MX2013002649A - Agente terapeutico contra el dolor. - Google Patents
Agente terapeutico contra el dolor.Info
- Publication number
- MX2013002649A MX2013002649A MX2013002649A MX2013002649A MX2013002649A MX 2013002649 A MX2013002649 A MX 2013002649A MX 2013002649 A MX2013002649 A MX 2013002649A MX 2013002649 A MX2013002649 A MX 2013002649A MX 2013002649 A MX2013002649 A MX 2013002649A
- Authority
- MX
- Mexico
- Prior art keywords
- pain
- therapeutic agent
- inventors
- useful
- treatment
- Prior art date
Links
- 208000002193 Pain Diseases 0.000 title abstract 6
- 239000003814 drug Substances 0.000 title abstract 2
- 229940124597 therapeutic agent Drugs 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- -1 triazole compound Chemical class 0.000 abstract 2
- 208000000094 Chronic Pain Diseases 0.000 abstract 1
- 208000001640 Fibromyalgia Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000004296 neuralgia Diseases 0.000 abstract 1
- 208000021722 neuropathic pain Diseases 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
- 150000003852 triazoles Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se proporciona un producto farmacéutico, particularmente, una composición farmacéutica que es útil para el tratamiento del dolor. Los actuales inventores han realizado estudios exhaustivos al usar los animales modelo con dolor para el propósito de proporcionar un agente terapéutico contra el dolor. Consecuentemente, han encontrado que el inhibidor de 11ß-hidroxiesteroide deshidrogenasa tipo 1 (11ß-HSD1, por sus siglas en inglés), particularmente, un compuesto de triazol que tiene un grupo cíclico en la posición 3 (o en la posición 5) de un anillo de triazol, tiene un buen efecto de mejorar el dolor crónico. Es decir, de acuerdo con la presente invención, una composición farmacéutica que comprende un inhibidor de 11ß-HSD1, particularmente, el compuesto de triazol de la presente invención, como un ingrediente activo, es útil para el tratamiento del dolor (particularmente, del dolor neuropático o de la fibromialgia).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010200305 | 2010-09-07 | ||
| PCT/JP2011/070205 WO2012033070A1 (ja) | 2010-09-07 | 2011-09-06 | 疼痛治療剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2013002649A true MX2013002649A (es) | 2013-04-05 |
Family
ID=45810669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013002649A MX2013002649A (es) | 2010-09-07 | 2011-09-06 | Agente terapeutico contra el dolor. |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US9765040B2 (es) |
| EP (1) | EP2614824B1 (es) |
| JP (1) | JP5822079B2 (es) |
| KR (1) | KR101747486B1 (es) |
| CN (2) | CN107041885A (es) |
| AU (1) | AU2011299905B2 (es) |
| BR (1) | BR112013005532A2 (es) |
| CA (1) | CA2809778C (es) |
| CY (1) | CY1116274T1 (es) |
| DK (1) | DK2614824T3 (es) |
| EA (1) | EA022338B1 (es) |
| ES (1) | ES2533310T3 (es) |
| HR (1) | HRP20150544T1 (es) |
| IL (1) | IL224920A (es) |
| MX (1) | MX2013002649A (es) |
| PH (1) | PH12013500371A1 (es) |
| PL (1) | PL2614824T3 (es) |
| PT (1) | PT2614824E (es) |
| SI (1) | SI2614824T1 (es) |
| TW (1) | TWI486336B (es) |
| UA (1) | UA112418C2 (es) |
| WO (1) | WO2012033070A1 (es) |
| ZA (1) | ZA201301458B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9266840B2 (en) | 2011-10-18 | 2016-02-23 | Astellas Pharma Inc. | Bicyclic heterocyclic compound |
| US9994658B2 (en) | 2015-10-02 | 2018-06-12 | Exxonmobil Chemical Patents Inc. | Polymerization process using bis phenolate compounds supported on organoaluminum treated layered silicate supports |
| US11039755B2 (en) * | 2015-12-03 | 2021-06-22 | Robert S. Katz | Methods and systems for diagnosing and treating fibromyalgia |
| RU2643583C1 (ru) * | 2016-10-24 | 2018-02-02 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Уральский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО УГМУ Минздрава России) | Способ лечения хронических болевых синдромов, сформировавшихся на основе посттравматического стрессового расстройства, сочетающегося с последствиями боевой черепно-мозговой травмы |
| WO2018117063A1 (ja) * | 2016-12-20 | 2018-06-28 | アステラス製薬株式会社 | 焦燥性興奮治療剤 |
| MX2021005801A (es) * | 2018-11-20 | 2021-08-05 | Sparrow Pharmaceuticals Inc | Metodos para administrar corticosteroides. |
| IL316907A (en) | 2022-05-16 | 2025-01-01 | Sparrow Pharmaceuticals Inc | METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOD EXCESS |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPR878201A0 (en) * | 2001-11-09 | 2001-12-06 | Fujisawa Pharmaceutical Co., Ltd. | New compounds |
| AR040241A1 (es) | 2002-06-10 | 2005-03-23 | Merck & Co Inc | Inhibidores de la 11-beta-hidroxiesteroide deshidrogrenasa 1 para el tratamiento de la diabetes obesidad y dislipidemia |
| RU2352568C9 (ru) | 2002-08-09 | 2009-06-27 | Астразенека Аб | [1,2,4]оксадиазолы (варианты), способ их получения, фармацевтическая композиция и способ ингибирования активации метаботропных глютаматных рецепторов-5 |
| JO2397B1 (en) | 2002-12-20 | 2007-06-17 | ميرك شارب اند دوم كوربوريشن | Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors |
| DE602004027171D1 (de) | 2003-04-11 | 2010-06-24 | High Point Pharmaceuticals Llc | Verbindungen mit Aktivität an der 11Beta-Hydroxasteroiddehydrogenase |
| EP1673464A2 (en) * | 2003-10-10 | 2006-06-28 | Novo Nordisk A/S | Conjugation of peptides |
| EP1680114A4 (en) | 2003-10-28 | 2008-09-24 | Amgen Inc | TRIAZOL COMPOUNDS AND RELEVANT PROCEDURES |
| JP2005170939A (ja) * | 2003-11-20 | 2005-06-30 | Takeda Chem Ind Ltd | 糖尿病の予防・治療剤 |
| JP2007514731A (ja) | 2003-12-19 | 2007-06-07 | ファイザー インコーポレイテッド | 糖尿病及び肥満症の治療のための１１−ベータ−ヒドロキシステロイドデヒドロゲナーゼ１型（１１−β−ｈｓｄ−１）の阻害剤としてのベンゼンスルホニルアミノ−ピリジン−２−イル誘導体及び関連化合物 |
| US7507832B2 (en) * | 2003-12-22 | 2009-03-24 | Eli Lilly And Company | Triazole PPAR modulators |
| EP1790641A4 (en) | 2004-09-16 | 2009-08-26 | Astellas Pharma Inc | DERIVATIVE OF TRIAZOLE OR SALT OF SAID DERIVATIVE |
| EP1812407A2 (en) | 2004-11-02 | 2007-08-01 | Pfizer, Inc. | Novel compounds of substituted and unsubstituted adamantyl amides |
| DE602006010546D1 (de) | 2005-06-16 | 2009-12-31 | Pfizer | N-(pyridin-2-yl)sulfonamidderivate |
| CN101198605A (zh) | 2005-06-16 | 2008-06-11 | 辉瑞大药厂 | N-(吡啶-2-基)-磺酰胺衍生物 |
| WO2006134481A1 (en) | 2005-06-16 | 2006-12-21 | Pfizer Inc. | Inhibitors of 11-beta hydroxysteroid dehydrogenase type 1 |
| US7853951B2 (en) * | 2005-07-25 | 2010-12-14 | Intel Corporation | Lock sequencing to reorder and grant lock requests from multiple program threads |
| EP1922068A4 (en) | 2005-08-16 | 2010-08-11 | Icagen Inc | INHIBITORS OF VOLTAGE-CONTROLLED SODIUM CHANNELS |
| AR058807A1 (es) * | 2005-09-29 | 2008-02-27 | Astrazeneca Ab | 5-(fenilisoxazoletoxi)-triazol-3-il piridinas sustituidas, para el tratamiento de trastornos mediados por el receptor mglur5 |
| TWI391378B (zh) | 2006-03-16 | 2013-04-01 | Astellas Pharma Inc | 喹啉酮衍生物或其製藥學上可被容許之鹽 |
| US20090082367A1 (en) | 2006-03-16 | 2009-03-26 | Astellas Pharma Inc. | Triazole derivative or a salt thereof |
| SMT201700154T1 (it) * | 2008-07-03 | 2017-05-08 | Astellas Pharma Inc | Derivato di triazolo o suo sale |
| FR2948211B1 (fr) * | 2009-07-17 | 2011-08-05 | Airbus Operations Sas | Methode de routage des liaisons physiques d'une plateforme avionique |
| WO2011068927A2 (en) | 2009-12-04 | 2011-06-09 | Abbott Laboratories | 11-β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11B-HSD1) INHIBITORS AND USES THEREOF |
-
2011
- 2011-06-09 UA UAA201304329A patent/UA112418C2/uk unknown
- 2011-09-06 ES ES11823545.6T patent/ES2533310T3/es active Active
- 2011-09-06 WO PCT/JP2011/070205 patent/WO2012033070A1/ja not_active Ceased
- 2011-09-06 BR BR112013005532A patent/BR112013005532A2/pt not_active Application Discontinuation
- 2011-09-06 CN CN201710421919.1A patent/CN107041885A/zh active Pending
- 2011-09-06 TW TW100132078A patent/TWI486336B/zh not_active IP Right Cessation
- 2011-09-06 DK DK11823545.6T patent/DK2614824T3/en active
- 2011-09-06 SI SI201130469T patent/SI2614824T1/sl unknown
- 2011-09-06 CA CA2809778A patent/CA2809778C/en not_active Expired - Fee Related
- 2011-09-06 PH PH1/2013/500371A patent/PH12013500371A1/en unknown
- 2011-09-06 US US13/820,873 patent/US9765040B2/en not_active Expired - Fee Related
- 2011-09-06 KR KR1020137008722A patent/KR101747486B1/ko not_active Expired - Fee Related
- 2011-09-06 CN CN201180042963.2A patent/CN103079564B/zh not_active Expired - Fee Related
- 2011-09-06 HR HRP20150544TT patent/HRP20150544T1/hr unknown
- 2011-09-06 PT PT118235456T patent/PT2614824E/pt unknown
- 2011-09-06 EA EA201390345A patent/EA022338B1/ru not_active IP Right Cessation
- 2011-09-06 MX MX2013002649A patent/MX2013002649A/es active IP Right Grant
- 2011-09-06 EP EP11823545.6A patent/EP2614824B1/en active Active
- 2011-09-06 JP JP2012532977A patent/JP5822079B2/ja not_active Expired - Fee Related
- 2011-09-06 PL PL11823545T patent/PL2614824T3/pl unknown
- 2011-09-06 AU AU2011299905A patent/AU2011299905B2/en not_active Ceased
-
2013
- 2013-02-26 ZA ZA2013/01458A patent/ZA201301458B/en unknown
- 2013-02-26 IL IL224920A patent/IL224920A/en not_active IP Right Cessation
-
2015
- 2015-05-13 CY CY20151100424T patent/CY1116274T1/el unknown
-
2017
- 2017-07-31 US US15/664,733 patent/US20170327474A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12014500529A1 (en) | Substituted n- [1-cyano-2- (phenyl) ethyl] -2-azabicyclo [2.2.1] heptane-3-carboxamide inhibitors of cathepsin c | |
| NZ708593A (en) | Novel pyrazole derivative | |
| PH12013500145B1 (en) | Agonists of gpr40 | |
| WO2013066835A3 (en) | Compounds and methods | |
| WO2013066839A3 (en) | Compounds and methods | |
| MX2013002649A (es) | Agente terapeutico contra el dolor. | |
| MX338554B (es) | Compuestos de fenil carbamato para usarse en aliviar o tratar el dolor. | |
| UA109661C2 (uk) | Фармацевтична композиція співкристалів трамадолу і коксибів | |
| UA98839C2 (en) | N,n-disubstituted aminoalkylbiphenyl antagonists of prostaglandin d2 receptors | |
| EA201291306A1 (ru) | Состав сухого порошка, содержащий антимускариновое средство | |
| MX2014007969A (es) | Hidroxiamidas de ácido cinámico como inhibidores de la histona desacetilasa 8. | |
| WO2010087565A3 (ko) | 피페린의 신규한 용도 | |
| MY167898A (en) | Co-crystals and salts of ccr3-inhibitors | |
| WO2013061004A8 (fr) | Nouveaux composés di-substitués de la diamino-3,4-cyclobutène-3-dione-1,2 utiles dans le traitement de pathologies médiées par des chimiokines | |
| MX2014004858A (es) | Compuestos de 3,4-diamino-3-ciclobuten-1,2-diona disustituidos utiles en el tratamiento de patologias mediadas por quimiocinas. | |
| MX2015001917A (es) | Composiciones farmaceuticas de memantina. | |
| WO2012128582A3 (en) | A COMPOUND FOR INHIBITING HUMAN 11-β-HYDROXY STEROID DEHYDROGENASE TYPE 1, AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | |
| PH12019500618A1 (en) | Pharmaceutical composition and method for treatment of non-alcoholic fatty liver disease | |
| MX362830B (es) | Agente terapeutico o profilactico para enfermedades del tracto biliar. | |
| MY152040A (en) | Triazolopyridazines as par1 inhibitors, production thereof, and use as medicaments | |
| MY148732A (en) | Triazolium salts as par1 inhibitors, production thereof, and use as medicaments | |
| MY152685A (en) | Imidazopyridazines as par1 inhibitors, production thereof, and use thereof as medicaments | |
| GEAP202516217A (en) | Compounds and compositions as sppl2a inhibitors | |
| EP2599487A4 (en) | THERAPEUTIC OR PROPHYLACTIC AGENT FOR NEUROPATHIC PAIN | |
| MX2010008586A (es) | Amidas de acido 3-(4-fluorofenil)-3-hidroxi-2-amino-propionico y compuestos relacionados que tienen actividad analgesica. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |