es) |
| EP (1) | EP3873910A1 (es) |
| JP (1) | JP2022506337A (es) |
| KR (1) | KR20210099563A (es) |
| CN (1) | CN112996791A (es) |
| AR (1) | AR117189A1 (es) |
| AU (1) | AU2019370734A1 (es) |
| CA (1) | CA3118381A1 (es) |
| EA (1) | EA202191223A1 (es) |
| IL (1) | IL282598A (es) |
| PH (1) | PH12021550970A1 (es) |
| SG (1) | SG11202104116VA (es) |
| TW (1) | TW202031659A (es) |
| UY (1) | UY38434A (es) |
| WO (1) | WO2020089455A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR116947A1 (es) * | 2018-11-02 | 2021-06-30 | Aicuris Gmbh & Co Kg | Derivados de urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas-indol-2-carboxamidas activas contra el virus de la hepatitis b (vhb) |
| US12415816B2 (en) | 2018-11-07 | 2025-09-16 | Dana-Farber Cancer Institute, Inc. | Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof |
| DK4097099T3 (da) | 2020-02-07 | 2024-07-15 | Gasherbrum Bio Inc | Heterocyckliske GLP1-agonister |
| EP4146639A1 (en) | 2020-05-06 | 2023-03-15 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| EP4211139A4 (en) * | 2020-09-10 | 2024-12-18 | Gasherbrum Bio, Inc. | HETEROCYCLIC GLP-1 AGONISTS |
| TW202241889A (zh) | 2020-12-23 | 2022-11-01 | 美商雅捷可斯治療公司 | 作為ｊａｋ２抑制劑之６－雜芳基氧基苯并咪唑及氮雜苯并咪唑 |
| WO2023009709A1 (en) * | 2021-07-29 | 2023-02-02 | Ajax Therapeutics, Inc. | Pyrazolo piperazines as jak2 inhibitors |
| WO2023086320A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | Forms and compositions of inhibitors of jak2 |
| JP7782035B2 (ja) | 2021-11-09 | 2025-12-08 | エイジャックス セラピューティクス， インコーポレイテッド | Ｊａｋ２阻害剤としての６－ヘテロアリールオキシベンゾイミダゾール及びアザベンゾイミダゾール |
| CN115232086B (zh) * | 2022-07-19 | 2024-05-03 | 扬州市普林斯医药科技有限公司 | 一种4-苄基-2(3h)-噁唑酮的制备方法 |
| AU2024222719A1 (en) | 2023-02-16 | 2025-08-21 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| CN116396204B (zh) * | 2023-03-29 | 2024-09-24 | 无锡科华生物科技有限公司 | 一种4,6,7-三氟-1h-吲哚-2-羧酸的制备方法 |
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| DE60033657T2 (de) | 1999-04-23 | 2007-11-08 | Extenday IP Ltd., Kumeu | Foliebefestigungs- und verankerungsteil |
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| KR20200083552A (ko) * | 2017-11-02 | 2020-07-08 | 아이쿠리스 게엠베하 운트 코. 카게 | B형 간염 바이러스 (hbv)에 활성인 신규 고활성 피라졸로-피페리딘 치환된 인돌-2-카르복스아미드 |
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| AR116947A1 (es) * | 2018-11-02 | 2021-06-30 | Aicuris Gmbh & Co Kg | Derivados de urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas-indol-2-carboxamidas activas contra el virus de la hepatitis b (vhb) |
| UY38437A (es) * | 2018-11-02 | 2020-05-29 | Aicuris Gmbh & Co Kg | Nuevas urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (hbv) |
| UY38435A (es) * | 2018-11-02 | 2020-05-29 | Aicuris Gmbh & Co Kg | Nuevas urea 6,7-dihidro-4h-pirazol[1,5-a] pirazinas activas contra el virus de la hepatitis b (vhb) |
-
2019
- 2019-10-31 AR ARP190103182A patent/AR117189A1/es not_active Application Discontinuation
- 2019-10-31 UY UY0001038434A patent/UY38434A/es not_active Application Discontinuation
- 2019-11-01 TW TW108139831A patent/TW202031659A/zh unknown
- 2019-11-01 JP JP2021523655A patent/JP2022506337A/ja active Pending
- 2019-11-01 AU AU2019370734A patent/AU2019370734A1/en not_active Abandoned
- 2019-11-01 WO PCT/EP2019/079969 patent/WO2020089455A1/en not_active Ceased
- 2019-11-01 EA EA202191223A patent/EA202191223A1/ru unknown
- 2019-11-01 PH PH1/2021/550970A patent/PH12021550970A1/en unknown
- 2019-11-01 CA CA3118381A patent/CA3118381A1/en not_active Abandoned
- 2019-11-01 US US17/290,347 patent/US20220081444A1/en not_active Abandoned
- 2019-11-01 KR KR1020217016304A patent/KR20210099563A/ko not_active Ceased
- 2019-11-01 CN CN201980072954.4A patent/CN112996791A/zh active Pending
- 2019-11-01 SG SG11202104116VA patent/SG11202104116VA/en unknown
- 2019-11-01 EP EP19801777.4A patent/EP3873910A1/en not_active Withdrawn
-
2021
- 2021-04-22 IL IL282598A patent/IL282598A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2019370734A1 (en) | 2021-05-27 |
| KR20210099563A (ko) | 2021-08-12 |
| UY38434A (es) | 2020-05-29 |
| EA202191223A1 (ru) | 2021-07-29 |
| TW202031659A (zh) | 2020-09-01 |
| WO2020089455A1 (en) | 2020-05-07 |
| SG11202104116VA (en) | 2021-05-28 |
| CN112996791A (zh) | 2021-06-18 |
| PH12021550970A1 (en) | 2022-03-21 |
| JP2022506337A (ja) | 2022-01-17 |
| EP3873910A1 (en) | 2021-09-08 |
| IL282598A (en) | 2021-06-30 |
| CA3118381A1 (en) | 2020-05-07 |
| US20220081444A1 (en) | 2022-03-17 |
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