NO20005928L - Bicykliske pyrimidiner og bicykliske 3,4-dihydropyrimidiner som inhibitorer av cellulær proliferasjon - Google Patents
Bicykliske pyrimidiner og bicykliske 3,4-dihydropyrimidiner som inhibitorer av cellulær proliferasjonInfo
- Publication number
- NO20005928L NO20005928L NO20005928A NO20005928A NO20005928L NO 20005928 L NO20005928 L NO 20005928L NO 20005928 A NO20005928 A NO 20005928A NO 20005928 A NO20005928 A NO 20005928A NO 20005928 L NO20005928 L NO 20005928L
- Authority
- NO
- Norway
- Prior art keywords
- bicyclic
- dihydropyrimidines
- inhibitors
- cellular proliferation
- pyrimidines
- Prior art date
Links
- -1 Bicyclic pyrimidines Chemical class 0.000 title 2
- 230000004663 cell proliferation Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8670898P | 1998-05-26 | 1998-05-26 | |
| US12615899P | 1999-03-25 | 1999-03-25 | |
| PCT/US1999/010187 WO1999061444A2 (en) | 1998-05-26 | 1999-05-10 | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20005928L true NO20005928L (no) | 2000-11-23 |
| NO20005928D0 NO20005928D0 (no) | 2000-11-23 |
Family
ID=26775058
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20005928A NO20005928D0 (no) | 1998-05-26 | 2000-11-23 | Bicykliske pyrimidiner og bicykliske 3,4-dihydropyrimidiner som inhibitorer av cellulær proliferasjon |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US7501425B1 (no) |
| EP (1) | EP1080092B1 (no) |
| JP (1) | JP2002516327A (no) |
| KR (1) | KR20010043829A (no) |
| CN (1) | CN1138778C (no) |
| AP (1) | AP2000001964A0 (no) |
| AT (1) | ATE402177T1 (no) |
| AU (1) | AU763839B2 (no) |
| BG (1) | BG104960A (no) |
| BR (1) | BR9911590A (no) |
| CA (1) | CA2329703C (no) |
| DE (1) | DE69939168D1 (no) |
| EA (1) | EA003640B1 (no) |
| EE (1) | EE200000706A (no) |
| ES (1) | ES2310039T3 (no) |
| GE (1) | GEP20033093B (no) |
| HR (1) | HRP20000799A2 (no) |
| HU (1) | HUP0102514A3 (no) |
| ID (1) | ID27589A (no) |
| IL (1) | IL139599A0 (no) |
| IS (1) | IS5687A (no) |
| NO (1) | NO20005928D0 (no) |
| NZ (1) | NZ508268A (no) |
| PL (1) | PL344248A1 (no) |
| SK (1) | SK17532000A3 (no) |
| TR (1) | TR200003429T2 (no) |
| WO (1) | WO1999061444A2 (no) |
| YU (1) | YU73300A (no) |
Families Citing this family (108)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2310039T3 (es) | 1998-05-26 | 2008-12-16 | Warner-Lambert Company Llc | Pirimidinas biciclicas y 3,4-dihidropirimidinas biciclicas como inhibidores de la proliferacion celular. |
| WO2000024744A1 (en) * | 1998-10-23 | 2000-05-04 | F. Hoffmann-La Roche Ag | Bicyclic nitrogen heterocycles |
| CZ20021743A3 (cs) * | 1999-10-21 | 2002-08-14 | F. Hoffmann-La Roche Ag | Bicyklické dusíkové heterocykly substituované alkylaminoskupinou jako inhibitory P38 proteinkinázy |
| CA2388142C (en) | 1999-10-21 | 2008-12-09 | F. Hoffmann-La Roche Ag | Heteroalkylamino-substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase |
| CN1425008A (zh) | 2000-01-24 | 2003-06-18 | 沃尼尔·朗伯公司 | 3-氨基喹唑啉-2,4-二酮抗菌剂 |
| US7053070B2 (en) | 2000-01-25 | 2006-05-30 | Warner-Lambert Company | Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors |
| MXPA02007221A (es) * | 2000-01-25 | 2002-11-29 | Warner Lambert Co | Inhibidores de pirido [2,3-d)pirimidin-2,7-diamina cinasa. |
| MY141144A (en) * | 2000-03-02 | 2010-03-15 | Smithkline Beecham Corp | 1, 5-disubstituted-3,4-dihydro-1h-pyrimido 4,5-dipyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases |
| US7235551B2 (en) | 2000-03-02 | 2007-06-26 | Smithkline Beecham Corporation | 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases |
| SK12472002A3 (sk) * | 2000-03-06 | 2003-04-01 | Warner-Lambert Company | 5-Alkylpyrido[2,3-d]pyrimidínové inhibítory tyrosínových kináz |
| US6506749B2 (en) | 2000-08-31 | 2003-01-14 | Syntex (U.S.A.) Llc | 7-oxo-pyridopyrimidines (I) |
| CN1275964C (zh) * | 2000-08-31 | 2006-09-20 | 霍夫曼-拉罗奇有限公司 | 作为细胞增殖抑制剂的7-氧代吡啶并嘧啶 |
| IL155367A0 (en) | 2000-10-23 | 2003-12-23 | Smithkline Beecham Corp | NOVEL 2,4,8-TRISUBSTITUTED-8h-PYRIDO[2,3,-d]PYRIMIDIN-7-ONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME, PROCESSES FOR THE PREPARATION THEREOF, AND USE THEREOF IN THE PREPARATION OF MEDICAMENTS FOR TREATING CSBP/p38 KINASE MEDIATED DISEASES |
| GB0029015D0 (en) | 2000-11-28 | 2001-01-10 | Univ London | Medical device |
| AU2002251788A1 (en) | 2001-01-19 | 2002-08-12 | Smithkline Beecham Corporation | Novel compounds and uses thereof |
| AU2002256615B2 (en) | 2001-02-12 | 2007-09-13 | F. Hoffmann-La Roche Ag | 6-substituted pyrido-pyrimidines |
| US7105667B2 (en) | 2001-05-01 | 2006-09-12 | Bristol-Myers Squibb Co. | Fused heterocyclic compounds and use thereof |
| DE60208541D1 (de) | 2001-05-30 | 2006-03-30 | Warner Lambert Co | Antibakterielle mittel |
| JP4291696B2 (ja) * | 2002-01-22 | 2009-07-08 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 2−(ピリジン−2−イルアミノ)−ピリド[2,3−d]ピリミジン−7−オン |
| US7176310B1 (en) | 2002-04-09 | 2007-02-13 | Ucb Sa | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents |
| BR0309053A (pt) | 2002-04-19 | 2005-02-22 | Smithkline Beecham Corp | Compostos |
| PA8577501A1 (es) * | 2002-07-25 | 2004-02-07 | Warner Lambert Co | Inhibidores de quinasas |
| CN100432073C (zh) | 2002-08-06 | 2008-11-12 | 霍夫曼-拉罗奇有限公司 | 作为p-38map激酶抑制剂的6-烷氧基-吡啶并-嘧啶 |
| US7084270B2 (en) | 2002-08-14 | 2006-08-01 | Hoffman-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
| US7129351B2 (en) * | 2002-11-04 | 2006-10-31 | Hoffmann-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
| TW200413381A (en) * | 2002-11-04 | 2004-08-01 | Hoffmann La Roche | Novel amino-substituted dihydropyrimido [4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents |
| WO2004065378A1 (en) * | 2003-01-17 | 2004-08-05 | Warner-Lambert Company Llc | 2-aminopyridine substituted heterocycles as inhibitors of cellular proliferation |
| WO2004089955A1 (en) * | 2003-04-10 | 2004-10-21 | F.Hoffmann-La Roche Ag | Pyrimido compounds |
| DE10325133A1 (de) * | 2003-06-04 | 2004-12-23 | Bayer Cropscience Ag | Triazolopyrimidine |
| CN1860118A (zh) | 2003-07-29 | 2006-11-08 | Irm责任有限公司 | 作为蛋白激酶抑制剂的化合物和组合物 |
| DE602004005238T2 (de) | 2003-11-13 | 2007-11-08 | F. Hoffmann-La Roche Ag | Hydroxyalkylsubstituierte pyrido-7-pyrimidin-7-one |
| JP4812763B2 (ja) * | 2004-05-18 | 2011-11-09 | ライジェル ファーマシューティカルズ, インコーポレイテッド | シクロアルキル置換ピリミジンジアミン化合物およびそれらの用途 |
| KR100853975B1 (ko) * | 2004-08-31 | 2008-08-25 | 에프. 호프만-라 로슈 아게 | 3-페닐 디히드로피리미도[4,5-d]피리미디논의 아미드유도체, 이의 제조 방법 및 약제로서의 용도 |
| KR100853974B1 (ko) * | 2004-08-31 | 2008-08-25 | 에프. 호프만-라 로슈 아게 | 7-아미노-3-페닐 디히드로피리미도[4,5-d]피리미디논의아미드 유도체, 그의 제조 방법 및 약학제로서의 용도 |
| EP1828186A1 (en) | 2004-12-13 | 2007-09-05 | Sunesis Pharmaceuticals, Inc. | Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as raf kinase inhibitors |
| JP2008535822A (ja) | 2005-03-25 | 2008-09-04 | グラクソ グループ リミテッド | 新規化合物 |
| PE20100741A1 (es) | 2005-03-25 | 2010-11-25 | Glaxo Group Ltd | COMPUESTOS DERIVADOS DE 3,4-DIHIDROPIRIMIDO[4,5-d]PIRIMIDIN-2(1H)-ONA COMO INHIBIDORES DE QUINASA p38 |
| JP2008537937A (ja) | 2005-03-25 | 2008-10-02 | グラクソ グループ リミテッド | ピリド[2,3−d]ピリミジン−7−オンおよび3,4−ジヒドロピリミド[4,5−d]ピリミジン−2(1H)−オン誘導体の製造方法 |
| PE20100737A1 (es) | 2005-03-25 | 2010-11-27 | Glaxo Group Ltd | Nuevos compuestos |
| ES2329419T3 (es) | 2006-01-31 | 2009-11-25 | F. Hoffmann-La Roche Ag | 7h-pirido(3,4-d)pirimidin-8-onas, su preparacion y uso como inhibidores de proteinas cinasas. |
| MX2009013728A (es) * | 2007-06-15 | 2010-01-25 | Banyu Pharma Co Ltd | Derivados de bicicloanilina. |
| EA019156B1 (ru) | 2008-02-01 | 2014-01-30 | Такеда Фармасьютикал Компани Лимитед | Производные оксима в качестве ингибиторов hsp90 |
| CA2745959A1 (en) * | 2008-12-12 | 2010-06-17 | Msd K.K. | Dihydropyrimidopyrimidine derivatives |
| WO2010067886A1 (en) * | 2008-12-12 | 2010-06-17 | Banyu Pharmaceutical Co.,Ltd. | Dihydropyrimidopyrimidine derivative |
| EP2379559B1 (en) * | 2009-01-06 | 2017-10-25 | Dana-Farber Cancer Institute, Inc. | Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders |
| CA2750716A1 (en) * | 2009-02-25 | 2010-09-02 | Msd K.K. | Pyrimidopyrimidoindazole derivative |
| SA111320200B1 (ar) * | 2010-02-17 | 2014-02-16 | ديبيوفارم اس ايه | مركبات ثنائية الحلقة واستخداماتها كمثبطات c-src/jak مزدوجة |
| BR112013002375B1 (pt) * | 2010-08-05 | 2020-05-12 | Temple University - Of The Commonwealth System Of Higher Education | Composto, processo de preparação do mesmo, composição farmacêutica, e, usos de um composto |
| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
| PE20140502A1 (es) | 2011-04-22 | 2014-05-02 | Signal Pharm Llc | Pirimidinas sustituidas de diaminocarboxamida y diaminocarbonitrilo, composiciones de las mismas y metodos de tratamiento con las mismas |
| EP2899183B1 (en) | 2011-10-14 | 2018-09-19 | Bristol-Myers Squibb Company | Substituted Tetrahydroisoquinoline Compounds as Factor Xia Inhibitors |
| HRP20170784T8 (hr) | 2011-10-14 | 2018-05-18 | Bristol-Myers Squibb Company | Supstituirani spojevi tetrahidroizohinolina kao inhbitori xia faktora |
| WO2013056034A1 (en) | 2011-10-14 | 2013-04-18 | Bristol-Myers Squibb Company | Substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| PE20190736A1 (es) | 2012-06-13 | 2019-05-23 | Incyte Holdings Corp | Compuestos triciclicos sustituidos como inhibidores del receptor del factor de crecimiento de fibroblastos (fgfr) |
| US8802697B2 (en) * | 2012-07-11 | 2014-08-12 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor |
| WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
| EP2906541B1 (en) | 2012-10-12 | 2017-11-22 | Bristol-Myers Squibb Company | Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| US9315519B2 (en) | 2012-10-12 | 2016-04-19 | Bristol-Myers Squibb Company | Guanidine substituted tetrahydroisoquinoline compounds as factor XIa inhibitors |
| HRP20180465T1 (hr) | 2012-10-12 | 2018-05-04 | Bristol-Myers Squibb Company | Kristalni oblici inhibitora faktora xia |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| TWI647220B (zh) | 2013-03-15 | 2019-01-11 | 美商西建卡爾有限責任公司 | 雜芳基化合物及其用途 |
| AU2014228746B2 (en) | 2013-03-15 | 2018-08-30 | Celgene Car Llc | Heteroaryl compounds and uses thereof |
| ES2892423T3 (es) | 2013-03-15 | 2022-02-04 | Celgene Car Llc | Compuestos de heteroarilo y usos de los mismos |
| JP6479763B2 (ja) | 2013-03-25 | 2019-03-06 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 第xia因子阻害剤としての置換アゾール含有のテトラヒドロイソキノリン |
| KR102269032B1 (ko) * | 2013-04-19 | 2021-06-24 | 인사이트 홀딩스 코포레이션 | Fgfr 저해제로서 이환식 헤테로사이클 |
| AU2014287209B2 (en) * | 2013-07-09 | 2019-01-24 | Dana-Farber Cancer Institute, Inc. | Kinase inhibitors for the treatment of disease |
| CN110354128A (zh) | 2013-10-18 | 2019-10-22 | 卫材R&D管理有限公司 | 嘧啶fgfr4抑制剂 |
| AU2014339972B9 (en) | 2013-10-25 | 2019-05-30 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor |
| TW201609671A (zh) | 2013-12-20 | 2016-03-16 | 標誌製藥公司 | 經取代之二胺基嘧啶基化合物、其組合物及使用其之治療方法 |
| NO2760821T3 (no) | 2014-01-31 | 2018-03-10 | ||
| UY35971A (es) | 2014-01-31 | 2015-07-31 | Bristol Myers Squibb Company Una Corporación Del Estado De Delaware | Macrociclos con grupos p2? aromáticos como inhibidores del factor xia |
| CN103880861B (zh) * | 2014-02-21 | 2016-02-03 | 温州医科大学 | 一种作用于FGF受体的4,6-二甲基-噁唑并[5,4-d]嘧啶-5,7(4H,6H)-二酮衍生物 |
| CN107074821B (zh) | 2014-09-04 | 2020-05-22 | 百时美施贵宝公司 | 为fxia抑制剂的二酰胺大环化合物 |
| US9453018B2 (en) | 2014-10-01 | 2016-09-27 | Bristol-Myers Squibb Company | Pyrimidinones as factor XIa inhibitors |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| ES2895769T3 (es) | 2015-02-20 | 2022-02-22 | Incyte Corp | Heterociclos bicíclicos como inhibidores de FGFR |
| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| CA2982562C (en) | 2015-04-14 | 2023-06-13 | Eisai R&D Management Co., Ltd. | Crystalline fgfr4 inhibitor compound and uses thereof |
| JP7372740B2 (ja) | 2016-05-10 | 2023-11-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 細胞生存性及び/又は細胞増殖を低減するための薬物の組み合わせ |
| CN107459519A (zh) * | 2016-06-06 | 2017-12-12 | 上海艾力斯医药科技有限公司 | 稠合嘧啶哌啶环衍生物及其制备方法和应用 |
| US10954242B2 (en) | 2016-07-05 | 2021-03-23 | The Broad Institute, Inc. | Bicyclic urea kinase inhibitors and uses thereof |
| TWI808958B (zh) | 2017-01-25 | 2023-07-21 | 美商特普醫葯公司 | 涉及二芳基巨環化合物之組合療法 |
| CN111163771B (zh) | 2017-02-28 | 2023-07-14 | 通用医疗公司 | 嘧啶并嘧啶酮类作为sik抑制剂的用途 |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| SI3788047T1 (sl) | 2018-05-04 | 2024-11-29 | Incyte Corporation | Trdne oblike inhibitorja fgfr in postopki priprave le-teh |
| SG11202010882XA (en) | 2018-05-04 | 2020-11-27 | Incyte Corp | Salts of an fgfr inhibitor |
| WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| US11607416B2 (en) | 2019-10-14 | 2023-03-21 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| EP4069696A1 (en) | 2019-12-04 | 2022-10-12 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| WO2021113462A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Derivatives of an fgfr inhibitor |
| WO2021146424A1 (en) | 2020-01-15 | 2021-07-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| BR112022022342A2 (pt) * | 2020-05-08 | 2023-01-03 | Georgiamune Llc | Moduladores de akt3 |
| WO2021257857A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Naphthyridinone compounds as jak2 v617f inhibitors |
| WO2021257863A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Pyrrolotriazine compounds as jak2 v617f inhibitors |
| US11767323B2 (en) | 2020-07-02 | 2023-09-26 | Incyte Corporation | Tricyclic pyridone compounds as JAK2 V617F inhibitors |
| WO2022006457A1 (en) | 2020-07-02 | 2022-01-06 | Incyte Corporation | Tricyclic urea compounds as jak2 v617f inhibitors |
| WO2022046989A1 (en) | 2020-08-27 | 2022-03-03 | Incyte Corporation | Tricyclic urea compounds as jak2 v617f inhibitors |
| US11919908B2 (en) | 2020-12-21 | 2024-03-05 | Incyte Corporation | Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors |
| WO2022182839A1 (en) | 2021-02-25 | 2022-09-01 | Incyte Corporation | Spirocyclic lactams as jak2 v617f inhibitors |
| WO2022221170A1 (en) | 2021-04-12 | 2022-10-20 | Incyte Corporation | Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent |
| WO2022261159A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| WO2022261160A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| JP2025509672A (ja) | 2022-03-17 | 2025-04-11 | インサイト・コーポレイション | Jak2 v617f阻害剤としての三環式尿素化合物 |
| WO2024199388A1 (zh) * | 2023-03-29 | 2024-10-03 | 微境生物医药科技(上海)有限公司 | 作为myt1抑制剂的化合物 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2949466A (en) | 1958-03-04 | 1960-08-16 | Parke Davis & Co | Pyrimidine compounds and means of producing the same |
| ES338687A1 (es) | 1966-04-06 | 1968-04-01 | Monsanto Co | Procedimiento para obtener composiciones de fluidos funcio-nales. |
| US3912723A (en) | 1971-03-29 | 1975-10-14 | Pfizer | 2-Phenyl-as-triazine-3,5(2H,4H)diones |
| DK157451C (da) | 1979-06-14 | 1990-05-21 | Wellcome Found | Analogifremgangsmaade til fremstilling af 2,4-diamino-6-alkoxybenzyl-5-methylpyridooe2,3-daapyrimidiner eller farmaceutisk acceptable syreadditionssalte deraf |
| US4425346A (en) | 1980-08-01 | 1984-01-10 | Smith And Nephew Associated Companies Limited | Pharmaceutical compositions |
| JPS60226882A (ja) | 1984-04-24 | 1985-11-12 | Nippon Zoki Pharmaceut Co Ltd | 新規ピリミドピリミジン誘導体 |
| AU598093B2 (en) * | 1987-02-07 | 1990-06-14 | Wellcome Foundation Limited, The | Pyridopyrimidines, methods for their preparation and pharmaceutical formulations thereof |
| AU658646B2 (en) * | 1991-05-10 | 1995-04-27 | Rhone-Poulenc Rorer International (Holdings) Inc. | Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| IL112249A (en) | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| US5679683A (en) | 1994-01-25 | 1997-10-21 | Warner-Lambert Company | Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
| EP0786997A4 (en) | 1994-10-27 | 1998-03-11 | Merck & Co Inc | MUSCARINE ANTAGONISTS |
| ATE190978T1 (de) * | 1994-11-14 | 2000-04-15 | Warner Lambert Co | 6-aryl-pyrido(2,3-d)pyrimidine und -naphthyridine zur hemmung der durch protein-tyrosin-kinase hervorgerufenen zellvermehrung |
| IL117923A (en) | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
| SK284073B6 (sk) | 1996-04-12 | 2004-09-08 | Warner-Lambert Company | Polycyklické zlúčeniny, ich použitie a farmaceutické kompozície na ich báze |
| ES2301194T3 (es) * | 1997-02-05 | 2008-06-16 | Warner-Lambert Company Llc | Pirido 2,3-d pirimidinas y 4-aminopirimidinas como inhibidores de la proliferacion celular. |
| ZA986732B (en) * | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
| DE69828408T2 (de) * | 1997-08-20 | 2005-12-08 | Warner-Lambert Co. Llc | Naphthyridinone zur hemmung der durch protein-tyrosin-kinase und zellzyklus kinase hervorgerufenen zellvermehrung |
| JP4038624B2 (ja) | 1997-11-29 | 2008-01-30 | 日本農薬株式会社 | 縮合複素環誘導体及びその中間体並びに有害生物防除剤 |
| ES2310039T3 (es) | 1998-05-26 | 2008-12-16 | Warner-Lambert Company Llc | Pirimidinas biciclicas y 3,4-dihidropirimidinas biciclicas como inhibidores de la proliferacion celular. |
| WO2000024744A1 (en) | 1998-10-23 | 2000-05-04 | F. Hoffmann-La Roche Ag | Bicyclic nitrogen heterocycles |
| CZ20021743A3 (cs) | 1999-10-21 | 2002-08-14 | F. Hoffmann-La Roche Ag | Bicyklické dusíkové heterocykly substituované alkylaminoskupinou jako inhibitory P38 proteinkinázy |
| CA2388142C (en) | 1999-10-21 | 2008-12-09 | F. Hoffmann-La Roche Ag | Heteroalkylamino-substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase |
| MY141144A (en) | 2000-03-02 | 2010-03-15 | Smithkline Beecham Corp | 1, 5-disubstituted-3,4-dihydro-1h-pyrimido 4,5-dipyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases |
-
1999
- 1999-05-10 ES ES99924165T patent/ES2310039T3/es not_active Expired - Lifetime
- 1999-05-10 PL PL99344248A patent/PL344248A1/xx not_active Application Discontinuation
- 1999-05-10 AU AU40734/99A patent/AU763839B2/en not_active Ceased
- 1999-05-10 AT AT99924165T patent/ATE402177T1/de not_active IP Right Cessation
- 1999-05-10 HR HR20000799A patent/HRP20000799A2/hr not_active Application Discontinuation
- 1999-05-10 EA EA200001171A patent/EA003640B1/ru not_active IP Right Cessation
- 1999-05-10 YU YU73300A patent/YU73300A/sh unknown
- 1999-05-10 US US09/623,737 patent/US7501425B1/en not_active Expired - Fee Related
- 1999-05-10 EE EEP200000706A patent/EE200000706A/xx unknown
- 1999-05-10 BR BR9911590-5A patent/BR9911590A/pt not_active Application Discontinuation
- 1999-05-10 TR TR2000/03429T patent/TR200003429T2/xx unknown
- 1999-05-10 ID IDW20002452A patent/ID27589A/id unknown
- 1999-05-10 GE GEAP19995700A patent/GEP20033093B/en unknown
- 1999-05-10 DE DE69939168T patent/DE69939168D1/de not_active Expired - Fee Related
- 1999-05-10 NZ NZ508268A patent/NZ508268A/xx unknown
- 1999-05-10 IL IL13959999A patent/IL139599A0/xx unknown
- 1999-05-10 KR KR1020007013279A patent/KR20010043829A/ko not_active Ceased
- 1999-05-10 AP APAP/P/2000/001964A patent/AP2000001964A0/en unknown
- 1999-05-10 WO PCT/US1999/010187 patent/WO1999061444A2/en not_active Ceased
- 1999-05-10 CN CNB998065587A patent/CN1138778C/zh not_active Expired - Fee Related
- 1999-05-10 JP JP2000550849A patent/JP2002516327A/ja not_active Abandoned
- 1999-05-10 HU HU0102514A patent/HUP0102514A3/hu unknown
- 1999-05-10 SK SK1753-2000A patent/SK17532000A3/sk unknown
- 1999-05-10 EP EP99924165A patent/EP1080092B1/en not_active Expired - Lifetime
- 1999-05-10 CA CA002329703A patent/CA2329703C/en not_active Expired - Fee Related
-
2000
- 2000-10-27 IS IS5687A patent/IS5687A/is unknown
- 2000-11-17 BG BG104960A patent/BG104960A/xx unknown
- 2000-11-23 NO NO20005928A patent/NO20005928D0/no not_active Application Discontinuation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20005928D0 (no) | Bicykliske pyrimidiner og bicykliske 3,4-dihydropyrimidiner som inhibitorer av cellulær proliferasjon | |
| NO20012984D0 (no) | Succinoylamino benzodiazepiner som inhibitorer av AB proteinproduksjon | |
| PT1181269E (pt) | Inibidores da proliferacao celular | |
| DK1000039T3 (da) | Substituerede quinazolinderivater og anvendelse deraf som tyrosinkinaseinhibitorer | |
| NO20041975L (no) | Bicyklisk oksopyridin og oksopyrimidinderivater | |
| MXPA03006010A (es) | Derivados de arilamina sustituida y metodos de uso. | |
| DK1047694T3 (da) | Bicykliske heteroaromatiske forbindelser som proteintyrosinkinaseinhibitorer | |
| NO990123D0 (no) | Bicykliske heteroaromatiske forbindelser som protein-tyrosin-kinase-inhibitorer | |
| NO990124D0 (no) | Bicykliske heteroaromatiske forbindelser som protein-tyrosin-kinase-inhibitorer | |
| MXPA03007049A (es) | Inhibidores heterociclicos de erk2 y usos de los mismos. | |
| NO20021781D0 (no) | Heteroalkylamino-substituerte bicykliske nitrogenheterocykler som inhibitorer for P38-proteinkinase | |
| ATE318603T1 (de) | Pyrrolotriazin kinasehemmer | |
| NO20033635L (no) | Pyrimidinderivater for inhibering av celle-formering | |
| DK1220849T3 (da) | Sammensætninger med bicykliske forbindelser og fremgangsmåde til stabilisering heraf | |
| NO20001926L (no) | Iso-CBI- og iso-CI-analoger av CC-1065 og duocarmycinene | |
| ID24244A (id) | Susunan produk tisu lembab dalam tempatnya | |
| PL364230A1 (en) | Benzimidazole compounds for modulating ige and inhibiting cellular proliferation | |
| DE69939419D1 (de) | CDMA Empfänger und CDMA Sende/Empfänger | |
| NO980718D0 (no) | Bicykliske 4-aralkylaminopyrimidinderivater og tyrosinkinaseinhibitorer | |
| NO995267L (no) | Leptin som en inhibitor av tumorcelleproliferering | |
| EE04703B1 (et) | Migreeni kordumise ärahoimine | |
| EE03871B1 (et) | Tsüanoguanidiinid kui rakkude paljunemise inhibiitorid | |
| NO20021007D0 (no) | Substituerte 3-fenyl-5-alkoksy-1,3,4-oksdiazol-2-oner og deres anvendelse som lipasehemmere | |
| ID30023A (id) | Kombinasi senyawa aktif fungisida | |
| EP1467978A4 (en) | "COMPOUNDS THAT CONTAIN VACCINATES DRUG LIPASE, THEIR SYNTHESIS AND USE" |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |