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MX2009005504A - Derivados de espiro piperidina como antagonistas del receptor via. - Google Patents

Derivados de espiro piperidina como antagonistas del receptor via.

Info

Publication number
MX2009005504A
MX2009005504A MX2009005504A MX2009005504A MX2009005504A MX 2009005504 A MX2009005504 A MX 2009005504A MX 2009005504 A MX2009005504 A MX 2009005504A MX 2009005504 A MX2009005504 A MX 2009005504A MX 2009005504 A MX2009005504 A MX 2009005504A
Authority
MX
Mexico
Prior art keywords
spiro
sup
receptor antagonists
piperidine derivatives
via receptor
Prior art date
Application number
MX2009005504A
Other languages
English (en)
Inventor
Mark Rogers-Evans
Raffaello Masciadri
Patrick Schnider
Hasane Ratni
Caterina Bissantz
Christophe Grundschober
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2009005504A publication Critical patent/MX2009005504A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se refiere a nuevos derivados de indol-2-il-carbonil-espiro-piperidina que actúan como antagonistas del receptor V1a, su manufactura, composiciones farmacéuticas que los contienen y a su uso como medicamentos. Los compuestos activos de la presente invención son útiles para la prevención y/o tratamiento de ansiedad, trastornos depresivos y otras enfermedades. Los compuestos de la presente invención se representan mediante la fórmula general (I) en donde R1 a R11, X e Y son como se definió en la descripción.
MX2009005504A 2006-12-07 2007-11-29 Derivados de espiro piperidina como antagonistas del receptor via. MX2009005504A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06125634 2006-12-07
PCT/EP2007/062985 WO2008068185A1 (en) 2006-12-07 2007-11-29 Spiro-piperidine derivatives as via receptor antagonists

Publications (1)

Publication Number Publication Date
MX2009005504A true MX2009005504A (es) 2009-06-03

Family

ID=39295880

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009005504A MX2009005504A (es) 2006-12-07 2007-11-29 Derivados de espiro piperidina como antagonistas del receptor via.

Country Status (21)

Country Link
US (3) US20080139554A1 (es)
EP (1) EP2102207B1 (es)
JP (1) JP2010511661A (es)
KR (1) KR101050568B1 (es)
CN (1) CN101547923A (es)
AR (1) AR064135A1 (es)
AT (1) ATE469900T1 (es)
AU (1) AU2007328995B2 (es)
BR (1) BRPI0720004A2 (es)
CA (1) CA2670674A1 (es)
CL (1) CL2007003482A1 (es)
DE (1) DE602007006990D1 (es)
ES (1) ES2344131T3 (es)
IL (1) IL198544A (es)
MX (1) MX2009005504A (es)
NO (1) NO20091830L (es)
PE (1) PE20081252A1 (es)
RU (1) RU2009119394A (es)
TW (1) TW200838518A (es)
WO (1) WO2008068185A1 (es)
ZA (1) ZA200903496B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080153863A1 (en) 2006-12-22 2008-06-26 Caterina Bissantz Spiropiperidine derivatives
NZ588217A (en) 2008-04-29 2012-10-26 Novartis Ag Spiro-indole derivatives for treating malaria, leishmaniasis and Chagas disease
JP6629855B2 (ja) * 2014-11-14 2020-01-15 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ スピロチアゾロン
EP3414247B1 (en) * 2016-02-08 2021-04-21 F. Hoffmann-La Roche AG Spiroindolinones as ddr1 inhibitors
CN111212842B (zh) 2017-09-05 2022-10-25 布莱克索恩治疗公司 血管加压素受体拮抗剂以及与其相关的产品和方法

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Also Published As

Publication number Publication date
ATE469900T1 (de) 2010-06-15
US20080139554A1 (en) 2008-06-12
JP2010511661A (ja) 2010-04-15
WO2008068185A1 (en) 2008-06-12
US8202993B2 (en) 2012-06-19
AU2007328995B2 (en) 2012-04-26
PE20081252A1 (es) 2008-09-04
US20080146568A1 (en) 2008-06-19
CA2670674A1 (en) 2008-06-12
RU2009119394A (ru) 2011-01-20
ZA200903496B (en) 2010-03-31
IL198544A (en) 2012-06-28
CN101547923A (zh) 2009-09-30
KR20090079255A (ko) 2009-07-21
DE602007006990D1 (de) 2010-07-15
TW200838518A (en) 2008-10-01
AR064135A1 (es) 2009-03-18
AU2007328995A1 (en) 2008-06-12
CL2007003482A1 (es) 2008-07-04
EP2102207B1 (en) 2010-06-02
IL198544A0 (en) 2010-02-17
US20080139553A1 (en) 2008-06-12
BRPI0720004A2 (pt) 2013-12-17
KR101050568B1 (ko) 2011-07-19
NO20091830L (no) 2009-07-06
ES2344131T3 (es) 2010-08-18
EP2102207A1 (en) 2009-09-23

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