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SG11201908470UA - Enzymatic production of hexoses - Google Patents

Enzymatic production of hexoses

Info

Publication number
SG11201908470UA
SG11201908470UA SG11201908470UA SG11201908470UA SG 11201908470U A SG11201908470U A SG 11201908470UA SG 11201908470U A SG11201908470U A SG 11201908470UA SG 11201908470U A SG11201908470U A SG 11201908470UA
Authority
SG
Singapore
Prior art keywords
international
march
pct
hexoses
enzymatic
Prior art date
Application number
Inventor
Daniel Joseph Wichelecki
Edwin O Rogers
Original Assignee
Bonumose Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bonumose Llc filed Critical Bonumose Llc
Publication of SG11201908470UA publication Critical patent/SG11201908470UA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C12N9/92—Glucose isomerase (5.3.1.5; 5.3.1.9; 5.3.1.18)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/02—Monosaccharides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/24—Preparation of compounds containing saccharide radicals produced by the action of an isomerase, e.g. fructose
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01001—Phosphorylase (2.4.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03011—Fructose-bisphosphatase (3.1.3.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y501/00—Racemaces and epimerases (5.1)
    • C12Y501/03—Racemaces and epimerases (5.1) acting on carbohydrates and derivatives (5.1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y503/00—Intramolecular oxidoreductases (5.3)
    • C12Y503/01—Intramolecular oxidoreductases (5.3) interconverting aldoses and ketoses (5.3.1)
    • C12Y503/01008—Mannose-6-phosphate isomerase (5.3.1.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y503/00—Intramolecular oxidoreductases (5.3)
    • C12Y503/01—Intramolecular oxidoreductases (5.3) interconverting aldoses and ketoses (5.3.1)
    • C12Y503/01009—Glucose-6-phosphate isomerase (5.3.1.9)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y504/00—Intramolecular transferases (5.4)
    • C12Y504/02—Phosphotransferases (phosphomutases) (5.4.2)
    • C12Y504/02002—Phosphoglucomutase (5.4.2.2)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

StarchGlzoie Ilhosphde Gtose60:chan FIG. 1 FIG. 1 continued (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 20 September 2018 (20.09.2018) WIPO I PCT o °nolo Dii onoin ioo Imo oimIE (10) International Publication Number WO 2018/169957 Al (51) International Patent Classification: C12N 9/90 (2006.01) C12P 19/18 (2006.01) C12P 19/02 (2006.01) C12P 19/24 (2006.01) (21) International Application Number: PCT/US2018/022185 (22) International Filing Date: 13 March 2018 (13.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/470,620 13 March 2017 (13.03.2017) US 62/470,605 13 March 2017 (13.03.2017) US 62/480,798 03 April 2017 (03.04.2017) US 62/482,148 05 April 2017 (05.04.2017) US (71) Applicant: BONUMOSE LLC [US/US]; 1725 Discovery Drive, Suite 220, Charlottesville, VA 22911 (US). (72) Inventors: WICHELECKI, Daniel Joseph; 717 Lee Street Apartment #7, Blacksburg, VA 24060 (US). ROGERS, Edwin O.; 34 Centerbury Road, Charlottesville, VA 22903 (US). (74) Agent: JHAVERI, Sulay D.; J.A. Lindeman & Co., PLLC, 3190 Fairview Park Drive, Suite 1070, Falls Church, VA 22042 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: ENZYMATIC PRODUCTION OF HEXOSES 1-1 © (57) : Disclosed herein are methods of producing hexoses from saccharides by enzymatic processes. The methods utilize O fructose 6-phosphate and at least one enzymatic step to convert it to a hexose. [Continued on next page] WO 2018/169957 Al MIDEDIMOMMIDEFIEDEMIIMIMINHENDIMIE Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))
SG11201908470U 2017-03-13 2018-03-13 Enzymatic production of hexoses SG11201908470UA (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762470620P 2017-03-13 2017-03-13
US201762470605P 2017-03-13 2017-03-13
US201762480798P 2017-04-03 2017-04-03
US201762482148P 2017-04-05 2017-04-05
PCT/US2018/022185 WO2018169957A1 (en) 2017-03-13 2018-03-13 Enzymatic production of hexoses

Publications (1)

Publication Number Publication Date
SG11201908470UA true SG11201908470UA (en) 2019-10-30

Family

ID=63523885

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201908470U SG11201908470UA (en) 2017-03-13 2018-03-13 Enzymatic production of hexoses

Country Status (13)

Country Link
US (5) US11345909B2 (en)
EP (1) EP3596212A4 (en)
JP (3) JP7140401B2 (en)
KR (2) KR20240125077A (en)
CN (1) CN110914422A (en)
BR (1) BR112019018108A2 (en)
CA (1) CA3056604C (en)
IL (2) IL317454A (en)
MA (1) MA49847A (en)
MX (2) MX2019009863A (en)
RU (1) RU2766710C2 (en)
SG (1) SG11201908470UA (en)
WO (1) WO2018169957A1 (en)

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MX2019008159A (en) 2017-01-06 2019-12-09 Greenlight Biosciences Inc Cell-free production of sugars.
CN110079488A (en) * 2018-01-25 2019-08-02 中国科学院天津工业生物技术研究所 A kind of engineered strain producing psicose, construction method and application
CA3118101A1 (en) * 2018-10-29 2020-05-07 Bonumose, Inc. Enzymatic production of hexoses
KR102233375B1 (en) * 2018-12-11 2021-03-31 씨제이제일제당 주식회사 A novel psicose-6-phosphatase, a composition for producing psicose comprising the same, and a method for producing psicose using the same
CN113544264B (en) * 2019-02-12 2025-06-03 博努莫斯股份有限公司 Enzymatic production of mannose
CN109750011B (en) * 2019-02-20 2022-05-10 中国科学院天津工业生物技术研究所 Mannose-6-phosphate phosphatase and biological preparation method of mannose
CA3141820A1 (en) * 2019-05-31 2020-12-03 Bonumose, Inc. Enzymatic production of fructose
US20240200109A9 (en) * 2019-07-17 2024-06-20 Bonumose, Inc. Immobilized enzyme compositions for the production of hexoses
MX2022000381A (en) * 2019-07-17 2022-04-06 Bonumose Inc Immobilized enzyme compositions for the production of hexoses.
US20220372535A1 (en) * 2019-10-28 2022-11-24 Samyang Corporation Fructose-6-phosphate 3-epimerase and use thereof
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WO2021236632A2 (en) * 2020-05-18 2021-11-25 Bonumose, Inc. Enzymatic production of allulose
CN112680482B (en) * 2021-01-12 2022-12-20 中国科学院天津工业生物技术研究所 A kind of biological preparation method of mannitol
WO2022169793A1 (en) * 2021-02-02 2022-08-11 Bonumose, Inc. Enzymatic enrichment of food ingredients for sugar reduction
CN113913481B (en) * 2021-12-13 2022-03-25 中国科学院天津工业生物技术研究所 The biological preparation method of mannose
CN114645070B (en) * 2022-02-28 2022-12-20 北京焉支山科技有限公司 Preparation method of hexose-6-phosphoric acid composition and application thereof in cosmetics
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WO2025049645A1 (en) * 2023-08-31 2025-03-06 Nutrishus Brands Inc. Disaccharide with metabolic benefits and monosaccharide mixtures

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CN110079488A (en) * 2018-01-25 2019-08-02 中国科学院天津工业生物技术研究所 A kind of engineered strain producing psicose, construction method and application
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MX2019009863A (en) 2020-02-13
JP2022173237A (en) 2022-11-18
MA49847A (en) 2021-06-02
WO2018169957A1 (en) 2018-09-20
US11993796B2 (en) 2024-05-28
IL269219B2 (en) 2025-05-01
US11345909B2 (en) 2022-05-31
BR112019018108A2 (en) 2022-06-14
EP3596212A1 (en) 2020-01-22
IL269219B1 (en) 2025-01-01
KR20190128681A (en) 2019-11-18
CA3056604A1 (en) 2018-09-20
JP2025061690A (en) 2025-04-11
IL269219A (en) 2019-11-28
EP3596212A4 (en) 2021-06-02
US20200010824A1 (en) 2020-01-09
US20240352440A1 (en) 2024-10-24
KR20240125077A (en) 2024-08-19
CA3056604C (en) 2025-11-25
US20220290117A1 (en) 2022-09-15
CN110914422A (en) 2020-03-24
KR102694973B1 (en) 2024-08-16
US20200131547A1 (en) 2020-04-30
US11236320B2 (en) 2022-02-01
RU2019132203A (en) 2021-04-14
RU2019132203A3 (en) 2021-07-01
JP2020509765A (en) 2020-04-02
RU2766710C2 (en) 2022-03-15
IL317454A (en) 2025-02-01
US20200131499A1 (en) 2020-04-30
US10745683B2 (en) 2020-08-18
MX2023007865A (en) 2023-07-07
JP7140401B2 (en) 2022-09-21

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