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MX2009004244A - Derivados de pteridina como inhibidores de cinasa tipo polo utiles en el tratamiento de cancer. - Google Patents

Derivados de pteridina como inhibidores de cinasa tipo polo utiles en el tratamiento de cancer.

Info

Publication number
MX2009004244A
MX2009004244A MX2009004244A MX2009004244A MX2009004244A MX 2009004244 A MX2009004244 A MX 2009004244A MX 2009004244 A MX2009004244 A MX 2009004244A MX 2009004244 A MX2009004244 A MX 2009004244A MX 2009004244 A MX2009004244 A MX 2009004244A
Authority
MX
Mexico
Prior art keywords
optionally substituted
ring
polo
treatment
alkyl
Prior art date
Application number
MX2009004244A
Other languages
English (en)
Inventor
Stephen John Davies
Sanjay Ratilal Patel
David Festus Charles Moffat
Kenneth William John Baker
Oliver James Philps
Original Assignee
Chroma Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0621205A external-priority patent/GB0621205D0/en
Priority claimed from GB0715614A external-priority patent/GB0715614D0/en
Application filed by Chroma Therapeutics Ltd filed Critical Chroma Therapeutics Ltd
Publication of MX2009004244A publication Critical patent/MX2009004244A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se describen compuestos de la fórmula (I) que son inhibidores de cinasas tipo Polo (PLKs), y son útiles en el tratamiento de enfermedades proliferativas de células: (ver fórmula (I)) en donde R1 y R2 son hidrógeno, o un grupo (C1-C6)alquilo, (C2-C6)alquenilo, (C2-C6)alquinilo o (C3-C6)cicloalquilo sustituido opcionalmente; R3 y R3´ se seleccionan independientemente de hidrógeno, -CN, hidroxilo, halógeno, (C1-6)alquilo, (C2-C6)alquenilo, (C2-C6)alquinilo, o (C3-C6)cicloalquilo sustituido opcionalmente, -NR5R6 o alcoxi de C1-C4, en donde R5 y R6 son independientemente hidrógeno o (C1-C6)alquilo sustituido opcionalmente; el anillo A es un anillo carbocíclico o heterocíclico mono- o bi-cíclico o un sistema de anillos que tiene hasta 12 átomos de anillo; T es un radical de la fórmula R-L1-Y1- en donde R es un motivo de alfa aminoácido o éster de aminoácido, enlazado al anillo A por el enlazador R-L1-Y1- como se define en las reivindicaciones.
MX2009004244A 2006-10-25 2007-10-19 Derivados de pteridina como inhibidores de cinasa tipo polo utiles en el tratamiento de cancer. MX2009004244A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0621205A GB0621205D0 (en) 2006-10-25 2006-10-25 Inhibitors of PLK
GB0715614A GB0715614D0 (en) 2007-08-10 2007-08-10 Inhibitors of plk
PCT/GB2007/003998 WO2008050096A1 (en) 2006-10-25 2007-10-19 Pteridine derivatives as polo-like kinase inhibitors useful in the treatment of cancer

Publications (1)

Publication Number Publication Date
MX2009004244A true MX2009004244A (es) 2009-05-14

Family

ID=38896021

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009004244A MX2009004244A (es) 2006-10-25 2007-10-19 Derivados de pteridina como inhibidores de cinasa tipo polo utiles en el tratamiento de cancer.

Country Status (13)

Country Link
US (1) US20100216802A1 (es)
EP (1) EP2079743B1 (es)
JP (1) JP2010507639A (es)
KR (1) KR20090071668A (es)
AT (1) ATE542820T1 (es)
AU (1) AU2007310604B2 (es)
BR (1) BRPI0718120A2 (es)
CA (1) CA2665736A1 (es)
EA (1) EA200900593A1 (es)
IL (1) IL198082A0 (es)
MX (1) MX2009004244A (es)
NZ (1) NZ577153A (es)
WO (1) WO2008050096A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0619753D0 (en) * 2006-10-06 2006-11-15 Chroma Therapeutics Ltd Enzyme inhibitors
BRPI0622100A2 (pt) * 2006-10-30 2011-12-27 Chroma Therapeutics Ltd hidroxamatos como inibidores de desacetilase de histona
US8129387B2 (en) 2006-12-14 2012-03-06 Vertex Pharmaceuticals Incorporated Substituted 5,6-dihydroimidazo[1,5-F]pteridines useful as protein kinase inhibitors
GB0803747D0 (en) 2008-02-29 2008-04-09 Martin Enzyme and receptor modulation
GB0807451D0 (en) * 2008-04-24 2008-05-28 Chroma Therapeutics Ltd Inhibitors of PLK
CN102076690A (zh) 2008-06-23 2011-05-25 维泰克斯制药公司 蛋白激酶抑制剂
KR20110033239A (ko) * 2008-06-23 2011-03-30 버텍스 파마슈티칼스 인코포레이티드 단백질 키나제 억제제
GB0903480D0 (en) 2009-02-27 2009-04-08 Chroma Therapeutics Ltd Enzyme Inhibitors
CN102656151A (zh) * 2009-09-04 2012-09-05 扎里卡斯药品有限公司 治疗疼痛和癫痫的取代的杂环衍生物
CN102020643A (zh) * 2009-09-22 2011-04-20 上海恒瑞医药有限公司 二氢喋啶酮类衍生物、其制备方法及其在医药上的应用
GB201211310D0 (en) 2012-06-26 2012-08-08 Chroma Therapeutics Ltd CSF-1R kinase inhibitors
RS59458B1 (sr) 2012-10-17 2019-11-29 Macrophage Pharma Ltd N-[2-{4-[6-amino-5-(2,4-difluorobenzoil)-2-oksopiridin-1(2h)-il]-3,5-difluorofenil}etil]-l-alanin i njegov tetrabutil ester
WO2014134306A1 (en) 2013-03-01 2014-09-04 Zalicus Pharmaceuticals, Ltd. Heterocyclic inhibitors of the sodium channel
WO2015116696A1 (en) 2014-01-28 2015-08-06 Massachusetts Institute Of Technology Combination therapies and methods of use thereof for treating cancer
WO2015117055A1 (en) * 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Dihydropteridinone derivatives and uses thereof
WO2015117087A1 (en) 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
RU2016134947A (ru) 2014-01-31 2018-03-01 Дана-Фарбер Кансер Институт, Инк. Производные диаминопиримидин бензолсульфона и их применение
BR112018004618A2 (pt) 2015-09-11 2018-09-25 Dana-Farber Cancer Institute, Inc. ciano tienotriazoldiazepinas e usos das mesmas
BR112018009798A8 (pt) 2015-11-25 2019-02-26 Dana Farber Cancer Inst Inc inibidores de bromodomínio bivalentes e usos dos mesmos
GB201713975D0 (en) 2017-08-31 2017-10-18 Macrophage Pharma Ltd Medical use
US11773096B2 (en) 2018-08-10 2023-10-03 Yale University Small-molecule PI5P4K alpha/beta inhibitors and methods of treatment using same
CN111039944B (zh) * 2018-10-12 2021-11-23 中国科学院合肥物质科学研究院 Mst1激酶抑制剂及其用途
KR102260995B1 (ko) * 2018-11-28 2021-06-04 국립암센터 Plk1의 활성 억제제를 유효성분으로 포함하는 암 예방 또는 치료용 약학적 조성물
CN115947728B (zh) * 2021-10-09 2024-01-09 沈阳药科大学 含磺酰基的二氢喋啶酮衍生物及其应用
EP4479042A1 (en) 2022-02-18 2024-12-25 Massachusetts Institute Of Technology Cancer treatment by combined inhibition of polo-like kinase and microtubule polymerization
CN118047779B (zh) * 2022-11-09 2025-02-11 沈阳药科大学 含苯联杂芳基的二氢喋啶酮衍生物及其用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1632493A1 (de) * 2004-08-25 2006-03-08 Boehringer Ingelheim Pharma GmbH & Co.KG Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
CA2575804A1 (en) * 2004-08-26 2006-03-02 Boehringer Ingelheim International Gmbh Pteridinones used as plk (polo like kinase) inhibitors
JP2008510771A (ja) * 2004-08-27 2008-04-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ジヒドロプテリジノン、その製造方法および医薬薬剤としてのその使用

Also Published As

Publication number Publication date
CA2665736A1 (en) 2008-05-02
WO2008050096A1 (en) 2008-05-02
ATE542820T1 (de) 2012-02-15
JP2010507639A (ja) 2010-03-11
AU2007310604B2 (en) 2012-02-02
US20100216802A1 (en) 2010-08-26
EA200900593A1 (ru) 2010-06-30
BRPI0718120A2 (pt) 2013-11-12
AU2007310604A1 (en) 2008-05-02
EP2079743A1 (en) 2009-07-22
KR20090071668A (ko) 2009-07-01
NZ577153A (en) 2012-02-24
IL198082A0 (en) 2009-12-24
EP2079743B1 (en) 2012-01-25

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