[go: up one dir, main page]

MX2009006921A - Derivados azaespiro. - Google Patents

Derivados azaespiro.

Info

Publication number
MX2009006921A
MX2009006921A MX2009006921A MX2009006921A MX2009006921A MX 2009006921 A MX2009006921 A MX 2009006921A MX 2009006921 A MX2009006921 A MX 2009006921A MX 2009006921 A MX2009006921 A MX 2009006921A MX 2009006921 A MX2009006921 A MX 2009006921A
Authority
MX
Mexico
Prior art keywords
present
concerned
derivatives
azaspiro derivatives
compounds
Prior art date
Application number
MX2009006921A
Other languages
English (en)
Inventor
Mark Rogers-Evans
Raffaello Masciadri
Patrick Schnider
Hasane Ratni
Caterina Bissantz
Christophe Grundschober
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2009006921A publication Critical patent/MX2009006921A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a con nuevos derivados de indol-3-il-carbonil-azaespiropiperidina como antagonistas del receptor V1a, con su elaboración, con composiciones farmacéuticas que los contienen y su utilización como medicamentos. Los compuestos activos de la presente invención son útiles en la prevención y/o tratamiento de la ansiedad y trastornos depresivos y otras enfermedades. En particular, la presente invención está relacionada con los compuestos de la fórmula general (I) (ver fórmula (I)) en donde R1 a R6, U, V, W, X, Y y Z son como se ha definido en la especificación.
MX2009006921A 2006-12-29 2007-12-19 Derivados azaespiro. MX2009006921A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06127334 2006-12-29
PCT/EP2007/064183 WO2008080844A1 (en) 2006-12-29 2007-12-19 Azaspiro derivatives

Publications (1)

Publication Number Publication Date
MX2009006921A true MX2009006921A (es) 2009-07-06

Family

ID=39201403

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009006921A MX2009006921A (es) 2006-12-29 2007-12-19 Derivados azaespiro.

Country Status (22)

Country Link
US (3) US8044202B2 (es)
EP (1) EP2125827B1 (es)
JP (1) JP2010514727A (es)
KR (1) KR101129861B1 (es)
CN (1) CN101589046B (es)
AR (1) AR064547A1 (es)
AT (1) ATE486877T1 (es)
AU (1) AU2007341379B2 (es)
BR (1) BRPI0720827A2 (es)
CA (1) CA2674154A1 (es)
CL (1) CL2007003832A1 (es)
DE (1) DE602007010359D1 (es)
DK (1) DK2125827T3 (es)
ES (1) ES2351949T3 (es)
MX (1) MX2009006921A (es)
NO (1) NO20092342L (es)
PE (1) PE20081844A1 (es)
PL (1) PL2125827T3 (es)
PT (1) PT2125827E (es)
RU (1) RU2009124419A (es)
TW (1) TW200835483A (es)
WO (1) WO2008080844A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101547923A (zh) * 2006-12-07 2009-09-30 弗·哈夫曼-拉罗切有限公司 作为via受体拮抗剂的螺环-哌啶衍生物
EP2097376A2 (en) * 2006-12-22 2009-09-09 F. Hoffmann-Roche AG Spiro-piperidine derivatives
CN104945420A (zh) 2009-06-29 2015-09-30 因塞特公司 作为pi3k抑制剂的嘧啶酮类
AR078948A1 (es) * 2009-11-30 2011-12-14 Lilly Co Eli Compuestos de espiropiperidina, composicion farmaceutica que lo comprenden y su uso para preparar un medicamento util para tratar la diabetes
US8680108B2 (en) * 2009-12-18 2014-03-25 Incyte Corporation Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors
US8759359B2 (en) 2009-12-18 2014-06-24 Incyte Corporation Substituted heteroaryl fused derivatives as PI3K inhibitors
JP5816678B2 (ja) 2010-04-14 2015-11-18 インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ ＰＩ３Ｋδ阻害剤としての縮合誘導体
US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
CA2822070C (en) 2010-12-20 2019-09-17 Incyte Corporation N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors
US9108984B2 (en) 2011-03-14 2015-08-18 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors
WO2012135009A1 (en) 2011-03-25 2012-10-04 Incyte Corporation Pyrimidine-4,6-diamine derivatives as pi3k inhibitors
ES2464598T3 (es) 2011-07-22 2014-06-03 Université Joseph Fourier Nuevos derivados bis-indólicos, procedimiento para su preparación, y sus utilizaciones como fármaco
ES2873001T3 (es) 2011-09-02 2021-11-03 Incyte Holdings Corp Heterociclaminas como inhibidores de PI3K
CN102568615B (zh) * 2011-12-13 2013-05-22 华中科技大学 一种小型精密调平装置
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
WO2015191677A1 (en) 2014-06-11 2015-12-17 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors
JP6816005B2 (ja) 2015-02-27 2021-01-20 インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ Ｐｉ３ｋ阻害剤の塩及びその調製のためのプロセス
US9988401B2 (en) 2015-05-11 2018-06-05 Incyte Corporation Crystalline forms of a PI3K inhibitor
WO2016183060A1 (en) 2015-05-11 2016-11-17 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
MA52761A (fr) 2018-06-01 2021-04-14 Incyte Corp Schéma posologique destiné au traitement de troubles liés à la pi3k
CN114929709B (zh) 2019-10-29 2024-08-30 比奥根Ma公司 螺环o-糖蛋白-2-乙酰胺基-2-脱氧-3-d-吡喃葡萄糖苷酶抑制剂

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2761992B1 (fr) * 1997-04-09 1999-06-11 Hoechst Marion Roussel Inc Nouveaux steroides 4-halogenes, leur procede et intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
TWI279402B (en) * 1999-08-20 2007-04-21 Banyu Pharma Co Ltd Spiro compounds having NPY antagonistic activities and agents containing the same
GB0003397D0 (en) 2000-02-14 2000-04-05 Merck Sharp & Dohme Therapeutic agents
GEP20084571B (en) * 2003-12-22 2008-12-25 Pfizer Triazole derivatives as vasopressin antagonists
GB0400700D0 (en) * 2004-01-13 2004-02-18 Pfizer Ltd Compounds useful in therapy
GB0504556D0 (en) * 2005-03-04 2005-04-13 Pfizer Ltd Novel pharmaceuticals

Also Published As

Publication number Publication date
DE602007010359D1 (de) 2010-12-16
US8044202B2 (en) 2011-10-25
EP2125827B1 (en) 2010-11-03
AU2007341379B2 (en) 2012-05-24
PE20081844A1 (es) 2009-01-26
DK2125827T3 (da) 2010-12-20
PT2125827E (pt) 2010-11-22
ES2351949T3 (es) 2011-02-14
US20080161332A1 (en) 2008-07-03
JP2010514727A (ja) 2010-05-06
CA2674154A1 (en) 2008-07-10
US20080161333A1 (en) 2008-07-03
BRPI0720827A2 (pt) 2014-03-04
WO2008080844A9 (en) 2009-10-08
US20080281103A1 (en) 2008-11-13
PL2125827T3 (pl) 2011-04-29
KR20090094172A (ko) 2009-09-03
US8034937B2 (en) 2011-10-11
RU2009124419A (ru) 2011-02-10
KR101129861B1 (ko) 2012-04-24
WO2008080844A1 (en) 2008-07-10
AU2007341379A1 (en) 2008-07-10
US8039624B2 (en) 2011-10-18
NO20092342L (no) 2009-07-02
AR064547A1 (es) 2009-04-08
CN101589046B (zh) 2011-09-21
CL2007003832A1 (es) 2008-07-25
ATE486877T1 (de) 2010-11-15
CN101589046A (zh) 2009-11-25
EP2125827A1 (en) 2009-12-02
TW200835483A (en) 2008-09-01

Similar Documents

Publication Publication Date Title
MX2009006921A (es) Derivados azaespiro.
MX2009007411A (es) Derivados de espiropiperidina-glicinamida.
MX2009005507A (es) Derivados de espiro-piperidina.
MX2009007104A (es) Derivados de oxindol sustituido y su uso como ligandos del receptor de vasopresina.
NO20074592L (no) Acetylenyl-pyrazolo-pyrimidinderivater som mGluR2-antagonister
GB0625648D0 (en) Compounds
MX2009006540A (es) Derivados de ester y amida de indazolilo para el tratamiento de enfermedades mediadas por un receptor de glucocorticoides.
MY147588A (en) (3-amino-1,2,3,4-tetrahydro-9h-carbazol-9-yl)-acetic acid derivatives
TW200740789A (en) Pyridine and pyrimidine derivatives as mGluR2 antagonists
TW200806300A (en) New therapeutic combinations for the treatment of depression
PT1716152E (pt) Compostos heterocíclicos fundidos e sua utilização como antagonistas do receptor metabotrópico para o tratamento de distúrbios gastrointestinais
MX2009006454A (es) Derivados de espiro-piperidina.
MY143581A (en) Carboxamide derivatives as muscarinic receptor antagonists
TW200716120A (en) Pyrazolo-pyrimidine derivatives as mGluR2 antagonists
MY183111A (en) 3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9h-carbazole derivatives and their use as prostaglandin d2 receptor modulators
TW200700391A (en) Pyridine-2-carboxamide derivatives as mglur5 antagonists
TW200738627A (en) Trialkylsilyl-indoles
MX2009005544A (es) Indoles.
MX2009005541A (es) Indoles que actuan como antagonistas del receptor v1a.
MX2008012093A (es) Nuevas combinaciones terapeuticas para el tratamiento o la prevencion de trastornos psicoticos.
TW200833696A (en) Spiro-piperidine derivatives
MX2009005504A (es) Derivados de espiro piperidina como antagonistas del receptor via.
GB0525069D0 (en) Organic compounds
TW200640465A (en) New pharmaceutically active compounds for the treatment of respiratory diseases
MX2009006920A (es) Indoles.

Legal Events

Date Code Title Description
HH Correction or change in general
FG Grant or registration