NO980718D0 - Bicykliske 4-aralkylaminopyrimidinderivater og tyrosinkinaseinhibitorer - Google Patents

Bicykliske 4-aralkylaminopyrimidinderivater og tyrosinkinaseinhibitorer

Info

Publication number: NO980718D0
Authority: NO; Norway
Prior art keywords: bicyclic; tyrosine kinase; kinase inhibitors; aralkylaminopyrimidine; derivatives
Prior art date: 1996-06-21

Application number

NO980718A

Other languages

English (en)

Other versions

NO980718L (no

Inventor

Maria Gabriella Brasca

Dario Ballinari

Antonio Longo

Franco Buzzetti

Original Assignee

Pharmacia & Upjohn Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-06-21

Filing date

1998-02-20

Publication date

1998-02-20

1998-02-20 Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa

1998-02-20 Publication of NO980718D0 publication Critical patent/NO980718D0/no

1998-04-08 Publication of NO980718L publication Critical patent/NO980718L/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Oncology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Epidemiology (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Compositions Of Macromolecular Compounds (AREA)
Processes Of Treating Macromolecular Substances (AREA)

NO980718A 1996-06-21 1998-02-20 Bicykliske 4-aralkylaminopyrimidinderivater og tyrosinkinaseinhibitorer NO980718L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9613021.6A GB9613021D0 (en)	1996-06-21	1996-06-21	Bicyclic 4-aralkylaminopyrimidine derivatives as tyrosine kinase inhibitors
PCT/EP1997/002965 WO1997049689A1 (en)	1996-06-21	1997-06-03	Bicyclic 4-aralkylaminopyrimidine derivatives as tyrosine kinase inhibitors

Publications (2)

Publication Number	Publication Date
NO980718D0 true NO980718D0 (no)	1998-02-20
NO980718L NO980718L (no)	1998-04-08

Family

ID=10795666

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO980718A NO980718L (no)	1996-06-21	1998-02-20	Bicykliske 4-aralkylaminopyrimidinderivater og tyrosinkinaseinhibitorer

Country Status (20)

Country	Link
US (1)	US6057326A (no)
EP (1)	EP0853616B1 (no)
JP (1)	JPH11511761A (no)
KR (1)	KR19990043993A (no)
CN (1)	CN1198158A (no)
AR (1)	AR008614A1 (no)
AT (1)	ATE205836T1 (no)
AU (1)	AU3094197A (no)
BR (1)	BR9702328A (no)
CA (1)	CA2228492C (no)
DE (1)	DE69706823T2 (no)
EA (1)	EA199800215A1 (no)
ES (1)	ES2165061T3 (no)
GB (1)	GB9613021D0 (no)
HU (1)	HUP9902026A3 (no)
IL (1)	IL123124A0 (no)
NO (1)	NO980718L (no)
PL (1)	PL325122A1 (no)
WO (1)	WO1997049689A1 (no)
ZA (1)	ZA975380B (no)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6347480B1 (en) *	1997-07-07	2002-02-19	Southpac Trust International, Inc.	Method for wrapping a floral grouping with a sheet of material constructed of paper and having printed and embossed patterns thereon
PL194689B1 (pl)	1996-02-13	2007-06-29	Astrazeneca Uk Ltd	Pochodne chinazoliny, ich kompozycje farmaceutyczne oraz ich zastosowania
EP0885198B1 (en)	1996-03-05	2001-12-19	AstraZeneca AB	4-anilinoquinazoline derivatives
GB9718972D0 (en)	1996-09-25	1997-11-12	Zeneca Ltd	Chemical compounds
US6608060B1 (en)	1996-12-18	2003-08-19	Vertex Pharmaceuticals Incorporated	Inhibitors of p38
US6147080A (en) *	1996-12-18	2000-11-14	Vertex Pharmaceuticals Incorporated	Inhibitors of p38
US5945418A (en) *	1996-12-18	1999-08-31	Vertex Pharmaceuticals Incorporated	Inhibitors of p38
DE19653646A1 (de) *	1996-12-20	1998-06-25	Hoechst Ag	Substituierte Purinderivate, Verfahren zu deren Herstellung, sie enthaltende Mittel und deren Verwendung
TR200500745T2 (tr) *	1999-02-10	2005-05-23	Astrazeneca Ab	Damar gelişimi inhibitörleri olarak kuinazolin türevleri.
WO2001032632A2 (en) *	1999-11-01	2001-05-10	Eli Lilly And Company	Pharmaceutically active 4-substituted pyrimidine derivatives
JP3522727B2 (ja)	1999-11-05	2004-04-26	アストラゼネカアクチボラグ	Ｖｅｇｆ阻害剤としてのキナゾリン誘導体
DE60121931T2 (de)	2000-04-07	2007-03-01	Astrazeneca Ab	Chinazolinverbindungen
US20040235867A1 (en) *	2001-07-24	2004-11-25	Bilodeau Mark T.	Tyrosine kinase inhibitors
KR100468352B1 (ko) *	2002-09-24	2005-01-27	한국과학기술연구원	신규 피라졸로피리미딘계 유도체, 그의 제조방법 및 이를 유효성분으로 하는 약학적 조성물
MXPA06001758A (es) *	2003-08-15	2006-08-11	Irm Llc	Anilino purinas sustituidas en la posicion 6 utiles como inhibidores de rtk.
JP4934432B2 (ja) *	2004-02-19	2012-05-16	レクサンファーマシューティカルズインコーポレイテッド	キナゾリン誘導体およびキナゾリン誘導体の治療への使用
US7151176B2 (en) *	2004-10-21	2006-12-19	Bristol-Myers Squibb Company	Pyrrolotriazine compounds
EP1863792B1 (en) *	2005-03-28	2009-01-21	Brystol-Myers Squibb Company	Atp competitive kinase inhibitors
KR101703941B1 (ko) *	2008-11-10	2017-02-07	내셔날 헬스 리서치 인스티튜트	티로신 키나아제 억제제로서의 접합 이환 및 삼환 피리미딘 화합물
UA110113C2 (xx) *	2010-07-29	2015-11-25		Біциклічні азагетероциклічні карбоксаміди
JP5961187B2 (ja) *	2010-12-20	2016-08-02	インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅＨｏｌｄｉｎｇｓＣｏｒｐｏｒａｔｉｏｎ	Ｐｉ３ｋ阻害剤としてのｎ−（１−（置換フェニル）エチル）−９ｈ−プリン−６−アミン
US20220162215A1 (en) *	2019-04-03	2022-05-26	Mitokinin, Inc.	Compositions and methods of using the same for treatment of neurodegenerative and mitochondrial disease

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GT198900008A (es) *	1988-01-29	1990-07-17		Derivados de quinolina, quinazolina y cinolina.
ZA902280B (en) *	1989-03-29	1990-12-28	Merrell Dow Pharma	Selective adenosine receptor agents
JP2762430B2 (ja) *	1991-01-18	1998-06-04	宇部興産株式会社	アラルキルアミノピリミジン類の製法
US5710158A (en) *	1991-05-10	1998-01-20	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
JPH06172321A (ja) *	1992-10-08	1994-06-21	Agro Kanesho Co Ltd	置換アミノピリミジン誘導体、その製造法及びそれを有効成分とする有害生物駆除剤
GB9313638D0 (en) *	1993-07-01	1993-08-18	Erba Carlo Spa	Arylidene and heteroarylidene oxindole derivatives and process for their preparation
GB9326136D0 (en) *	1993-12-22	1994-02-23	Erba Carlo Spa	Biologically active 3-substituted oxindole derivatives useful as anti-angiogenic agents
IL112249A (en) *	1994-01-25	2001-11-25	Warner Lambert Co	Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
GB9406137D0 (en) *	1994-03-28	1994-05-18	Erba Carlo Spa	N-substituted beta-aryl- and betaheteroaryl-alpha-cyanoacrylamide derivatives and process for their preparation
GB9412719D0 (en) *	1994-06-24	1994-08-17	Erba Carlo Spa	Substituted azaindolylidene compounds and process for their preparation
GB9423997D0 (en) *	1994-11-28	1995-01-11	Erba Carlo Spa	Substituted 3-arylidene-7-azaoxindole compounds and process for their preparation

1996
- 1996-06-21 GB GBGB9613021.6A patent/GB9613021D0/en active Pending
1997
- 1997-06-03 WO PCT/EP1997/002965 patent/WO1997049689A1/en not_active Ceased
- 1997-06-03 ES ES97925987T patent/ES2165061T3/es not_active Expired - Lifetime
- 1997-06-03 BR BR9702328A patent/BR9702328A/pt not_active Application Discontinuation
- 1997-06-03 EP EP97925987A patent/EP0853616B1/en not_active Expired - Lifetime
- 1997-06-03 EA EA199800215A patent/EA199800215A1/ru unknown
- 1997-06-03 AU AU30941/97A patent/AU3094197A/en not_active Abandoned
- 1997-06-03 IL IL12312497A patent/IL123124A0/xx unknown
- 1997-06-03 AT AT97925987T patent/ATE205836T1/de not_active IP Right Cessation
- 1997-06-03 KR KR1019980701225A patent/KR19990043993A/ko not_active Withdrawn
- 1997-06-03 US US09/000,238 patent/US6057326A/en not_active Expired - Fee Related
- 1997-06-03 PL PL97325122A patent/PL325122A1/xx unknown
- 1997-06-03 DE DE69706823T patent/DE69706823T2/de not_active Expired - Fee Related
- 1997-06-03 HU HU9902026A patent/HUP9902026A3/hu unknown
- 1997-06-03 JP JP10502193A patent/JPH11511761A/ja not_active Ceased
- 1997-06-03 CA CA002228492A patent/CA2228492C/en not_active Expired - Fee Related
- 1997-06-03 CN CN97190942A patent/CN1198158A/zh active Pending
- 1997-06-18 ZA ZA9705380A patent/ZA975380B/xx unknown
- 1997-06-20 AR ARP970102715A patent/AR008614A1/es unknown
1998
- 1998-02-20 NO NO980718A patent/NO980718L/no unknown

Also Published As

Publication number	Publication date
WO1997049689A1 (en)	1997-12-31
EP0853616A1 (en)	1998-07-22
KR19990043993A (ko)	1999-06-25
EA199800215A1 (ru)	1998-08-27
HUP9902026A3 (en)	2000-07-28
DE69706823D1 (en)	2001-10-25
EP0853616B1 (en)	2001-09-19
JPH11511761A (ja)	1999-10-12
AU3094197A (en)	1998-01-14
HUP9902026A2 (hu)	2000-04-28
PL325122A1 (en)	1998-07-06
ZA975380B (en)	1998-01-05
ES2165061T3 (es)	2002-03-01
AR008614A1 (es)	2000-02-09
DE69706823T2 (de)	2002-04-11
ATE205836T1 (de)	2001-10-15
BR9702328A (pt)	1999-07-20
NO980718L (no)	1998-04-08
CA2228492C (en)	2007-05-08
GB9613021D0 (en)	1996-08-28
CA2228492A1 (en)	1997-12-31
MX9801408A (es)	1998-05-31
US6057326A (en)	2000-05-02
CN1198158A (zh)	1998-11-04
IL123124A0 (en)	1998-09-24

Publication	Publication Date	Title
NO980718D0 (no)	1998-02-20	Bicykliske 4-aralkylaminopyrimidinderivater og tyrosinkinaseinhibitorer
DK1000039T3 (da)	2004-08-16	Substituerede quinazolinderivater og anvendelse deraf som tyrosinkinaseinhibitorer
FI950859A7 (fi)	1995-02-24	Arylideeni- ja heteroarylideeni-oksindolijohdannaiset tyrosiinikinaasi-inhibiittoreina
EP0608897A3 (en)	1997-02-12	Tyrosine kinase inhibitors and benzoylacrylamide derivatives.
NO992336D0 (no)	1999-05-14	Raf-kinase-inhibitorer
DK0915880T3 (da)	2008-02-11	Azolotriaziner og pyrimidiner
NO20002121D0 (no)	2000-04-26	Benzotiazol-protein-tyrosin-kinaseinhibitorer
AU2396897A (en)	1997-11-12	5-aminopyrazoles useful as selective inhibitors of the protein tyrosine kinase p56ick
NO974453L (no)	1997-11-19	Proteinkinase C-hemmere
FI945706A7 (fi)	1995-06-08	Proteiinikinaasi C-inhibiittoreita
DE69600784D1 (de)	1998-11-19	Proteinkinase-C-Inhibitor
DE69716615D1 (de)	2002-11-28	Heterozyklische metalloproteaseinhibitoren
DE69435267D1 (de)	2010-03-18	Proteinkinase C Inhibitoren
DK0811006T3 (da)	2003-08-04	Benzopyranholdige forbindelser og fremgangsmåde til deres anvendelse
NO20001323D0 (no)	2000-03-14	Dipeptid-apoptose inhibitorer og deres anvendelse
DK1015444T3 (da)	2003-08-18	Pyrimidinderivater og fremgangsmåder til fremstilling deraf
DK0906301T3 (da)	2003-02-10	Benzofurylderivater og anvendelsen deraf
PT927183E (pt)	2004-12-31	Inibidores espirociclicos de metaloproteases
AU3885900A (en)	2000-10-09	Inhibitors of the egf-receptor tyrosine kinase and their use
FI955661L (fi)	1996-01-19	Substituoidut beta-aryyli- ja beta-heteroaryyli-alfa-syanoakryyliamidijohdannaiset tyrosiinikinaasi-inhibiittoreina
PT934280E (pt)	2003-08-29	Derivados 2-cianoiminoimidazolo inibidores da pde iv
NO986174D0 (no)	1998-12-29	Triazinderivater og anvendelse derav
DK0906268T3 (da)	2002-03-18	Alkoxyaminosubstituerede fluorenoner og deres anvendelse som proteinkinase C-inhibitorer
NO984921D0 (no)	1998-10-22	Tienopyridinderivater og deres anvendelse
AU2876000A (en)	2000-08-29	Tyrosine kinase inhibitors and methods of using the same