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NO20091830L - Spiro-piperidinderivater som VIa reseptorantagonister - Google Patents

Spiro-piperidinderivater som VIa reseptorantagonister

Info

Publication number
NO20091830L
NO20091830L NO20091830A NO20091830A NO20091830L NO 20091830 L NO20091830 L NO 20091830L NO 20091830 A NO20091830 A NO 20091830A NO 20091830 A NO20091830 A NO 20091830A NO 20091830 L NO20091830 L NO 20091830L
Authority
NO
Norway
Prior art keywords
spiro
receptor antagonists
piperidine derivatives
via receptor
present
Prior art date
Application number
NO20091830A
Other languages
English (en)
Norwegian (no)
Inventor
Patrick Schnider
Hasane Ratni
Caterina Bissantz
Christophe Grundschober
Mark Rogers-Evans
Rafaello Masciadri
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20091830L publication Critical patent/NO20091830L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20091830A 2006-12-07 2009-05-11 Spiro-piperidinderivater som VIa reseptorantagonister NO20091830L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06125634 2006-12-07
PCT/EP2007/062985 WO2008068185A1 (en) 2006-12-07 2007-11-29 Spiro-piperidine derivatives as via receptor antagonists

Publications (1)

Publication Number Publication Date
NO20091830L true NO20091830L (no) 2009-07-06

Family

ID=39295880

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20091830A NO20091830L (no) 2006-12-07 2009-05-11 Spiro-piperidinderivater som VIa reseptorantagonister

Country Status (21)

Country Link
US (3) US20080139554A1 (es)
EP (1) EP2102207B1 (es)
JP (1) JP2010511661A (es)
KR (1) KR101050568B1 (es)
CN (1) CN101547923A (es)
AR (1) AR064135A1 (es)
AT (1) ATE469900T1 (es)
AU (1) AU2007328995B2 (es)
BR (1) BRPI0720004A2 (es)
CA (1) CA2670674A1 (es)
CL (1) CL2007003482A1 (es)
DE (1) DE602007006990D1 (es)
ES (1) ES2344131T3 (es)
IL (1) IL198544A (es)
MX (1) MX2009005504A (es)
NO (1) NO20091830L (es)
PE (1) PE20081252A1 (es)
RU (1) RU2009119394A (es)
TW (1) TW200838518A (es)
WO (1) WO2008068185A1 (es)
ZA (1) ZA200903496B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090082502A (ko) 2006-12-22 2009-07-30 에프. 호프만-라 로슈 아게 스피로-피페리딘 유도체
SI2285808T1 (sl) 2008-04-29 2014-03-31 Novartis Ag Spiro-indolni derivati za zdravljenje parazitskih bolezni
EA201790919A1 (ru) * 2014-11-14 2017-08-31 Ф. Хоффманн-Ля Рош Аг Спиротиазолоны
WO2017137334A1 (en) * 2016-02-08 2017-08-17 F. Hoffmann-La Roche Ag Spiroindolinones as ddr1 inhibitors
CN111212842B (zh) * 2017-09-05 2022-10-25 布莱克索恩治疗公司 血管加压素受体拮抗剂以及与其相关的产品和方法

Family Cites Families (40)

* Cited by examiner, † Cited by third party
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US3531467A (en) 1966-12-23 1970-09-29 Hoffmann La Roche Process for the preparation of 2,3,4,5-tetrahydro - 5 - aryl - 1h - 1,4 - benzodiazepine derivatives
US4209625A (en) * 1977-04-21 1980-06-24 American Hoechst Corporation Spiro[indoline-3,4'-piperidine]s
DE3818830A1 (de) 1988-06-03 1989-12-14 Boehringer Mannheim Gmbh Bicyclische carboxamide, verfahren zu ihrer herstellung, deren vorstufen, und diese verbindungen enthaltende arzneimittel
EP0450761A1 (en) 1990-03-02 1991-10-09 Merck & Co. Inc. Spirocyclic oxytocin antagonists
DK78692D0 (da) 1992-06-12 1992-06-12 Lundbeck & Co As H Dimere piperidin- og piperazinderivater
AU5292393A (en) 1992-10-07 1994-04-26 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
US5670509A (en) 1993-09-27 1997-09-23 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
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US5576321A (en) 1995-01-17 1996-11-19 Eli Lilly And Company Compounds having effects on serotonin-related systems
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JP4216193B2 (ja) 2001-11-27 2009-01-28 エフ．ホフマン−ラ ロシュ アーゲー ベンゾチアゾール誘導体
FR2833948B1 (fr) 2001-12-21 2004-02-06 Sod Conseils Rech Applic Nouveaux derives de benzimidazole et leur utilisation en tant que medicament
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WO2004026855A1 (en) 2002-09-20 2004-04-01 H. Lundbeck A/S Method for manufacture of dihydroisobenzofuran derivatives
JP2006505570A (ja) 2002-10-17 2006-02-16 アムジエン・インコーポレーテツド ベンズイミダゾール誘導体およびそれのバニロイド受容体リガンドとしての使用
WO2004069809A1 (en) 2003-02-03 2004-08-19 Janssen Pharmaceutica N.V. Mercaptoimidazoles as ccr2 receptor antagonists
US7244852B2 (en) * 2003-02-27 2007-07-17 Abbott Laboratories Process for preparing 2-methylpyrrolidine and specific enantiomers thereof
DE602004027171D1 (de) * 2003-04-11 2010-06-24 High Point Pharmaceuticals Llc Verbindungen mit Aktivität an der 11Beta-Hydroxasteroiddehydrogenase
WO2005046682A1 (en) 2003-11-04 2005-05-26 Elixir Pharmaceuticals, Inc. Therapeutic compounds and uses thereof
CA2551038C (en) * 2003-12-22 2010-04-27 Pfizer Inc. Triazole derivatives as vasopressin antagonists
JP2007516298A (ja) 2003-12-23 2007-06-21 アリーナ ファーマシューティカルズ， インコーポレイテッド 新規なスピロインドリンまたはスピロイソキノリン化合物、それらの使用方法および組成物
GB0400700D0 (en) * 2004-01-13 2004-02-18 Pfizer Ltd Compounds useful in therapy
CN1993323B (zh) 2004-08-05 2011-04-20 霍夫曼-拉罗奇有限公司 吲哚，吲唑或二氢吲哚衍生物
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KR101180817B1 (ko) * 2004-10-13 2012-09-07 소니 주식회사 재생 장치, 촬상 장치, 화면 표시 방법 및 사용자인터페이스
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ES2376378T3 (es) 2007-01-12 2012-03-13 F. Hoffmann-La Roche Ag Derivados de espiropiperidina-glicinamida.

Also Published As

Publication number Publication date
ES2344131T3 (es) 2010-08-18
KR20090079255A (ko) 2009-07-21
US20080139553A1 (en) 2008-06-12
JP2010511661A (ja) 2010-04-15
AU2007328995B2 (en) 2012-04-26
US20080146568A1 (en) 2008-06-19
DE602007006990D1 (de) 2010-07-15
CA2670674A1 (en) 2008-06-12
BRPI0720004A2 (pt) 2013-12-17
EP2102207A1 (en) 2009-09-23
ZA200903496B (en) 2010-03-31
US20080139554A1 (en) 2008-06-12
AR064135A1 (es) 2009-03-18
ATE469900T1 (de) 2010-06-15
IL198544A0 (en) 2010-02-17
WO2008068185A1 (en) 2008-06-12
MX2009005504A (es) 2009-06-03
RU2009119394A (ru) 2011-01-20
EP2102207B1 (en) 2010-06-02
TW200838518A (en) 2008-10-01
PE20081252A1 (es) 2008-09-04
CL2007003482A1 (es) 2008-07-04
IL198544A (en) 2012-06-28
AU2007328995A1 (en) 2008-06-12
CN101547923A (zh) 2009-09-30
KR101050568B1 (ko) 2011-07-19
US8202993B2 (en) 2012-06-19

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