NI201300101A - Modulación de la expresión del transductor de señales y activador de la transcripción 3 (stat3) - Google Patents
Modulación de la expresión del transductor de señales y activador de la transcripción 3 (stat3)Info
- Publication number
- NI201300101A NI201300101A NI201300101A NI201300101A NI201300101A NI 201300101 A NI201300101 A NI 201300101A NI 201300101 A NI201300101 A NI 201300101A NI 201300101 A NI201300101 A NI 201300101A NI 201300101 A NI201300101 A NI 201300101A
- Authority
- NI
- Nicaragua
- Prior art keywords
- expression
- stat3
- modulation
- signal transducer
- transcription activator
- Prior art date
Links
- 101710140204 Signal transducer and transcription activator Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000004495 STAT3 Transcription Factor Human genes 0.000 abstract 1
- 108010017324 STAT3 Transcription Factor Proteins 0.000 abstract 1
- 230000000692 anti-sense effect Effects 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 108020004999 messenger RNA Proteins 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A61P35/00—Antineoplastic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- C12N2310/11—Antisense
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
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- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3521—Methyl
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- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3525—MOE, methoxyethoxy
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- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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Abstract
Se describen en la presente compuestos antisentido y métodos para disminuir la expresión de ARNm y proteínas STAT3. Dichos métodos, compuestos y composiciones son de utilidad para tratar, prevenir o aliviar enfermedades hiperproliferativas.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161471015P | 2011-04-01 | 2011-04-01 | |
| US201161471001P | 2011-04-01 | 2011-04-01 | |
| US201161471035P | 2011-04-01 | 2011-04-01 | |
| US201161471045P | 2011-04-01 | 2011-04-01 | |
| US201161558308P | 2011-11-10 | 2011-11-10 | |
| US201161558316P | 2011-11-10 | 2011-11-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NI201300101A true NI201300101A (es) | 2014-07-08 |
Family
ID=46932413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NI201300101A NI201300101A (es) | 2011-04-01 | 2013-09-30 | Modulación de la expresión del transductor de señales y activador de la transcripción 3 (stat3) |
Country Status (35)
| Country | Link |
|---|---|
| US (4) | US8816056B2 (es) |
| EP (2) | EP2697243B1 (es) |
| JP (1) | JP5943993B2 (es) |
| KR (2) | KR20190092590A (es) |
| CN (2) | CN103562215B (es) |
| AU (1) | AU2012236206C1 (es) |
| BR (1) | BR112013024768B1 (es) |
| CA (1) | CA2831915C (es) |
| CL (1) | CL2013002773A1 (es) |
| CO (1) | CO6821885A2 (es) |
| CY (1) | CY1121460T1 (es) |
| DK (1) | DK2697243T3 (es) |
| DO (1) | DOP2013000216A (es) |
| EA (2) | EA029317B1 (es) |
| EC (1) | ECSP13012909A (es) |
| ES (1) | ES2709495T3 (es) |
| GT (1) | GT201300232A (es) |
| HR (1) | HRP20182169T1 (es) |
| HU (1) | HUE042173T2 (es) |
| IL (2) | IL228569A (es) |
| LT (1) | LT2697243T (es) |
| ME (1) | ME03317B (es) |
| MX (1) | MX340086B (es) |
| MY (1) | MY163004A (es) |
| NI (1) | NI201300101A (es) |
| PE (2) | PE20142463A1 (es) |
| PH (1) | PH12013502049A1 (es) |
| PL (1) | PL2697243T3 (es) |
| PT (1) | PT2697243T (es) |
| RS (1) | RS58489B1 (es) |
| SG (1) | SG193504A1 (es) |
| SI (1) | SI2697243T1 (es) |
| SM (1) | SMT201900060T1 (es) |
| WO (1) | WO2012135736A2 (es) |
| ZA (1) | ZA201308153B (es) |
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| EP2697243B1 (en) | 2011-04-01 | 2018-10-31 | Ionis Pharmaceuticals, Inc. | Modulation of signal transducer and activator of transcription 3 (stat3) expression |
| JP6587934B2 (ja) | 2012-03-28 | 2019-10-09 | ソマロジック・インコーポレーテッド | Pdgfおよびvegf結合アプタマー、および、pdgfおよびvegfが介在する病気の治療へのそれらの使用 |
| WO2014062691A2 (en) * | 2012-10-15 | 2014-04-24 | Isis Pharmaceuticals, Inc. | Compositions for modulating c9orf72 expression |
| EP2906697A4 (en) | 2012-10-15 | 2016-06-22 | Ionis Pharmaceuticals Inc | METHOD FOR MONITORING THE C9ORF72 EXPRESSION |
| ME03363B (me) * | 2012-10-31 | 2019-10-20 | Ionis Pharmaceuticals Inc | Lečenje raka |
| US9127276B2 (en) | 2013-05-01 | 2015-09-08 | Isis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
| JP6487913B2 (ja) * | 2013-07-02 | 2019-03-20 | アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. | 成長ホルモン受容体のモジュレータ |
| US9695424B2 (en) | 2013-09-09 | 2017-07-04 | Somalogic, Inc. | PDGF and VEGF aptamers having improved stability and their use in treating PDGF and VEGF mediated diseases and disorders |
| EP3055414A4 (en) | 2013-10-11 | 2017-07-19 | Ionis Pharmaceuticals, Inc. | Compositions for modulating c9orf72 expression |
| PH12016502062B1 (en) | 2014-05-01 | 2023-01-27 | Ionis Pharmaceuticals Inc | Compositions and methods for modulating complement factor b expression |
| CN110903337A (zh) | 2014-05-01 | 2020-03-24 | Ionis制药公司 | 用于调节生长激素受体表达的组合物和方法 |
| CN106255755B (zh) | 2014-05-01 | 2020-07-24 | Ionis制药公司 | 用于调节血管生成素样蛋白3表达的组合物和方法 |
| WO2015179693A1 (en) | 2014-05-22 | 2015-11-26 | Isis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
| US10731163B2 (en) * | 2014-09-02 | 2020-08-04 | Max-Delbrück-Centrum Für Molekulare Medizin In Der Helmholtz-Gemeinschaft | Oligonucleotide targeted to the A20-3′ untranslated region |
| AU2015335029B2 (en) | 2014-10-24 | 2021-09-23 | Astrazeneca Ab | Combination |
| MY181815A (en) * | 2015-04-16 | 2021-01-08 | Ionis Pharmaceuticals Inc | Compositions for modulating c9orf72 expression |
| CA2991052A1 (en) | 2015-07-02 | 2017-01-05 | City Of Hope | Compounds and compositions including phosphorothioated oligodeoxynucleotide, and methods of use thereof |
| US20180312845A1 (en) | 2015-07-10 | 2018-11-01 | Ionis Pharmaceuticals, Inc. | Modulators of diacyglycerol acyltransferase 2 (dgat2) |
| US9744187B2 (en) | 2015-10-14 | 2017-08-29 | Bio-Path Holdings, Inc. | p-Ethoxy nucleic acids for liposomal formulation |
| US11260073B2 (en) | 2015-11-02 | 2022-03-01 | Ionis Pharmaceuticals, Inc. | Compounds and methods for modulating C90RF72 |
| CN113952353A (zh) | 2015-11-06 | 2022-01-21 | Ionis制药公司 | 调节载脂蛋白(a)表达 |
| WO2017078099A1 (ja) * | 2015-11-06 | 2017-05-11 | 東レ株式会社 | 癌の治療及び/又は予防用医薬組成物 |
| WO2017188898A1 (en) | 2016-04-29 | 2017-11-02 | Nanyang Technological University | G-quadruplex-containing antisense oligonucleotides |
| CN105985961B (zh) * | 2016-07-22 | 2019-01-29 | 广西师范大学 | 抑制EGFR基因表达的siRNA及其应用 |
| KR20190053905A (ko) | 2016-09-16 | 2019-05-20 | 바이오-패쓰 홀딩스 인크. | 리포솜 안티센스 올리고뉴클레오타이드와의 병용 요법 |
| KR20190065341A (ko) | 2016-10-06 | 2019-06-11 | 아이오니스 파마수티컬즈, 인코포레이티드 | 올리고머 화합물들의 접합 방법 |
| EP3548005A4 (en) | 2016-11-29 | 2020-06-17 | Puretech Health LLC | Exosomes for delivery of therapeutic agents |
| WO2018195249A1 (en) * | 2017-04-19 | 2018-10-25 | Bio-Path Holdings, Inc. | P-ethoxy nucleic acids for stat3 inhibition |
| JP7284709B2 (ja) | 2017-04-19 | 2023-05-31 | バイオ-パス ホールディングス, インコーポレイテッド | Bcl2阻害のためのp-エトキシ核酸 |
| GB2574793B (en) * | 2018-05-01 | 2022-09-28 | Flexenable Ltd | Organic liquid crystal display device with one or more oxygen permeable films |
| TWI869213B (zh) * | 2018-09-19 | 2025-01-01 | 美商Ionis製藥公司 | Pnpla3表現之調節劑 |
| EP4013875A1 (en) * | 2019-08-14 | 2022-06-22 | Codiak BioSciences, Inc. | Extracellular vesicles with stat3-antisense oligonucleotides |
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| EP4058152A4 (en) | 2019-11-14 | 2024-05-08 | The Board of Regents of the University of Oklahoma | PROSTATE CANCER TREATMENTS USING OLIGONUCLEOTIDES INTERFERENCE |
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