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MX2020011713A - Organismo metabolicamente diseñados para la produccion de bio productos de valor agregado. - Google Patents

Organismo metabolicamente diseñados para la produccion de bio productos de valor agregado.

Info

Publication number
MX2020011713A
MX2020011713A MX2020011713A MX2020011713A MX2020011713A MX 2020011713 A MX2020011713 A MX 2020011713A MX 2020011713 A MX2020011713 A MX 2020011713A MX 2020011713 A MX2020011713 A MX 2020011713A MX 2020011713 A MX2020011713 A MX 2020011713A
Authority
MX
Mexico
Prior art keywords
products
production
added value
metabolically engineered
engineered organisms
Prior art date
Application number
MX2020011713A
Other languages
English (en)
Inventor
Jo Maertens
Joeri Beauprez
Mey Marjan De
Original Assignee
Inbiose Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inbiose Nv filed Critical Inbiose Nv
Publication of MX2020011713A publication Critical patent/MX2020011713A/es

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    • C—CHEMISTRY; METALLURGY
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    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
    • C—CHEMISTRY; METALLURGY
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • C12N9/2431—Beta-fructofuranosidase (3.2.1.26), i.e. invertase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/305—Pyrimidine nucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01007—Sucrose phosphorylase (2.4.1.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01008—Maltose phosphorylase (2.4.1.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01022—Lactose synthase (2.4.1.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01069—Galactoside 2-alpha-L-fucosyltransferase (2.4.1.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01026—Beta-fructofuranosidase (3.2.1.26), i.e. invertase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y504/00—Intramolecular transferases (5.4)
    • C12Y504/02—Phosphotransferases (phosphomutases) (5.4.2)
    • C12Y504/02002—Phosphoglucomutase (5.4.2.2)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente invención se refiere a organismos genéticamente diseñados, especialmente microorganismos tales como bacterias y levaduras, para la producción de bioproductos de valor agregado tal como sacárido especializado, sacárido activado, nucleósido, glicósido, glicolípido o glicoproteína. Más específicamente, la presente invención se refiere a células hospederas que se diseñan metabólicamente de modo que puedan producir los productos especializados valiosos en grandes cantidades y en una tasa alta al evitar los problemas técnicos clásicos que se presentan en los procesos de producción biocatalíticos o fermentativos.
MX2020011713A 2010-07-12 2013-01-11 Organismo metabolicamente diseñados para la produccion de bio productos de valor agregado. MX2020011713A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10169304 2010-07-12

Publications (1)

Publication Number Publication Date
MX2020011713A true MX2020011713A (es) 2021-01-08

Family

ID=44060925

Family Applications (8)

Application Number Title Priority Date Filing Date
MX2017015397A MX386398B (es) 2010-07-12 2011-07-12 Organismos metabólicamente diseñados para la producción de bioproductos de valor agregado.
MX2013000460A MX353506B (es) 2010-07-12 2011-07-12 Organismo metabolicamente diseñados para la produccion de bio productos de valor agregado.
MX2020011714A MX2020011714A (es) 2010-07-12 2013-01-11 Organismo metabolicamente diseñados para la produccion de bio productos de valor agregado.
MX2020011713A MX2020011713A (es) 2010-07-12 2013-01-11 Organismo metabolicamente diseñados para la produccion de bio productos de valor agregado.
MX2020011691A MX2020011691A (es) 2010-07-12 2013-01-11 Organismos metabolicamente diseñados para la produccion de bio productos de valor agregado.
MX2020011693A MX2020011693A (es) 2010-07-12 2013-01-11 Organismos metabolicamente diseñados para la produccion de bio productos de valor agregado.
MX2020011715A MX2020011715A (es) 2010-07-12 2013-01-11 Organismo metabolicamente diseñados para la produccion de bio productos de valor agregado.
MX2020011690A MX2020011690A (es) 2010-07-12 2013-01-11 Organismos metabolicamente diseñados para la produccion de bio productos de valor agregado.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
MX2017015397A MX386398B (es) 2010-07-12 2011-07-12 Organismos metabólicamente diseñados para la producción de bioproductos de valor agregado.
MX2013000460A MX353506B (es) 2010-07-12 2011-07-12 Organismo metabolicamente diseñados para la produccion de bio productos de valor agregado.
MX2020011714A MX2020011714A (es) 2010-07-12 2013-01-11 Organismo metabolicamente diseñados para la produccion de bio productos de valor agregado.

Family Applications After (4)

Application Number Title Priority Date Filing Date
MX2020011691A MX2020011691A (es) 2010-07-12 2013-01-11 Organismos metabolicamente diseñados para la produccion de bio productos de valor agregado.
MX2020011693A MX2020011693A (es) 2010-07-12 2013-01-11 Organismos metabolicamente diseñados para la produccion de bio productos de valor agregado.
MX2020011715A MX2020011715A (es) 2010-07-12 2013-01-11 Organismo metabolicamente diseñados para la produccion de bio productos de valor agregado.
MX2020011690A MX2020011690A (es) 2010-07-12 2013-01-11 Organismos metabolicamente diseñados para la produccion de bio productos de valor agregado.

Country Status (16)

Country Link
US (5) US9701992B2 (es)
EP (3) EP4242320A3 (es)
JP (3) JP5998130B2 (es)
CN (3) CN107603935A (es)
AU (1) AU2011278315B2 (es)
CA (1) CA2804713C (es)
DE (1) DE202011111144U1 (es)
DK (1) DK3235907T5 (es)
ES (1) ES2955617T3 (es)
FI (1) FI3235907T3 (es)
MX (8) MX386398B (es)
MY (1) MY185012A (es)
NZ (1) NZ605093A (es)
PH (1) PH12013500068A1 (es)
SG (2) SG10201504733XA (es)
WO (1) WO2012007481A2 (es)

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