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PE20181518A1 - Modulacion de la expresion del transductor de senales y activador de la transcripcion 3 (stat3) - Google Patents

Modulacion de la expresion del transductor de senales y activador de la transcripcion 3 (stat3)

Info

Publication number
PE20181518A1
PE20181518A1 PE2018001314A PE2018001314A PE20181518A1 PE 20181518 A1 PE20181518 A1 PE 20181518A1 PE 2018001314 A PE2018001314 A PE 2018001314A PE 2018001314 A PE2018001314 A PE 2018001314A PE 20181518 A1 PE20181518 A1 PE 20181518A1
Authority
PE
Peru
Prior art keywords
expression
stat3
modulation
signal transducer
transcription activator
Prior art date
Application number
PE2018001314A
Other languages
English (en)
Inventor
Eric E Swayze
Susan M Freier
Robert A Macleod
Youngsoo Kim
Original Assignee
Ionis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ionis Pharmaceuticals Inc filed Critical Ionis Pharmaceuticals Inc
Publication of PE20181518A1 publication Critical patent/PE20181518A1/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/323—Chemical structure of the sugar modified ring structure
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    • C12N2310/3341—5-Methylcytosine
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/30—Chemical structure
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    • C12N2310/3521—Methyl
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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  • Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Se refiere a un compuesto que comprende un oligonucleotido modificado que consiste en 12 a 30 nucleosidos unidos que tiene una secuencia de nucleobase que comprende una porcion de por lo menos 12 nucleobases contiguas complementarias de una porcion de igual longitud de las nucleobases 3008 a 3033 de la SEQ ID NO: 1 en donde la secuencia de nucleobases es complementaria de la SEQ ID NO:1. Tambien se refiere a un metodo para disminuir la expresion de ARNm y proteinas STAT3. Dichos compuestos son utiles para el tratamiento de enfermedades hiperproliferativas.
PE2018001314A 2011-04-01 2012-03-30 Modulacion de la expresion del transductor de senales y activador de la transcripcion 3 (stat3) PE20181518A1 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201161471035P 2011-04-01 2011-04-01
US201161471001P 2011-04-01 2011-04-01
US201161471015P 2011-04-01 2011-04-01
US201161471045P 2011-04-01 2011-04-01
US201161558308P 2011-11-10 2011-11-10
US201161558316P 2011-11-10 2011-11-10

Publications (1)

Publication Number Publication Date
PE20181518A1 true PE20181518A1 (es) 2018-09-21

Family

ID=46932413

Family Applications (2)

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PE2013002156A PE20142463A1 (es) 2011-04-01 2012-03-30 Modulacion de la expresion del transductor de senales y activador de la transcripcion 3 (stat3)
PE2018001314A PE20181518A1 (es) 2011-04-01 2012-03-30 Modulacion de la expresion del transductor de senales y activador de la transcripcion 3 (stat3)

Family Applications Before (1)

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PE2013002156A PE20142463A1 (es) 2011-04-01 2012-03-30 Modulacion de la expresion del transductor de senales y activador de la transcripcion 3 (stat3)

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US (4) US8816056B2 (es)
EP (2) EP2697243B1 (es)
JP (1) JP5943993B2 (es)
KR (2) KR20190092590A (es)
CN (2) CN107012144A (es)
AU (1) AU2012236206C1 (es)
BR (1) BR112013024768B1 (es)
CA (1) CA2831915C (es)
CL (1) CL2013002773A1 (es)
CO (1) CO6821885A2 (es)
CY (1) CY1121460T1 (es)
DK (1) DK2697243T3 (es)
DO (1) DOP2013000216A (es)
EA (2) EA201792185A3 (es)
EC (1) ECSP13012909A (es)
ES (1) ES2709495T3 (es)
GT (1) GT201300232A (es)
HR (1) HRP20182169T1 (es)
HU (1) HUE042173T2 (es)
IL (2) IL228569A (es)
LT (1) LT2697243T (es)
ME (1) ME03317B (es)
MX (1) MX340086B (es)
MY (1) MY163004A (es)
NI (1) NI201300101A (es)
PE (2) PE20142463A1 (es)
PH (1) PH12013502049A1 (es)
PL (1) PL2697243T3 (es)
PT (1) PT2697243T (es)
RS (1) RS58489B1 (es)
SG (1) SG193504A1 (es)
SI (1) SI2697243T1 (es)
SM (1) SMT201900060T1 (es)
WO (1) WO2012135736A2 (es)
ZA (1) ZA201308153B (es)

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