MXPA06001526A - Derivados de amida. - Google Patents
Derivados de amida.Info
- Publication number
- MXPA06001526A MXPA06001526A MXPA06001526A MXPA06001526A MXPA06001526A MX PA06001526 A MXPA06001526 A MX PA06001526A MX PA06001526 A MXPA06001526 A MX PA06001526A MX PA06001526 A MXPA06001526 A MX PA06001526A MX PA06001526 A MXPA06001526 A MX PA06001526A
- Authority
- MX
- Mexico
- Prior art keywords
- infection
- caused
- herpes
- varicella
- hsv
- Prior art date
Links
- 150000001408 amides Chemical class 0.000 title 1
- 208000015181 infectious disease Diseases 0.000 abstract 6
- 241000701085 Human alphaherpesvirus 3 Species 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 201000006082 Chickenpox Diseases 0.000 abstract 1
- 208000001688 Herpes Genitalis Diseases 0.000 abstract 1
- 208000000903 Herpes simplex encephalitis Diseases 0.000 abstract 1
- 208000007514 Herpes zoster Diseases 0.000 abstract 1
- 241000700586 Herpesviridae Species 0.000 abstract 1
- 241000700588 Human alphaherpesvirus 1 Species 0.000 abstract 1
- 241000701074 Human alphaherpesvirus 2 Species 0.000 abstract 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 abstract 1
- -1 N-{2-[(4-substituted phenyl)amino]-2-oxoethyl}tetrahydro-2H-thiopyran-4-carboxamide Chemical class 0.000 abstract 1
- 208000035415 Reinfection Diseases 0.000 abstract 1
- 206010046980 Varicella Diseases 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 201000004946 genital herpes Diseases 0.000 abstract 1
- 230000002085 persistent effect Effects 0.000 abstract 1
- 241001529453 unidentified herpesvirus Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrane Compounds (AREA)
Abstract
Se proporciona un compuesto novedoso util en drogas, en particular, en drogas para diversas enfermedades provocadas por infeccion con los virus que pertenecen a la familia Herpesviridae, es decir, para prevenir o tratar infecciones con diversos herpesvirus, mas especificamente hablado, varicela (viruela de las aves) causada por la infeccion con el virus de varicela zoster, herpes zoster causado por infeccion recurrente con el virus de la varicela zoster persistente, herpes labial y herpes encefalitis causado por infeccion con HSV-1, herpes genital causado por infeccion con HSV-2, etc. Un derivado de N-{2-[(4-fenilo sustituido)amino]-2-oxoetil}tetrahidro-2H-tiopiran-4-carboxamida que tiene un sustituyente heteroarilo especifico de 5 o 6 miembros en la posicion 4, tiene una actividad antivirral favorable y haciendolo posible tratar las enfermedades anteriores mediante la administracion oral en una dosis pequena.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003290850 | 2003-08-08 | ||
| PCT/JP2004/011573 WO2005014559A1 (ja) | 2003-08-08 | 2004-08-05 | アミド誘導体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA06001526A true MXPA06001526A (es) | 2006-05-25 |
Family
ID=34114142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA06001526A MXPA06001526A (es) | 2003-08-08 | 2004-08-05 | Derivados de amida. |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7465748B2 (es) |
| EP (1) | EP1652843B1 (es) |
| JP (1) | JP4549974B2 (es) |
| KR (1) | KR101157074B1 (es) |
| CN (1) | CN100445271C (es) |
| AU (1) | AU2004263448B2 (es) |
| BR (1) | BRPI0413430B8 (es) |
| CA (1) | CA2535199C (es) |
| CY (1) | CY1115461T1 (es) |
| DK (1) | DK1652843T3 (es) |
| ES (1) | ES2462292T3 (es) |
| MX (1) | MXPA06001526A (es) |
| NO (1) | NO335467B1 (es) |
| PL (1) | PL1652843T3 (es) |
| PT (1) | PT1652843E (es) |
| RU (1) | RU2336273C2 (es) |
| SI (1) | SI1652843T1 (es) |
| TW (1) | TW200505894A (es) |
| WO (1) | WO2005014559A1 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030171411A1 (en) * | 2001-12-21 | 2003-09-11 | Kodra Janos Tibor | Amide derivatives as therapeutic agents |
| WO2004002481A1 (en) * | 2002-06-27 | 2004-01-08 | Novo Nordisk A/S | Aryl carbonyl derivatives as therapeutic agents |
| TW200505894A (en) * | 2003-08-08 | 2005-02-16 | Yamanouchi Pharma Co Ltd | Tetrahydro-2H-thiopyran-4-carboxamide derivative |
| MXPA06007667A (es) * | 2004-01-06 | 2006-09-01 | Novo Nordisk As | Heteroaril-ureas y su uso como activadores de glucocinasa. |
| WO2006082821A1 (ja) * | 2005-02-02 | 2006-08-10 | Astellas Pharma Inc. | ヘルペスウイルスが関与する疾患の予防若しくは治療剤 |
| DE602006016069D1 (de) * | 2005-02-02 | 2010-09-23 | Astellas Pharma Inc | Therapeutischer wirkstoff zur behandlung von herpes progenitalis nach der entwicklung von läsionen |
| ES2342558T3 (es) * | 2005-02-02 | 2010-07-08 | Astellas Pharma Inc. | Agente para prevencion/tratamiento de una enfermedad causada por un herpesvirus resistente a acyclovir. |
| JP5011739B2 (ja) * | 2005-02-03 | 2012-08-29 | アステラス製薬株式会社 | テトラヒドロ−２ｈ−チオピラン−４−カルボキサミド誘導体を含有する医薬組成物 |
| EP1904438B1 (en) * | 2005-07-08 | 2012-02-29 | Novo Nordisk A/S | Dicycloalkylcarbamoyl ureas as glucokinase activators |
| JP2009500377A (ja) * | 2005-07-08 | 2009-01-08 | ノボ・ノルデイスク・エー／エス | ジシクロアルキルウレア型グルコキナーゼ活性化剤 |
| JP4960355B2 (ja) * | 2005-07-14 | 2012-06-27 | ノボ・ノルデイスク・エー／エス | ウレア型グルコキナーゼ活性化剤 |
| WO2008084043A1 (en) * | 2007-01-09 | 2008-07-17 | Novo Nordisk A/S | Urea glucokinase activators |
| JP5226008B2 (ja) * | 2007-01-11 | 2013-07-03 | ノボ・ノルデイスク・エー／エス | ウレアグルコキナーゼアクチベーター |
| DE102008014523A1 (de) * | 2008-03-15 | 2009-09-17 | Robert Bosch Gmbh | Heizgerät |
| JP5381978B2 (ja) * | 2008-04-02 | 2014-01-08 | アステラス製薬株式会社 | アミド誘導体含有医薬組成物 |
| SI2565191T1 (sl) | 2008-05-14 | 2014-12-31 | Astellas Pharma Inc. | Derivati 4-(indol-7-ilkarbonilaminometil)cikloheksan karboksilne kisline kot EP4 receptorski antagonisti, uporabni za zdravljenje kronične ledvične odpovedi ali diabetične nefropatije |
| JPWO2010047295A1 (ja) * | 2008-10-20 | 2012-03-22 | アステラス製薬株式会社 | 帯状疱疹関連痛の予防又は治療薬 |
| CN108623577B (zh) * | 2018-05-08 | 2020-09-25 | 山东百诺医药股份有限公司 | 阿莫奈韦及其中间体的制备方法 |
| EP4487909A3 (en) | 2018-06-12 | 2025-03-19 | vTv Therapeutics LLC | Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs |
| WO2020038812A1 (en) * | 2018-08-20 | 2020-02-27 | Rijksuniversiteit Groningen | New process for the preparation of amenamevir |
| TW202038947A (zh) | 2018-11-28 | 2020-11-01 | 德商創新分子有限責任公司 | 在與溶瘤病毒之組合療法中治療癌症的解旋酶引子酶抑制劑 |
| US12391658B2 (en) | 2020-02-18 | 2025-08-19 | Vtv Therapeutics Llc | Sulfoxide and sulfone glucokinase activators and methods of use thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT871619E (pt) * | 1995-12-29 | 2003-03-31 | Boehringer Ingelheim Pharma | Derivados de fenil-tiazol com propriedades anti-virus do herpesc |
| US6288091B1 (en) * | 1995-12-29 | 2001-09-11 | Boehringer Ingelheim Ltd. | Antiherpes virus compounds and methods for their preparation and use |
| AU3289299A (en) * | 1998-02-19 | 1999-09-06 | Tularik Inc. | Antiviral agents |
| WO2000029399A1 (en) * | 1998-11-12 | 2000-05-25 | Boehringer Ingelheim (Canada) Ltd. | Antiherpes compounds |
| WO2000053591A1 (de) * | 1999-03-08 | 2000-09-14 | Bayer Aktiengesellschaft | Thiazolylharnstoff-derivate und ihre verwendung als antivirale mittel |
| AU5155500A (en) * | 1999-05-24 | 2000-12-12 | Cor Therapeutics, Inc. | Inhibitors of factor xa |
| EP1183235A2 (en) * | 1999-05-24 | 2002-03-06 | Cor Therapeutics, Inc. | INHIBITORS OF FACTOR Xa |
| JP3913172B2 (ja) * | 2000-11-10 | 2007-05-09 | アステラス製薬株式会社 | アミド誘導体 |
| DE10139060A1 (de) | 2001-08-08 | 2003-02-20 | Merck Patent Gmbh | Phenylderivate |
| AU2003235889A1 (en) | 2002-05-09 | 2003-11-11 | Rational Drug Design Laboratories | Amide derivatives |
| TW200505894A (en) * | 2003-08-08 | 2005-02-16 | Yamanouchi Pharma Co Ltd | Tetrahydro-2H-thiopyran-4-carboxamide derivative |
-
2004
- 2004-07-06 TW TW093120267A patent/TW200505894A/zh not_active IP Right Cessation
- 2004-08-05 MX MXPA06001526A patent/MXPA06001526A/es active IP Right Grant
- 2004-08-05 PL PL04748296T patent/PL1652843T3/pl unknown
- 2004-08-05 SI SI200432152T patent/SI1652843T1/sl unknown
- 2004-08-05 KR KR1020067002614A patent/KR101157074B1/ko not_active Expired - Lifetime
- 2004-08-05 AU AU2004263448A patent/AU2004263448B2/en not_active Expired
- 2004-08-05 ES ES04748296.3T patent/ES2462292T3/es not_active Expired - Lifetime
- 2004-08-05 RU RU2006106922/04A patent/RU2336273C2/ru active
- 2004-08-05 JP JP2005513013A patent/JP4549974B2/ja not_active Expired - Lifetime
- 2004-08-05 PT PT47482963T patent/PT1652843E/pt unknown
- 2004-08-05 US US10/567,565 patent/US7465748B2/en not_active Expired - Lifetime
- 2004-08-05 BR BRPI0413430A patent/BRPI0413430B8/pt not_active IP Right Cessation
- 2004-08-05 CN CNB2004800222586A patent/CN100445271C/zh not_active Expired - Lifetime
- 2004-08-05 WO PCT/JP2004/011573 patent/WO2005014559A1/ja not_active Ceased
- 2004-08-05 CA CA2535199A patent/CA2535199C/en not_active Expired - Lifetime
- 2004-08-05 EP EP04748296.3A patent/EP1652843B1/en not_active Expired - Lifetime
- 2004-08-05 DK DK04748296.3T patent/DK1652843T3/da active
- 2004-08-06 US US10/912,232 patent/US6903125B2/en not_active Expired - Lifetime
-
2006
- 2006-03-07 NO NO20061100A patent/NO335467B1/no unknown
-
2014
- 2014-06-11 CY CY20141100425T patent/CY1115461T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0413430B1 (pt) | 2019-04-30 |
| KR101157074B1 (ko) | 2012-06-22 |
| US6903125B2 (en) | 2005-06-07 |
| SI1652843T1 (sl) | 2014-06-30 |
| TW200505894A (en) | 2005-02-16 |
| ES2462292T3 (es) | 2014-05-22 |
| WO2005014559A1 (ja) | 2005-02-17 |
| DK1652843T3 (da) | 2014-05-05 |
| JPWO2005014559A1 (ja) | 2006-10-05 |
| EP1652843B1 (en) | 2014-04-02 |
| TWI341311B (es) | 2011-05-01 |
| NO20061100L (no) | 2006-03-07 |
| US20060229295A1 (en) | 2006-10-12 |
| NO335467B1 (no) | 2014-12-15 |
| CN100445271C (zh) | 2008-12-24 |
| RU2006106922A (ru) | 2006-08-27 |
| CY1115461T1 (el) | 2017-01-04 |
| CN1832930A (zh) | 2006-09-13 |
| BRPI0413430A (pt) | 2006-10-17 |
| EP1652843A1 (en) | 2006-05-03 |
| BRPI0413430B8 (pt) | 2021-05-25 |
| US20050032855A1 (en) | 2005-02-10 |
| PL1652843T3 (pl) | 2014-09-30 |
| US7465748B2 (en) | 2008-12-16 |
| KR20060073928A (ko) | 2006-06-29 |
| CA2535199C (en) | 2010-12-14 |
| AU2004263448A1 (en) | 2005-02-17 |
| CA2535199A1 (en) | 2005-02-17 |
| EP1652843A4 (en) | 2010-07-28 |
| AU2004263448B2 (en) | 2009-02-05 |
| RU2336273C2 (ru) | 2008-10-20 |
| JP4549974B2 (ja) | 2010-09-22 |
| PT1652843E (pt) | 2014-06-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| GB | Transfer or rights |