MX2017012846A - Heteromultimeros de receptor de superfamilia de tgf-beta tipo i y tipo ii y usos de los mismos. - Google Patents
Heteromultimeros de receptor de superfamilia de tgf-beta tipo i y tipo ii y usos de los mismos.Info
- Publication number
- MX2017012846A MX2017012846A MX2017012846A MX2017012846A MX2017012846A MX 2017012846 A MX2017012846 A MX 2017012846A MX 2017012846 A MX2017012846 A MX 2017012846A MX 2017012846 A MX2017012846 A MX 2017012846A MX 2017012846 A MX2017012846 A MX 2017012846A
- Authority
- MX
- Mexico
- Prior art keywords
- type
- polypeptide complexes
- extracellular domain
- tgf
- certain aspects
- Prior art date
Links
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 5
- 210000004027 cell Anatomy 0.000 abstract 4
- 108020003175 receptors Proteins 0.000 abstract 4
- 210000001519 tissue Anatomy 0.000 abstract 3
- 101001059454 Homo sapiens Serine/threonine-protein kinase MARK2 Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 102100028904 Serine/threonine-protein kinase MARK2 Human genes 0.000 abstract 2
- -1 ALK5 Proteins 0.000 abstract 1
- 102100034134 Activin receptor type-1B Human genes 0.000 abstract 1
- 102100034135 Activin receptor type-1C Human genes 0.000 abstract 1
- 102100025511 Anti-Muellerian hormone type-2 receptor Human genes 0.000 abstract 1
- 101710089052 Anti-Muellerian hormone type-2 receptor Proteins 0.000 abstract 1
- 102100025423 Bone morphogenetic protein receptor type-1A Human genes 0.000 abstract 1
- 102100027052 Bone morphogenetic protein receptor type-1B Human genes 0.000 abstract 1
- 101000799189 Homo sapiens Activin receptor type-1B Proteins 0.000 abstract 1
- 101000799193 Homo sapiens Activin receptor type-1C Proteins 0.000 abstract 1
- 101000934638 Homo sapiens Bone morphogenetic protein receptor type-1A Proteins 0.000 abstract 1
- 101000984546 Homo sapiens Bone morphogenetic protein receptor type-1B Proteins 0.000 abstract 1
- 101100490437 Mus musculus Acvrl1 gene Proteins 0.000 abstract 1
- 102000043168 TGF-beta family Human genes 0.000 abstract 1
- 108091085018 TGF-beta family Proteins 0.000 abstract 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 abstract 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 abstract 1
- 108091068141 Type II family Proteins 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000000845 cartilage Anatomy 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000000750 endocrine system Anatomy 0.000 abstract 1
- 210000003743 erythrocyte Anatomy 0.000 abstract 1
- 230000003394 haemopoietic effect Effects 0.000 abstract 1
- 230000011132 hemopoiesis Effects 0.000 abstract 1
- 239000000833 heterodimer Substances 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 abstract 1
- 230000009753 muscle formation Effects 0.000 abstract 1
- 230000001537 neural effect Effects 0.000 abstract 1
- 230000011164 ossification Effects 0.000 abstract 1
- GPTFURBXHJWNHR-UHFFFAOYSA-N protopine Chemical compound C1=C2C(=O)CC3=CC=C4OCOC4=C3CN(C)CCC2=CC2=C1OCO2 GPTFURBXHJWNHR-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N9/10—Transferases (2.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
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- Genetics & Genomics (AREA)
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- Diabetes (AREA)
- Wood Science & Technology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
Abstract
En ciertos aspectos, la descripción proporciona complejos de polipéptidos heteroméricos solubles que comprenden un dominio extracelular de un receptor de serina/treonina cinasa tipo I de la familia TGF-beta y un dominio extracelular de un receptor de serina/treonina cinasa tipo II de la familia de TGF-beta. En algunas modalidades, la descripción proporciona complejos de polipéptidos solubles que comprende un dominio extracelular de un receptor de tipo II seleccionado de: ActRIIA, ActRllB, TGFBRII, BMPRII y MISRII. En algunas modalidades, la descripción proporciona complejos de polipéptidos solubles que comprenden un dominio extracelular de un receptor tipo I seleccionado de: ALK1, ALK.2, ALK3, ALK4, ALK5, ALK6 y ALK7. Opcionalmente el complejo soluble es un heterodímero. En ciertos aspectos, tales complejos de polipéptidos solubles pueden usarse para regular (promover o inhibir) el crecimiento de tejidos o células incluyendo, por ejemplo, células de músculo, hueso, cartílago, grasa, tejido neural, tumores, células cancerosas y/o células de linaje hematopoyético, incluyendo glóbulos rojos. En ciertos aspectos, tales complejos de polipéptidos solubles pueden ser usados para mejorar la formación de músculo, formación de hueso, hematopoyesis, parámetros metabólicos y trastornos asociados con estos tejidos, redes celulares y sistemas endocrinos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562143579P | 2015-04-06 | 2015-04-06 | |
| PCT/US2016/000033 WO2016164089A2 (en) | 2015-04-06 | 2016-04-06 | Tgf-beta superfamily type i and type ii receptor heteromultimers and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2017012846A true MX2017012846A (es) | 2018-11-09 |
| MX391964B MX391964B (es) | 2025-03-21 |
Family
ID=57072866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017012846A MX391964B (es) | 2015-04-06 | 2016-04-06 | Heteromultimeros de receptor de superfamilia de tgf-beta tipo i y tipo ii y usos de los mismos. |
Country Status (15)
| Country | Link |
|---|---|
| US (7) | US10227393B2 (es) |
| EP (5) | EP3889171B1 (es) |
| JP (3) | JP7037363B2 (es) |
| KR (2) | KR20180002661A (es) |
| CN (4) | CN115073610A (es) |
| AU (4) | AU2016244750B2 (es) |
| BR (1) | BR112017021510A2 (es) |
| CA (2) | CA2981737A1 (es) |
| DK (1) | DK3280728T3 (es) |
| EA (2) | EA037293B1 (es) |
| ES (1) | ES2863564T3 (es) |
| HK (2) | HK1250373A1 (es) |
| MA (4) | MA54328A (es) |
| MX (1) | MX391964B (es) |
| WO (2) | WO2016164089A2 (es) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105658672A (zh) | 2013-08-22 | 2016-06-08 | 阿塞勒隆制药公司 | TGF-β受体II型变体及其用途 |
| US10588980B2 (en) | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
| MA41919A (fr) | 2015-04-06 | 2018-02-13 | Acceleron Pharma Inc | Hétéromultimères alk4:actriib et leurs utilisations |
| BR112017021510A2 (pt) | 2015-04-06 | 2018-07-03 | Acceleron Pharma Inc | heteromultímeros do receptor tipo i e tipo ii da superfamília tgf-beta e sua utilização |
| JP6810702B2 (ja) | 2015-04-06 | 2021-01-06 | アクセルロン ファーマ インコーポレイテッド | シングルアームｉ型およびｉｉ型受容体融合タンパク質およびその使用 |
| RS61881B1 (sr) | 2015-04-22 | 2021-06-30 | Biogen Ma Inc | Novi hibridni actriib proteini zamke za ligand za lečenje bolesti gubljenja mišića |
| CN116327952A (zh) | 2015-08-04 | 2023-06-27 | 阿塞勒隆制药公司 | 用于治疗骨髓增生性病症的方法 |
| CN105254764A (zh) * | 2015-08-27 | 2016-01-20 | 上海康岱生物医药技术有限公司 | ACVR1-Fc融合蛋白及其制法和用途 |
| EP3439741A4 (en) | 2016-04-06 | 2020-05-06 | Acceleron Pharma Inc. | ALK7 ANTAGONISTS AND USES THEREOF |
| AU2017296040C1 (en) | 2016-07-15 | 2023-06-22 | Acceleron Pharma Inc. | Compositions and methods for treating pulmonary hypertension |
| WO2018067874A1 (en) | 2016-10-05 | 2018-04-12 | Acceleron Pharma Inc. | Variant actriib proteins and uses thereof |
| JP2019529509A (ja) * | 2016-10-05 | 2019-10-17 | アクセレロン ファーマ インコーポレーテッド | 腎臓疾患を治療するための組成物および方法 |
| EP3522913A4 (en) | 2016-10-05 | 2020-10-28 | Acceleron Pharma Inc. | ALK4 HETEROMULTIMERS: ACTRIIB AND THEIR USES |
| AU2017338915B2 (en) * | 2016-10-05 | 2024-11-21 | Acceleron Pharma Inc. | TGF-beta superfamily type I and type II receptor heteromultimers and uses thereof |
| JOP20190085A1 (ar) | 2016-10-20 | 2019-04-17 | Biogen Ma Inc | طرق علاج الضمور العضلي ومرض العظام باستخدام بروتينات احتجاز مركب ترابطي actriib هجين حديثة |
| EP3538123A4 (en) | 2016-11-10 | 2020-10-14 | Keros Therapeutics, Inc. | ACTIVIN RECEPTOR TYPE IIA VARIANTS AND THEIR METHODS OF USE |
| EP3541833B1 (en) * | 2016-11-17 | 2024-01-24 | 2seventy bio, Inc. | Tgf beta signal convertor |
| AU2018214979A1 (en) * | 2017-02-01 | 2019-08-15 | Acceleron Pharma Inc. | TGFβ and actrii antagonists for use in increasing immune activity |
| DK3628049T3 (da) | 2017-05-04 | 2023-08-14 | Acceleron Pharma Inc | Tgf-beta-receptortype-ii-fusionsproteiner og anvendelser deraf |
| EP3424957A1 (en) * | 2017-07-03 | 2019-01-09 | advanceCOR GmbH | Fusion protein |
| WO2019086331A2 (en) * | 2017-11-02 | 2019-05-09 | Bayer Aktiengesellschaft | Bispecific antibodies binding alk-1 and bmpr-2 |
| CN120399032A (zh) | 2018-01-12 | 2025-08-01 | 科乐斯疗法公司 | 激活素受体iib型变体及其使用方法 |
| EP3749682B1 (en) * | 2018-02-09 | 2025-09-24 | Acceleron Pharma Inc. | Treating heterotopic ossification |
| AU2019231205A1 (en) * | 2018-03-06 | 2020-09-24 | The Trustees Of The University Of Pennsylvania | Prostate-specific membrane antigen cars and methods of use thereof |
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