ME03363B - Lečenje raka - Google Patents
Lečenje rakaInfo
- Publication number
- ME03363B ME03363B MEP-2019-68A MEP201968A ME03363B ME 03363 B ME03363 B ME 03363B ME P201968 A MEP201968 A ME P201968A ME 03363 B ME03363 B ME 03363B
- Authority
- ME
- Montenegro
- Prior art keywords
- dna
- synthetic oligonucleotide
- sequence
- compound
- phase
- Prior art date
Links
- 238000011282 treatment Methods 0.000 title description 3
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 108091034117 Oligonucleotide Proteins 0.000 claims description 128
- 150000001875 compounds Chemical class 0.000 claims 17
- 230000000692 anti-sense effect Effects 0.000 claims 7
- 230000003442 weekly effect Effects 0.000 claims 6
- 239000002777 nucleoside Substances 0.000 claims 5
- 125000003835 nucleoside group Chemical group 0.000 claims 3
- 208000003950 B-cell lymphoma Diseases 0.000 claims 2
- 208000028564 B-cell non-Hodgkin lymphoma Diseases 0.000 claims 2
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 2
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 2
- LRSASMSXMSNRBT-UHFFFAOYSA-N 5-methylcytosine Chemical group CC1=CNC(=O)N=C1N LRSASMSXMSNRBT-UHFFFAOYSA-N 0.000 claims 1
- 101000826373 Homo sapiens Signal transducer and activator of transcription 3 Proteins 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 229940104302 cytosine Drugs 0.000 claims 1
- -1 ethyl nucleoside Chemical class 0.000 claims 1
- 102000051841 human STAT3 Human genes 0.000 claims 1
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 1
- 101100107522 Mus musculus Slc1a5 gene Proteins 0.000 description 10
- 101150071661 SLC25A20 gene Proteins 0.000 description 7
- 101150102633 cact gene Proteins 0.000 description 7
- 241000282326 Felis catus Species 0.000 description 5
- 241000341910 Vesta Species 0.000 description 3
- 101100209986 Rattus norvegicus Slc18a1 gene Proteins 0.000 description 2
- 239000011435 rock Substances 0.000 description 2
- ABEXEQSGABRUHS-UHFFFAOYSA-N 16-methylheptadecyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC(C)C ABEXEQSGABRUHS-UHFFFAOYSA-N 0.000 description 1
- 241001474033 Acar Species 0.000 description 1
- 101100380241 Caenorhabditis elegans arx-2 gene Proteins 0.000 description 1
- 208000001613 Gambling Diseases 0.000 description 1
- 101000666730 Homo sapiens T-complex protein 1 subunit alpha Proteins 0.000 description 1
- 101000595467 Homo sapiens T-complex protein 1 subunit gamma Proteins 0.000 description 1
- 241000764238 Isis Species 0.000 description 1
- 101100476480 Mus musculus S100a8 gene Proteins 0.000 description 1
- 101150050559 SOAT1 gene Proteins 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 102100038410 T-complex protein 1 subunit alpha Human genes 0.000 description 1
- 102100036049 T-complex protein 1 subunit gamma Human genes 0.000 description 1
- 101150088517 TCTA gene Proteins 0.000 description 1
- 101150092805 actc1 gene Proteins 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 101150110946 gatC gene Proteins 0.000 description 1
- 238000005417 image-selected in vivo spectroscopy Methods 0.000 description 1
- 238000012739 integrated shape imaging system Methods 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4718—Cytokine-induced proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3233—Morpholino-type ring
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/35—Special therapeutic applications based on a specific dosage / administration regimen
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Description
Ionis Pharmaceuticals, lnc. <br>2855 Gazelle Court <br>Carlsbad, ?? 9201 ? <br>SAD <br>LECENJE R??? <br>POPIS SEKVENCI <br>[0297] <br>< 11 ?> ISIS Phannaceuticals Inc. <br><120> LECENJE R??? <br><130> BIOL0216US.L2 <br><160> 129 <br><170> FastSEQ za Windows (verzija 4.0) <br><2 10> 1 <br><211> 4978 <br><212> DNA <br><213> ???? sapiens <br><400> 1 <br>1 gqtttccgga gctgcggcgg cgcagactgg gagggggagc cgggggttcc gacgtcgcag 60 <br>ccgagggaac aagccccaac cggatcctgg acaggcaccc cggcttggcg ctgtctctcc 120 <br>ccctcggctc ggagaggccc ttcggcctga gggagcctcg ccgcccgtcc ccggcacacg 180 <br>cgcagccccg gcctctcggc ctctgccgga gaaacaqttg ggacccctga ttttagcagg 240 <br>atggcccaat ggaatcagct acagcagctt gacacacgqt acctggagca gctccatcag 300 <br>ctctacaqtg acagcttccc aat ggagctg cggcaqtttc tggccccttg gattgagaqt 360 <br>caagattggg catatgcggc cagcaaagaa tcacatgcca ctttgqtgtt tcataatctc 420 <br>ctgggagaga ttgaccagca gtataqccgc ttcctgcaag aqtcqaatgt tctctatcaq 480 <br>cacaatctac gaaqaatcaa gcaqtttctt cagaqcaqqt atcttqaqaa qccaatgqag 540 <br>attgcccgga ttqtggcccg gtgcctgtgg gaagaatcac gccttctaca gactgcagcc 600 <br>actgcggccc agcaagqggg ccagqccaac caccccacag cagccqtggt qacggagaag 660 <br>cagcaqatgc tggagcagca cct tcaggat qtccqgaaqa gaqtqcaqga tctagaacag 720 <br>aaaatgaaaq tgqtaqaqaa tct ccagqat qactttgatt tcaactataa aaccctcaaq 780 <br>aqtcaagqaq acatgcaaqa tct qaatqqa aacaaccaqt caqtqaccag qcaqaagatg 840 <br>caqcaqctgg aacaqatqct cactgcqctg qaccagatqc ggaqaagcat cqtqaqtgag 900 <br>ctggcggggc ttttgtcagc gatggagtac qtgcagaaaa ctctcacgga cgaggagctg 960 <br>gctgactqga agaggcqgca acagattgcc tgcattggag gcccgcccaa catctgccta 1020 <br>gatcgqctag aaaactggat aacqtcatta gcagaatctc aacttcagac ccqtcaacaa 1080 <br>attaaqaaac tqqaqqaqtt qcaqcaaaaa qtttcctaca aaqqqqaccc cattqtacaq 1140 <br>caccqqccqa tqctqqaqqa qaqaatcqtq qaqctqttta qaaacttaat qaaaaqtqcc 1200 <br>tttqtqqtqq aqcqqcaqcc ctqcatqccc atqcatcctq accqqcccct cqtcatcaaq 1260 <br>accqqcqtcc aqttcactac taaaqtcaqq ttqctqqtca aattccctqa qttqaattat 1320 <br>caqcttaaaa ttaaaqtqtq cattqacaaa qactctqqqq acqttqcaqc tctcaqaqqa 1380 <br>tcccggaaat ttaacattct gqgcacaaac acaaaaqtqa tgaacatqga agaatccaac 1440 <br>aacggcagcc tctctgcaqa attcaaacac ttgaccctga gggagcagag atqtgggaat 1500 <br>gggggccgag ccaattqtga tgcttccctg attqtgactg aggagctgca cctgatcacc 1560 <br>tttqaqaccq aqqtqtatca ccaaqqcctc aaqattqacc taqaqaccca ctccttqcca 1620 <br>qttqtqqtqa tctccaacat ctqtcaqatq ccaaatqcct qqqcqtccat cctqtqqtac 1680 <br>aacatgctga ccaacaatcc caagaatqta aactttttta ccaagccccc aattggaacc 1740 <br>tqggatcaag tqqccqagqt cctgagctqg caqttctcct ?????????? gcgaqgactg 1800 <br>agcatcgagc agctgactac actggcagaq aaactcttgg gacctgqtqt gaattattca 1860 <br>ggqtqtcaga tcacatgqqc taaattttqc aaagaaaaca tggctggcaa gggcttctcc 1920 <br>ttctggqtct gqctggacaa tat cattgac cttqtgaaaa aqtacatcct ggccctttqg 1980 <br>aacgaaggqt acatcatggg ctttatcaqt aaggagcgqg agcgqgccat ct tqagcact 2040 <br>aagcctccag gcaccttcct gctaaqattc aqtgaaaqca gcaaagaagg aggcqtcact 2100 <br>ttcacttggg tqgagaaqqa catcagcgqt aagacccaqa tccaqtccqt ggaaccatac 2160 <br>acaaaqcagc aqctgaacaa catqtcattt qctqaaatca tcatqggcta taaqatcatg 2220 <br>gatgctacca atatcctgqt qtctccactg qtctatctct atcctgacat tcccaaggag 2280 <br>gaggcattcq gaaaqtattg tcggccaqag agccaggaqc atcctgaagc tgacccaggt 2340 <br>aqcgctgccc catacctgaa gaccaagttt atctqtqtqa caccaacqac ctgcagcaat 2400 <br>accattgacc tgccgatqtc cccccgcact ttaqattcat tgatgcagtt tqgaaataat 2460 <br>ggtgaagqtg ctgaaccctc aqcaggaggg caqtttgaqt ccctcacctt tgacatggag 2520 <br>ttgacctcgg aqtgcgctac ctcccccatg tgaggaqctg agaacggaag ctgcaqaaag 2580 <br>atacqactga ggcqcctacc tgcattctgc cacccctcac acagccaaac cccagatcat 2640 <br>2 ctgaaactac taactttqtq qttccagatt ttttttaatc tcctacttct gctatctttq 2700 <br>aqcaatctqg gcacttttaa aaatagaqaa atgaqtgaat qtgqqtqatc tqcttttatc 2760 <br>taaatqcaaa taaqqatqtq ttctctgaqa cccatgatca qqqqatqtqq cqqqqqqtqq 2820 <br>ctaqaqgqaq aaaaaqgaaa tgtcttqtqt tqttttgttc ccctqccctc ctttctcaqc 2880 <br>agctttttqt tattqttgtt qttqttctta gacaaqtgcc tcctgqtgcc tgcggcatcc 2940 <br>ttctgcctqt ttctqtaaqc aaatgccaca qqccacctat aqctacatac tcctqgcatt 3000 <br>gcacttttta accttqctqa catccaaata gaagatagga ctatctaagc cctagqtttc 3060 <br>tttttaaatt aaqaaataat aacaattaaa qqqcaaaaaa cactqtatca qcataqcctt 3120 <br>tctqtattta agaaacttaa qcagccqqqc atgqtggctc acgcctgtaa tcccagcact 3180 <br>ttgggaqgcc gaggcggatc ataaqqtcag qagatcaaga ccatcctggc taacacgqtg 3240 <br>aaaccccqtc tctactaaaa qtacaaaaaa ttaqctqqqt qtqqtqqtqq gcqcctqtag 3300 <br>tcccaqctac tcqgqagqct qaggcaqqag aatcqcttqa acctgagagq cgqagqttgc 3360 <br>aqtqaqccaa aattqcacca ctqcacactq cactccatcc tqqqcqacaq tctqaqactc 3420 <br>tqtctcaaaa ?????????? aaaaaagaaa cttcaqttaa cagcctcctt gqtqctttaa 3480 <br>gcattcagct tccttcaqqc tqqtaattta tataatccct gaaacqgqct tcaqqtcaaa 3540 <br>cccttaagac atctgaaqct gcaacctqgc ctttgqtgtt gaaataqqaa gqtttaagga 3600 <br>gaatctaaqc attttagact tttttttata aatagactta ttttcctttg taatqtattg 3660 <br>gccttttaqt gagtaaggct gggcagaggg tgcttacaac cttgactccc tttctccctg 3720 <br>gacttqatct gctqtttcag aggctagqtt qtttctqtqg qtqccttatc agqgctggqa 3780 <br>tacttctgat tctggcttcc ttcctgcccc accctcccqa ccccaqtccc cctqatcctg 3840 <br>ctagaggcat qtctccttqc gtgtctaaag qtccctcatc ctgtttgttt taggaatcct 3900 <br>ggtctcagga cctcatggaa gaagagqqqg aqagaqttac agqttggaca tgatqcacac 3960 <br>tatggggccc cagcgacgtg tctqgttgag ctcagggaat atggttctta gccagtttct 4020 <br>tgqtgatatc caqtggcact tgtaatggcg tcttcattca qttcatgcag ggcaaaggct 4080 <br>tactgataaa cttgaqtctg ccctcqtatg aggqtqtata cctggcctcc ctctgaggct 4140 <br>gqtgactcct ccctgctggg gccccacagg tgaggcagaa cagctagagg gcctccccgc 4200 <br>ctgcccgcct tggctggcta gctcgcctct cctgtgcgta tgggaacacc tagcacqtgc 4260 <br>tggatgggct gcctctgact cagaggcatg gccggatttg gcaactcaaa accaccttgc 4320 <br>ctcagctgat caqagtttct gtggaattct gtttgttaaa tcaaattagc tggtctctga 4380 <br>attaaggggg agacgacctt ctctaagatg aacagggttc gccccaqtcc tcctgcctgg 4440 <br>agacagttga tqtqtcatqc agagctctta cttctccaqc aacactcttc aqtacataat 4500 <br>aagcttaact gataaacaga atatttagaa agqtqagact tgggcttacc attgqqttta 4560 <br>aatcataggg acctaggqcg aqgqttcaqg qcttctctqg agcaqatatt qtcaaqttca 4620 <br>tqgccttagg tagcatqtat ctgqtcttaa ctctgattgt agcaaaaqtt ctqagaggaq 4680 <br>ctgagccctg ttqtgqccca ttaaagaaca qgqtcctcag gccctgcccg cttcctqtcc 4740 <br>actgccccct ccccatcccc aqcccagccq aggqaatccc qtqqqttqct tacctaccta 4800 <br>taagqtggtt tataaqctqc tgtcctggcc actgcattca aattccaatg tgtacttcat 4860 <br>aqtqtaaaaa tttatattat tgtqaqqttt tttgtctttt tttttttttt ttttttttgg 4920 <br>tatattgctg tatctacttt aacttccaga aataaacqtt atataggaac cgtaaaaa 4978 <br><210> 2 <br><211 > 79001 <br><212> DNA <br><213> Homo sapiens <br><400> 2 <br>ataaaaatta aaaaccctga taqtatcaqc acatacacag aaatcactcc attatgcaaa 60 <br>qttcatcctc tattatqaaa qqcaaaatqt ctacatttcc tatcaaccac tqqcttcaat 120 <br>tcaqtaaaac ttqcatacca agtaqgcaag qtqgaaaaqa aaaaqgcaga acatttcatg 180 <br>tatttcaatt cagacgcata aaaatgtcaa qccctacacg ttatcagctt tcqtatacac 240 <br>cqtcttctgc attcgcctqt acgggccaat gggctagctq qtcgqcqttt gatqcttgaa 300 <br>gtgatggaac gqaqtacggg gttaaatcca ctaccctctc cccacgcact ctagtaatta 360 <br>ctctatttcc acqtcatgtt tccggqtgtg tqtqtccctq ctcacqcaga aactqaaqtt 420 <br>caaaqcaggc ggaqtcaccc atqttctttt tqttqtcccc agaacccaat tcagqaqttq 480 <br>gqtccccaga gqatctggaq atacctgqqg actatctaac tagctgattc ccgcqtgqta 540 <br>aqaqqctctc aacctcqcca ccacqtqqtq ccaaqqqccq qqaaaaqqqa qaqcqqqcaq 600 <br>qaqqqaqctq tatcaqqqqc atttaaaqtq ccttqacqtc acqcactqcc aqqaactcaq 660 <br>ctgaqttttc aqcagqacat tccgqtcatc ttccctccct ccccccgqgc ttctqtgccc 720 <br>aaqtcctcgq ctcttccctc gctqtggcgg aqqqaqqaqc accqaactgt cggaacagcc 780 <br>aqcacagggq cqtatcaqtc tcctcttggc tccqcccttt ctcctagctg ctctcctcat 840 <br>tqqtcaqtgg gcgqgqcttc ggctqtaccg cacacgcact gggacctctg gqtgqccgaa 900 <br>cgagctggcc tttcatgaat tatgcatqac ggcgtgcctc qgccaggctg qqqctqqqcq 960 <br>aggattggct gaaggqgctg taattcaqcg qtttccggag ctgcggcggc gcagactggg 1020 <br>? a.qqqqqa.qcc qgggqttccg acgtcgcagc cqagqgaaca agccccaacc qgatcctgga 1080 <br>caggcacccc ggcttggcgc tgtctctccc cctcggctcg gagaggccct tcggcctgag 1140 <br>ggagcctcgc cgcccgtccc cggcacacgc gcagccccgg cctctcggcc tctgccggag 1200 <br>aaacaggtga aggggqtgca ggqtggggcc qttggggagg cctggggacc cgggggctcc 1260 <br>gcagcgqcag qqqqcctctq ggaccttggq gatqttqtga tggacgctgc aqtggqgccg 1320 <br>gqagagatga agagacgcgg agggtcgccc tgagggaaga ctcttcggga tgacaggagc 1380 <br>gggcctcgga agggactcgg ggcgctggag qgaaqtttcg ttcttcggag aaacagaacg 1440 <br>cgctcgaggg ggcaccgtgg ggcgagggcg cactcggttg cggcggcagg agtgagggac 1500 <br>aqtcccccga tttcctgctc cctggggccc tggggacqtt ccggccaccg gagcgactqt 1560 <br>cacgccqacq qqqatcaccg qcqcqaqtqq qqqqtcqqaa agcqcctcct ccccqcccqq 1620 <br>tcggcggctc ccgctgagcc actt cctccg cttgccctgt tcccgctcct tcaggagaca 1680 <br>qctqtqccct tttggaqqca qgaataqqtq tqtctqtcqc ctgcaqcctt acqqqctqqc 1740 <br>tqqtcqtqqq taqgctttat tgcataagaa tcaaqtttcc tgtagggaaa ttqacaqacc 1800 <br>gqtactcttt ctaaattccc tcgcatcttt ttctaggtta aattatgctc cccccacgtc 1860 <br>cccgccttgt aaaaaagaga aaaaaagaca aaataaaatc cccatcaacc cgtcaagcca 1920 <br>gctctagaga gagaaataaa cctcttgaca ttgtcctttt ccaaatacct ggtaaagtcg 1980 <br>gccagaagat aaataattga gccattgcat ttactggatt gtggtgttgc ttaattgcat 2040 <br>aggacggaat gaaccaattg agagtgggag ttttctgtct cagagccaag atcttgggta 2100 <br>aatgcagaqg agagggaaac aaagacaggc tggccttgaa aaaaccatgt gtgcaaactt 2160 <br>tacatqcatt tqqqqqqtqt gqtt gcactg aaqttaacaa gattcaaacc qtcgcccaag 2220 <br>ttgqtatttc catqtttggt acacatcact ctgtgccata tcagqtcgtt gttaagtgtg 22 ? ? <br>gtgacaaaat caqtgqttag tcat tttttt aattaaaaat qtqtataqtg tgtacctgct 2340 <br>gqtcttactg tatgtgcaac taaaggttta catagtctgt qtatgggttg taaatttttg 240Q <br>gctqqctqtg ctgataaagc attgggcttg aataaagcaa agcagaaaat catctcaatc 2460 <br>ttttatatqt ggatttaqac tqtqttatqa cttqqttcag ccaqttttct atcttatttt 2520 <br>atattaaata tqtctqtqtt ctct gaqtca gcacatttat ttccttatta catgttccag 2580 <br>acaggagtgc tagcccaqtt tttqttcaqt ttgcacaqtg ggatggggaa acaaqtctgg 2640 <br>aatttaaaaa aaaatqtttt agaggttgga gccttgattt tagtctctat attagcacat 2700 <br>ccatcacaaa gaaccattag taaattcatg aatcttttgt tttttatqta gttcatttga 2760 <br>gaagaataat cacttaqaaa tatccacaqt gccagqcatg gtqqtqcaca cctctqatcc 2820 <br>cagctaattg aaggctgagg tgggaggatt ccttgagtcc aggagttgag tctggtctgg 2880 <br>gcaacatqgt qagaqgccaq gaat tggqtc taqa.qtctag tctaaqcacc ataatgagaa 2940 <br>cccatcttta agaaagaaag aaaqgaaagg aggaagaaag gaaaqaaaaa qaaataccca 3000 <br>cagcacaqtt atgaattaac ccacaaagga cttgtgaqqt ggqtagttca cataacaatt 3060 <br>accctaatat cqtaqataaq aaaattqagg ccaaagqatc aaqacacttq qccaacqcaq 3120 <br>cagaqtgcca taqtgqtgga attt qtgcct ccttctqtat attttqtgaa aagtatcaqt 3180 <br>gaaattcttt tttttttttt tttt gaqtca gagtcttgct ctgttgccca ggctagaqtg 3240 <br>cagtggcgca atcttggctc actgcaacct ctgcctcctg gqttcaagcg attctcctgc 3300 <br>ctcagcctcc caaqtagctg ggactacagg cgtgcgccac cacqcccagc taatttttqt 3360 <br>a.tttttagta qa.qa.ccqqqq tttt accata ttggccaggc tggtcttga.a ctcctgacct 3420 <br>tqtgatttgc ccacctctat ctcccaaaqt gctgggatta caggtgtgag ccaccgcgcc 3480 <br>caqtaaqtat cagtgaaatt ctaacatata tctqaacaqt aaaataccac caataqgctq 3540 <br>aaaqacttca tggqaggtaa atat tcaata aacaqqtqaa aaaaqaaata caaatqgagc 3600 <br>ttgcttagat tatttttcta attgctatgt ctaacttggg aaqtgaggaa ctgtttttgg 3660 <br>tcagcataat ttaccatcaq aatt taqcta tttactaatg aaaaqaaata ctaatctaqq 3720 <br>tttqttttag attaaggaca qtcatgacct aaatqtcatt taaaccagag tgcattqtgg 3780 <br>cttgatcagt gqtcatttct gtct ctagaa aqttgcttta acttctctgc ctctacqtqt 3840 <br>ctcttgacat tcagatatga ggtgggqtag agqtgqtgac caactttcca gacgcctgag 3900 <br>tccaaacctt cttagcttat ggtt ttctta ggtgatqtgc aaatcaacaa atatatactt 3960 <br>tttttttttt ttttttqaqt tqqaqttgca ctctatcacc caqqctqgaq tqcaqtgqca 4020 <br>tgatcqtggc tcactgcaac ctcctcctcc cgggttcaag tgattctcgc acctcagcct 4080 <br>cctgaqtagc tgggattaca gqtgcccgcc actacgcccg gctaattttt gtatttttag 4140 <br>taqagata.ag qtttca.ctat a.ttqaccagg ctgqtctcaa actcctgacc tcaagagatc 4200 <br>tgcccacctc agcctcccaa agtqctggga ttacaggcqt gaaccacctt gcctggccaa 4260 <br>catatatata ccttttgcaa cttt qtcaga qttgctatga agaataaqtt gtatcttqtt 4320 <br>cacagaaatt gcaqtctact gggggagctg ataaatqttt taaccatcca atqtaacatg 4380 <br>ttqtcatcaa aqaqatqgtq aqactttaca cttgtqct;,.a caagqtaqct qttctacata 4440 <br>aaaqaacata caqtacagat qtagaacttt tctgttatca tagaacqttc tattggacaq 4500 <br>tqctaqqctq aatqctacaq atct tcaqaq aaaqqaqaqq ttatgagqcc tgqaqttqtc 4560 <br>tagaaaqtct ttttgccaaa qagggatttc a.actggqtcc caaataatgg gtggaatttg 4620 <br>atagqtgtaa agaatttqcg qtggtttatg cctqtaatcc cagcactttg gqaggctgag 4680 <br>gcaggaggat tgcttgagcc caggagtttg agaccagctt gggcaacgtg gtaaaactcc 4740 <br>ctctccccta aaaataaaaa aaat tagcca qqcctqqtqq cgtggacctg taqtcccagc 4800 <br>4 tactgqtgag actaagqtgg ga.ggatcacc caagccccgg ggqttaaggc tgcagtgagc 4860 <br>cqtgatcccg ccaccgcact ccagcctggg tgacagaqtg agaccctqtc tccaaaaaaa 4920 <br>aaaaaaattc ctggtagccc Qgtagactag gaggqtaaqt aggggagaag tgattactta 4980 <br>caaaagacat tgaatacagg accaaggaat ttcaqttctg ttcttttqta ggggaagctt 5040 <br>ttaaaacttt CQggQcgccq Q\1CQCQQtgg ctcacqcctQ taatcccaqc actttgqqag 5100 <br>gcccagacgc gcggatcacg aggccaggag atcgagacca tcctggctaa cacggtgaaa 5160 <br>ccccatctct actaaaaata caaaaaaaag tagccgggcg ttqtggcqgg cqtctqtaqt 5220 <br>cccagctact cgggaggctg aggcaggaga agagcqtgaa ctcgggaggc ggagcttgca 5280 <br>qtgagccgat atcgcaccac tgcactccag cctgggcgac agagcgagac tccgtctcaa 5340 <br>?????????? aataaataaa t&aataaat& aataaaactt tqqa\;Jccgaa gcactg&tqt 5400 <br>ttaatcatag aqtgcttact atqtgttagg cacaggcctg attgcctgat gctggttaat 5460 <br>ttQt.acaaag taaatcaQt.g catatqccct ctqccctagg ggaqttatta actggaQt.ct 5520 <br>qacatt<;Jtac aaaqqtag<;Jt atcctqacta Qt.ttqatttQ Qt.actttqgg tQaaaaaaQt. 5580 <br>atagtgtgct taaqtgcaga aqtgtttttt gaggattttt gattggatac ?????????? 5640 <br>tcatatttta tgtctttggc &ctt aaaaat ttcaccataa cttttgagtc atttataaaa 5700 <br>accactgaaa gaqtacttga gggacatccc cgaatcctga agaacttctg gtqttctgga 5760 <br>gcagcctcag tgagatccag gaggatggca ttgctgggct ggcccagccc ttattgatta 5820 <br>tgqtgtaaag aattaatatg gtggttatat actctttqtt agacaccttg gcttacaaga 5880 <br>cqtaagcgta aagtgtagtg cgct ttagtc agtatggcca catggtcctt tggtggtaaa 5940 <br>ttqtttgaqa tqcctccaqt tttt aaaaqq aQt.aqcatat cgqqccaqqa qcaqtqqctc 6000 <br>atgcctataa tcccagcact ttggaaggcc gaggcaagag gattgcttga gcccaggaqt 6060 <br>tcaagaccag cctgggcaac atagtgagac cactttqttt ctttaaaaaa aaaaaaaagg 6120 <br>caaaaacagg ctgggcatgg tggctgatgc ctgtaatccc agcgctttqt gaggcagagg 6180 <br>tgagcggatc acttgagqtc aggagtttga gaccagcctg gccaacatgg taaaaccccg 6240 <br>tctctactaa aaatacaaaa attaQccagQ tQtQQtQqca CII.CQCCtQta Qttccaqcta 6300 <br>ctctggaggc tgagccagga gaat tgcttg aacctgggag gtggagqctg cagtgagcca 6360 <br>aqatcctqcc actqcactcc aqactgqqqg acagaqtqaq acattctqac aQtgctacac 6420 <br>tgaatgctac atgtcttcag aggaaggaga ggttatgagg cctgggaata acatatggaa 6480 <br>gaatgaattt ctqttatgqt caqttctcat ttqtcatqtt aggattactg caactcttac 6540 <br>ccaqccqq<;Jt QtgQtqgctc atqcctqtaa ttccaqcact ttqQQagqct Qtqggcgqat 6600 <br>cacgaggtca ggagatcgag accatcctgg ctaacacgqt gaaactccgc ctctactaaa 6660 <br>aatacaaaaa attagcccag cgtggtggca gacgcctqta qtcccagcta ctcaggaggc 6720 <br>tgaggcagga gaatggcatg agtcctggag gcggagcttg caqtgagctg agatcgtgcc 6780 <br>actgcactcc agcctgggca acagagtggg actccatctc ?????????? gaaaaaaaaa 6840 <br>aqQattaccg caactcttta attcagatca gcaaacat<;Jt tqagagccaq qtattgcqtc ? ?? <br>aggcaggatc caagqataat gaaatattgt ccgttttcat gaaactggag atqttgcagg 6960 <br>gaccgaggtg tgtgctatgc cagt atggaa gtaggacagg ggagacgaca gggcagtgag 7020 <br>tggttcaaga ctctqgctct gaaqtcaaac agatctgqga ctgaatcctg gatctgccac 7080 <br>ttcctaqtca gaatctgagc ctct attttc ttatctgtaa aagaagatta taacagtgct 7140 <br>tatcttqtag gtactqttga cgat tcaata agataatgtg gataaaatgc ttagcataqt 7200 <br>gcctggcaca taqtaagagc tcggtaaatc taagttctta ctaaatatcc aagaaaagag 7260 <br>attaattctt ttcaggaqtg agagaaaQtc atcattattQ aqQqQcttta tcagatQQga 7320 <br>acacctgaat aqgqttttat aggatgaata qgaattcttt ccacgaaqtt gcqttacaaa 7380 <br>aagttgcatt caagqctgaa ggaacatgag ggtgcagagg cttaaaacag ccttgtgtqt 7440 <br>tcaqQqaqct ataaqtaqaa qttcttaatt taQQaqaact aaaccaaQqQ qaaaQQaQqc 7500 <br>caaggaacca cagttcttat ccct tttctg ttaataattg ggtttaaatg tcattaaaat 7560 <br>aagttatttt gtccttttta gaaaagtaat aacatgctat tataaaaaaa aagacttgta 7620 <br>ggaatataaa atqtgtgttt tacatqtatc ctgttaattg acttgctttt attcagattt 7680 <br>tttgcagccc tttctgttta ccaggttatc ttggagacat atttattcca aattcctttt 7740 <br>tttttttttt tttgagatqq agtctcgctc tgtcgcccaQ qctggaqtqc aqtr;~r;~cr;~cta 7800 <br>tcttggctca ttgcaaqctc cgcctcccgg qttcacgcca ctctcctgcc tcagcctccc 7860 <br>gagtaqctqg gactacaggc gcccqccacc acqcccaqct aatgtttttt tttttatatt 7920 <br>tttagtagcg acagqgtttc accgtgttaq ccaggatqqt ctcaatctcc tcacattqtq 7980 <br>~tccgcctqc ctcggcctcc caaagtqctg qg~ttacagg cgtqaqccag cacgcctggc 8040 <br>cttccaaatt ccttttaaca gcct aqcaaa agaataataa gqaaggtaaa tctgccccta 8100 <br>caagaaaata atgcttcgac gatccqgctt tccttcctgc tacccccagc cataagaata 8160 <br>aatqaccttq ctcatcactq aaat ttt&cc tqacctttqa atttttaact gcqtcaqcca 8220 <br>aagaacttat attttgagta ttcctaaqgt gattgctatt gtagttttga aacacttggt 8280 <br>tqgtatQt.tt gaqqqtttca tqQtccaaaq ttactataqc aqttaaaaqa Qtgqactatc 8340 <br>aggtcagacc tattgggctt taat cccagt tctgccttct cttagacctt gggcctqttg 8400 <br>ttttcacttc tctqgttttc agtt tctctg tccacaattg tgqaaacgag gtccacttqt 8460 <br>agagtaattg agaggatqaa gcaagatgat gcatatcaag tactttgcat agtgccqgqc 8520 <br>aqacagqtaa cattcaagtg ctaataatta ctattattac tatttatttt ttqaqacagg 8580 <br>5 ttctcactct gtcacctagg ctggagtgca gcggtgagat cacagctcat gacagccttg 8640 <br>acctcctagg ctcaagtgat cctcctgcct cagccttcgg ggtagctggg gctacaggtg 8700 <br>tqtgctacca ccctcaqcta attt tctaat ttttttgaqt caqgatctcg tcacgttgcc 8760 <br>taggctgaat tactcttatt aaaaactata atatcaggcc qa.qtqcqqtq gctcacgcct 8820 <br>qtaatcccaq cactttgqqa qqccaaqqcq qqtqqatcac ctqaqqtcaq qaqttcaaqa 8880 <br>ccagcctgcc caacagaqtg agaccccccc cqtctctact aaaaatataa aaattagcca 8940 <br>gttgtggtgg tgggcacctg taat cccagc tactcgggag gctgaggcag gataatcgct 9000 <br>tgaacccggg aggcggaggt tgcggtgaac cgagatcgtg ccactgcact acagcctggg 9060 <br>tgacagagtg agactctgtc tcaaaaaaac cgaaaaacaa aaagcataat tagggtggta 9120 <br>acqcttil.til.c ataqqqqc11.q qtqq11.ataaa acat11.attaq q11.qqtcqqqc atqqtqqctc 9180 <br>acgcctgtaa ttccagcact ttgggaggcc gaqqcgqqtc aggagttcaa qaccagcctg 9240 <br>cccaacataq tqaqaccccq tctctactaa aaatataaaa tttaqcctqt tqtqqtqqcq 9300 <br>qqtqcctqta qtcccaqcta cccqqqaqqc tqaqqcaqqa qaattqcttt tqaacccaqq 9360 <br>aqgtqqqqgt tqcaqtqagc tgaqatcgcq ccgctqcact cca.qcctqqg agacagagca 9420 <br>agactccgtc ?????????? ?????????? actqtcatat caaaaactaa actaaaatgg 9480 <br>taatatctgt tagatattac aaagtcaggc aaattatgat tcatggcagc cactaatgac 9540 <br>ccaaaggaga gaaagaataa ttagcagatt ctaacctaat gggaaa11.aaa ctaaatg11.at 9600 <br>agggatgggg gacttacatt ctgttagagg aaattgaggc tqtcatataa aaggaatagg 9660 <br>taaggcaaac tqtaaattcc tgtt tacaca aatgcccttc tgataaatct ctgcattgcc 9720 <br>cacaqtccat oattacctct ccct tatttt aaqtaatatt taacacatta aaaatqqatt 9780 <br>accacccaag gaattgctcc cgacccagaa aqtgcagqta qtqttqa.aqq tttgagggga 9840 <br>agaggaatga ttagagttgg ttgtgtctca ggaagaagcc aacaggagga accttatttt 9900 <br>gagtcaggta aagaaggtgg gagtgaggag gcatcccqgt ggccaggtat gaagctggga 9960 <br>gctgattgct gcacattact cagctgaatt aaatqtgccc tcacatctgt gtgtqtgcgt 10020 <br>acatqcaaat qtacatqtqt atqaqttaqt tqqaqqqqta qaccttt11.tt ttcctqtcct 10080 <br>gtail.ctttcc tttgc11.aact aatctgtatt cagaacagtg ttgcagttaa gaaccaccca 10140 <br>qcttqtccat qaaacaqqtt ctct cacccc atctccccaq ttttaqaqaa qqcaqqaaaq 10200 <br>aaaaggcagt gcttttcttt tttcctggcc gtatgcgggg ca.qqaa.qa.a.q cca.qca.qa.qc 10260 <br>ttgaaagaga aaqtaaacct tctgggaaat aaacggcttg gcttccctat tgtggaggag 10320 <br>gaqtqcaaat tattaqgqqq atqtttgqqt aqtttttqta qaaqccattt ctqaaaactq 10380 <br>atttggatta gtgaaggtaa gcccaattta ggaaaaccct gcccagtctg gtgtcagcca 10440 <br>cctgtttccc gctttgtttg attga.tttga ttagtttgtg gtattctgac ctctcatttt 10500 <br>tattac11.aga gttggaagat ttgagtctga acttgagcac ctgcttcggt gaaagcttcc 10560 <br>taaaatgcat gttttttcac attt tttctc atgttcattt tgttttgctt tttagcaaac 10620 <br>actttttctq acaqaatcta aaaqcattaq acttttcttq ttttcccctt ctctccccac 10680 <br>aatgtaatct tgaaaaccca aatgttagct qtgtaaatta cctctcccqt ?????????? 10740 <br>aagtgcaata ttgcattgag ttagcattga aatagtcggc ctttgaattt ttttctactt 10800 <br>qtgqtttaga cataataaat attt catctc agactgactt tctcgacaaa tcagttttgc 10860 <br>atttgggcct cttttcatca gtat gtttag ggaaagcaca tttattgaaa cattaaccaa 10920 <br>aatgaaacat aattaggagg ccgggagcga tggctcacgc ctgtaatccc agca.ctttgg 10980 <br>gagaccaagg catgtggatt gctt gaggtc aggagttcaa gaccatcctt gccgacttgg 11040 <br>tqaaatcctg tttctactqa aaat acaaaa aactagctqq qtqtqqtqac qcqtqcctqt 11100 <br>aatcccil.qct actctqqagq ctaaaqcaaq aqaatcqctt qaacctqqqa qqca.qa.qqtt 11160 <br>gcaqtgaqtc gagatcgtgc cact gcactc cagcctgggc aacagagact ccqtctcaaa 11220 <br>?????????? ?????????? aqcataatta qqqtqqtaac qcttatacat aqqqqca.qqt 11280 <br>ggaa.taattg aagcattctg ga.gccagaaa taa.tcaactg a.ttaa.gaata a.tctggctgg 11340 <br>qtgcggtqgc tcacgcctgt aatcccagct actcil.gqagg ctgaggcagg agaatcgctt 11400 <br>gaacctggga ggtggaggtt gcagtgagcc gagatcgcgc cattgcactc cagcctgggc 11460 <br>tatggagcaa gactccatct ?????????? ?????????? atcctgtttc tgcagaaata 11520 <br>tcccaqqtqt cctqqqtcaq caqtqcccca taqattccac qqacqtttac cctaaqtttt 11580 <br>ccaatgggag ttcatacctc tatacccaqt gagaatattt tctgaqtaat gggaatgaga 11640 <br>ttggaga.tqt a.gggtagaga aga.t ccata.c aqtctttggg ttaaactttt tcctctttgc 11700 <br>ctagga.a.a.ga. ttaatgctaa tctt aaccac aga.tttgtag taagaatqta. tcagttttqt 11760 <br>cattcagttc tagactccag tttt ctttat tgtaatacca atattttaga gtaaattttg 11820 <br>aaatgaatca gtacaaaaga tatgtagtaa gtggaaagtt agtccgcacc ttatccttgg 11880 <br>qactctttcc cagggaca.gc tagttaccta ctatttatct ctcctgagtt acttcatatg 11940 <br>tatqcatqca aacatqttat tctctqqqtq ttqttccttc catatataqc aqcaaataca 12000 <br>ccaaactctg tattttgctt tttqtcactt tatcttagag aatactcaat gcaaatacat 12060 <br>qtqtatatac ctcatqttta aaaaatctac ataqtaaaat taqccaqqca tqqtaqtqtq 12120 <br>tqcctqta.at cccagctact cgggaggctg tggtgggaga atcacttgaa ccctgagatc 12180 <br>acaccactgg actccagcct gggccacaga gcaagattct qtctcaaaaa ?????????? 12240 <br>?????????? actacagagt agtattctag gctatgcata tcataaattt gatttcctaa 12300 <br>tgataggcat agatgatttg cctgggcggc aaattagcgt tggctgtgtc tcaggaagaa 12360 <br>? qccaacagga ggaaccttat tttqagtcag qttccaaaqa caqaaacatt gtctqacatt 12420 <br>tqtttttggg cttatatgaa taaatctqta cacatatatt tttaatqttt taatcqtaat 12480 <br>atgtatacta tttggaaatg tggcttttta gttaacagag tqcatqtttt accccattgc 12540 <br>acttaaacat taacttgggg ataattaaat gaqtctqtca cttggacagg caggaattqt 12600 <br>?????????? aacccataaa ccqccaattt tttttttttq aqacaqaqcc tcattctqtt 12660 <br>qcccaggctg gaqtgcaqtg qtgcqatctg ggcccactqt aagctcagcc tcccggqttc 12720 <br>atgccattct cctqcctcag cctcccaaqt agctgqqact acaggcgccc qtcacaatgc 12780 <br>ccggctaatt ttttqtattt ttaqtaqaqt cgggqtttca ccatqttaqc caggatqqtc 12840 <br>tctatctcct gaccttqtga tccgcccqct ttgqcctccc aaaqtgctgq aattacagqt 12900 <br>qtqaqccacc gcacctgqcc qqtttttttt tttttttttq aqatqqaqtc ttqctctqtt 12960 <br>qccaqqctgg aqtgcaatgg catgatctcc gctcactqca acctccacct cccqqqttca 13020 <br>aqtqattctc ctqcctcaoc ctcctqaqta qctqqqacta caqqcqtqtq ccaccacqca 13080 <br>caqctaattt ttqtaatttt aqtaqaqatq qqqtttcatt aataatcatt aatattaqac 13140 <br>aactqtcaga ctcacaqtgg tggatacaaa ctttctcaaa ttctgatttt tactctaaag 13200 <br>ctcaaatttt atcattqgca acaaatattg tcagttgctt tccctga.a.ca gacagcttcc 13260 <br>cttctttcat ttttgagaaa atat ctgcca qtatcccaqt tggtttatca atcattcttt 13320 <br>ctcttttttt ttttgagacg gaqtctcact ctqtcaccca ggctggaqtg caqtggcatg 13380 <br>atctcgqctc actqcaacct ccacctccca gqttccagca attctcctgc ctcagcctcc 13440 <br>cgaqtagctg ggattacaqg ggct agcagc cacacctggc taatttttgc atttttaqta 13500 <br>qaqacaqqqt tttaccatqt tqqccaqqct qatcttqaac tcctqacctc atqatatqcc 13560 <br>caccttgqcc tcccaaaqtg ctgggattac agqtqtgagc cattgcgccc ggctctatta 13620 <br>tttcttttct ttctttcttt ttcttttttt tttttqagat ggaqtttcgc tcttqttgcc 13680 <br>caggctgqag tgcaatqgcg cgat ctcqgc tcaccacaac ctccgcctcc cgaattcaag 1374Q <br>tgattctctt gcctaagcct cccgaqtagc tgggattaca ggcatqtgcc accacacccg 13800 <br>tctaqttttq tatttttatt aqaqatqqqq qtttctccat qttqqtcaqq ctqqtctcqa 13860 <br>actcccaacc tcaggagatc tgcctgcctc agcctcccaa agtactggga ttacaqtttt 13920 <br>qaqccacctq acccqqtttq cttattattt cttttaaatt taaaaaataa taaataaaqq 13980 <br>ggccatgaga gcgaagaqtt tgagaaagqt tgqtctaaag qttttaacat aagaatccct 14040 <br>gggttatttq cttaaaaaga agaaagaatc tatggatctg cctgagaggg tctgatgtag 14100 <br>ttt&tctqqq qtcatcctca c•qqcat&qc &q&tattctq attc&qatqq tccttqqtcc 14160 <br>tt•qtttgaq aaatqtqqct tt&caagqcc cataqaatat &&&qtcttct ttqgattaqt 14220 <br>gaaqtcatqt ccacaggqtt tagaaaatqt ttttqtttta gagataaagg taagtggaag 14280 <br>aqtagacatg tagtgaatga gggaaaatqt tttagagatt tctttttatt ctqtttactc 14340 <br>ttcttgqtat gcacqtacct gaat attaag gatattttat gaaqtcatga cattaccaga 14400 <br>ttaatqttqq ttttqtttta aqqtactttc tqactqctqq qqttaattcc tacaqacqat 14460 <br>tctgqtaaag aatagccttt aaqttttaaa aqtqttgact tatttcagat qtcttaataa 14520 <br>agttaacttc cagttattac atqtaacqta tataaagctc tcattttcct ttattctcgt 14580 <br>taattgtttg cataacaaat tcaaagggaa atttgcttqq cagagatcaq •tagcagaqa 14640 <br>tqagatttaa aaacaggtaa tttqgctact agcctgggag tttgaagatt ccaaqtttgc 14700 <br>atccatqtqt aqtcacttaa catt tctqtc cttatctqta aatgggaata acacctactt 14760 <br>qatagqqttg ttacattatc ttggccacct caqqttctct ttggctgagt gattgactgg 14820 <br>aaaacqcaat qtqaattcat gctt cagact gqgttctttt tttttttttt ttttqaqatq 14880 <br>qaqtttcact cttattqccc agqctgqaqt qcaatqqcac qatctcaqct cactgcaacc 14940 <br>tctgcctccc aggttcaaqc gatt ctcctg cctcaggctc ccgagtagct gggattacag 15000 <br>qcatqcacca ccatqcctqq ctaatttttt tqtattttta qtaqaqacqq qqtttcactq 15060 <br>tgttgqtcag actgqtttca aact cctqac ctcagqtgat ccacctgctt caqtctccca 15120 <br>aagtgctggg attacaggca tgagccaccg cacccagccc aggctagqtt ctatatgggt 15180 <br>gtgcttttta qaatttagat catgggctat ?????????? aactggataa tgtttctttc 15240 <br>tagattctct ctaagcgtqt attctctttc tttcctaggc acagccacca cttcacttac 15300 <br>attgtqggat tataatttca tgaqtaqtqq aatttcctta accttctctt qtqtqqq&qc 15360 <br>tqaaggacaa aatgagatat tctctgaaga qtggttacat catgcaaaac tatgatgtgt 15420 <br>aatgaggtca cttaqttttc taaqtacatt atacattttg ataagatttt catagaaaag 15480 <br>cttqtctcct tggggagatc actcatcttc catctt gact attatttaaa ctttatggqt 15540 <br>cagatttatc tttttaaaaa cttaaccata aagctcaatt aatttttttt tttttttttt 15600 <br>gagacggaqt ctcgctctgt tgcccaggct ggaqtgtagt ggcgcgatct cggctcactg 15660 <br>caagctctgc ctcccagqtt catgccattc tcctgcctca gcctcctgac tagatgggac 15720 <br>tacaqqcqcc cqccacqatq cccqqctaat tttttqtatt tttaqtaqaq acqqgqtttc 15780 <br>accqtqttaq gatqgtctcq atct cctqac ctcgtgatcc acccgcctcg gcctcccaaa 15840 <br>qtqctqqqat tacaaqcqtq aqccaccqcq cccqqctcaa ttaatatatt ttaaaaatta 15900 <br>atagacttta ttatttttat tttattttat ttttgaggca gagtctcgct ctqtcaccca 15960 <br>ggctgaqtgc agtgqtgtga tctt ggctca ctgcaaactc cacctcccgg gctcaaqtga 16020 <br>ttctcctgcc tcagcctcct aagtagctag gattacagqt gcctgccacc atacccggct 16080 <br>aqtttttgta attttaqtag atacgtqttt tctttctttt cttttctttt ttttgagatg 16140 <br>7 gagttt cact ctttttgccc aggctggaqt gcaatggcat gatctcggct cactgcaacc 16200 <br>tccgcctc= agqttcaaqt gatt ctcctg cctcagcctc ccaaqtagct gagattatag 16260 <br>ttgtctgcca. ccacgcctgq ctaatttttt gtatqtttga tagagacagg gtttcactat 16320 <br>qtta.gccagg atqtctcgat ctct tgacct cqtgat ccgc ctgccttggc ctcccaaaqt 16380 <br>qctqqqatta caqqcqtqaq ccactqcqqc caqtctaqac tttatttttt aaaqcaqtqt 16440 <br>tagtttt aca gaaaaattat qtggaaaqta cagagaqttt ccatataccc cttactttct 16500 <br>cccacaactt ctattattaa catcttgcat taqtataqta cqtcccttac aactaatgaa 16560 <br>ccaactcgat acattattat taaccaaatt cctgaqttta ttttatttct atttttattt 16620 <br>tattattatt attttttaga ggtagggtct cactqtqttg tccaggccag gttgcagtgg 16680 <br>catcatcata qcttqctata qcct qaaact cctqqqctca aqcaatcctc ctqcctcaqt 16740 <br>ctcccaa.aqt qttggaa.tta cagqtgtgag ccactctqtc cagcctga.ag tccatagttt 16800 <br>acattacatt tcactctqtt qagcattcta tqqattttga caaatqtqtq atgatqtata 16860 <br>tttqccaqta cacaattata taaaataqtt ttactqccct aqaaaccccc tqtqctccac 16920 <br>ctattcattc ctctgctga.a. ccactggcaa ccactgatct tttataata.t ctccataqtt 16980 <br>ttgtcttttc cagaatgtca tataqttgga catacaqtqt qtagcctttt cagattggct 17040 <br>tctttcaqta aatgatatqc attt caqqtt tcttcatqtt tttttqtgqc ttgataqqtt 17100 <br>qtttcttttc attgqtgaqt aatactctat tqtatggata taccacatqt tqtttatcaa 17160 <br>acattcacct gaaggataga catcttgqtt gcttccaaqt ttgagcaqtt atgaataaa.g 17220 <br>ctgctataaa cattccaqtg caggactttt cacctcctct ggataaatat caaggaqtgc 17280 <br>aattqctaqa tcatatqqta aqaqtatqtt taqttt tqta aqaaqctatc aaactatatt 17340 <br>caaaqtgact qtaccattat acat tcccat cagcaqtgag t gagaqttcc tqttactcca 17400 <br>catcttcacc agcattta.gt ggtqtcaqtg ttttggattt tagcca.tttt aatggqtqta. 17460 <br>ta.a.tgqta.ta cctattaa.aa. ttgqtttttt ttgga.gacag a.qtttca.ca.g tttcactctt 17520 <br>qttgccctgg ctggagtgca atggcgcaat ctcggctcac tgcagcctcc gcctcccaqt 17580 <br>ttcaaqtqat tctcctqcct caqcctccca aqtaqctqqq attacaqqtq cacqccacca 17640 <br>tqttctgcta atttttttqt attt taqtag agatgggqtt tcactqtqtt acccaggctg 17700 <br>qtcttqaact cctqaqctca qqtaatccac ctqcct caqc ttcccaaaqt qttaqqatta 17760 <br>caggcatgag ccaccgcacc tggcctcaat tttttt tttt ttttttttga gacagagttt 17820 <br>tgctcctqtt gaccaqgctg ga.gtgcaqtg gcacaatctc ggctcactgc aa.=tccgcc 17880 <br>tcctqaqttc a.a.qcqattct cctqccacaq cctcctqaqt aqctqqqatt a.taqqcqccc 17940 <br>gccactacgc ctgqctaatt tttttttttt tttta.attag agacgaqqtt tctccatqtt 18000 <br>gqtca.ggctg qtcttgaact ccccqttctc agqtgatccg cctgcctcag cctcccaaag 18060 <br>tgctgagatt acaggtqtga gccaccqtgc cccgcctqtt ttggctttta ctqtgaagac 18120 <br>qtqttagccg ctqtgatgac tagcaaqtqt gqccct ccac ccaqtcqctc tgggctccca 18180 <br>qctcctqcat cctqctqcaa actt qacatc ttccct caaq taacttqtaq ttqtctcctq 18240 <br>tctacttgcc caaaatataa ctct taaact tttctctctg caaqtttqtg cctctctccc 18300 <br>tqtctgactt ccccatctaa ataaatgqta gaccaccatc tactcctttg tgcaagccag 18360 <br>aa.atctagga atcatcctta. aa.tt ccctqt tctgtcttat ctctqctttc a.ttcaaaqca 18420 <br>tcagcaaatc ctgttgqttc tacctctgaa gttttctcaa atactqttac ttgactcatc 18480 <br>ctgacttttg tttctgcttt atgttaggct aaatgccctg aaaactcttt tgtacaaaac 18540 <br>acctagaaat actqqataaa ctgggcttaa cagqgaggcc cgqtqtqqtg gctcacgcct 18600 <br>qtaatcccaq aactttqqqa qqccaar;~qtq r;~qtr;~qatca.c ctqaqqtcaq qaqttccaqa 18660 <br>ccaqcctqqc caatacqtaq tqaaacccca cctctactaa ?????????? aaaaattaqc 18720 <br>tgggtgttgt gqtqcacacc tgtaggtggt gcatgcttga acttggqagg cggaggttgc 18780 <br>agcgagctga qatcqcqcca ctqcacttca qcctqqqtqa cagaqcaqga ttctgtctct 18840 <br>taaaaaaaaa ?????????? gaaaaacagg aaaatcttca gaagcaaaaa ccaaacaatc 18900 <br>tcaccaaaga aatgagaaga tggctgggcg cgqtggctca cgcctgtaat cccagcactt 18960 <br>tgqgaqqccg aggcqggcaq atcacccgag atggqcagat cacccqaqqt cagqaattcq 19020 <br>agaccagcct ggccaatatg gtgaaacccc gtctct gcta aaaatacaaa aattagccag 19080 <br>qtqtqqtqqc aqqcqcctqt aatcccaqct actcaqqaqr;~ ctqar;~qcaqq aqaatcqctt 19140 <br>gaacctggga ggcggagqtt gcaqtgagcc gagatcatgc cactgtactc taqcctgga.c 19200 <br>gacagagcaa gactctqtct ?????????? aaaggctggg tgtgqtggct catgcctata 19260 <br>atcctagcac tttgggaggc caaqgtgggc ggatcacttg aggccagqtg aacatggcga 19320 <br>aaccccatct cta.cta.a.aaa tact aa.a.qtt agctgggca.t gqtgqtggqt gcctqta.atc 19380 <br>ccagctactc gggaggcgag gcaggagaat cgcttgaacc aggaggtgga ggttacaqtg 19440 <br>aaccgagatc tcgccaccgc actctagtct gggcgacaga gcaagactcc gtctcaaaaa 19500 <br>?????????? ?????????? catqgccaaa qtqcaqtqac ttacatctqt ataatcccaa 19560 <br>tqttttggga ggctga.ggca. ggaggatcgc ttgaqtccag gaatttga.ga ccagcctggg 19620 <br>caacataqac ctcatcacca aaaaaaaaat attttttaat taqctqqqtt tqqcaqcatq 19680 <br>tacctqtagt cctagctact caggaggctg aggtgggagg atcacttagg cccaggaqtt 19740 <br>tgatagttcg agqttata.qt gagctatgat cctgccactg cactccagcc tgggccacag 19800 <br>aqtgagac= tqtctcttag ???.??????? ?????.????? aagaaactga attaaaaaca 19860 <br>acaagaacaa aaatgctgct tttt qttatt gaqttqtagc ccaaqtttct tgagggtaaa 19920 <br>8 gcattgaaaa gcaggcaqta atagatttgc tqtttaaaga gatttacttg cagcactatt 19980 <br>cacaatagca aagacatqga atcaacctaa atqcccatca qtgacaaatt ggataaagaa 20040 <br>aatgtggtac atacactqtg gaat actatg cagccataaa aaacaacgaq atcatqtttt 20100 <br>tgtttgtttq tttgtttgtt tgtt tttgag atggagtctt qctctattqc ccagqctgqa 20160 <br>atqcaqqtqq cacgatttca qctcactqca acctccgcct cccaqqttca aqcaattctc 20220 <br>tgcctcaqcc tcccgaqtag ctqqgattac agqtgccctc caccatgcct ggctaatttt 20280 <br>tqtatttcta qtagagatgg qqtt tcaccg tgttgggcag gctgttcttg aactcctgac 20340 <br>ctcatgatcc tcccacctcg gcct cccaaa qtgccgqgat tacgtgtgag ccaccgtqct 20400 <br>cggctgagat catgtttttg caqqaacatg gatggagctg qaqgctatta tccttaqcaa 20460 <br>aqtaatqcaq qaacaqaaaa ccqaaqacca cqtqttctca cttata&qtq qqaqctaa&t 20520 <br>qataagqact tgtgaacaca aaqaaqqaaa ccacagatac tqqggtttac ttqagqgtqg 20580 <br>aqaqtqqqaq qaqqqaqa.qq aacaqaaaaq ataactattQ qqtattqqqc ttaatactta 20640 <br>atattttatc aaaataaqct qtacaacaaa cccctctqac atqaqtttac ctatataaca 20700 <br>aacttgcacq tqtaacccca aacctaaaat aaaaqttaaa ?????????? aaqgctgqtt 20760 <br>gcattqggag gctgagqcaq qcaqaqcact tqaqqccagg aattcgaqac caqcttggct 20820 <br>aacgtqqaga aaccctqtct ctactaaaaa ttcaaaaatt aqccaqgtqt qgtqgtqcat 20880 <br>gcctgcaqtc ccagctacca gggaqgctga gqcagqaqaa ttqcttqaac tcagqaggca 20940 <br>qagqttgcag tgagctgaga ttgcaccact gcattccagc ctgggcqaca ggqcgagacc 21000 <br>ttqtctcaaa ?????????? ?????????? aaaacctqtc actttqggaa tatctcaaac 21060 <br>ctaqtcatcc aaqtqqttqt acqattttaq tqtctqcata tcaatattta qtqtqatcta 21120 <br>ctttcttaga ttctcaaata ctgccaatgq gcacatqtca tqaaataatg tcttttagaq 21180 <br>gacaaqagag tqctaaaqtc tcat tattgc agtttaagaa aaacaattct qtaacagttt 21240 <br>aactttatag gaaatqcctt ttgtttattt attttttttc ttttqaqqct taqattttta 2130~ <br>tttttatgtt tttagagatg gggtcttcct atgttaccca ggctqqcctt gaattcctqg 21360 <br>gctcaaqtqa tcttcctqct tcaqcctcct qagtaqctgq gactagacqt ccactactqc 21420 <br>tcctggctqq aagtttagat tttaatttaa actcttctat tgggaaactt tgtatqtttq 21480 <br>ctttaccact taacatttqc atgcattatt gtacctattg tctcctactt aaggaaqqqc 21540 <br>aqtttatgct qttatatgaa qtgaattaac ctcctatgqt acttcaqttt tctctatgct 21600 <br>aaaagtqtqt tctagatttt tgaaaaactt acttaatttt cattcattta ttcaaatatt 21660 <br>tqaqcattct qtaqttqctq qqqaaataqc aqtqaactqa aqaatqtctt tqttcttatq 21720 <br>gqgcttaagt tcctaqttqa tcat attgga aqqagataca tgaaaaaaqa aatatatgaa 21780 <br>caatggaggg cgatgaqtac tqtaaaggag aattcagcag gggagatgtt gctgttttag 21840 <br>atagagggqt qtcaagagac attqtgcaga gacctgaacg aaqtgaggga gcaagccatg 21900 <br>qagatatcta gggaaagagc ctat cagqtg gagaqaaqag tcctaqggca gaaacgggca 21960 <br>aqqtqtqttc caqqaqcaqa qaqgqqacaq ctqtqaqcaa qqqqaqaqtt qtaqqqaaqq 22020 <br>aqgcaaagag agacatctgq ggcaaaatgg attgactgqt qqqccqtgqt aggactttgg 22080 <br>attttttcct qaqtgqqttt tgagcagggg aatgaaatga tctgactctg gttttttttt 22140 <br>tttttggaqa caaaatcttg ctct qttgcc qaggctgaag tgcagtggcg caatctcgqc 22200 <br>tcattgcaac atctacttcc tgggttcaag ctatgctcct gcctcagcct cccqaqtagc 22260 <br>taggattaca ggcttgggcc accatgccgg cgaatt tctg tttttatttt tattttttat 22320 <br>ttatttttat qtttatgttt tttgagacgg agtctcqctg tqtcacccaq gctqgagtqc 22380 <br>aqtqqcqcga tctcaqctca ctqcaacctc tqcctccccq qttcaaqcaa cttctcctqc 22440 <br>ctcaqcctcc cqaqtaqctq aqat taocaqq cqcctqccac tacacctqqc taatttttqt 22500 <br>atttttaqta gaaacgggat ttcaccttgt tggccaggct gqtctcgaac tcctgacctt 22560 <br>aatttatctq ctcqccttqq cctcccaaaq tqctgqqatq acaqqtttqa qccaccqtgc 22620 <br>cagccaggac tcttattttg aaaggatctg taatqtggag aatagaagqt agagggacaa 22680 <br>qgatgaaagc atccaggcca qttagcctag tccagctatc taqqtaagag atgctggtgg 22740 <br>cctggattaa qgctqcqtca qtgggagqtt qtgagaaagg ctcaccttcc tttttttttt 22800 <br>tttttttttt ttttgagaca ggat cttact ctgtctccca gqctqgaqtg caqtggtgca 22860 <br>atctcagctt actacaacct ccqcctcctq qqctcaagtg atacccccac ctcaqcctcc 22920 <br>caagtagctg ggatcacagg cttgcgccac tatatccqqc taatttttgt atatttcgta 22980 <br>gagacagggt tttgccatqt tgcctagqct ggtctcaaac tcctgaqctc aaqtqatcca 23040 <br>cccgcctcag cctcctaaag tgct gggatt ataggcctga gccattqtgc ccqgtcactt 23100 <br>ccaqattttg aaqacagagc caacaggatt tgttaatqqa ttaggtqtgg caggaqgaqg 23160 <br>gggaqgaaga gagagagaga ctggagttga agttaagqct catttcaagg tttttaqcct 23220 <br>caa.catqtgc aggaatggag ttgtcacttg ctagaatqqg ggaga.ctqqa ggaqaagccg 23280 <br>gctgqqaqaq qtttttaatq aaqqqqttqg ctttqqatac attaaqtttq acatqcattt 23340 <br>taga.catcca ggtgga.gata ttqaagaggc agttggctat aagtgtctga tgttcatatt 23400 <br>aqcqqatqqq gctaqagaca taaatttqaq aattqtcaqt qtataaacqt tqttttqaaa 23460 <br>qaaaqtqqqq ctgaataatt tagaaaggag tqcatagaqa aaataaqttt actattaaaa 23520 <br>tagctttaac aggccgggca cgqtggctca tqcctqtaat cccagcactt tgggaggctg 23580 <br>ggqtgggcag atcaaaaqqt caggaqtttg agaccagcct ggccaatatg qtgaaaccct 23640 <br>qtctctactg aaaatacaaa aatt agccag gcgttqtacc gggcacctqt agtcccagct 23700 <br>9 acttgggagg ttqaggcagg agaatcactt caacccggga gqtggagqtt gcagtgagcc 23760 <br>aaqatcacqc cactqcactc catcctgggc aacagaqcaa qactccqtct ?????????? 23820 <br>?????????? ?????????? aaaaacttta acagcaaagc ctcttccttt aaaattatga 23880 <br>atttttttct tatggaa.gtt ggactctttc attatt aagt ctacattcaa tcactatgtt 23940 <br>aqtaaaaatg ttqttctaqt tgccqaatgc aataa.accag ctcagactta qtqgccta.aa 24000 <br>gcagcaa.tca tttgactatg t t cgaagatg ccqtgggcag gaatttaga.t aacagcaggg 24060 <br>atggcttgtc tttgctctgc gatgtctgag gtctcactga qaaaactcaa gcggctgggg 24120 <br>qtaataatca tctggaattt tctt tactcc tgtatctgat qtctgggctg cgatgactca 24180 <br>aaggctgatt tcagctgaga ctgtagacca cgtgcctact tqtggcctcc ccttttgcct 24240 <br>tgqqtttctc acaqaatqtq qctqqttctq 9'?l.\l?l.?l.tqog?l. cttcca?l.tq?l. ?l.?l.tC?l.\lqtqq 24300 <br>aaatgacatc tcgccgcttt cagcatgctc tattggttgg aacagttatg gacttagcta 24360 <br>qattcaaaqq aaqggaacaa aqaccccctc ctctcaqaqa qtqqqqcata atqaqagaat 24420 <br>ttaqggccat qttatccaac caccacaaat gccttctgaa tttqaqqttc tqcctcaaaa 24480 <br>qttcataqtt cctttgactg aaggacttct atatat ccaa gcatcqtcag ccccaggtat 24540 <br>e~.ttqttcce~.t qte~.aqtge~.cc aggacte~.cct taqtat ttcg tatagggae~.e~. qtge~.cctgae~. 24600 <br>taaatttgag aaaagaatct tcct tctctc caqtaagcac tgaggtaagc attgagccat 24660 <br>attotoggtt tatgactttg agoctcagaa atttaaattc ttggccaggc gcagtggctc 24720 <br>acgcctgtaa ccccaacact ttgggaggcc aaggcaggca gatcacttga ggtcaggagt 24780 <br>ttgagaccaa cctggccaaa atggtgaaac tccatctcta cgaaaaatac aaaaattagc 24840 <br>caqqtqtgqt qqcqqqcacc tgtaatccca gctact tgqg aggctgagqt aaqagaatgg 24900 <br>cttaagttct ctttatctgc tttatttcag ttgcct ctct tagatga.ata ttaatgactt 24960 <br>aca.tagcatt ttagatcagt ggat gttttt gtgatt cttt tatttgagct ttggccaa.ag 25020 <br>ataacagtac ccacaggttt tttccagcta ctcgctcttc tcccttcagt ggccctcgag 2508? <br>cctggaaaat ctgacatgac aatgtgcttg ctcaacctac cactgttttt cttttgaaaa 25140 <br>qtttqgcagc ctgtttctqa ctcctatgaa gqtqoottcc tcaqcattca coqtttatto 25200 <br>gaaaaatoct ttgcttctct ccaaactcga aattcaogot ooccaaacct atatotaggc 25260 <br>tqatctttca qqatqcaqtt qtcotqttqa tqccatqctt ttcagtatcq tqqccatcat 25320 <br>ctgttcagta qqqqaqqtqt actt ctgtaa tqqqaqqtqq tggttatgtg tgtgtgcaag 25380 <br>tgtttatttg gtgtcttaog ttagcctgtg ggaagttcta aatcaggatg gtocgtggtt 25440 <br>gccaqcaqag agctgctcct caaqtqaagg agqtagaatc aaagccaata qqaaaqagcc 25500 <br>tcagatgctt atatatgtac cgtggggatt cagagtgaaa gcagtcattg gactaggggt 25560 <br>gggqttaggg aqaqcctqtc tgacagacac aagaaaggga tggataacgc cacccagaga 25620 <br>oooaogcatt ttaggcaago ocaoototga ooooggooco oogtctqtgg qtqqqqqqco 25680 <br>aqgaggagat aagttgactt gaaggaagac aacact tatg aaagtcacct ggaggctggg 25740 <br>tqccatqqct catqcctata atcqcaqcac tttqqqaqqc cqaqqtaqqa qqacaacttq 25800 <br>agcccaggaq ttcgagacca tcct gggcaa catgqtgaga ctgagtctct ?????????? 25860 <br>aaoaaaaaag aaaattatcc agacatgqtg gcatgtgcct gtaatcccag ttactcagga 25920 <br>ggctgaggtg ggaggqttgc ttgagcccag gagqttgagg ctgcagtgag ctgtgatcgt 25980 <br>attattgcac tccagcctgg gtaacagagc aagaccctqt ctcaaaaaat gaaagtcatc 26040 <br>tgtagqctgg agagaggaac tggaaggggc taaaqttqgc tgagtagtta cagagcctga 26 1 00 <br>gataagggta aagattttgc attggacaat gagatgttag tgtgtqtttt tgaqctgggg 26160 <br>aqtqctqtqa ttttactctt attqaaqaat cactqaaqqa ttattcttqa atcaqtqatt 26220 <br>cttqatcatt cttqaatttt tcaaacaqcii'o &?l.?l.ctqqaaq aqttqqcct?l. ttcctcaqii<!--?l. 26280 <br /-->tattttctaa ttgggcgcag tgtcctcact tgggagaacc tggctacaca ctttagttgt 26340 <br>aattcactcc aqtcqttcat tcat tcaata cctatttttt caqcacctat tatgaqccag 26400 <br>acactatgct ggatgccagg gttcagggta ggacacgcta gtgagcaaaa gccaagactc 26460 <br>ttcttgtctt catggggctt tcagtccagc atagtggtta tgagtccaag ttaatggagt 26520 <br>cacaqtactt gggtgcaaqt catggtgatg qtgatagaag gaaggcatgt gtgagggcca 26580 <br>qtggcaggca ggagcctggt qttt ttgagg acctgaaqaa ggagcagogt gaqtgccagg 26640 <br>aacttaqcca ccaqctqqta ccaqcc?l.tac qaqaqqqqoa qaqccaqcc?l. qqatqtcqqt 26700 <br>catgctagta atgaqtacaa acacttacat gctgcacgct attgggctcc tgagtgctac 26760 <br>gtgttcatta gctcgatgaa tttgtacagc aaccctqtga ggtaagcact qttctctccc 26820 <br>ctttctatag atgaggaaat t aaggcacaa agaggataaa taactggcac cagctacacg 26880 <br>ctaaqtgatc gaaqtggtgg aaccaggatt caaatccatg ctattctgcc ttaligataac 26940 <br>aaatcttgtt ttttagccta agaacagagc agtcatcagg aqggttttaa qtaggggtqt 27000 <br>ggcaagatca aqtttqtgtc ttgaaaaggt ctctctaccc acaqtgtgga aaatggcctg 27060 <br>gaqqcaaqca cacaqatqtt qqqaqacaqt t?l.acaqctct tqccatqqcc ccctatqcat 27120 <br>tttggctctg atgtttctgc ctgatttttc tcttgcctct gcctcttttc ctgaggggat 27180 <br>qqcaqqtttt accattca.qc tqqagtacaa accctqaacc ctttttqqtt aaa.tatcta.c 27240 <br>ttgcttttcc tacagtatta tttt gagttg ctgtggctgt aatgtcttga gggaatcgag 27300 <br>cttgacagta atttatagaa caaacaqttt ttagagactg tgtggcccaa ttgccctctc 27360 <br>aatgttggca ctcctgccat gacatttacc atgctgaqca tgtga.ccgcc atctgaatac 2 7420 <br>caaatgccac aggaacctgg gaggttgtca cttactcctc cctttctctg agtcaccttt 27480 <br>10 qcccttcaqt caqtcaccaa qtcccatcac atgtagctct qtaatqtcac agaaqatgga 27540 <br>tqtctqcctc aaaacactta caat gctqct acctaaattg ggcagccacq acctcccacc 27600 <br>agqattattg cagcctqaqq gatctttttq aaatqtaaat caaactatca cttqtctgtt 27660 <br>taaaqctttt caaaqactta ccccattgcc cttggaagaa agtgcagata tcttgacagg 27720 <br>aqaqccttct ccaqcctcct cttctgccqt qqtctccttq tacaqtctct acaqtqtact 27780 <br>gcttcattag aaccctggag attattattt gctaqttctg ggctaagaac tggcacctgg 27840 <br>ctttqtagag ctcctcagga gatt ctgaqg cgtattcaga qttgagccct gatctctgct 27900 <br>ctgatttcqa gqttctcqtt atat ttatta atgatcacqa aaaaatttat tattattctt 27960 <br>tggcctcact ttaqcatcat ctgaggaatt tttttttttt tttgacaqag ttttgctctt 28020 <br>qttqcccaqq ctqqaqtqca atqqcqtqat ctcaqctcac tqcaacctcc qcctcccqqq 28080 <br>ttcaagagat tctcctgcct cagcctccca agtagctgaa attacaqgca tccaccacca 28140 <br>tqcctqctaa tqtttttqta tttt ttaqta qaqqtqqqct ttcacaqtqt tqqtcaqqct 28200 <br>qqttttqaac tcctqacqtc aqct qatcca cccacctaqq ccccccaqaq tqctqqqatt 28260 <br>acaqqtqtga gccaccqtqc ccagccqtag ctttcgaaat ttgaaacctg gtcccactgt 28320 <br>caqagqttcc aatttgqcac tggtttqqtt cccaggcatc tttcttgctg tatatatttt 28380 <br>ttagtgtcag ccagqqtgga gacctctgta ttacttcatg gggaagaatt tgggagaaga 28440 <br>tqttqtqagg agacagqttc taqtcctaga gtqatttatc ctttctcqta cagatttcca 28500 <br>gqtatttgaq gggccactct tctgtaattc atqtttttct ctcctaacct cactcctgtt 28560 <br>qcctqcatct tcttgctqaq caaaatattc aaggtcttca actcctcaca ccctggttgt 28620 <br>ccctccctqq atqtqtttqq ttqttttaqt qttccatttc aattttqata cacaqaatta 28680 <br>gaatagcatc caqatqtqqq tctqttacag ctagactact agatccttca aaatccaaqt 28740 <br>actaqtatqt ctattaaaat accataaqat cacattggct aqttacaatg qttgqtttqt 28800 <br>qqqttactta aaaatcaact aaaattcttt tttttttttt gagatggaqt tttqctcttq 28860 <br>ttgcctaggc tggaatgcaa tgacacaatc ttggctcact gccacctctg cctcccagqt 28920 <br>tcaaqcaatt cccctqcctt aqcctcctqa qtaqctqqqa ttacaqqcat qtqccaccat 28980 <br>qqccaqctaa ttctgtattt ttagtaqaga tgaggttttt ccatqttggt caggctggtc 29040 <br>tcqaactc= qacctcaqqt qatccacctq cctcaqcctc ccaaaqtqct qqgattacaq 29100 <br>gcgtgagcca ctgagcctgg ccaaaattcc cactttctaa tactcctqta qtagctggqt 29160 <br>acqqtqqqtc acatctqtaa tcccagcact tttqgaqgct qaqqctqqaq qatcgcttga 29220 <br>qcctaqq•qt tcqaqaccaq cctqqqcaaq atqqccaq•c qccatctcta attta•aaaa 29280 <br>aaqaaaa•ac •aqactcct• t•qtqgtgaa qaacagaca.t tccqaaaaca gactgtgcqt 29340 <br>tatqattcca gctccatqcc tttactacct qtqttqtqac tttqqataaa tcacttaaaa 29400 <br>atcttttttt tttttttttt tttt tqagac qqaqtcttqc tctqccqccc aqqctqgaqt 29460 <br>qcaqtqqcqc gatctcggct cact gcaagc tctgcctccc aqgttcacac cattctcctg 29520 <br>cctcaqcctc ccaaqtaqct ~;~~;~qactqcaq qtqcccqcca ctacacctqq ctaatttttt 29580 <br>gtatttttaq tagagacqgg gttt caccgt qttagccagg atggtctcga tctcctqtcc 29640 <br>tcgtgatcca. cccqcctcaq cctctcaaag tqttgggatt ac•ggcgtga qccaccgcac 29700 <br>ccggccaaat cactt•aaat tctqtgcctc aqtttctcct ctqtaaaqtg ggataaaaat 29760 <br>aqtacctatc tqatagqqtt qttacaatta tgaaatqagc aaataaqtat qtcaaqtqtt 29820 <br>taaaacagcg cctggcttct tqtaaaaaqt qctatataaa tcatagctat aatcattact 29880 <br>tatttcgact gctctttaac caagqttctt atttttcatc tttttctttt qttttgaata 29940 <br>tcacttaqtq ttttcacctt ttactctttt taqqacctaq aqccatccta ~;~qtqaaatac 30000 <br>qtatqqaqat attt~;~atcaq qtcaccaccc aqctctcctq acctcccttc tctccttaaa 30060 <br>ttaacatgcc aaatcacagc atcactgact ccttccctcc cgatatqata agaqtgtgca 30120 <br>ttqaaatqca tqtattttac ttaqcaqqqa aaqctqatta qtqattatca cacttaaccc 30180 <br>ctaqtgaatc tgatggatta acct gctttc caggacacta agqaaatqqg tttaagataa 30240 <br>gaaatatctg gctqgqtqcg qtgqctttac qcctqtaatc ccagcacttt ggqaqgccga 30300 <br>qqtqqqcaqa tcacqaqqtc aqqtqattga qatcatcctg qctaacacqa tqaaaccccc 30360 <br>tctttactaa aaatacaaaa aatt aqccgg qtqtqqtqgc gqgcgcctqq aqtcccagct 30420 <br>actcqqqaqq ctqaqqcaaq aqaatqqtqt qaacccaqqa qqcaqaqctt qcaqtqaqct 30480 <br>gagattgtgc ccaccgcatt ccaqcctqqq caacaqaqtg aqactacatc tcaaaaaaaa 30540 <br>?????????? aqtaagaaat qtccatgaaa gggagaccct qqgqqaaaqq aacaataact 30600 <br>gcagctctqa ggatctggca ccaqcagcac cagcacagag ggatgctqta caaccattat 30660 <br>tgatttta•c tttac?iac•g ttct tcaaag g•gaq•gaqt tccctqtttt actqaagaqa 30720 <br>aaqcccattt qqtaqtgaaa taccattccc aaagacaaat aqctaataaa tqtcaggcaq 30780 <br>qqttttgcac ccaqgcccat ccaqctcccg tctctactqt cctttccccc acaccacact 30840 <br>qatacaqaqq aatqtqtctq qttqqqqaaq tqqaaqtqtt cccaaqtqqq qaqqtcatct 30900 <br>qatqcacaaa tttgqtctqt tttqtgqqtt ttcttqtttt aqttttaqtt tttgtagagc 30960 <br>tcaqacctqt tcttaqqcaq cttt aacaat caactqtqca ctcaqtaatt qacaaatcat 31020 <br>qtttqttact tttaatttaq agggaattag qtttqttaag ctcttgctcc ttctttagag 31080 <br>atqqqqtcta gctctqtcac ccaqqctgga gcgcagtqqt atgatcacag ctcactgcaq 31140 <br>tctcaatctg ctcaaqtqat cctcctgcct caqcctccat qqqactacaa gcatgggcca 31200 <br>ccatqctagq ctaattttaa aaaaattttt ttqtaqaqgc aagqtctcac qqtqttgccc 31260 <br>11 aqgctggtct tgaactcctg agct caaqca atccctcttc caccttggcc tctcaaaqtg 31320 <br>ctagaattat aggcatgagc caccatgcct ggcctttact tctttcatat attcaaattt 31380 <br>tqtcatatta qtagqqaact ataactcaag ttttcttata qattqatqtt catttttaca 31440 <br>aqcttqa.tcq tcattgqttt ttaatttta.a. agcaa.a.tcct qttatatqta attqaaca.tt 31!100 <br>acaqta.a.tta taqtaatttq tttcaqattq qqcactcaaQ tqttaatatt ttqtctcttt 31560 <br>aqqaaatcaa aactagattt atat ataqac ttcttattqc aaqtatctaq tcttaaatct 31620 <br>tacaaaqqta ctatttqqac ttaaaactat qaaattqtqt qcttactata taaqtqtact 31680 <br>tattttqaqt tatqttttaa acttqaaatt ccattcttaa tgtctagaqt aattatqaat 31740 <br>qqttaaatta tqaatqactc taataqttta aaqctacaqt atttatttat ttatttattt 31800 <br>aatttatttt ttqaqatqqa qtttcqctct tqtcqcccaQ qctqqaqtqt aqtqqcacca 31860 <br>tcttgqttca ctgcaacctc tgcctcgcgg qttcaaqtga ttctcctgcc tca.gcctccc 31920 <br>aaqtqQCtqq qattacaqqt qtatttcacc atqcctqqct aatttttqta tttttaqtaq 31980 <br>aqacaqqctt ttqccatqtt aqcctqqctq qtctcqaact cctqacctca qqtQacctac 32040 <br>cctcctcagc ctcccaagga ttacaagcat gagccaccac acctggccta cagtatttta 32100 <br>atgtggactc tctqtcatcc attatgctqt ttatcctgtg qtgaaaattt tatgaagatt 32160 <br>qaatqttttt ctctaqcqtq aatt qctttc tcttactttt ctcatttttt tccttcctaa 32220 <br>tctacttgca gatacttcag attattttta qaacgtggta tgqtgaqaac aaataaattg 32280 <br>qqgtttccaa atctta.ataa. a.tta.tgtggc cctcaqtqqg attagca.ggg ttgtattgaa. 32340 <br>aacaccaata gaaacaaaat agtt ctttta tqcgctttaa ataaaaattt cttttcaggc 32400 <br>caqqcqcaqt qqctcacacc tqtaatccca qcaccctq?Q aqqctqaqqc aqqcaqatca 32460 <br>cctcaqgtca ggaqtttaag acaagcctgg ccaaca.tgqt gaagcgccqt ctctactaaa 32520 <br>aatacaaaaa ttaqccggqt atqatqgcgc atgcctgtaa tcccagctac tccaqaggct 32580 <br>gaggcatgag aatcacttqa a.ctcagqaga tggaggttgc aqtgagctga gatgqtgcca 32640 <br>ctqcactcta qcctgggcaa cagaqtgaga ttctqtctca ?????????? acaacaataa 32700 <br>caaaacatct cttttcaqqc caqqtactqt qqctcacqcc tqtaatccca qcactttqqq 32760 <br>aggccaaaac aggaggqtcg cttgagacca ggagtttgag accagcttgg gcagctgqtc 32820 <br>tctatttqaa ?????????? ?????????? atactctttt cataqaaaaa tqtttactac 32880 <br>acaataaact ttaaaagaat atgcagctqt attaatgcta tqactccaat gtaaaaaaaa 32940 <br>aaaaatatat atatatatat ?????????? aaacacattc tgaaatagat ttaaaggaat 33000 <br>tacatcaaca tqtcaa.tttt ta.ttttttcq qa.qaca.qqqt ctcqctqtqt ca=caaqct 33060 <br>qqagtacaqt gqtgcaatca cagctcactg cagccttgac ttcctggcct caagtgatcc 33120 <br>tcccccctca gcctcccaaa gtgctgggqt cacagaccac cacacctggc aacatgtcag 33180 <br>tttttqttct gcataqtggg atgqtgggat atggatqttt ttatctttta ttttcttttt 33240 <br>tatatttttc taaattttcc acat tgaaca ttattttata atctttcaaa catatctctt 33300 <br>aaaaqqactq qttcctataq aatt caqtqc aaqaaatctt ctqtqtttct ttatactttq 33360 <br>qttgccttga tcactgggcc tttcctgaca gcaaagaaga gqttaqtqta ggcagcagat 33420 <br>aaaacacagg tatgctctat ttaaaatgca tqtatttata ataaaaqtat aggtgqtacc 33480 <br>caaaggaaaa tgtcatgaca cattgcaaag tggaacagaa qttatcttta gatcactttc 33540 <br>tqttctggat tattqtatga gcctgatttt cqtctctctt tccgccttcc ctcaccctcg 33600 <br>ttgtaaatcc actaqtgcat ggat qtgaag tacaaqtctt aactttaaaa agttttatga 33660 <br>agctgtqtag taaatccctt ttgtaagtgg tcttgactgc qtttctcaat atatcttttg 33720 <br>qtttcattaq attcaaqtat ataaatqaqa actgtaactt tqqacaqact ttttcaqtca 33780 <br>tctttacqqt aataaqttcc caat taqaca ataqttattt qttttatqac ttqctqttqq 33840 <br>taggttatcc ccaagggact gagaaattcc tqttttgaaa aqtccaaaaa qtctttgatg 33900 <br>acttqctqtt tcattttttt cttttctctt caqttataqa aaacaqqatt acacccacct 33960 <br>tgcctttqta caqtgcatct actatctgct gacttaacct gaqtaaatgc tttgaattga 34020 <br>gccccatat4 atqtcctaag gc4gcct4ta tggaqtaatg a4ttgtcttc tctcttatgc 34080 <br>acccagaqtg qtaqttggca ctcaagttqt tcctcagata actttqtqtg ttctggggct 34140 <br>caatgaaqta qttattaaqt cacaggcttg gggagaacat tcatcctatg gcattgaatg 34200 <br>aaqtqttqcc caattctaqa atqtctaata aaattttttt ?????????? aqqcttaqaa 34260 <br>ttattccqta gatatgaaqt aatqtagtta gaacttaqtq gaqttcttta gattaacttg 34320 <br>taatttgaaa aaccaaaatt gaaattgtga aataacatgg gctctttgag qtcttttcca 34380 <br>qtaaaacaqt tacaqtaaag ctgcttggca qtgatt ttcc tagacacttt ggctagtcat 34440 <br>ctcctgtgao tgctqtta.at taaatatgqt ttqtagctaa gcagcctqta aggagaagac 34500 <br>tatggaaqta tttgcatatt ctct ccttga aaatactacc tgqtctttgg ctttaagtta 34560 <br>tacttttatt ttcccctqta gaataactat taaaqtatta cctatggtga ttagactaag 34620 <br>aaqtaaaaca tqaaatcaqt cattqttqqt qccctqqtqc cttctttttt ttttttttqa 34680 <br>gacaqaqtct cactctqttg cccaggctgg aqtqcaatqg cacgatcttg gctcactgca 34740 <br>acctctqcct cccaqqttca aqcqattctc ctqcctcaqc ctcccaaqta qctqaqacta 34800 <br>caggcgccca ccaccacgcc tggctaattt ttgaattttt aqtagagaca gggtttcact 34860 <br>atattggcta ggctgqtctc aaactcctga ccttqtgatc cgcccacctc agcctcccaa 34920 <br>aqtgctggga ttatagqtqt tagccactqt gcccagcctg qtgctttaat tttatggaaa 34980 <br>aaactactag ctgqtttctg tttt aagaaa taacacaqgc cgggtgccat gacttgcgct 35040 <br>12 tqtactccca gcaqtttggg aggccgaggc gggcggatca cgaggtcagg agtttgagac 35100 <br>cagcctggcc aacataqtga aaccccqtct ctactaaaaa tacaaaaatt agccgggcqt 35160 <br>gqtqgqqcat gcctqtaqtc ccaqctactc qgqaqqctga qqca.qqaqa.a. tcgcttgaac 35220 <br>ctqqqa.qqtq gaqgctgcaq tgagccaaga tcgccccact gcacaccagc ccggqtqaca 3!1280 <br>qtatttcatc tcaaaaaaaa ?????????? aaqaacacaa ttattqtact acttactaqc 35340 <br>cctcctctqt ccccaqctaa aaat aaqaac aqcaacaacc aaaaaatcct taqttatqta 35400 <br>ctqgaaatqa attaqataat tttcaataac ttacacqttt ttaqgatatg ttagtttqaa 35460 <br>aatqcaaata ttcatgcatg accccagtqt taatctatga tggagcagqt atagtqqgat 35520 <br>qctqtttcat gatttaattt ggaccttcag ggagtaqact qtgatgcctc tgcatttqta 35580 <br>tccaaqacaa ataattaaat aqtctatttt tqqctqqqca. tqatqcctca tqcctqcaqt 35640 <br>cccagcactt tqqqa.qqctq a.qqtqqqa.qq atcqcttgag gccaqqaqtt caagatcagt 35700 <br>ctqqqcaaca aaatqaqacc ttqtctctac aaaaactaca aaaaattaqc tqaacattqt 35760 <br>qqcttqtqcc cctaqtccca qctactcaqq tccctqaqtt aqqaqqattq cttqaqccca 35820 <br>qqa.qttqqa.q qttacaqtqa tctatatttq ccactqcact cca.qcctqqq tqa.ca.qa.qa.q 35880 <br><~.g<~.ccctqtc tcaaa<~.aata aaqtctgttt ttaaaatt<~.a ttttaaacac tqgaqtttat 35940 <br>tacaaaaagc aqttgqttct tttt ttaaat catttttttt taggagaacc accgcttttt 36000 <br>gqctacattq tctagaqtag caqtqttcaa taaaaataag atccaaqtca catatqtaat 36060 <br>qttaaqtttt cttttaqttt cttt ttcttt tcttttcttt tctcttcttt ctttctttct 36120 <br>ttcttttttt tttttttgat atgcagtctc actctgttgc ccaqgctqga qtqca.qtqqc 36180 <br>acqatctcqq cccactqcaa cctccqcctc ccqqqttcaa qcaattctcc tqcctcaqcc 36240 <br>tcccgaqtag ctgggactac agqcatqtgc caccataccc agctaatttt tqtattttta 36300 <br>qtagaqatgg agctttgcca tqtt ggccaq tctgqtctca aactcctgac ctcggqtgat 36360 <br>ccacatgctt tggcctccct aa.qtqctqqq attacaqgca tgaqccacca tqccctacca 36420 <br>atqttaaqtt ttctaqtagc catattaaaa gaaqtaaaaa qaaatggqtg aaqttaattt 36480 <br>taataatata ttttatttaa cccaatatat ctaaaatatt atcatttcaa catqaacaaq 36540 <br>atactttaca ttcttttqtt tttcactaag tcctcaaaat ccaqtqtqta ttttatattq 36600 <br>acaqcataqt tcaqtttqaa qcagccacat ttcaagtqct caqtaqccac atqtqqctaq 36660 <br>tqactccata ctqgactqtg taqqtttaqa qtttcaqtaa atttgtatqc aataqaatct 36720 <br>acataaattg gcatattatg cagatttctt tqtatgcaca tcaqttcttg catagcataa 36780 <br>qtc•gqtcat gatgctttta qtct atgagg cagiLtttttt tttttttttt tttgagiLcag 36840 <br>•qtctcactt gqtcacccag gctggaqtqt agatgcacaa tcttgqctca ctgcaacctc 36900 <br>catqtgaqgc agattttaac ttgqccctaa tqcaaatatt qtaaqaqaqa tctaatqgcc 36960 <br>tttqatttct tacagagggc aatcaataca tqccatgqtt acaatqcttc aqcatataqt 37020 <br>atgcacqtca. gccactgctt ttactctggc taqtqcttag tqtacctqta ccactgccca 37080 <br>qqcaqcattt qtcctqtqqc aqqtqaatct ta.qqqtqqaa. qqtqqca.a.qt aacattqctt 37140 <br>ttttttgaga gggaqtcttq ctqtattgcc cagqctqgag tgcaqtgqtq cgatctcggc 37200 <br>tcactacaac ctccacctcc cgqqttcaag tqattctcct gcctcaqcct cctgaqtagc 37260 <br>tgggattaca gacqgccacc accatgctcg gctaattttt qtatttttag tagaqacggg 37320 <br>qtttcactat qttqgccaqg ctgqtctcga actcctgacc tcgtgatcca cccqcctcgg 37380 <br>cctcccaaag ttctgqqatt acagqtgtga gccaccqtgc ccagcctaca tttttaaatt 37440 <br>aattaattat aagcaqqatc tcactgtqtt gqccagactg qtcttqaact qataagaqtt 37500 <br>caaqaccaqc ctaqqcaaca tqqtaaaacc ctqtctacta aaaaatacaa aaaaaaaaat 37560 <br>ta.qctqqqca. tqqtqqtqcq tqcctataat cccaqctact tqqqa.qqctq aqqcaqqaaa 37620 <br>atcqcttgaa cccqqqa.qa.c tqaaqttqca qtqa.qqtqa.q attqcaccac tgcactccag 37680 <br>cctaqqcqat tccatctcaa aaacaataac aacaaaataa cattqttgga atatttaqtt 37740 <br>aatttataga agcqtattgg cctaattggg qcaaa.tacct tattctgaca ttctctctat 37800 <br>ttgctttact gagctttttc accaqtggaa ttta.agccct tgatacatga ggagggaaaa 37860 <br>taccttqqa.q ctqtqctqca catqtaaaqt acacaqgaga tttagaaaac ttcgtaqcaa 37920 <br>aaaaaaqaqt gtaaaqtatc tcat taataq tttttqtqqg ctggacacqg tgqctcaagc 37980 <br>ctatactctt qqcacattqq qaqqctqaqa tqcatqaqtc taqqaqtttq aqaccaqcct 38040 <br>ggqcaacaca qtaqgacccc qtctctacaa aaataatcaq ccaqatqtgq tqcqcatctq 38100 <br>tagtcccaqt tacttqaqag qctqa.qqtqq qaggatcqtt tqaqctqqqa agttgaqqct 38160 <br>acaqtqaqct qtqattgaac cact gcactc caqcc:tgqqt qacaqaqtgc ctqtctccaa 38220 <br>aaaataaata aataaataat aatatqtttt qtatgttcat atqttgcaat aacattttgq 38280 <br>atatattaaa tgaaataaaa tacattaaaa ttaatttcac ctqtttcttt tcttttcttt 38340 <br>t:ttttttttt tttttgagat ggaqtctcgc tatqtcatca qgctqgaqtg caqtqqcacg 38400 <br>atctcqqctc actqcaacct cctcctcctg qqttc:aaqcq attcttctqc ctcaqcctcc 38460 <br>ctagtaqctq ggattaaagq catqtgccac cacacccagc taatttttgt atttttaqta 38520 <br>qaqacqqqqt ttcaccatat tqqccaqqa.t gqtctcgatc tcctgacctc atgatccqcc 38580 <br>tqccttqgcc tcccaaaqtt ctqggattac agqcqtgagc cactgcaccc aqcctctttt 38640 <br>aactttttaa qtatqqctac caqaaaattt aaaatgcatq tqtqgcctqt attctatttc 38700 <br>tqttqgatqc tqctqcctta qatt attaat tattcaatqt aaaqactgct gqqaqqtact 38760 <br>acctqcactt ccctqaatat atqcttqaga gctccaccaq ccqtcttcac agtaqcaaga 38820 <br>13 gggqtattct gagtctqtcc cccaaagagg gagggagaag tgcagccctc tcagqttctg 38880 <br>tcagaaaacc tgatcccagg ccaggcqtgg tagcttacgc ctgtaatccc agcactttgg 38940 <br>gaggttgagg caggaggatt gc t t aagccc aggaqttcga gaccagcctg ggcaacacag 39000 <br>tgaagaccct atctctacaa aaattttttt aaaaaaatta gccaggtgca gcaatgctgc 39060 <br>ctqtactccc aqctgcttgq qaqqctqaqq taqqaqgatt qcctqaqccc aqqaqttaqa 39120 <br>ggttgcagga qttagagqtt ccacqatcgc accttt catt ccgttacatt tgctgccttg 39180 <br>aqaacagaag acctgctgqt tttqttgcca gtttgctcag tcatttttat gaaaaagcca 39240 <br>gtgctaacta gqtgcttctt cqtgccttct ctgagaatca agaactctaq tatgtttgcg 39300 <br>tgtqttcagt ctctcattaa atqttctcac tatcccagag aaccatctca ttggaccttg 39360 <br>qtctqtacat accttcatct ttqqctctqa cttqtaatta tttttaqaac ttctcttttt 39420 <br>ttttttttqg agacagagtt ttgctctagt tgccagactg gaatgcagtg gcacgatctc 39480 <br>aqctcacctc aacctctqcc ttccaqqttc aaqcaattct cctqcctcaa cctcttqaqt 39540 <br>aqctqtaatt acaqqcatqt qccaccacqc ctqqct aatt ttqtqttttt aqtaqaqaca 39600 <br>gggtttctcc aagttggtca ggct gqtctc aaactcccga cctcagqtga tct gcccgcc 39660 <br>ttggcctccc aaagtgctgg gatt acaggc gtaagccact gcgcctggcc taattttaga 39720 <br>acttqttaaa acaacttggc ctct attgat atttccatga cccatgctat tcagaaagag 39780 <br>gattacagqt aattagctgg ctgqgtttct cataccagag catttcactg ggatgttcct 39840 <br>gaacctggga caacttttat gcct ggcatt tttctt tcct tctctqttqt cccagactaa 39900 <br>gcaattttta aaatagttat tatt tgttga qtaggagaat ctcaggcaga tcttcctgga 39960 <br>tcctcattta tacttttaaa cct qtaqtct tqqaat taqt qctctqtccc ?????????? 40020 <br>acatccaatt tctacatttt ggct acaqta cagqtt tact gtqtataact aaaagggctg 40080 <br>tggaggagaa agaaaggaac cgacatttgt tgggcatctg ttatgtgcca tgcactgagc 40140 <br>tqgatgctgt aggaatatct caat acctct qaggagtqgg aattattatc tctattttat 40200 <br>agacaaggga atagaaatct gggagttaag taatttttta atttcacaca cttctgqtag 40260 <br>ataatqgatt ctaqaacctg gcat aatagc cacttqtcat cccaqtqtaa aagaqatqtq 40320 <br>tggccagatg gggtggctca catatgtaat cccagcactt tgggaagccg aggcaggagg 40380 <br>atqacttqaq cccaqqaqtt caaqaccaqc ctqqqcatqt tttqtttqtc tcacqaaaca 40440 <br>ttttttaaa.a. aatgaqtqtg gcat gqtqtt qtqtgcctat aqtcccagct cctcgggagg 40500 <br>ctgaggtgqg aggatctctt gagcccatga tcatgccatt gcactctagc ctgggccaca 40560 <br>qaqcaaqact ctqtcttcaa aaaataataa aaaqqaqctg tqattatccc aaqqtqqqqa 40620 <br>ttgtgaatqt qtttgtattg ttct aaactg ggagaaacag gctggqtqtg ttggcttatg 40680 <br>cctqtaatct cagcactttg ggaggccaag gtgggaggat cacttgaqtc caggaqttca 40740 <br>aqgccaccct gggcaacagg caaaaaatag agaccccatc tctatttttt aaaaataaaa 40800 <br>taaact ggga gaaagaagca ggqtcctccc cagagcatct ttatccctag tcacagacct 40860 <br>qacacctqtq ttqgqcaatq qctacttcta qattqtttac ccctactqqq acttqtqqtq 40920 <br>aacatatgca cactttgqtt tacaqttggg acccct gatt ttagcagqat ggcccaatgg 40980 <br>aatcagctac agcaqcttqa cacacggtac ctggagcagc tccatcagct ctacagtgac 41040 <br>aqcttcccaa tgqagctgcq gcaqtttctg gccccttqga ttgagaqtca agattggtaa 41100 <br>qtccttctta aqtgactctc caaattgtta ggtttcaqtt tgaqtcaaga gacatgaact 41160 <br>cttaatqtca tgccttgctg ttccattaaa aaatqtatgg qtacagqtga tggggaaaat 41220 <br>gagatcagqa gataaagggg caccctttgg tcttqtaaag ccttttttat cttagaagqg 41280 <br>catqtqqqca actqtctttq acacattqaa accqcctqta tqqtqqtqqa tgtcttgaaq 41340 <br>qttqatttqq acctcattta cttqqqcaqa tcctct atat attctgataa tccaqtqat? 41400 <br>tgqtaqacat attttttctc tgaatqtgaa ttctqtcata gctagaactt tggqttgata 41460 <br>cttqtaattc ccctttaqtt aaaqqaaqqa qccacaqqqQ tqtattaqtc tqttctcaat 41520 <br>ttgctataaa gaaatacctg agactggqta atttat aaga aaagagqttt aatcggctca 41580 <br>tagttctgca ggctatatag gaagcatagc agcatctgct gctggggagg cctcagcaag 41640 <br>cttccaatca tggcggaagg cagagaggga gcaggcaqgt cacatggcca caqcaagagc 41700 <br>aagagagcaa qqqqqaqgtq ccacacactt ttaaactatc agatctcaca aga.actcact 41760 <br>qtctcqaqqa caqtatcaac aqqqatqqta ttaaaccatt catqagaaac ccacccccat 41820 <br>gatccaqtca ccttccacca ggccccacct caaacaqtgg gggttacatt tcagtatgag 41880 <br>atttgggcag ggatqtagat cca.aactaga tcacaggata agggaaqtag attccattca 41940 <br>tagagcagat aatggcacag atqtccagca actatt ttct tcactttaat atgctcaggc 42000 <br>tcactactga ttttgqttta a t tcaggcca qtqttaatat gacctggttt ttccagaatq 42060 <br>catactctga tttgqtgaag ggccaggagg tgattcacag atgttggaqa taqgccatcc 42 120 <br>cagcctqqga ttacttattt qtactaataa atctgaccag aqttaattqa ggqtttaaag 42180 <br>caaaacaqca tatctqtcta cttt qctcaa atattttaca aatacaacaq attatgagaq 42240 <br>tggqtaataa tatctggaat aatt qttttt ttgttt tgtg qttttttttt tttttttttt 42300 <br>qaqatqqaqt ctqqctqtaq cccaqqctqq aqtqcaqtqq tacaqtctcq qctcactqca 42360 <br>cctctgcctc ttggattcaa gcqattctcc cgcctcagcc tcccgaqtag ctgggattac 42420 <br>aggtgcccac caccacacct ggct aatttt ttattt ttag tagagacagc qtttcaccat 42480 <br>qttqgccagg ttqgtctqqa actcctgacc tcaggtqatc cqcctgcctc aqcctcccaa 42540 <br>aqtqctggqa ttacaggcat qagccaccat qcctggcctg gaataattqt taataattat 42600 <br>14 tacattgatg gcattttatt gctgagcaag aagaat ctaa catgatgaat ggqttatagc 42660 <br>atcaggtttg ctttqttttt ttqttttttt cctctt tctt gatgqtgatt tctqtqtttg 42720 <br>tgtgtatgcq tcqgcttcag aqccattctt tatcat tctt ccttttccta gggcatatgc 42780 <br>ggccagcaaa gaatcacatg ccactttgqt qtttcataat ctcctgggag agattgacca 42840 <br>qcaqtatagc cgcttcctgc aagaqtcgaa tqttctctat cagcacaatc tacqaagaat 42900 <br>caagcaqttt cttcagqtat gatgagaaac tgaggacaag gagaaacagg acccgcagag 42960 <br>tcqqqtqtta qtgttctttc ctqgaagcat ctcttttctc atttgqctaa qtaacgagaa 43020 <br>tctatcttqt attttcaatc acaggagaag taattagccc tttctcaaag ctctqtatac 43080 <br>ttacccqtqa gcatcattac ctgaqaatca cttctcttqt cacaqttqaa qtaataaaqt 43140 <br>gattqttatg ttaatcatac atqttagcat qttaacqcqc;J tccactgata qqaaqatqac 43200 <br>tctcactqtt acatqttaaa tqtt tgacca taatgggata cttcttgact aaqtcaqtag 43260 <br>cttccctqca aqaccaqqat aqtatactqt qtaaaqactc aqacaaqqcc aqqcatqqtq 43320 <br>qctcacqcct qtaatcccaa caccttagga qqttqaqqtc;J qqaqgattqc ttqaqcctgg 43380 <br>gagttttgag accagcttgg qcaacataac aagacaccat ctctacaqaa atttttttta 43440 <br>aaaactagct gattqtgqtg gcat gcacct qtaqtcccag ctactcaqaa qqctqaqqtq 43500 <br>aqaaaattqt ttqaqcctgq qaqqtcqaag ctqcaataag ccqtqattqc gccactgcac 43560 <br>tccagcctgg cggacagaqt gaqagccaqt ctcaaaaaaa aaaaaaaaag actcaggcta 43620 <br>atgtqccttc tgttacagaa ataqtaacga cctccccttc gccccccgcc qacagagagc 43680 <br>cttcacccaq gctctqaaqc cttt qttccg ttqttt ccta qaataaatqc tttccttgat 43740 <br>qaatacatta qttttaaqqt qccacaqttc aqtccacatc tccatqqtct qct qctqatt 43800 <br>tttattctct ttctctccta cttatagaqc agqtatcttg agaagccaat ggagattgcc 43860 <br>cggattqtgg cccgqtgcct gtgggaagaa tcacgccttc tacagactqc agccactgcq 43920 <br>gcccaqqtqa gacctgagac aaaacaaatc cctgqtctgg gaggaatgga aaatcaaaca 4398q <br>actttataat qagataaatt attagatcta ctaaaaaaga aggaaaaqaa attaaataga 44040 <br>tcaataat~ taaaaataca ttqaaaaact ctaaaaaaaa aqaaaqttcc ?????????? 44100 <br>atacattqaa aaactctaaa aaaaagaaag ttccaccaaa aqaatccaac agacccaatq 44160 <br>qtttaaaaqt tttqttttt;~t tctqacaaat tttctttt;~tt tttctttttt tttttttctt;~ 44220 <br>aqacaqaqtt ttgctcttqt tacccaqqct agaqtqcaat ggcgcgatct tggctcactg 44280 <br>caacctccac ctccaggqtt caaqtgattc tcctqcctca gcctcaaqaq tagctgggat 44340 <br>tataqqcqtq tgccaccaca cccaqctaat tttqtatttt taqtagagac gqgqtttctt 44400 <br>catqttgqtc aqgctqqtct cgaactcctg acctcagqtg atccgcccgc ctcagcctcc 44460 <br>cacaqtgctg gqattacagg cqtgaqccac tqtqcccqqc ctqttctqac aaactttcat 44520 <br>aqtacaqatt attccaatat catt caaact tttccaaaqt ataqqaaaac aaqgqatqtt 44580 <br>ttcagcttat tttatgaqgc tqgaaaaatc ctcatatcaa aacctaaaaa acagccagqt 44640 <br>qtaqtaqctc acqcctqtaa tcccagcact ttgqgaggct gagacgggca qattgcctga 44700 <br>gcctcagqaq ttcqagacca gctqqqgcaa tqtagcgaga cctcatctct cttttttttt 44760 <br>ttttttgaga cagagtctct ctctqtcqtc caqqct qgag tqcaqtqqtq ccatcttagc 44820 <br>tcactgcaac ctccgcctcc caqqttcaag cqattctctt qcctcagcct cccqactagc 44880 <br>tqggactaca qqtqtqtqcc accaaqcctq gctaat tttt tqtatttttt ttagtaqaqa 44940 <br>tgqgqtttca ccttgttagg caqqatgqtc ttgatctcct gacttcatga tccaccggcc 45000 <br>acaqcctccc aaaqtqctqq qatt atagqc atqagccacc acqcccaqcc tttttttttt 45060 <br>ttttgaqaca qagtcttgct ctqttqcca? qctqqaqtqc aqtgqcqtqa tctcaqctca 45120 <br>ctqcaacttc tgcctcccaq qttcaa?cta ttcccctqcc tcac;Jcctccc aaqtaqctgg 45180 <br>gactacaggc gcgcgccacc acacccagct aatttt ttqt qtttttaqta gagatgggqt 45240 <br>ttcactqtqt tagccaggat qqtctcgatc tcttgacctc qtgatccgcc cgcctcggcc 45300 <br>tcccaaaqtg ctgggattac aggcqtgagc aaccgcacct ggcttaatta aggatctttc 45360 <br>taa<~.caca<~.g aaaga<~.t<~.tt tatcag<~.<~.ac caa<~.gggagc atgatgcaca qtggtgaaac 45420 <br>actattct= qtaaaaacag caaaagataa qqatqtcttt taccattqat acttttctqa 45480 <br>gggatccagc ctatgcaaaa agaaaaagaa atgaggqtac aaatattgga aagcaaggga 45540 <br>caqaactctt attattt<~.ca q<~.tagat<~.gg tcttcctcga aqatccaaga qaaacaaaac 45600 <br>taacaataac aattggaact agcaagqttt aqa.aagqcca ttgtatacaa gataaatatt 45660 <br>tttaqaatct gcaqttcccc taat caqtag cagcaqtaac ctgttagaag atqtaatgaa 45720 <br>aqtaaaqatc t gggccaggc acqatgtctc acgcctqtaa tccaagcact ttgggaggcc 45780 <br>aagqtgggca. gatcatgagg tcaagaga.tt gagaccatcc tggccaacat qatgaaaccc 45840 <br>catctctact aaaaatacaa aaat tagctg gqtqtgqtgg tacgcgcctg taqtcccagc 45900 <br>tactcgggaa gctqqggcaq gagaatcgct tgaacctqgg aggcggagqt tgtaqtgaac 45960 <br>caaqattqcq ccactgcact cctgqgcqac agagcqaqac tccqactgaa ?????????? 46020 <br>aaaaaaaaaq aaagatctga ttcatagtag taaaactaaa tqtatgcaat ttgcatatac 46080 <br>tattgqtatg tatqgqaaaa tatctqqaaa cacatatact aaatcattaa aqtaqtcgqt 46140 <br>catagqagac ttttttactt tctqtgaggg qttttaccqt ctttaatatc ctataatcag 46200 <br>ggacattttt tctttttctc cqtgaccccc tgcttt ttaa aaaattqtgg tgaaatacac 46260 <br>ataacattac atttcaa.a.tt ta.cctttqta. accttt qttt tttttttttt tttttgagac 46320 <br>agtctcactc tgtcacccag gctggagtgc aqtgqtqtga tcacagctca ctgcagcctc 46380 <br>15 aaccacctgg gccctagcga tcct cctgcc tcagccttat gaqtagctgg gactacaggc 46440 <br>acatgccacc atgcccaqct aatttttttt tttttttttt ttgqtagaga tgggctcttg 46500 <br>ccatgtttcc caqgctgqtg ttgaactcct gggctcatca actgatgaga aagagctctc 46560 <br>caqgcaqaaa qaagatcatg ttcaaagaca qaaacaqaaa tqtqtattct tqqqaqaaqt 46620 <br>qtaqaaaqtt caqcatctqa ttqqqtcqqq qaaqacaaqc taqtcaaqqc cacatqatqt 46680 <br>tttaattaqt catgcctaac aqtggggccc tggaagagca qtttaccaca aggggccaac 46740 <br>tgcttcgqtt tgaacccgca gccctgccac ttgctctqta accttaaqta aacaattttt 46800 <br>actctctctg ttcctccaat gggaqtgata acaatacctt cttcatagaa ttaattcata 46860 <br>catqtaaaat qcttagaaca qtatctqaca cataaatqca aaataattta actgctttct 46920 <br>qctqctqctq acatcactat catcaccctc accattactq taqqaaatqq qqacccaqtq 46980 <br>aaqaattttt tttttttctt ttqagacaga qtctcactct qtcacccagg ccgqaqtgca 47040 <br>qtqacqcqat ttcqqcccac tqcaacctct qcctctcaqq ttcaaqcqat tctcatqtct 47100 <br>caqcttccca aqtaqctqqq attacaqqca tqaqccacca cactqqqcta attttttqta 47160 <br>tttttaqtqa gataggqttt caccatattg qccaqgctgg tctcaaactc ctgacctcag 47220 <br>qtgatccatc cacctcqqcc tcccaaagtq ctqggattac aggcataagc cactqtgtcc 47280 <br>ggccctagtg aggaatttta agcagaaaac tgatatgctc aggtgtgagc qaqqtqqtaq 47340 <br>qtaacactta ctgtgcaqtg ccctqtagcc caagagqtta gcacacaggc atttgctcaq 47400 <br>gcaqcactag gattttctgc tqtggaaaac ctttqtattt tatcctgctc cacaagataa 47460 <br>aaataaqtgq tttaaqtcaa tttggataga qqctccaact taccatgqqa qqtaggaaaq 47520 <br>ccaaaqttat cccaaqqatq tttt caatcq tacqqattaq qqqtctqcaa actqtqaqcq 47580 <br>tqgcccaaat ccaqcctgct gctt qttttt qtaaatgagg ttttttcqqa acccagccac 47640 <br>actcatttat ttatqcatta tctqtggctq ctttgqtgct qca.qtqqca.q ggctatttqt 47700 <br>ggcaqggact qtatgaccca ggaaaccaaa aatatttacc ctctgtccct tagagaaaaa 47760 <br>qtttgcaacc cctqatataa agct ataaqt tqqttatttg tggcctcaac ccaqqcctca 47820 <br>ctqctatttt ttctqtttac aatacctqqc atqctcttaa qtqtctaqaa ttqqttaaaq 47880 <br>atagaagaqt qgatqtaatc cctgctacca aggqctqtca ggctaqttgg gattataaqt 47940 <br>?????????? tcaaaqtqaq aaaaacacaq aaaaqqatqt qtQtcatttt qtctaaQQaa 48000 <br>qttqaataag atttctcaqq aaaaqaaaca tttqaactga atttgaagqt gaqtgagttc 48060 <br>aqgtgtqttt qqqctqaaqc ccaqqccatq ctqaqtqqat a.qcqqqtqqq aaqaqaqtqt 48120 <br>qqaaacacac tqcatqcaqq qaaqaqttqq qaqtctqqqiJ tqaccaaqqc acar;Jqqaqqq 48180 <br>aaaqttqaaq ttatcaattq tqtqaaacaq ctttctqtqt tggcctqaga tqtttataqc 48240 <br>tqqaaqcaqt qqqqagccaa tacaqttttt tacqaaqqta ttaqaqqtqq gtttctqtqg 48300 <br>qtqatcqtta atcatqtttt ctccctttaa qtqtaqtcct qcttqaqaaa taqacatqaq 48360 <br>aaagqaatqa agqttaaaac atcagctqta ttqttgqtaa aactagaatg gaaaqtqtgg 48420 <br>cttqagctqq taaccataqq qqct ttccaa tqcctqtqcc ctqaqttaqa tcttqqqqta 48480 <br>qaqaqactgq atqtqcagaq caqcaccccc ?????????? aqccatccat atqgaqcttc 48540 <br>agctgccata gaccaacaag qcaqagggat aqgcctctag acctqcttct aqaaaccagg 48600 <br>ctgctqctct tqcttatqqt gggccctaqq aaggcaagaq tqaqaqqaqq gaqqcaccaq 48660 <br>cttaqqtqct qgqttctttq aaqatctqtg tgtacacaqa qtctttctct ccatcttacc 48720 <br>aatcagatqa qtcactqtca ctqtgggaaq aaqtaqqgqc atqqqtcacc tt=caaaac 48780 <br>ttctaaqaaq tttqtattct qtqqqcttqq atagggacca tgqgaaaqqa agagaatqqt 48840 <br>tqcccataaa actqgctqta qtqtqqcctc aaacttctqq acttaaatqa tcctcccacc 48900 <br>tcaqcctccc aaqtagctaq aact acaqqt atatqccacc atqcccaqct aqttaaaaaa 48960 <br>aaattttttt ttttttttgq ttgagatgaq qtctctttct atgttccctq gg=gqtctc 49020 <br>aaactcccaq cctcaaqtQa tcct cctqcc ttgqtttccc aaaqtqctaq qattataqqt 49080 <br>gggagctacc atgcctaqcc caagcctqta attttttttt tttttttttg agatqgaqtt 49140 <br>tcacttttqt tqctcaggct gqaqtqcatg qcgcaqtctt qgctcaccac aacctccacc 49200 <br>tcccqqqttc aggcqattct cctt cctcag cctcccqaqt agctqqqatt acaqqcatqc 49260 <br>accaccaagc tcagctaact ttqtattttt agtagagatg gqtttctccq tgtcggtcag 49320 <br>qctgqtctca aactcctgac ctcaqqtaat ctqcccacct tqqcctccca aaqtqctqqq 49380 <br>attacaqgca tcaqccaccg cacctggcac qaacctqtaa tttttaaqtt tcatatgcta 49440 <br>tttatttttt qttatttctt taat tcattc attcatttat tcattcqaqa tqqggcctca 49500 <br>ctatqttgac tagqctaqtt ttgaactcct qgcctcaagc aqtcctccca cttcagcctt 49560 <br>cccaaqtgct gatattataq qtqtgagctg ctacatccag ccttctttct tctttttctt 49620 <br>tttccatqtg ctatttgaca t ttt ccaaqg taccagcctc cccttctccc caagataata 49680 <br>tcttttaata tggaatttca tccctagggc aggacttttt ttttattatc cctcagaaat 49740 <br>atactqqaca ccacqtttaa qtaqacatcc aacatctqct qtcataaatt qttttqaatt 49800 <br>ttttgacata cttgcccatg agqtttttga aggcat:agac catqtcttag ctgaacatgt 49860 <br>qqtctcttaq tqccataaaq qqqqtttatq qtatqacctq tqtaqtqtca cctqtqtaqt 49920 <br>gacagcacca. ctgcctctqt ttcccttcct cttqtgatgg cagcaqcqtc tcaagccaaa 49980 <br>caaqaaggqt aqttaggqtg ggat ggaagc tqgqtagagg tattcctctc cccataqttc 50040 <br>tqtgttcaca. tqtgcattga cctccttttt ggcagcaagg qqgccaggcc ?????????? 50100 <br>cagcagccqt gqtqacgqaq aagcagcaga tgctggagca qcaccttcaq gatgtccgqa 50160 <br>16 agagagtgca ggtgatgcaa gttacaagcc tcgggcaggg agctttcatt aatttttttt 50220 <br>tttttttttg agacagggtc ttgctctgcc actcagqctg ggctgcagtg gcatgatcac 50280 <br>aqctcactgc aqcctcgacc tctcaggccc aagcgatcct cctacctcat cctcccaaqt 50340 <br>agccgggacc acaggcatgc accaccacgc ccagctaatt ?????????? aatttqtaga !50400 <br>qatqqqqqtc tccctqtqtt qtccaqqctq atcatqaact cctqqqctca aqtqatcctc 50460 <br>ccaactcagc ctctcaaagt gctggcatta caggcgtgag ccactgcacc tggccaacag 50520 <br>ggagccttct cttggggata ctgcctgcag gtcctgcatg tatctttttt gaggttttgg 50580 <br>cttcatttga attctcctca gaaactttat attttctqtt cccaaggaaa tctttcttta 50640 <br>cttctgtttt tttgtttgct tattttaaac aggatctaga acagaaaatg aaaqtggtag 50700 <br>aqaatctcca <;~qat<;~acttt qatttcaact ataaaaccct caaqaqtcaa qqaqqcaaqt 50760 <br>gaatattaga gatqttaaaa tctctagaaa qtgagtttqt qttqttgaqt tgaaagactc 50820 <br>atttqtctta actctqttta qatcttaaqq cqqqcqqqqc qcaaqqqaqq tacqqqtcct 50880 <br>caaaqqaqcc tqqtcattaa qqacaqqaqt attccctcaq qtccaqqaqt attccctcaq 50940 <br>qtccaggaqt attccctcag qtcaaggaqt attccctcag qtcaaggaqt attccctcag 51000 <br>qtccaggaqt attccctcag qtccaggaqt attccctcag qtccaggaqt attccctcag 51060 <br>qtccaggagt attccctcag gtccaggagt attccctcag qtcaaggaqt attccctcag 51120 <br>qtccaggaqt attccctcag gtccaggaqt attccctcag qtccaggaqt attccctcag 51180 <br>qtccaggagt attccctcag qtccaggagt attccctcag qtcaaggagt attccctcag 51240 <br>qtccaqgagt attccctcag qtccaggagt attccctcag qtccaggagt attccctcag 51300 <br>qtcaaqqaqt attccctcao qtccaqqaqt attccctcaq qtccaqqaqt attccctcaq 51360 <br>qtccaggaqt attccctcag qtccaggagt attccctcag gtccaggaqt attccctcag 51420 <br>gtccaggagt attccctcag qtccaggaqt attccctcag qtccaggaqt attccctcag 51480 <br>gtcaaggaqt attccctcag qtccaggaqt attccctcag qtccaggaqt attccctca.g 51540 <br>qtccaggagt attccctcag qtcaaggaqt attccctcag gtcaaggaqt attccctcag 51600 <br>qtcaaqqaqt tttttcttcc ttcqcaqaca tqcaaqatct qaatqqaaac aaccaqtcaq 51660 <br>tgaccaggca gaagatgcag cagctggaac agatgctcac tgcgctggac cagatgcgga 51720 <br>qaqtaaqqqc ataqqtcqqa ccacttcccc catqtgtctc gctcacttgc gggatttcag 51780 <br>cqtcttgtgg cagaacttgc ttggtttcta agaagttcct gctctggaqt tgactaaaga 51840 <br>atgtgqttag agacaqtctg aggaaatqtt ttctgacttt qttttgqttt ccaaccagag 51900 <br>catcqtqa.qt qa.qctqqcqq qqcttttqtc aqcqa.tqqa.q tacqtqcaqa. aa.a.ctctca.c 51960 <br>qqa.cqaqqaq ctggctgact ggaagaggcg gcaacagatt gcctgcattg gaggcccgcc 52020 <br>caacatctgc ctagatcggc tagaaaactg gtaaaggatg aaagaagctt ttcctttctt 52080 <br>tctcgaaagc tagattgaat tctgatctta actgcaggcc cacagaattg gtactatatc 52140 <br>tccaacqtgg ggacttttcc atat tcaaat ttaqcccaag aattaaaqtt tttactttat 52200 <br>ttcqqccaqq cqctqtqqct cacacctqta atcccaqcac tttqqqaqac ca?atqqqc 52260 <br>ggatcacttg agqtcaggag tttgagacca gcctggccaa catggtgaaa acacatctct !52320 <br>actaaaaaca taaaaaaatt agccgggcgt qqtqqtqcqc acctgtaqtc ccaqctactc 52380 <br>tgggcggctg aggcaggaga atcacttgaa cctgggatat ggaagttgca qtqaqcqqaq 52440 <br>atcttactac cgcacaccaa ccaqcctggg agacagaqtg agactccatc tcaaaaaaat 52500 <br>aaaaataaaa taaagttttt actt tatttg gagaaacttt qttttaaaaa atqtatttat 52560 <br>attattatat tttaaqtata ttttacttaa taattcaatt aaggcttttg qtttaactqt 52620 <br>atttaacaqa ta<;~acaaacc tttt aatttt aqttatttta qtaatctaaa atqacacatq 52680 <br>ccctttttaa qq<;~aaaaaat tcaaatacaq aaaattaatc aaqaqaaqaa aaaattttta 52740 <br>aatgaaatca tcagcaqtac tagtagttaa aatttaqttg atgctcaatc tagacatctg !52800 <br>tcattatqta tatacacatt atqtatatac acataaaqat aqaaatttat acaqtttata 52860 <br>ttaggatcat ttttttttct tttt ttggag tcaggqtctc actqtgttac ccagtctaga 52920 <br>qtacagttat gcaqtcatgg ctcactggag ccttgacctc ctgggctcag gcagtcttcc 52980 <br>caccttagcc ttctcaqtag ctgggactac aggcatgcac caccacacct ggctaatttt 53040 <br>taaatttttt atagagacag gqtcttactt tqttqcctgg gctgqtctca aattcctggg 53100 <br>ctcaaqqqat catcccactt cqqcctctca aaaqctctqq aattataqat qt<;~aqctqcc 53160 <br>gtgcccagcc caggatcttc ctttatatgc ttttctgtaa tttgcacttt taccttcatc 53220 <br>cagcatatct tactgcaacc cttcctqtgc aaggccctat agtgagcatg ttgcaccagc 53280 <br>ttgccttagg agaaacttga gatacagagc ctgcactgga aatttagcgc aactctacat 53340 <br>gagaatgcct qtctattcat atcctcacta accctgaqtg ttqttaattt actgaaagca 53400 <br>qttttaaatg cttcctgacc agggaacgaa gaagcttaag ttctgggaat ggqaggatag 53460 <br>aagtgccaga aaagagctca ggaqttcaga aatccctgca gcgqtccccc tccctctcct 53520 <br>ttcactttct qtctttctqq tctt ttqqtc tttgtt acac taqtqataaa ccatcaaaqa 53580 <br>atgatggaat gatgctaact tctctctttt tttaat tttt ttgagacaga qtctcactct 53640 <br>gtcacccaqq ttaqaqtqca qtqqcatqat cttqqcttac tqcaacctcc tcctcccaqq 53700 <br>ttcaagcgat tcttaqtcac aaccttccaa qtagctggga ttacaggccc atgccaccat 53760 <br>gcctggctat ttttttqtat tttaqtagat cgacctgcct cggcctctca aatttttggg 53820 <br>attacagqtg tcagccactg cacctggcct aatatctcta ttcttggaga tagatttaat 53880 <br>gagctttttc tccctctcta ttcacttatt ccttqtgcat qttatcaata ttttgaaaca 53940 <br>17 taatqtcatg tcctttgatc agtt gaaggc tqaca.ttgaa aaggctta.tq qggattqgqt 54000 <br>qttqtggctc acgcctqtaa atcccaatgc tttgggaggc agagtcqgga ggatcacttq 54060 <br>aacccaggag tttgagacca gcct gggcaa caaagtgaga tcccatccct acaaaaattt 54120 <br>aaaaaa.ctag acatgtgcca ttacacttca gcctqggtga cagagtgaga ct=atctca ~4180 <br>aaaaactaaa ctaaactaaa caqqcatqqt qqcacacacc tataqttcta qctactcaqq 54240 <br>aagctgaggt aggaggatca ctcatgtcca gqagttggag gaggcaqtga qctatgatca 54300 <br>tgccattgca ctgcactagg ccacagagtg ggaccctqtc tcaaaaaaaa aaaaagaaag 54360 <br>aaagaaaaga aagggctcat gtagttcaag cccttctctt catgcaaggg gatgctaagg 54420 <br>cccatgatgg tgaagqgcct ggcaaagctt gcacagatag tgtgtgacag agctggctca 54480 <br>aacccatctt tqqqaqctqt ctaatctctt tttctqaqtc tttatqttca taqacaaqtt 54540 <br>aggatgagta aaqtaagtgc taaattccat atttcgtgtt ctgcatatct gggctcagat 54600 <br>qcttqtcatt ttccaqtqat aact ccatca atqcctccta qtqqtataaa ttttaatact 54660 <br>tcttqtqtqc ccaqccccct cttaqaaatt tqaqatttta qqaaqqqa.ct aqtaataaa.a 54720 <br>gqtaa.aataa attattttct ggccaggcat gqtggctcac acctqtaatq ccagtacttc 54780 <br>qqqa.gqtcqa. ggca.qa.tqqa tcacctqagg tcaggaqttc aaqaccaqcc tqgccaacaa 54840 <br>qqcaaa.atcc catctcta.ct aaaaatgcaa aaattatccq gqagtggtqq tgggtgcctq 54900 <br>taatcccagc tacttqqqag gctgaggcag qagaatcact tqaacttqqq aggcqqagqt 54960 <br>tqcaqtqagc tqagactqtg ccactqcact cca.gcctgqg caacaga.qta agactctatc 55020 <br>tcaaaaaaaa ?????????? aaaaaggcca gqcqca.gtqq cttacacctg taatctctca 55080 <br>qqaqqctcaq qcaqqaqaat cact tqaacc cqqqaaatqq aqqttqcaqt qaqccqaqat 55140 <br>tgcaccactg cactccaqct caaaaaataa ataaataaat aaattatttt ctttttttat 55200 <br>ttattttttc aqcatccacc caacatqqtq aaaaattcct cttttctta.a tgtcactqa.a 55260 <br>ctgtaaactt aaqatqaaaa. a.ttqta.a.att tca.tqctata ta.tatttca.c caca.ataaaa 55320 <br>aaattccttg ttctta.ttqt a.qtqqtctcc atqtcttcag ta.tttccttc cccttctcca. 55380 <br>tctcacctqt atacattcac tttqqtaatt aqcatctttc ttaatttatt qqcaqqataa 55440 <br>cqtcattagc agaatctcaa cttcagaccc qtcaacaaat taagaaactg gaggagttgc 55500 <br>aqcaaaa.a.qt ttccta.caaa. qqqqa.cccca ttqtacaqca ccqqccqatq ctqqaqqaqa 55560 <br>gaatcqtgga gctqtttaqa aact taatga aaagqtaatt tagcatcctt qtccctttcc 55620 <br>ctcatctaaa aaatacctaa. agactcacqt ggtaqagtga qaqqcqqqct gacttctqgt 55680 <br>ca.tqqccqtq qcqcqtqa.qc cca.t cttctc tttcctca.qt qcctttqtqq tqqa.qcqqca. 55740 <br>qccctqca.tq cccatgca.tc ctgaccqqcc cctcgtca.tc aaqaccqqcq tccaqttca.c 55800 <br>tactaaaqtc aggtaggcca tgccacttcc atttccagta gaqattttac tgagggacac 55860 <br>tqttaqqqtg aggqtagaqt tqgtqqccag qqtcattctt tccaggtgtq qtqtcacagg 55920 <br>ca.gtacactg ttgcqqqgtt gaaatttgtt qccatactat ctgcttgctc tctgattctg 55980 <br>atqtcaaaaq caaaaqaqca qtcatctttt tqaaqqtacc tqqqcatatt cctatqattq 56040 <br>tagacctgga gtctcagqcc acagcttctc cttctqccca aqqqaca.aaa taatqtca.tc ~6100 <br>tattttctgt tctttgaqgc tact cttccc tqtgqatttt aaggqaaaqa gtaaggctta 56160 <br>qtga.tggqg& agctga.gaqq ccccaqqgca gqtgqqtggt qqqcctgta.q ggtqa.ggtqt 56220 <br>tactttcaca ctcaaqtcag aacaggtqtg ctgqqqtttt gaccttctgc agcaaaattt 56280 <br>ccctcctcag aaacttaqta tggtqttcgg tttcaqqatt aataqaacaa aatgccagct 56340 <br>qcacaqcatg tqttcctqta atat ttttca ttatatqqct ttqattatcc ttttqtgaat 56400 <br>ctctcacaac tttaaqttgt taqttcttaq atqttt tctc aqtacctttq qcttqaaqqa 56460 <br>qtqatactca tcttttqttt ttqtttqaqa caqqqtctca ctctcaccca qqctqgtqtq 56520 <br>caqtggcatq atctcaqctc actgcaacct ccatctccca qqttcaaqtq attcttqtqc ~6~80 <br>ctcaqcctcc tqaqtaactq qqaataqaqq tqcqtqccac cacacccqqc taattttttt 56640 <br>ttttttqaga caqaqtctcg ctct ttcggc caggccaqag tqcgtqttqc aatctcaact 56700 <br>cactgcaacc tccacctccc aggttcaagc gattctcctg ccttaqcctc cctgagtagc 56760 <br>tggaccggca cactcca.cca tgcccqqcta atttttgtat ttttagta.qa ga.caqggttt 56820 <br>ctccatgttg gccaggctgg tctcaaaact cctgacctca gtaatccacc caccccggcc 56880 <br>tccaaaaqtq ctqqqattac aqat qtqaqc caccacqctc qqcctttttt tttttttttt 56940 <br>tttttttqaq atqqagtctt tctctatcac ccaggctaga qtqctgaqqt qtgatctcqq 57000 <br>atcactqcaq cctctqcctc ctggqttcaa gtgattctcc tgcctcagcc tcccaaqtag 57060 <br>ctgggattac agqtacctgc caccatgccc ggctgatttt tqtattttta qtagagacgg 57120 <br>ggtttcacca tcttggccag gctgqtctcg aactcctgao cttgtgatoo acctgccttg 57180 <br>goctcccaaa gtgctgggat tacaggtgtg aqtcaccgca ccoagcocta ttttaatttt 57240 <br>tttaaagaga gagatagggg ccaggcacgg tggctctcgc ctqtaatccc agcactttgg 57300 <br>qaqqccaaqq tqqgtqqatc acct qaqgtc qqqaqttcqa qaccatcctq accaacatqq 57360 <br>agaaactctg tctctactaa aaat acaaaa ttagct gagc qtggtggcgc gcgcctqtaa 57420 <br>tcccaqctac ttqaqaqqot qa.qqcaqqaq aatcacttqa acccaggaqg cqqaqqttqc 57480 <br>qqtgaacgga gattgcgcca ttgcactcca qcctggqtaa cgagagaaac tqtctcaaaa 57540 <br>aaaaaaaaag agaaagagag atagqatctc gctctqtcat ctagqctaga qtgcagtggc 57600 <br>atgatcatag atcactgtag cctt gaactc ctgggcacaa qtgatcctct tgcctcagcc 57660 <br>tcccgagtaa ctgcgactac aggtacatgc taccacaccc cgctaatttt taaatttttt 57720 <br>18 atagatqtgg gctctcactt t qtt gcccag actqttatgg aactcctggg ctcaagggat 57780 <br>cctcccagct tggcctccca caqtgctgag attatagatg tgagcctqta attatagaca 57840 <br>qcttqqccta tttacctgtt qqaaatgaag aattatgaat tttacatttc ttcaagaaaa 57900 <br>ggttatggga gagttactga cttt ttttcc ttggattttt tctttttaaa taggttgctg 57960 <br>qtcaaattcc ctqaqttqaa ttat caqctt aaaatt aaa9 tqtc;Jcattga caaqtaaqta 58020 <br>ctcctatctt agctctqttt ttcaaatgag gaatagaaaa atgagaactt tgacagacat 58080 <br>catttgaact agagactctg tctt tattca gagatcttca ttttgtggac aaaaqttttc 58140 <br>aaaagccttg gggtgcattg tcat ttacqt qtctgaacaa agccacaaag ctggggqtac 58200 <br>agatttgatt tqtggttgct attqtgacaa ccagtccctc ttttccttgt ttagtttttt 58260 <br>acttqtacat qtcattcatq catattatat ataac;Jactqa gatcatqtqt taattaacga 58320 <br>ctgggatacg ttctgcaaaa tgtatcatta ggcaat tttg ttqtgcaaat gttgtagagt 58380 <br>atataqtcct tacacaaacc tqqqtqqcaq aacctactqc acacctacqc tatotoocaq 58440 <br>aqcctactqq tcqtaqqct9 taaacctqta caqtat qtta ctqtqctc;Jaa taccqtaqqc 58500 <br>aattqtaaca catctcaatg aagtaggaat ttttcagctc catgataatc ttatgggacc 58560 <br>accatcatat atgcattttg ttqttgaccg aaacqtcqtt atatattctt tccatacata 58620 <br>gcatqtggaa agaatagatc tctttttttt aattqttcca cactttacca tataatggaa 58680 <br>tacgcaaaat ttcacaatac cttt caggat qtaaaataca tatacccttt gacqacatta 58740 <br>gaaaagagaa aatqtgqgcc gggcgcgqtg gctc at gcct qtaatcccag cactttggga 58800 <br>ggccgaggcg gqcggatcac qagqtcagga qatcqagacc atcctqgqta acacggtgaa 58860 <br>accccqtctc tactaaaaat ?????????? taqctqqqcQ tqqtqqcqqq cacctqtaqt 58920 <br>cccagctact caggaqgctg agqcaggaga atqgcatgaa cctgggagqt ggaqtttgca 58980 <br>gtgagccaag atcacaccac tgcactccag cctgggcgac agagactcca tctcaaaaaa 59040 <br>aaaaaaaaag aaaagaaaag agaaaatgtg qctqqqcqcq gtggctcacg cctgtaatct 59100 <br>caqcactttg ggaggctgag qtgggcagat cacctgagqt cgagaqttcg aaaccagccc 59160 <br>gaccaacatq qaqaaacctt qtct ctacta aaaatacaaa attac;Jccaqq tqtqttqqcq 59220 <br>catgcccqta atcccagcta cacgggaggc tgaggcagga gaatcacttg aactcaggag 59280 <br>qtqqaqqttq tqqtqaqccq aqat cacacc attqcactcc aqcctqqqca acaaqaqcqa 59340 <br>aactatctca ?????????? aagaaaaaag aaaagataaa atgcattctt atttttaqtt 59400 <br>gatqtaatta tqtggaaatt tcat gaggat gcactggaaa ataatgaaat aagggagttg 59460 <br>acqaaqqtqq taqqtttaat aaqtacatat qcaatatqaa acataqqttc cccttcctat 59520 <br>ggggaggcaa ccaactgtgc ctgctacgca gaqqtgttat gttqcgctqa tcaactgtaa 59580 <br>ctgaataqtt taaagaaatg cccaggagca cagagqtttt ttcatgacag taaataacag 59640 <br>qtgqtcaaag taggcttttt gaagaaacac agagcctatt ttattaacaa caqtctqtqt 59700 <br>tcttacagag actctqqgga cqtt gcagct ctcagagqgt aaqttcagcc taqaqqcttc 59760 <br>cttttqttcc qtttaaccta actt catcct ccqqctactt gqtcacctac ataqttgatt 59820 <br>qttcccctqt gattcaqatc ccqgaaattt aacattctqg gcacaaacac aaaaqtqatg 59880 <br>aacatqqaag aatccaacaa cggcagcctc tctgcagaat tcaaacactt ggtatgtggg 59940 <br>agqagctccc cttcacaaag qgcctctqgc tgccggagaq ggctagggag agcctcacag 60000 <br>gacacctgcc tttttctttt cttacagacc ctgagggagc agagatgtgg gaatgggggc 60060 <br>cgagccaatt qtgatqtaag tttt qttggg gatgaaagac aactgggqtg ttttccttga 60120 <br>gggagagaqg gqtaaagatc cttcttaatc cccagaatta gaaacatcaa cctgttcttt 60180 <br>caqctqtaqt tattccaaaa aqtcacttca qqccaaaqtc;J acatqaacaq aaqttccatq 60240 <br>tqccatqqaq ctctctqqct tqqaacattt ccqtqaatat ctqqqaqttq qctcctcctt 60300 <br>aaggagaaqt ggaaaqtccc ttgctgaqtt qttctccaca cccatqtgqt ataaagcagc 60360 <br>tttccacctt IJCCtqqqqct ttccaaattc cccatccaqc tcctqcqqct qaccctqctt 60420 <br>ggctccattt ttaqtgccct qtttttctct cccact gagg tgggatagag gqtgtaaaag 60480 <br>caacagattt gaqttaaact ttaaaataaa tgaccacctt gcattagctt gcttaggaaa 60540 <br>agaqtacata aaataaaatg ?????????? aacccatctt qttctttatc ccccttattt 60600 <br>tctgcttttc attgattcag attattggat tcttattqtc aagaataaac tttaaacaaa 60660 <br>?????????? aaqqtaaatq tq&cq'>J&&qq ctaqtt ttca qtcattttta aaaattqtqa 60720 <br>tgccccqttc tttttcttac attt qtcccc tgaacaattc ttcctcttta aaatqtagca 60780 <br>qtcctagctq qqcqtgctgg ctcacacccc qtactttgqg atgccaaqqc aggctgqtca 60840 <br>cttgagqtca ggaqttcaag accagcctgg ccaacatgqt gaaagcccqt ctctactaaa 60900 <br>gatacaaaaa ttagctgggt qtqqtqqtqc acqcctqtag tcccaqttac tggggaggct 60960 <br>gagqcatqaq aatcgcttga acct gaqagg tggagcttqc agtgagccaa gattttgcca 61020 <br>ctgcactcta gcctgggcaa cagaqtgaaa ctctqtctca aaaaaataaa taaaataaaa 61080 <br>tqtaqcaqtc ctttttaaaa atqtc;Jc;Jaatt ttacttc;Jaca qtaqaqtqaa qtac;Jcctqta 61140 <br>tgcaatgata tgggaaaatg tacatgacat attaagaaaa agcaaaatgt aaaataatt t 61200 <br>qaataqtatt attaqtatat qtqttttaaa aatacactat actcttatqt qtattcatat 61260 <br>qtatattaag aaattctgga ggaatatacc agcaqtgcta tqtqtattag tgctgctqtt 61320 <br>ggtatccatg gctattctag actqtctctg tgatat ttgc attttaaact gaatatatta 61380 <br>cttttataat cagaaaaata qtat taaaaa tgaatt ataa tttaatttct tttttctttt 61440 <br>ttttttttqa gtcggaqtct cgtt ctatcg gattgcaqtg qtgcgatctc agctcactgc 61500 <br>19 aacctctgcc tcctaggttc aagcgattct cctgtctcag cctcccaagt agctgggacg 61560 <br>ataggtgcat gccaccacgc ctggctaatt tttgcatttt tagtagagac agggtttcac 61620 <br>catattggtc aggctggtct tgaactcctg acctcgtgat ccacccatct cggcctccga 61680 <br>aagtgctgqg attacaggca tgaqccgctg tgcccagact agaattcaat ttttgagaat 61740 <br>tcattqacaa ctcttactta aaat aaqqtt qctqtactqa tqtqaqacat tqttgtaqtc 61800 <br>aqtttggaaa acaatttggc agtataaaaa tgaacatacc tqtaaaccaa cggtgccatt 61860 <br>cccaggattt aatagcagag aaat ctttgc atatatgtcc caggagacat atataaaqtg 61920 <br>gacatcagcc tgattataag ctct aaatgc aacccaaata aatacccatc aacattagaa 61980 <br>tgaatacatt atttgtgqta tagacacaat ggaatactcc gcagctgtga aaaqgaatac 62040 <br>actqcaqata cacataacca tqtqqattca tttcacatca aqtqaaaaqt qaatcccaaa 62100 <br>agaattcatt ggagtccata agtgtaaggt tcacaaatgt cccaaactaa acaatacctg 62160 <br>cattgcttaq ataaacaaat atgqtaaaac tqtaaaaaaa ?????????? caaqacaaaa 62220 <br>aqqqctaqqa aatqataaac ccaaaaqaca aaataqcaqt tatttctqaq qqaqqaqqqa 62280 <br>agggga.tggg gttgggga.ag ggcacccaga gaattt tagg agtgatgga.c ttttccttaa 62340 <br>attgaatgqt gggttcatat tgtt ttgtta ttctttgtgc cttacqtatt ttacaaataa 62400 <br>ccaattggat ctatgtaata ttat aataca aactgagtaa aggattaggt tgaggatcac 62460 <br>agcattggaa gttcttggtg ttgaagagag taaqtgccga gcaagttqtg tc=tggcag 62520 <br>tttgtttgtg accacctggt ggct taccct tcttggtqtg gtgaggcttg gcatgtcact 62580 <br>ttccttggct gtggctgtta qtactgaatg ccattctctc tgaggaaaag tgtccttctc 62640 <br>tttttta.ttq attqactgat tgat tqaqac aqaqtctcac tctqtca.ccc aqqctqqaqt 62700 <br>gcagtqqcgt gatctcqgct cact gcatcc tctgcctcct gggttcaagc gattctcctg 62760 <br>cctcagcctc ctgagtagct gggactacag gcgcccacta ccacacccag ctaatttttg 62820 <br>tattcttaqt agaaacgggg tttcaccaaa ttattggcca ggctgqtctc gaactcctga 62880 <br>ccatqtgatc cacctqcctc ggcctcccaa aatgctgqga ttgtaggtqt gagccatcac 62940 <br>qctcagcctt tttttttatt taat ttaatt tttttttaag acaggqtctc actctqtcac 63000 <br>cccagctaga gtgcagtggc acaatcatag ctcgctgcag cctccatctc ctaggctcaa 63060 <br>qccatcctcc cacctcaqcc tctcqaqtaq ctqqqqctat aqqtqtqcac ?????????? 63120 <br>agctaatttt tgtatttttt gcagagatgg agttttgctg tgctgcttag actggtctcg 63180 <br>aactcctgqg ctcaggcaat cctcctgcct tggcctccca aagtgctggg attacaggca 63240 <br>tqaqccace<l cacctqqcct="" aaqaqtqtcc="" ttctcqttac="" tqtaqqcttc="" cctqattqtq="" 63300="" <br=""></l>actgaggagc tgcacctgat cacctttgag accgaggtqt atcaccaagg cctcaagatt 63360 <br>gacctagagg taaqttctgc agcagaatcg gtga.gaggct acqtacaggg gtgactcagg 63420 <br>acaaaaactt ccactgggat tttt acaaga gaaqqtqgaa tgattactqt ttgcttaaca 63480 <br>ctqtgtttat ttttgcttac tttt ctccaa aaaaat cctt ggcatcccat ctggcaataa 63540 <br>aqtcttqctt qaatqcttaq aagatqtqtq tatattcagc tttcagcaaa cttqatatqa 63600 <br>aaatctctat ttaqaaattg attggccggg cgcgqtqgct cacgcctgta atcccagcac 63660 <br>tttgggaggc tgaqgcgqqt ggat cacqaq qtcaqgagtt cqagaccaqc ctgqccaaca 63720 <br>tqacgaaacc ccqtctctac taaaatacaa aaattagctq gqtatgqtgg cggacgccta 63780 <br>taatcccagc tactcgggag gctgaqgcaq gaqaatcact tgaacctgqg aggcaqaggt 63840 <br>tgcagtgagc tqaqattqtg ccat tgcact ccagcctqgg tgacagagtg agactccqtc 63900 <br>tcaaaaaaaa aaaaaagaaa ttaqaactga ctttataaag tttgggcata agaqtcttag 63960 <br>caqccaqtqt qtttaqtata caqaaaattq tggcaatqac attctccttt cccaactttc 64020 <br>ttqattttta aattaaqata tacctaqaaa aqcaqqaatc ctqqtctttq attcctqaqa 64080 <br>cctccctgtt tcatgtgaag atacagcttc aagtcttqga gaatgcctcc aaggtcttaa 64140 <br>aaatqqqqaa tctqtqqatt qtqaqtcaaq ctttqaqcaa qtcaqqtttt acaaqqqacc 64200 <br>gqta.tattcc gactgcagcc tgagttgtgt ggccacgctg ggcattcttt ccactatgag 64260 <br>tgctcactga qctqactcac tcacactcct cgcctaqaqt tqqcagcaqq tgtggtttat 64320 <br>qgcatgtcct ttcattctga gccccgtgag atgcgggtqa aqagatttcc aaqgctqtqa 64360 <br>gagcccctct gcctccccag ctcagtcccc actccctccg cagacccact ccttgccaqt 64440 <br>tqtqqtqatc tccaacatct qtcaqatqcc aaatqcctqq qcqtccatcc tqtqqtacaa 64500 <br>catgctgacc aacaatccca agqttaqtgc cccctccttt tagttgqtgc cccgggatct 64560 <br>cttgcgactt agqqqtacct agtatagaca atgagcacca tccctcatct aaacaaqcaa 64620 <br>atgtgttctt tccaatagaa tgtaaacttt tttaccaagc ccccaattgg aacctgqgat 64680 <br>caaqtqqccg aggtcctqag ctggcagttc tcctccacca ccaaqcqaqg actgagcatc 64740 <br>qagcaqctga ctacactqgc agagaaactc ttgggtccgc atttcacccc ttctccctcc 64800 <br>cqcccacccg cccagaaaag ggat ccggcc catagggctg ttcatttggg ccatgtctac 64860 <br>tqaqcattaq qccatqtttc tttcctqaqc aaqqcqctqt qctqqtqcca qqaaacaqqq 64920 <br>qagttgqgga gttqgggtgc agagacagtt tqcagttttc agtcgaggtg atcatttttg 64980 <br>aqqtqqqaqq taqatttctt ttct cctqqt tqctqtctca ttcacccact ctatctaact 65040 <br>ttagaagatc ttttaagtqt gtgttggaaq qtggcactaa aqqcttqaca ttccctqtcc 65100 <br>atttttttaa taaactatag gctaqttgqt tttttttqtc ttattttatt tatttattta 65160 <br>tttttttgag acgaqtcttg ctct qttgcc caggctggag tgcaqtaqtg tgatctcggc 65220 <br>tcactgcaac ctccgccttc tggqttcaag cgattcttct gcctcggcct cccgagtagc 65280 <br>20 tgagactaca gqtgctcacc accacgccca gctaattttt qtatttttag tagagacggg 65340 <br>qttttaccat qttggccagg ataqtctccg tctcttcacc tcqtgatccg cccacctcgg 65400 <br>cctcctaaag tgctgggatt acaqgcttga gccactqtqc ccaqcqtaqq ctagttttta 65460 <br>aaaaagaatt aqtggaatat tttatqtgcc acctgggcta gaaqtagctt tgttctaata 65520 <br>aaqctqttqc caccaaatac acct qtctqa cacccqatqt caqcttqtta qtqaqtqctq 65580 <br>ctqttgqttc ccagcctacc acccqagqtt gggaagagca qqqqqacttq ttatatcacc 65640 <br>ctccatccct gctgggctac ccaqcaacac aaqtgaqtca aatgatggga taqtqtttqt 65700 <br>cctcatqtgc ?????????? caqtqcctac cttcaaagat qtqaaagctq attattttqt 65760 <br>gqcccattqt qqqatgaatg tgtqtgtqtt ctgttttaaq aaataacctc ttgaccccaa 65820 <br>qctqaa11.atq tactacttqa ctct ttttct ttccttcaqq acctqqtqtq aattattc11.q 65880 <br>qqtqtcaqat cacatgqgct aaat tttqca aaqtaagcaa tcttqttaaa ttctcqtqqq 65940 <br>aatqqqaatq ctcacctqca cqqctqtcqt tqaqqqctct qqcttqaaqq ccctqaactc 66000 <br>ttqqtccaqc qqccaqtaqq acct qcctqa aqqtaqacqq qcctqaqqat ttqqqtqatq 66060 <br>cactgcac= ctaggaaggg aaqqqctggg atggcaqtag acttggcttt cccattactc 66120 <br>ttttctccag gaaaacatgg ctggcaaggq cttctccttc tqgqtctqgc tgqacaatat 66180 <br>tqtgcacaga tqtaaccaag tcccctqctc tcagcaaqcc aqtqqcaqqq gatqqatgcc 66300 <br>ctqttaqcaa taacaacatt qttcctcctc cttqgctcca gqtacatcat gggctttatc 66360 <br>aqtaaqgagc gggagcgggc catcttqaqc actaagcctc caggcacctt cctgctaaga 66420 <br>ttcaqtqaaa qcaqcaaaqa aqqaqqcqtc actttcactt qqqtqqa.qaa qqacatca.qc 66480 <br>gqtaagggag gctccca.ccc accccacctg ctqqtggctg ctgaggcctc atcactgctt 66540 <br>ctaqttgcaa gcacctactq ccccctgqtg gqtqgagatq qccttgactc cctqtttcac 66600 <br>tcagactcgc aaaacacatt tgcqtgactt ctaaatcctt ccagctgaaq gattgqtttg 66660 <br>ctttqttttg cttgctccag tgactatttg ttgagaattt tqcaatttaa attgtattct 66720 <br>tcatctcttt ttctacttaa ccct qttaat atatcttac<j caaqtaqtta="" tattcaaqtt="" 66780="" <br=""></j>tattttctat gacccaacta qtagcctctt cttaat taga agccagcctg aatatttcca 66840 <br>caqtgccagg ccactgaaca ggqtqttcag qqtctcaaca ctaggqtggc ttaaqtcttt 66900 <br>tccccttcga gqaaagaaaa aatqgqcaqt tttctctqag atgacctagc tgtaggttcc 66960 <br>atgatctttc cttcccatqt cctqtgacaq qtaaqaccca qatccaqtcc qtgqaaccat 67020 <br>acacaaaqca. qcaqctqaac aa.catqtcat ttqctqa.aat catca.tqqqc tataaqatca 67080 <br>tqqatgctac ca.atatcctg qtqtctccac tgqtctatct ctatcctqac attcccaagg 67140 <br>aggaggcatt cqqaaaqtat tqtcqgccag agagccagqa qcatcctgaa gctqacccag 67200 <br>qtaqttqttq attttccatg ttcctggcat ttaatttttq ggaaaaqttg gaaattttgg 67260 <br>gatccttqqa qgatagataq qcaaatgcct gaataacctq ggggataatt atttctcctt 67320 <br>atqqqaaaqa attqtaqtqa qtqcttttqt tqqqqtqacc qatQqqattt Qaqaqqaqaa 67380 <br>tcaqaatcac ttagaqtaqt qtaqttcctq ctccacagag aqtqcatgag tctaaagaqg 67440 <br>gqatacagcc tgqgcaatat gqtgaaacct cqtctctaca aaaaatccaa aaaaattacc 67500 <br>cqqtqtqqtq qcacqcattt qtaqtcqtaq ctacttgqqa qqctqaqqtq gqaqgatcac 67560 <br>ctgagccaaq gagttcaagg ctqtaqtgag cgqtqatcat qccaccgcac tccaqcctgg 67620 <br>ctgatagaqt gagatactqt qtcaaaaaat aaaaataaag aggggatcaa tacacatacg 67680 <br>tcccccaaaa catgcctgaa acacqagaag qgaaaqtgag ggcaqttaac agqatqccct 67740 <br>qct<;J<;JC&caq tqcttcttaq taqatqct11.q aa<;~Qttt<;~a<;~ <;~cccaqattt caqCCC/l<;IC/1 67800 <br>ti!.t<;I<;ICtttt tqcctqtii.II.C tq!l4ccatqt ca<;~tqtqcca qat<;~qtct<;~a 11.<;1114&<;1\lqtt 67860 <br>tctggaggaa attattatta gctgcatggq aqtatqqttt acactaqaqt agaagagctq 67920 <br>qqaqcatcac qttt<;~aaqqq qaaqacaqtq actqqqtqqa qqqqcaaqqq attaqtattt 67980 <br>agaqtqtqca actattgaaa ataaqqtata ttttaatqtg taagaggaca tqtacttata 68040 <br>tqttatatat aaZittatttt agct gggtqa aqtgqctcat gcctataqtc ctagcacttt 68100 <br>qqgaggccca ggcqqqaqqa tcacttqagc ctggqaqttt gaqaacaqcc taqacaacat 68160 <br>aqtqaqaccc tZitctataca aaaataattt tttttaaatt aqccacqtqt gqtqqtttqt 68220 <br>qcctqtaqtc ctZiqctactc QQ'\l&\lQCtqil. qqtQ9911.9911. ttqctta11.qc CCII.<;IQ&qqtt 68280 <br>qaggctgcag tqaqccatga tcgcaccact qcactccaqc ctqqqtqaca qagcaaqacc 68340 <br>ttqactcacc ?????????? ?????????? qagagaqaaa ttaaaaatac tqtaatctca 68400 <br>qctqqqcatq qqqqttcaca cctgcaqtcc tagcactttq qqaqqctqa.a. qcaqqaqqat 68460 <br>cacttqaqgc caqqaactca agaccagcct gqcaacatag caaqacccca ctacacacac 68520 <br>?????????? acZicacaaaq aaqagaaaga aaaaaacgaa acaZiaactqt aatctctgca 68580 <br>qctqtcctca qtqtqqa.qqq qqtaqccctq tctqttcccc ttcaqcactt gctqttttqa 68640 <br>ctctctqqqt tctttqtqca qqtcttqat<;~ qqqaqtctct qqtttqccat tctttqtttq 68700 <br>atttaacttt ctqtaatcat aaaqccaatg atqqqctttt tttttttttt tttttttaga 68760 <br>ctaaqtcttq ctctatcacc caaqctqqaq tqcaqtqqca ccatctcqqc tcactqcaac 68820 <br>ctccacctcc cqqttcaagc aatt ctcctg cctcaqcctc ccqaqtagct gggattatgg 68880 <br>gcttqtqcca ccatqcccag ctgatttttg tatttt ttqt agaqaaaqgg tttcgccatg 68940 <br>ttqgccaggc tggcctcqaa ctcctgacct cagqtqatct gcccacttca gcctcccaaa 69000 <br>qtgctqgqat tacaqqcqtq agccactqtg cctgqcctaa tgatqggctc tttaatqtqa 69060 <br>21 tccttta.ggg ttggcgcctt gccctagttg ctgttga.a.aa. a.a.cta.ttttt gtccaaa.ta.g 69120 <br>?????????? gaaacctacc aact tccctc ccactttttc ctaggaattc cttctgaggg 69180 <br>atttcttgag atggggcaga atggggcttg gaagagggag ttggagctaa ttgaccgttg 69240 <br>cctttctcct ttgttggggt cctgagtctt gttcctgctg taagagttac tcacttcctg 69300 <br>tctqccacct atctcccttt qcat qtqtqc ttcaqttqqg aqatctgttt atcaqcccct 69360 <br>gccacacggc tctttgttcc ttc t gcagag gacgtt gggg tcccacggct ggtccttttg 69420 <br>actcattttg ctttcaaggt cccacctccc agtctgaggc tgcatcctcc attaccatcg 69480 <br>cccttcctgt gggctgggag gccaggtcct ttcctgccca gcgatgtcag cgtttcctca 69540 <br>qqqqccaqqc actcatcagg agaa.aggaac taattacttg agtaatttgc cttgccttgc 69600 <br>tqaqaqqaqt qtqccctqaq qqactccatq tqaqtqtqqt qa.cqqqtqtq qqqqtqtccc 69660 <br>tgtgttattt taaaatgggt gcct tcagga cgatgagcat gtgaccattt cctctctatt 69720 <br>tccatcacaa qaqtattatq qtatqaqqqt ctcagqttaq attatcctcc caaqactctt 69780 <br>ctctcttcct tctctactqq aaqcccacat aqcatttcct tatqqcttqa qqqaqaqqtt 69840 <br>cqgaqcca.ct tacaaa.ttaq a.ta.aagta.ca. ttta.caatct tgtacaaa.gc cacacaatqa 69900 <br>agtcattttt ctcagctttt tttttttttt tttttttttt tttgagcctg agtctcgctc 69960 <br>tatcgtccag actggagtgc aqtggcgcga tcttgcttca ctgaaacctc tgcctcccag '70020 <br>gttcaagaga ttctcatacc tcagcctcct gagtagctqg gattacagac atgcaccact '70080 <br>atgcctggct aatttttgga tttt taqtag agaccgggtt tcaccctgtt ggccaggctg '70140 <br>gtctcgaacc cctgacctca aqtgatcttc ccgcctgqgc ctcccaaagt gctgggatta '70200 <br>taggtqtgag ccacaqtgcc cagccttqtt tttgtttttq ttttqttttg acaqtctqtc '70260 <br>actctgtcac ccaggctgga qtgcagtggt gcgatctcac ctcacttcag cctctgcctc '70320 <br>ccaggttca.a gtgattctcc tgtctcagcc tcctgagtag ctgggattac aggcgtgcca '70380 <br>ccacgcccag ctatttttgt aatt tcatta aagacagqgt ttccccatqt tgqtgaggct '70440 <br>qqtcttgaac tcctggcctc aaqtgatcca cctgcttcag cctcccaaag tgcagggatt '70500 <br>acaqqcatqa qccactqtqc ctqqcctcaq ctatcttgaa tqctqqaqaa ttaa.atcctt '70560 <br>ttctgtctaq ggtgtcagct ccct aagggc tgggccaaaa cagttggatt tataagacac '70620 <br>tagaqtcttq cctcaqtagc tcc t ttqaat tctgcactga attgatcaqt ttcttggccc '70680 <br>aaagtaaact cagatggcag cccaagagcc actctgcagt gccttctttc acatggtcat '70740 <br>catgctctct gatccctcag gttctgtcta agcctcatgt tttatgaccg tgctgttctc '70800 <br>aqcccacctc accctqcccc atqccttctc aatqqtttqt tcacctqaat tccccaqatt '70860 <br>tc•tgccagt atcccca•gg ttccttgacc tcttggtgta agcattcagc •tcta••att '70920 <br>cattttattc ccqtcaacgc attt ctaact qtagaacaag aattataaat gacaaagctc '70980 <br>atagaaaatt ggcaccttgt cttccccctc cctcttattt tatacataaa agagaatatq '71040 <br>ggctgggcat tgtggccaag gctgggcatg atagct cata cttgtaatcc agcactttgg '71100 <br>qa.qqqtqa.qq caqatqqatc acct qaqqtc aqqagttcaa qaccaqcctq qccaacatqq '71160 <br>tgaaacctca tctctactaa aatt acaaaa aaaaaattag ctaggcatgg tggcagatgc '71220 <br>ctgtaatcca gctactcagg aggctgatga aggagaatca cttgaaccct ggaggcagag '71280 <br>gttgtagag• gcca•gatgg cgct actgca ctccaacctg ggcgaaagag agcaagactc '71340 <br>cgtctca.a.a.a aaaaaa.aa.qa. caa.aaattag ccaggca.tgg tggtgccacc tgtagtccca '71400 <br>gctgcttggg a.gccta.a.ggc a.gga.gaatcg ttttgacctg ggagtaggag gttgcggtaa '71460 <br>ccgagattgt gccactgcac ttgagcctgg gcaacagagt gagactctgt ctcaaaacaa '71520 <br>taagaacaac aqcaacaaaa gagagagacc atgccttqct ccaggtctct tagctattqa '715 8 ? <br>;aq;atqtacct qqaccc;aqqt ctccqqtctt ct;aqttq;aaq caattqtact gccttac;a;aa '71640 <br>gtcacattct ctttggtgct ttttqattga cgtattt;atc caactagaaa gttactcatg '71700 <br>ccctcatcca aaaatqtqqt aqaqqccaqa ttaqtqctqq taqqaataaq agatataacc '71760 <br>tttggctttq gaaccacaag ca.tt agcaqt ctcca.t qttc tttaaaqa.ct tgqtgatatt '71820 <br>ggtatttagg ctggacacca tgcaaagact acacaggctc ggttcctgc;a tgcagagaag '71880 <br>ttatctaaga gatatgacca ggccggaata gaatgctcag accacgtgga ggctqttaaa '71940 <br>cttttacata atctaqqqaa agaagggaca caaggtggca ttagtctagg gtcaggtggg '72000 <br>aa;aaqqttat ~;~ctgaaaaqt ctct gcagct caggaca~;~ct tt~;~t~;~caaa~;~ aactgaaqtt '72060 <br>cacagctgct agtgcctggg agatcaaata gtataaatga gggcagacaa ccctgagggg '72120 <br>caqatgqagc tttccagaca atct tggcat gaggatqaqt gagtttcaaa tcagtcctgc '72180 <br>cgagqcagat ggcttcctcc agct ctgctt actqa.a.tgcq aagtcacagt cagtaaga.a.a '72240 <br>actggttttc ttcttcccag gcgctqcccc atacctgaag accaagttta tctgtgtgac '72300 <br>accgtaagtg gcttcctttc cccgttttgc cttcat ttct aatatcctca gttatccctg '72360 <br>ggaatgggac actggqtgag agtt aatctg ccaaaggttg gaagcccctg ggctatgttt '72420 <br>aqtactco.aa qtqaccttqt qtqtttaaa;a aqcttqaqct tttatttttc tqttgqa~;~ac '72480 <br>cagagtttga tggcttgtgt gtqtgtqttt tgttct tttt tttttttcca ttgtgtcttg '72540 <br>tcaacccc= qtttcccctc ctgctqcccc ccatttccta caqaacqacc tqcaqcaata '72600 <br>ccattqa.cct gccgatgtcc ccccgcactt taqattcatt gatqcaqttt ggaaataatg '72660 <br>gtqaaggtgc tgaaccctca gcaggagggc agtttggtga. gtatttggtt gacagacttt '72'720 <br>gtccctataa gggaagttgg tcccctttgt gtgatgctct cacatgtaca caccgagagc '72780 <br>tggtcactcg gaatggtaqq agat tctaga qctttqcttt ccaaaaqaga tggtatgaat '72840 <br>22 qcca.ca.tqtq tqaqta.ta.a.a. tctt cta.qca qcca.cactqq aaataqacqa. a.cttaatttt 72900 <br>tacaatatat tttatttaac ccactaaatc caacatactc tcaatttaac atttcaqaaa 72960 <br>aaqttqaqqc tgggtgaqtg gctcatgcct gtaatcccag cactttggga ggccgagqtg 73020 <br>gqtggatcac ttgagqtcag gaqttcgaga ccaqtctgac caaaatctct aaaatataaa 73080 <br>aattaqctqq qcatqqtqqc qcat acctqt aatcccaqct actcaaqaaq ctqaqqtqqq 73140 <br>a.qqatcqctt gagcctqqqa qqtqqaqqtt qcaqtqaqca gagatcqtgc cactqcactc 73200 <br>caqcctqqqc qacaqaqtqa. qact ccatct caa.a.taa.aca aaactaaact aaaaaqaaaa 73260 <br>aqttqaqacc tttttttatt cttt tttttc atactaaqcc tttaaaatcc aqtqqqcttt 73320 <br>tgacaqccac agcacaqctc agtt tgqaca aaccaaatct caaatqcttq gtgqccacqt 73380 <br>qtqtctcqqq qctcctqaat taaacaqtaq atcaaqqqca qaaqatctca qqacaqcctt 73440 <br>agagcttctq taaacatgga gctctgggaa tcaqtt aagg tqqgaatgag aaaggaccct 73500 <br>tcccqaqqca oootcctcca qqqaqqaqqq taaatctqqc ttttctqacc atccctqqqc 73560 <br>cttaaqqqqc aqqaoattoo ataqcaqtqq taocctoooc cctqtcctct qaaqqqctqq 73620 <br>qqqcqtqqcc tqccaqttqc aqaqqgtgga caactqaact aqttttccct qtctqtccct 73680 <br>ccagaqtccc tcacctttga catqqaqttq acctcqqaqt qcqctacctc ccccatqtqa 73740 <br>ggagctgaga acggaagctq caqaaagata cgactgaqgc gcctacctgc attctgccac 73800 <br>ccctcacaca gccaaacccc agat catctq aaactactaa ctttgtqgtt ccagattttt 73860 <br>tttaatctcc tacttctqct atct ttgagc aatctgggca cttttaaaaa tagagaaatg 73920 <br>aqtgaatqtg gqtgatctgc tttt atctaa atgcaaataa ggatgtqttc tctgagaccc 73980 <br>atqatcaqoo qa.tqtqqcqq qqqqtqqcta qaqqqaqaaa aaqqaaatqt cttqtqttqt 74040 <br>tttqttcccc tgccctcctt tctcagcagc tttttqttat tqttqttqtt qttcttagac 74100 <br>aaqtqcctcc tggtgcctgc ggcatccttc tgcctgtttc tgtaagcaaa tgccacaggc 74160 <br>cacctatagc tacatactcc tggcattgca ctttttaacc ttgctgacat ccaaatagaa 74220 <br>qataqgacta tctaagccct aqqtttcttt ttaaattaag aaataataac aattaaaggg 74280 <br>?????????? tqtatcaqca taqcctttct qtatttaaqa aacttaaqca qccqqqcatq 74340 <br>qtgqctcacg cctqtaatcc cagcactttg ggaggccgag gcggatcata agqtcaggag 74400 <br>atcaaqacca tcctqqctaa cacqqtqaaa ccccqtctct actaaaaqta caaaaaatta 74460 <br>qctggqtqtg qtggtgggcq cctqtaqtcc cagctactcg ggaggctqaq qcagqaqa.at 74520 <br>cgcttgaacc tgagaggcgg agqttgcagt gagccaaaat tgcacca.ctg cacactgcac 74580 <br>tcciLtcctqq qcqaciLqtct qiLqiLctctqt ctciLiLiLiLiLaiL aaaaaaiLiLiLiL iL/it.iLQiL/it.iLCtt 74640 <br>cagttiLacag cctccttggt gctt taagca ttcagcttcc ttcaggctgg taatttatat 74700 <br>aatccctgaa acgggcttca qgtcaaaccc ttaagacatc tgaagctgca acctggcctt 74760 <br>tggtqttgaa atagqaagqt ttaaggagaa tctaagcatt ttagactttt ttttataaat 74820 <br>agacttattt tcctttqtaa tqtattggcc ttttaqtgag taaggctggg cagaggqtgc 74880 <br>ttacaacctt qactcccttt ctccctooac ttoatctqct qtttcaqaqq ctaqqttqtt 74940 <br>tctgtggqtg ccttatcagg gctgggatac ttctgattct ggcttccttc ctgccccacc 75000 <br>ctcccgaccc cagtccccct gatcctgcta gaggcatqtc tccttgcgtg tctaaagqtc 75060 <br>cctcatcctg tttqttttag gaat cctgqt ctcaggacct catggaagaa gagggggaga 75120 <br>qagttacagq ttggacatqa tqcacactat qgqgccccaq cqacqtqtct gqttqagctc 75180 <br>agqqaatatq qttcttaqcc aqtt tcttgg tgatatccaq tgqcacttqt aatggcqtct 75240 <br>tcattcaqtt catgcagggc aaaggcttac tqataaactt gagtctgccc tcgtatgagg 75300 <br>qtqtatacct qqcctccctc tqaqqctqqt qactcctccc tqctqqqqcc ccacaqqtqa 75360 <br>qqcaoaacaq ctaqaqqqcc tccccqcctq cccoccttqq ctqqctaqct cqcctctcct 75420 <br>qtgcqtatqg gaacacctag cacqtgctgq atggqctgcc tctgactcaq &ggcatggcc 75480 <br>qqatttqqca actcaaaacc acct tqcctc aqctqatcaq aqtttctqtq qaattctqtt 75540 <br>tqttaaatca aattaqctgg tctctgaatt aaggggqaga cgaccttctc taagatgaac 75600 <br>agqgttcgcc ccaqtcctcc tgcctggaga cagttqatqt qtcatgcaga gctcttactt 75660 <br>ctccagcaac actcttcagt acat aataag cttaactgat aaacagaata tttagaaagg 75720 <br>tgagacttgg gcttaccatt ggqtttaaat catagggacc tagggcgagg qttcagggct 75780 <br>tctctqqaqc aqatattqtc aaqttcatqq ccttaqqtaq catotatctq qtcttaactc 75840 <br>tgattqtagc aaaagttctg agaqgagctg aqccctqttg tggcccatta aagaacaggg 75900 <br>tcctcaggcc ctgcccgctt cctqtccact gccccctccc catccccaqc ccagccgagg 75960 <br>gaatcccqtg gqttgctta.c cta.cctata.a. gqtgqtttat aagctgctqt cctggccact 76020 <br>gcattcaaat tccaatgtgt actt catagt gtaaaaattt atattattqt gaggtttttt 76080 <br>gtcttttttt tttttttttt tttt tgqtat attgctqtat ctactttaac ttccagaaat 76140 <br>aaacqttata taggaaccgt ctgatagcat ggcagctctg tttggctgqt ggaggcttcc 76200 <br>ttttcccctq cataaqttct qaqqqqqcct cacacacaqq tqqqqcctqq qataaqqqcc 76260 <br>ggaaagggtc ttgagaggag qtqqttgcct taatcccccc cgccaacccc cttatgttag 76320 <br>ccaccaqccc qqaqqtaaqq qqtqcctqqa qqa.qcaqqaq qtcaatagtc caacqqcaqa 76380 <br>aaggtqtcag aqtggagqcc tccctccccg qccccctcct accccccaga gcggcctcqt 76440 <br>cctqtctggg qtcagataag ccacctaagc gqggtggggg gtagatactc ccaccgcacc 76500 <br>aaggcctccc cttccacagt tggctccttt atcactttcc cttcaqttca cccagcgggg 76560 <br>acaacacgca gacacccggt ggtggctgca gqgcccccgg cagccagcgg tgataatgca 76620 <br>23 qqqa.a.a.qqcq ccccaacctc aqctacqcqq qcqcccacaq qqcttctccc <br>cqtqccccaq cqccctqqag accqcqcctq qqaqctacqa qcqaqcacct <br>aqatqqatca qattaqcccc ctqqqqcqqt qqcacctqcc cqtcccctcc <br>tctcccaccc ccqccttccc cctqctctqq qccccctqca cctccctctt <br>cqccgcccct ctccctcgct tgagctctga gctcagaagg aacctgcccg <br>tcccagcccc gcccagggag cgcgcqtccc tgagcccaaq qgccccaqcq <br>ctqqctqcaq ccqqcaqtqc qqqqqtccaq ccqqqqcqaq ccqqtcccgc <br>tccgcctcgc acaqtcgccg gcagccaqct gaaaacagcq cagccgcqtq <br>ctqqtctctq qqaaqqaqqa qqatqqqacq qttqttqcqq ctctqqqact <br>ccqaqqqttq aqaaqcatct tqqcqccqqq ccctcaqccg ccaqcttcqa <br>aqcaqcagct gctaaqqaqa agcctggqtc agaqttctgc ccacccqcgc <br>catttcccca aacctcqaqt cccctqcttt ttaaqqaatc tqtqccccct <br>cttacccttc tgagaaqcat tqacaqtatt ccaqqqqtqq ccaqcaccct <br>gcaaaqcgqg cagaqttaaa atttaagact aaaaatqaca gcatcaggca <br>aaggaacaga acaaccaqct ccagqqqttc ccatcaccca qqqaqqccac <br>accagqagcc atagcaqcaa atttatqaaa aaaatatttt attccaaaac <br>caaatqtqtg qtctttqtac aaaqtacaaa aaaacccctc ttctcatccc <br>caqagaaqtt taaaccttgg gctctcaatc ttccatqqtc agctgcccct <br>cctacaqcct caqaggqagq aqcqtqtqgg qttqqqaqca aqgcctcacc <br>caqttacqca acagcqcaaq qcctgctcca qgccccacct ccagcqqaqt <br>caqcttttac ccctcactcc aqattccaca qqcacqcaqc acatqqctqa <br>qtctttcact gcaqtttttt qtttttqttt tttccaggag gcaagaggac <br>aqtcccqqqq cccctqtcca cccaccatat cctaqaccca atcttttcta <br>qacaaqqtta caaacaqaga gqcaaqcaaa qaaqqctqqq qcccaacqga <br>tatatatccc gqqaaacqtq qqcaacaqca tcataqactt qaatqaaqcc <br>caqccaagca agqactaatt caqaqcaqct cagaaa.ccct cactcaaacc <br>ctqtqctaaq qacatqqccq qqcccaqacg cqctctcata qgqttcacaq <br>qtccacqttc actaaaqtat aaaatactac tcgaaaatqa accccaqcct <br>aqatgaatcq gttacatcaa cacatqaqqa caqatqcatt tacataqacc <br>ctctttctct ctctctqtct ctctqtctct ctctcttagg agggcaaaqc <br>gqaqtqaaac ttcaqcttac aqacqttacc tqtctcccct ccccttctga <br>tcaaataqct gctqaqcaqa tqaqqqqccc aqqaqqaata qqtctqqctq <br>ctqcaqtqac aqaqqctcqq tctctaccat qacaqaqaca qactcqqcqc <br>gccatgatct gaaaaqagqc caccqctqct qcaqccacat cccaqqactq <br>qcaqqcqtaq ctcatqcaca aqqacacaca ?????????? cacacaaqca <br>tgcaaaqqtq tcaqtqtaca caqccttact aaactcacaa cacgaccgct <br>tattqtttcc aaaqaqaaqc qtqqqattca aacattcatq aqaqqqaqcc <br>qtqaaaagac cqqcaqqqqq cgaqaqgcgg gaqtcaagac tqtccattqg <br>aqttcctcca cgtqcctqqc cacatccatg qtctcatcca gqtcgaattc <br>tcgaqtacat ggtcagqgct gqtaaagaca qqqqqatqtc ? <br><210> ? <br><211> 16 <br><212> DNA <br><21?> V e~tacka sekvenca <br><220> <br><22?> Sintetski oligonukleotid <br><400> ? <br>actgccgcag ctccat 16 <br><210> 4 <br><211 > 14 <br><212> DNA <br><21?> V e~tacka sekvenca <br><220> <br><22?> Sintetski oligonukleotid <br><400> 4 <br>24 <br>cacccctaca 76680 <br>tccctcqcaq 76740 <br>cctcctctct 76800 <br>qqqgcccacg 76860 <br>caaacctggc 76920 <br>acaqcaggga 76980 <br>ttqctqcacc 77040 <br>qtqccacctq 77100 <br>qcccctgqcc 77160 <br>qqctqctqqq 77220 <br>ccatctccat 77280 <br>aaactqqctc 77340 <br>qaaaaccaca 77400 <br>tgcacgcggg 77460 <br>caacgcccca 77520 <br>actqtttaca 77580 <br>cacctccctt 77640 <br>qactgcqaqt 77700 <br>agaacacaqc 77760 <br>caaaccaqat 77820 <br>tttqcaqctt 77880 <br>caaccctcca 77940 <br>cctctttqtc 78000 <br>qqqqaqaqaa 78060 <br>caaqqccaag 78120 <br>qgcggccccc 78180 <br>aqaqtctqqa 78240 <br>cccttctqag 78300 <br>cacacactct 78360 <br>ttctcactcc 78420 <br>atcatctcat 78480 <br>cattqaqtqc 78540 <br>actcttqqat 78600 <br>cacaqqqqaq 78660 <br>catgcatqcc 78720 <br>tcacattgca 78780 <br>tctqqcaqaq 78840 <br>tcqqcqtaaq 78900 <br>tccatcctga 78960 <br>79001 gagattctct ???? 14 <br><210> 5 <br><211 > 16 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonuk]eotid <br><400> 5 <br>agatcttgca tgtctc 16 <br><210> 6 <br><211> 16 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 6 <br>ataattcaac tcaggg 16 <br><210> 7 <br><211> 16 <br><212> DNA <br><213> Vestacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 7 <br>actttttcac aaggtc 16 <br><210> 8 <br><211 > 16 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 8 <br>ccatgatctt atagcc 16 <br><210> 9 <br>25 <211> 16 <br><212> DNA <br><2 13> V e~ta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 9 <br>gatagcagaa gtagga 16 <br><2 10> 10 <br><211> 16 <br><212> DNA <br><213> V e~ta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 10 <br>caaggttaaa aagtgc 16 <br><2 10> 11 <br><2 11> 14 <br><2 12> DNA <br><213> V e~ta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 11 <br>aaggttaaaa agtg 14 <br><210> 12 <br><211> 16 <br><212> DNA <br><213> V e~ta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 12 <br>ctamggat gtcagc ? 6 <br><210> 13 <br><211> 14 <br><212> DNA <br>26 <213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 13 <br>tatttggatg tcag 14 <br><210> 14 <br><211> 16 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 14 <br>tagatagtcc tatctt 16 <br><210> 15 <br><211 > 14 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 15 <br>agatagtcct atct 14 <br><210> 16 <br><211 > 16 <br><212> DNA <br><213> Vestacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 16 <br>aagaaaccta gggctt 16 <br><210> 17 <br><211 > 14 <br><2 12> DNA <br><213> v estacka sekvenca <br><220> <br>27 <223> Sintetski oligonukleotid <br><400> 17 <br>agaaacctag ggct 14 <br><210> 18 <br><211 > 16 <br><212> DNA <br><213> Vestacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 18 <br>gctgatacag tgtttt 16 <br><210> 19 <br><211 > 14 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 19 <br>ctgatacagt gttt 14 <br><210> 20 <br><211 > 16 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 20 <br>atacagaaag gctatg 16 <br><210> 21 <br><211> 14 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 21 <br>28 tacagaaagg ctat ? 4 <br><210> 22 <br><211> 16 <br><212> DNA <br><213> V e~tacka sekvenca <br><220> <br><223> Sintetski oJigonukleotid <br><400> 22 <br>gcttaagttt cttaaa 16 <br><210> 23 <br><211> 14 <br><212> DNA <br><213> V e~tacka sekvenca <br><220> <br><223> Sintetski oJigonukleotid <br><400> 23 <br>cttaagtttc ttaa 14 <br><210> 24 <br><211 > 16 <br><212> DNA <br><213> V e~tacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 24 <br>agcaccaagg aggctg 16 <br><210> 25 <br><211> 14 <br><212> DNA <br><213> V e~tacka sekvenca <br><220> <br><223> Sintetski o1igonukleotid <br><400> 25 <br>gcaccaagga ggct 14 <br><210> 26 <br>29 <211 > 16 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 26 <br>aagctgaatg cttaaa 16 <br><210> 27 <br><211> 14 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 27 <br>agctgaatgc ttaa 14 <br><210> 28 <br><211> 16 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 28 <br>ttaccagcct gaagga 16 <br><210> 29 <br><211> 14 <br><212> DNA <br><213> V estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 29 <br>taccagcctg aagg 14 <br><210> 30 <br><211> 16 <br><212> DNA <br>30 <213> v esta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 30 <br>cagggattat ataaat 16 <br><210> 31 <br><211> 14 <br><212> DNA <br><213> v esta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 31 <br>agggattata taaa 14 <br><210> 32 <br><211> 16 <br><212> DNA <br><213> v esta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 32 <br>acctgaagcc cgtttc 16 <br><210> 33 <br><211> 14 <br><212> DNA <br><213> v esta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 33 <br>cctgaagccc gttt 14 <br><210> 34 <br><211> 16 <br><212> DNA <br><213> Vesta~ka sekvenca <br><220> <br>31 <223> Sintetski oligonukleotid <br><400> 34 <br>tgtcttaagg gtttga 16 <br><210> 35 <br><211> 14 <br><212> DNA <br><213> V estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 35 <br>gtcttaaggg tttg 14 <br><210> 36 <br><211> 16 <br><212> DNA <br><213> Vestacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 36 <br>ggttgcagct tcagat 16 <br><210> 37 <br><211> 14 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 37 <br>gttgcagctt caga 14 <br><210> 38 <br><211 > 16 <br><212> DNA <br><213> V estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 38 <br>32 tcaacaccaa aggcca 16 <br><210> 39 <br><211> 14 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 39 <br>?????????? ggcc 1 4 <br><210> 40 <br><211> 16 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 40 <br>tccttaaacc ttccta 16 <br><210> 41 <br><211 > 14 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 41 <br>ccttaaaccttcct 14 <br><210> 42 <br><211> 16 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 42 <br>aaaatgctta gattct 16 <br><210> 43 <br>33 <211> 14 <br><212> DNA <br><213> V e~ta6ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 43 <br>aaatgcttag attc 14 <br><210> 44 <br><211> 16 <br><212> DNA <br><213> V e~tacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 44 <br>aaataagtct atttat 16 <br><210> 45 <br><211> 14 <br><212> DNA <br><213> V e~tacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 45 <br>aataagtcta ttta 14 <br><210> 46 <br><211> 16 <br><212> DNA <br><213> V e~tacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 46 <br>ggccaataca ttacaa 16 <br><210> 47 <br><211 > 14 <br><212> DNA <br>34 <213> V estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 47 <br>gccaatacat taca 14 <br><210> 48 <br><211> 16 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 48 <br>tgcccagcct tactca 16 <br><210> 49 <br><211 > 14 <br><2 12> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 49 <br>gcccagcctt actc 14 <br><210> 50 <br><211> 16 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 50 <br>gttgtaagca ccctct 16 <br><210> 51 <br><211 > 14 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br>35 <223> Sintetski oligonukleotid <br><400> 51 <br>ttgtaagcac cctc 14 <br><210> 52 <br><211 > 16 <br><212> DNA <br><213> V estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 52 <br>agaaagggagtcaagg 16 <br><210> 53 <br><211 > 14 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 53 <br>gaaagggagt caag 14 <br><210> 54 <br><211> 16 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 54 <br>gcagatcaag tccagg 16 <br><210> 55 <br><211> 14 <br><212> DNA <br><213> Vestacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 55 <br>36 cagatcaagt ccag 14 <br><210> 56 <br><211> 16 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 56 <br>agcctctgaa acagca 16 <br><210> 57 <br><211> 14 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 57 <br>gcctctgaaa cagc 14 <br><210> 58 <br><211> 16 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 58 <br>cccacagaaa caacct 1 6 <br><210> 59 <br><211> 14 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 59 <br>ccacagaaac ???? 14 <br><210> 60 <br>37 <211 > 16 <br><212> DNA <br><213> V estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 60 <br>agccctgata aggcac 16 <br><210> 61 <br><211 > 14 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 61 <br>gccctgataa ggca 14 <br><210> 62 <br><211> 16 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 62 <br>aatcagaagt atccca 16 <br><210> 63 <br><211> 14 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 63 <br>atcagaagta tccc 14 <br><210> 64 <br><211> 16 <br><212> DNA <br>38 <213> v estacka sekvenca <br><220> <br><223> Sintetski oligonuk\eotid <br><400> 64 <br>gcctctagca ggatca 16 <br><210> 65 <br><211 > 14 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 65 <br>cctctagcag gatc 14 <br><210> 66 <br><211> 16 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 66 <br>cacgcaagga gacatg 16 <br><210> 67 <br><211> 14 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonuk\eotid <br><400> 67 <br>acgcaaggag acat 14 <br><210> 68 <br><211> 16 <br><212> DNA <br><213> Vestacka sekvenca <br><220> <br>39 <223> Sintetski oligonukleotid <br><400> 68 <br>tgagggacct ttagac 16 <br><21 ?> 69 <br><211 > 14 <br><212> DNA <br><213> Vestacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 69 <br>gagggacctt taga 14 <br><210> 70 <br><211 > 16 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 70 <br>caggattcct ?????? 16 <br><210> 71 <br><211> 14 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 71 <br>aggattccta ???? 14 <br><210> 72 <br><211> 16 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 72 <br>40 atgaggtcct gagacc 16 <br><210> 73 <br><211 > 14 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 73 <br>tgaggtcctg agac 14 <br><210> 74 <br><211 > 16 <br><212> DNA <br><213> Vestacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 74 <br>catcatgtcc aacctg 16 <br><210> 75 <br><211> 14 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 75 <br>atcatgtcca acct 14 <br><210> 76 <br><211 > 16 <br><212> DNA <br><213> v estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 76 <br>gggccccata gtgtgc 16 <br><210> 77 <br>41 <211> 14 <br><212> DNA <br><213> v esta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 77 <br>ggccccatag tgtg 14 <br><2 10> 78 <br><211> 16 <br><212> DNA <br><213> v esta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 78 <br>agctcaacca gacacg 16 <br><2 10> 79 <br><211> 14 <br><212>DNA <br><213> v esta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 79 <br>gctcaaccag ???? 14 <br><210> 80 <br><211> 16 <br><212> DNA <br><2 13> v esta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 80 <br>gaaccatatt ccctga 16 <br><210> 81 <br><211> 14 <br><212> DNA <br>42 <213> V e~ta<:ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 81 <br>aaccatattc cctg 14 <br><210> 82 <br><211> 16 <br><212> DNA <br><213> V e~ta<:ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 82 <br>caagaaactg gctaag 16 <br><210> 83 <br><211 > 14 <br><212> DNA <br><213> V e~ta<:ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 83 <br>aagaaactgg ctaa 14 <br><210> 84 <br><211 > 16 <br><212> DNA <br><213> V e~ta<:ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 84 <br>gccactggat atcacc 16 <br><210> 85 <br><211> 16 <br><212> DNA <br><213> V e~ta<:ka sekvenca <br><220> <br>43 <223> Sintetski oligonukleotid <br><400> 85 <br>aactgaatga agacgc 16 <br><210> 86 <br><211 > 16 <br><212> DNA <br><213> V e~tacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 86 <br>gcttattatg tactga 16 <br><210> 87 <br><211> 14 <br><212> DNA <br><213> V e~tacka sekvenca <br><220> <br><223> Sintetski oligonukJeotid <br><400> 87 <br>cttattatgt actg 14 <br><210> 88 <br><211> 16 <br><212> DNA <br><213> Ve~tacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 88 <br>gcccaagtct cacctt 16 <br><210> 89 <br><211 > 14 <br><212> DNA <br><213> V e~tacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 89 <br>44 cccaagtctc acct 14 <br><210> 90 <br><211> 16 <br><212> DNA <br><213> Ve~ta~ka sekvenca <br><220> <br><223> Sintetski oligonukJeotid <br><400> 90 <br>cccaatggta agccca 16 <br><210> 91 <br><211 > 14 <br><212> DNA <br><213> Ve~ta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 91 <br>ccaatggtaa gccc 14 <br><210> 92 <br><211 > 16 <br><212> DNA <br><213> V e~ta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 92 <br>aacccaatgg taagcc 16 <br><210> 93 <br><211> 14 <br><212> DNA <br><213> V e~ta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 93 <br>acccaatggt aagc 14 <br><210> 94 <br>45 <211> 16 <br><212> DNA <br><213> V e~ta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 94 <br>taggtcccta tgattt 16 <br><210> 95 <br><211> 14 <br><212> DNA <br><213> V e~ta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 95 <br>aggtccctat gatt 14 <br><210> 96 <br><211> 16 <br><212> DNA <br><213> V e~ta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 96 <br>aagccctgaa ccctcg 1 ? <br><210> 97 <br><211> 14 <br><212> DNA <br><213> V e~ta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 97 <br>agccctgaac cctc 14 <br><210> 98 <br><211> 16 <br><212> DNA <br>46 <213> ? estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 98 <br>cctaaggcca tgaact 16 <br><210> 99 <br><211 > 14 <br><212> DNA <br><213> ? estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 99 <br>ctaaggccat gaac ? 4 <br><210> 100 <br><2] 1> 16 <br><212> DNA <br><213> ? estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 100 <br>accagataca tgctac 16 <br><210> 101 <br><211> 14 <br><212> DNA <br><213> ? estacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 101 <br>ccagatacat gcta 14 <br><210> 102 <br><211 > 16 <br><212> DNA <br><213> ? estacka sekvenca <br><220> <br>47 <223> Sintetski oligonukleotid <br><400> 102 <br>tacaatcaga gttaag 16 <br><210> 103 <br><211 > 14 <br><212> DNA <br><213> v esta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 103 <br>acaatcagag ttaa 14 <br><210> 104 <br><211> 16 <br><212> DNA <br><213> v esta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 104 <br>tcctctcaga actttt 16 <br><210> 105 <br><211 > 14 <br><212> DNA <br><213> v esta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 105 <br>cctctcagaa cm 14 <br><210> 106 <br><211> 16 <br><212> DNA <br><213> v esta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 106 <br>48 gctcctctca gaactt 1 6 <br><210> 107 <br><211> 14 <br><212> DNA <br><213> v esta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 107 <br>ctcctctcag aact 14 <br><210> 108 <br><211> 16 <br><212> DNA <br><213> v esta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 108 <br>ttctttaatg ggccac 16 <br><210> 109 <br><211 > 14 <br><212> DNA <br><2 1 ?> V esta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 109 <br>tctttaatgg gcca 14 <br><210> 110 <br><21 1> 16 <br><212> DNA <br><213> v esta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 110 <br>acgggattcc ctcggc 16 <br><210> 11 1 <br>49 <211> 14 <br><212> DNA <br><213> v esta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 111 <br>cgggattccctcgg 14 <br><210> 112 <br><211> 16 <br><212> DNA <br><213> v esta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 112 <br>gtaggtaagc ?????? 16 <br><210> 113 <br><211 > 14 <br><212> DNA <br><213> v esta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 113 <br>taggtaagca ???? 14 <br><210> 114 <br><211> 16 <br><212> DNA <br><213> v esta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 114 <br>gaatttgaat gcagtg 16 <br><210> 115 <br><211> 14 <br><212> DNA <br>50 <213> v esta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 115 <br>aatttgaatg cagt 14 <br><210> 116 <br><211 > 16 <br><212> DNA <br><213> v esta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 116 <br>tgaagtacac attgga 16 <br><210> 117 <br><211> 14 <br><212> DNA <br><213> v esta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 117 <br>gaagtacaca ttgg 14 <br><210> 118 <br><211 > 16 <br><212> DNA <br><213> v esta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 118 <br>ataaattttt acacta 16 <br><210> 119 <br><211> 14 <br><212> DNA <br><213> v esta~ka sekvenca <br><220> <br>51 <223> Sintetski oligonukleotid <br><400> 119 <br>taaattttta cact 14 <br><210> 120 <br><211 > 14 <br><212> DNA <br><213> V e~ta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 120 <br>caataatata aatt 14 <br><210> 121 <br><211 > 16 <br><212> DNA <br><213> V e~ta~ka sekvenca <br><220> <br><223> Sintetski o1igonukleotid <br><400> 121 <br>ctggaagtta aagtag 16 <br><210> 122 <br><2 11> 14 <br><212> DNA <br><213> V e~ta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 122 <br>tggaagttaa agta 14 <br><210> 123 <br><211> 16 <br><212> DNA <br><213> V e~ta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 123 <br>52 gtactctttc agtggt 16 <br><210> 124 <br><2 11 > 16 <br><212> DNA <br><213> V e~ta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 124 <br>atgcttagat tctcct 16 <br><210> 125 <br><211 > 16 <br><212> DNA <br><213> V e~ta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 125 <br>agcagatcaa gtccag 16 <br><210> 126 <br><211> 16 <br><212> DNA <br><213> V e~ta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 126 <br>aggtgttccc atacgc 16 <br><210> 127 <br><211> 16 <br><212> DNA <br><213> V e~ta~ka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 127 <br>taggtgttcc catacg 16 <br><210> 128 <br>53 <211 > 16 <br><212> DNA <br><213> V e~tacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 128 <br>ggttcctcct gttggc 16 <br><210> 129 <br><211> 17 <br><212> DNA <br><213> V e~tacka sekvenca <br><220> <br><223> Sintetski oligonukleotid <br><400> 129 <br>atgcttagat tctcctt 17 <br>54
Claims (9)
1. Antisense-jedinjenje, naznačeno time, što je komplementarno sa ljudskim STAT3 namenjeno za primenu u postupku tretiranja limfom B-ćelija u ljudskom subjektu u potrebi, pri čemu pomenuti postupak podrazumeva administriranje pomenutom subjektu pomenuto antisense-jedinjenje tokom prve faze, a tada i tokom druge faze, pri čemu pomenuta prva faza obuhvata administriranje ukupne sedmične doze pomenutog jedinjenja u rasponu od 100-750 mg (±12%) tokom prvih 1-10 sedmica, a pomenuta druga faza obuhvata administriranje ukupne sedmične doze u rasponu od l 00-250 mg (±12%) tokom barem l sedmice nakon prve faze; i pri čemu je pomenuto antisense jedinjenje jedno-lančani modifikovani oligonukleotid koji se sastoji od 16 povezanih nukleozida koji imaju nukleobaznu sekvencu SEQ ID Br.: 12, koja sadrži:praznina-segment koji se sastoji od deset povezanih deoksinukleozida; 5'-krilni segment koji se sastoji od 3 povezana nukleozida; i 3'-krilni segment koji se sastoji od 3 povezana nukleozida; gde je pomenuti praznina-segment pozicioniran između 5'-krilnog segmenta i 3'-krilnog segmenta; gde svaki nukleozid iz svakog krilnog segmenta sadrži ograničen etilni nukleozid; gde svaka intemukleozidna veza iz modifikovanog oligonukleotida je fosforotioatna veza; i gde svaki citozin iz modifikovanog oligonukleotida je 5-metilcitozin.
2.Jedinjenje za primenu u skladu sa zahtevom l, naznačeno time, što pomenuti limfomB-ćelija je ne-Hodgkin-ov limfom B-ćelija.
3.Jedinjenje za primenu u skladu sa zahtevom 2, naznačeno time, što pomenuti ne Hodgkin-ov limfom B-ćelija je limfom difuznih velikih B-ćelija (DLBCL).
4.Jedinjenje za primenu u skladu sa bilo kojim od prethodnih zahteva, naznačeno time, što pomenuta prva faza traje l sedmicu.
5.Jedinjenje za primenu u skladu sa bilo kojim od prethodnih zahteva, naznačeno time, što pomenuta prva faza obuhvata administriranje pomenutog jedinjenja kroz 3 podjednake doze unutar jedne sedmice.
6. Jedinjenje za primenu u skladu sa bilo kojim od prethodnih zahteva, nazna eno time, što je pomenuta ukupna sedmična doza pomenutog antisense-jedinjenja tokom prve faze bilo koja količina od sledećih: 100 mg (±12%), 125 mg (±12%), 150 mg (±12%),175 mg (±12%), 200 mg (±12%), 225 mg (±12%), 250 mg (±12%), 275 mg (±12%),300 mg (±12%), 325 mg (±12%), 350 mg (±12%), 375 mg (±12%), 400 mg (±12%),425 mg (±12%), 450 mg (±12%), 475 mg (±12%), 500 mg (±12%), 525 mg (±12%),550 mg (±12%), 575 mg (±12%), 600 mg (±12%), 625 mg (±12%), 650 mg (±12%),675mg (±12%), 700 mg (±12%), 725 mg (±12%), ili 750 mg (±12%).
7.Jedinjenje za primenu u skladu sa bilo kojim od prethodnih zahteva, nazna eno time, što je pomenuta ukupna sedmična doza antisense-jedinjenja tokom druge faze bilo koja količina od sledećih: 100 mg (±12%), 110 mg (±12%), 120 mg (±12%), 130 mg (±12%),140 mg (±12%), 150 mg (±12%), 160 mg (±12%), 170 mg (±12%), 180 mg (±12%),190 mg (±12%), 200 mg (±12%), 210 mg (±12%), 220 mg (±12%), 230 mg (±12%),240 mg (±12%), ili 250 mg (±12%).
8.Jedinjenje za primenu u skladu sa bilo kojim od prethodnih zahteva, nazna eno time, što pomenuta ukupna sedmična doza antisense-jedinjenja tokom prve faze je količina od 600 mg (±12%).
9.Jedinjenje za primemu u skladu sa bilo kojim od prethodnih zahteva, nazna eno time, što pomenuta ukupna sedmična doza antisense-jedinjenje u drugoj fazi je količina od200 mg (±12%).56
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