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WO2013066839A3 - Compounds and methods - Google Patents

Compounds and methods Download PDF

Info

Publication number
WO2013066839A3
WO2013066839A3 PCT/US2012/062514 US2012062514W WO2013066839A3 WO 2013066839 A3 WO2013066839 A3 WO 2013066839A3 US 2012062514 W US2012062514 W US 2012062514W WO 2013066839 A3 WO2013066839 A3 WO 2013066839A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
methods
hdac
enzymes
inhibition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2012/062514
Other languages
French (fr)
Other versions
WO2013066839A2 (en
Inventor
Shomir Ghosh
Mercedes Lobera
Ryan Paul Trump
Cunyu Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline LLC
Tempero Pharmaceuticals Inc
Original Assignee
GlaxoSmithKline LLC
Tempero Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GlaxoSmithKline LLC, Tempero Pharmaceuticals Inc filed Critical GlaxoSmithKline LLC
Publication of WO2013066839A2 publication Critical patent/WO2013066839A2/en
Anticipated expiration legal-status Critical
Publication of WO2013066839A3 publication Critical patent/WO2013066839A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention relates to compounds that inhibit histone deacetylase (HDAC) enzymes, the preparation of these compounds or salts of said compound, the use of these compounds in the treatment of neurodegenerative diseases or conditions ameliorated by inhibition of HDAC activity and pharmaceutical compositions that are comprised of these compounds.
PCT/US2012/062514 2011-10-31 2012-10-30 Compounds and methods Ceased WO2013066839A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161553757P 2011-10-31 2011-10-31
US61/553,757 2011-10-31
US201261596269P 2012-02-08 2012-02-08
US61/596,269 2012-02-08

Publications (2)

Publication Number Publication Date
WO2013066839A2 WO2013066839A2 (en) 2013-05-10
WO2013066839A3 true WO2013066839A3 (en) 2015-06-25

Family

ID=48193011

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/062514 Ceased WO2013066839A2 (en) 2011-10-31 2012-10-30 Compounds and methods

Country Status (1)

Country Link
WO (1) WO2013066839A2 (en)

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CN108289449A (en) * 2015-11-19 2018-07-17 巴斯夫欧洲公司 Qu Dai oxadiazoles for preventing and kill off plant pathogenic fungi

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EP2729459B1 (en) * 2011-07-07 2018-08-22 Merck Patent GmbH Substituted azaheterocycles for the treatment of cancer
EA201490228A1 (en) 2011-07-08 2014-08-29 Новартис Аг NEW DERIVATIVES OF TRIFTOROMETHYLOROXIAZOLE AND THEIR APPLICATION FOR THE TREATMENT OF DISEASE
US10064869B2 (en) 2014-06-04 2018-09-04 Thomas Helledays Stiftelse For Medicinsk Forskning MTH1 inhibitors for treatment of inflammatory and autoimmune conditions
CA2949785A1 (en) 2014-06-04 2015-12-10 Thomas Helledays Stiftelse For Medicinsk Forskning Mth1 inhibitors for treatment of cancer
US10081624B2 (en) 2014-08-26 2018-09-25 Takeda Pharmaceutical Company Limited Heterocyclic compound
ES2793014T3 (en) 2015-07-17 2020-11-12 Takeda Pharmaceuticals Co Oxadiazole derivatives useful as HDAC inhibitors
EP3327019A4 (en) 2015-07-17 2019-04-03 Takeda Pharmaceutical Company Limited HETEROCYCLIC COMPOUND
EP3328844B1 (en) 2015-07-27 2019-11-27 Chong Kun Dang Pharmaceutical Corp. 1,3,4-oxadiazole sulfamide derivatives as histone deacetylase 6 inhibitor and pharmaceutical composition comprising the same
RU2697665C1 (en) 2015-07-27 2019-08-16 Чонг Кун Данг Фармасьютикал Корп. 1,3,4-oxadiazole sulphonamide derivatives as histone deacetylase inhibitors 6 and pharmaceutical composition containing thereof
EP3330259B1 (en) 2015-07-27 2020-06-10 Chong Kun Dang Pharmaceutical Corp. 1,3,4-oxadiazole amide derivative compound as histone deacetylase 6 inhibitor, and pharmaceutical composition containing same
PL3331864T3 (en) * 2015-08-04 2022-02-21 Chong Kun Dang Pharmaceutical Corp. 1,3,4-oxadiazole derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same
JPWO2017033946A1 (en) 2015-08-25 2018-06-07 武田薬品工業株式会社 Heterocyclic compounds
DK3356358T3 (en) 2015-10-02 2020-08-03 Syngenta Participations Ag MICROBIOCIDE OXADIAZOLE DERIVATIVES
JP6864673B2 (en) * 2015-10-02 2021-04-28 シンジェンタ パーティシペーションズ アーゲー Microbial oxadiazole derivative
ES2940413T3 (en) 2015-10-12 2023-05-08 Chong Kun Dang Pharmaceutical Corp Compounds derived from oxadiazolamine as histone deacetylase 6 inhibitors, and the pharmaceutical composition comprising them
CR20180310A (en) 2015-11-05 2018-11-30 Basf Se OXADIAZOLS REPLACED TO COMBAT HONGOD PHYTOOPATHOGENS
WO2017085098A1 (en) 2015-11-19 2017-05-26 Basf Se Substituted oxadiazoles for combating phytopathogenic fungi
BR112018011053A2 (en) 2015-12-02 2018-11-21 Syngenta Participations Ag microbiocidal oxadiazole derivatives
CN108430997B (en) * 2015-12-17 2021-06-04 先正达参股股份有限公司 Microbicidal oxadiazole derivatives
WO2017103223A1 (en) * 2015-12-18 2017-06-22 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
UY37062A (en) 2016-01-08 2017-08-31 Syngenta Participations Ag DERIVATIVES OF ARYL OXADIAZOL FUNGICIDAS
BR112018069412B1 (en) 2016-03-24 2022-09-20 Syngenta Participations Ag COMPOUNDS DERIVED FROM OXADIAZOLE MICROBIOCIDES, AGROCHEMICAL COMPOSITION, METHOD OF CONTROL OR PREVENTION OF INFESTATION OF USEFUL PLANTS BY PHYTOPATOGENIC MICROORGANISMS AND USE OF SUCH COMPOUND
CN108884062A (en) 2016-04-11 2018-11-23 巴斯夫欧洲公司 For preventing and treating the Qu Dai oxadiazole class of plant pathogenic fungi
WO2017178549A1 (en) * 2016-04-12 2017-10-19 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
CA3027013A1 (en) 2016-06-09 2017-12-14 Basf Se Substituted oxadiazoles for combating phytopathogenic fungi
WO2017222951A1 (en) 2016-06-23 2017-12-28 Merck Sharp & Dohme Corp. 3-aryl and heteroaryl substituted 5-trifluoromethyl oxadiazoles as histone deacetylase 6 (hdac6) inhibitors
CN106243083B (en) * 2016-07-12 2018-10-30 浙江宏冠生物药业有限公司 A kind of Imatinib preparation method
WO2018165520A1 (en) 2017-03-10 2018-09-13 Vps-3, Inc. Metalloenzyme inhibitor compounds
BR112019020134B1 (en) 2017-03-31 2023-05-09 Syngenta Participations Ag FUNGICIDAL COMPOSITIONS
WO2018177894A1 (en) 2017-03-31 2018-10-04 Syngenta Participations Ag Fungicidal compositions
EP3606913B1 (en) 2017-04-03 2022-04-27 Syngenta Participations AG Microbiocidal oxadiazole derivatives
WO2018184987A1 (en) 2017-04-05 2018-10-11 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
WO2018184986A1 (en) 2017-04-05 2018-10-11 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
BR112019020819B1 (en) 2017-04-05 2023-12-05 Syngenta Participations Ag COMPOUND OF FORMULA (I), AGROCHEMICAL COMPOSITION, METHOD FOR CONTROLLING OR PREVENTING INFESTATION OF USEFUL PLANTS BY PHYTOPATHOGENIC MICROORGANISMS AND USE OF A COMPOUND OF FORMULA (I)
WO2018184985A1 (en) 2017-04-05 2018-10-11 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
WO2018184984A1 (en) 2017-04-05 2018-10-11 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
WO2018184982A1 (en) 2017-04-05 2018-10-11 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
TWI829634B (en) * 2017-04-06 2024-01-21 美商富曼西公司 Fungicidal oxadiazoles
CN111032651A (en) 2017-07-31 2020-04-17 武田药品工业株式会社 Heterocyclic compounds
IL274973B2 (en) * 2017-12-05 2024-07-01 Oryzon Genomics Sa History of 4,2,1-oxadiazole as histone deacetylase inhibitors
CN112020503A (en) 2018-04-26 2020-12-01 先正达参股股份有限公司 Microbicidal oxadiazole derivatives
KR102316234B1 (en) 2018-07-26 2021-10-22 주식회사 종근당 1,3,4-Oxadiazole Derivative Compounds as Histone Deacetylase 6 Inhibitor, and the Pharmaceutical Composition Comprising the same
CN111285861B (en) * 2018-12-10 2021-08-17 浙江省化工研究院有限公司 A kind of pyrimidine amine compound containing trifluoromethyl oxadiazole substitution, its preparation method and application
AR118673A1 (en) 2019-04-18 2021-10-20 Syngenta Crop Protection Ag PROCEDURE FOR THE PREPARATION OF OXADIAZOLE DERIVATIVES MICROBIOCIDES
AU2020284606B2 (en) 2019-05-31 2023-01-19 Chong Kun Dang Pharmaceutical Corp. 1,3,4-oxadiazole homophthalimide derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same
BR112021025300A2 (en) * 2019-06-21 2022-02-01 Bayer Ag fungicidal oxadiazoles
BR112022005595A2 (en) 2019-09-27 2022-07-19 Takeda Pharmaceuticals Co COMPOUND, DRUG, METHODS FOR INHIBITING HISTONE DEACETYLASE 6 AND FOR PROPHYLAXIS OR TREATMENT OF ALZHEIMER'S DISEASE OR PROGRESSIVE SUPRANUCLEAR PALSY IN A MAMMAL, AND, COMPOUND USE
KR102537616B1 (en) 2020-02-25 2023-05-26 주식회사 종근당 1,3,4-Oxadiazole Derivative Compounds as Histone Deacetylase 6 Inhibitor, and the Pharmaceutical Composition Comprising the same
TW202438074A (en) 2023-02-28 2024-10-01 韓商鐘根堂股份有限公司 Oxadiazole derivative compounds, and the pharmaceutical composition comprising the same
WO2025031913A1 (en) 2023-08-04 2025-02-13 Syngenta Crop Protection Ag Methods of controlling or preventing infestation of plants by the phytopathogenic microorganism corynespora cassiicola

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US20080227834A1 (en) * 2005-09-29 2008-09-18 Sanofi-Aventis Derivatives of 2-aminothiazoles and 2-amino-oxazoles, processes for their preparation and their use as pharmaceutical compositions
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Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
US20050137212A1 (en) * 2002-03-01 2005-06-23 Rodolfo Cadilla Hppars activators
US20080227834A1 (en) * 2005-09-29 2008-09-18 Sanofi-Aventis Derivatives of 2-aminothiazoles and 2-amino-oxazoles, processes for their preparation and their use as pharmaceutical compositions
US20090062252A1 (en) * 2007-08-27 2009-03-05 Helicon Therapeutics, Inc. Therapeutic isoxazole compounds
WO2011088192A1 (en) * 2010-01-13 2011-07-21 Tempero Pharmaceuticals, Inc. Compounds and methods

Non-Patent Citations (1)

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Title
SHERMETEV ET AL.: "Synthesis of secondary and tertiary aminofurazans.", RUSSIAN CHEMICAL BULLETIN, INTERNATIONAL EDITION, vol. 53, no. 3, March 2004 (2004-03-01), pages 596 - 614 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108289449A (en) * 2015-11-19 2018-07-17 巴斯夫欧洲公司 Qu Dai oxadiazoles for preventing and kill off plant pathogenic fungi

Also Published As

Publication number Publication date
WO2013066839A2 (en) 2013-05-10

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