[go: up one dir, main page]

MX2009006920A - Indoles. - Google Patents

Indoles.

Info

Publication number
MX2009006920A
MX2009006920A MX2009006920A MX2009006920A MX2009006920A MX 2009006920 A MX2009006920 A MX 2009006920A MX 2009006920 A MX2009006920 A MX 2009006920A MX 2009006920 A MX2009006920 A MX 2009006920A MX 2009006920 A MX2009006920 A MX 2009006920A
Authority
MX
Mexico
Prior art keywords
present
concerned
compounds
indoles
benzopyrrolone
Prior art date
Application number
MX2009006920A
Other languages
English (en)
Inventor
Mark Rogers-Evans
Raffaello Masciadri
Patrick Schnider
Hasane Ratni
Caterina Bissantz
Christophe Grundschober
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2009006920A publication Critical patent/MX2009006920A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a nuevos derivados de indol-3-il-carbonil-piperidina-benzopirrolona, -benzoxazolona y -benzotriazol como antagonistas del receptor de V1a, a su obtención, a composiciones farmacéuticas que los contienen y a su utilización como medicamentos. Los compuestos activos de presente invención son útiles para la prevención y/o el tratamiento de ansiedad, trastornos depresivos y otras enfermedades. En particular, la presente invención se refiere a compuestos de fórmula general (I) (ver fórmula (I)) en donde X, Y y de R1 a R'° tienen los significados definidos en la descripción.
MX2009006920A 2006-12-28 2007-12-19 Indoles. MX2009006920A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06127307 2006-12-28
PCT/EP2007/064176 WO2008080842A1 (en) 2006-12-28 2007-12-19 Indoles

Publications (1)

Publication Number Publication Date
MX2009006920A true MX2009006920A (es) 2009-07-06

Family

ID=39198190

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009006920A MX2009006920A (es) 2006-12-28 2007-12-19 Indoles.

Country Status (18)

Country Link
US (3) US20080161315A1 (es)
EP (1) EP2125785B1 (es)
JP (1) JP2010514726A (es)
KR (1) KR101134255B1 (es)
CN (1) CN101583609A (es)
AR (1) AR064546A1 (es)
AT (1) ATE533760T1 (es)
AU (1) AU2007341377B2 (es)
BR (1) BRPI0720968A2 (es)
CA (1) CA2674133A1 (es)
CL (1) CL2007003831A1 (es)
ES (1) ES2375520T3 (es)
MX (1) MX2009006920A (es)
NO (1) NO20092356L (es)
PE (1) PE20081401A1 (es)
RU (1) RU2009124111A (es)
TW (1) TWI345468B (es)
WO (1) WO2008080842A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010093578A1 (en) * 2009-02-10 2010-08-19 Glaxo Group Limited Indolinyl-, benzofuranyl-, and benzothienyl- amides as modulators of chemokine receptors
KR102799902B1 (ko) * 2015-11-06 2025-04-28 에프. 호프만-라 로슈 아게 인돌린-2-온 유도체

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5686624A (en) * 1992-01-30 1997-11-11 Sanofi 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
CA2166975C (en) * 1993-07-16 2005-04-05 Mark G. Bock Benzoxazinone and benzopyrimidinone piperidinyl tocolytic oxytocin receptor antagonists
JPH0920779A (ja) * 1995-05-01 1997-01-21 Japan Tobacco Inc 縮合ヘテロ５員環アゼピン化合物類及びその医薬用途
US20080188478A1 (en) * 2005-04-26 2008-08-07 Pfizer Inc. Compounds Useful In Therapy
PL1912976T3 (pl) 2005-07-21 2009-04-30 Hoffmann La Roche Pochodne indol-3-ilokarbonylopiperydynobenzoimidazolu jako antagoniści receptora V1a
KR101020351B1 (ko) 2005-07-29 2011-03-08 에프. 호프만-라 로슈 아게 인돌-3-일-카본일-피페리딘 및 피페라진 유도체
WO2008068184A1 (en) * 2006-12-08 2008-06-12 F. Hoffmann-La Roche Ag Indoles which act as via receptor antagonists

Also Published As

Publication number Publication date
ES2375520T3 (es) 2012-03-01
KR20090094395A (ko) 2009-09-04
TW200835491A (en) 2008-09-01
NO20092356L (no) 2009-06-30
EP2125785A1 (en) 2009-12-02
CA2674133A1 (en) 2008-07-10
AU2007341377B2 (en) 2012-03-22
WO2008080842A1 (en) 2008-07-10
KR101134255B1 (ko) 2012-04-12
US8143281B2 (en) 2012-03-27
BRPI0720968A2 (pt) 2014-03-11
TWI345468B (en) 2011-07-21
CN101583609A (zh) 2009-11-18
AR064546A1 (es) 2009-04-08
US20080167344A1 (en) 2008-07-10
PE20081401A1 (es) 2008-10-24
US20080161315A1 (en) 2008-07-03
EP2125785B1 (en) 2011-11-16
JP2010514726A (ja) 2010-05-06
ATE533760T1 (de) 2011-12-15
AU2007341377A1 (en) 2008-07-10
RU2009124111A (ru) 2011-02-10
CL2007003831A1 (es) 2008-07-11
US20080161316A1 (en) 2008-07-03

Similar Documents

Publication Publication Date Title
MX2009006921A (es) Derivados azaespiro.
MX2009007411A (es) Derivados de espiropiperidina-glicinamida.
MX2009007104A (es) Derivados de oxindol sustituido y su uso como ligandos del receptor de vasopresina.
TNSN08283A1 (en) Cytotoxic agents comprising new tomaymycin derivatives and their therapeutic use
MX2009005507A (es) Derivados de espiro-piperidina.
MX2009006540A (es) Derivados de ester y amida de indazolilo para el tratamiento de enfermedades mediadas por un receptor de glucocorticoides.
NO20074592L (no) Acetylenyl-pyrazolo-pyrimidinderivater som mGluR2-antagonister
MY153258A (en) Pyrazinone derivatives and their use inthe threatment of lung diseases
GB0625648D0 (en) Compounds
GEP20135744B (en) Quinuclidine carbonate derivatives and medicinal compositions containing the same
MY147588A (en) (3-amino-1,2,3,4-tetrahydro-9h-carbazol-9-yl)-acetic acid derivatives
TW200806300A (en) New therapeutic combinations for the treatment of depression
TW200621262A (en) New dihydropteridione derivatives, process for their manufacture and their use as medicament
PH12012501863A1 (en) 3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9h-carbazole derivatives and their use as prostaglandin d2 receptor modulators
DE602008001725D1 (de) 1-(1-benzylpiperidin-4-yl)benzimidazol-5-carbonsäurederivate zur behandlung von diabetes mellitus
TW200612936A (en) Indole derivatives
MY147677A (en) Piperazinyl derivatives useful in the treatment of gpr38 receptor mediated diseases
MX2009006454A (es) Derivados de espiro-piperidina.
TW200738627A (en) Trialkylsilyl-indoles
TW200700391A (en) Pyridine-2-carboxamide derivatives as mglur5 antagonists
MX2007011695A (es) Derivados de oxindol sustituido, medicamentos que contienen dichos derivados y uso de los mismos.
MX2009005541A (es) Indoles que actuan como antagonistas del receptor v1a.
MX2009005544A (es) Indoles.
TW200736189A (en) Indene derivatives, their preparation and use as medicaments
MX2008002805A (es) Derivados de carboxamida como antagonistas del receptor muscarinico.

Legal Events

Date Code Title Description
HH Correction or change in general
FG Grant or registration