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WO2009072635A1 - ヘテロ環化合物による造血幹細胞の増幅方法 - Google Patents

ヘテロ環化合物による造血幹細胞の増幅方法 Download PDF

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Publication number
WO2009072635A1
WO2009072635A1 PCT/JP2008/072207 JP2008072207W WO2009072635A1 WO 2009072635 A1 WO2009072635 A1 WO 2009072635A1 JP 2008072207 W JP2008072207 W JP 2008072207W WO 2009072635 A1 WO2009072635 A1 WO 2009072635A1
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Prior art keywords
stem cells
hematopoietic stem
hematopoietic
amplifying
heterocyclic compound
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Ceased
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PCT/JP2008/072207
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English (en)
French (fr)
Inventor
Taito Nishino
Norihisa Ishiwata
Katsuaki Miyaji
Shunsuke Iwamoto
Yasuyuki Asai
Makiko Yui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nissan Chemical Corp
Reprocell Inc
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Nissan Chemical Corp
Reprocell Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40717814&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2009072635(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to CA2708050A priority Critical patent/CA2708050C/en
Priority to EP08858085.7A priority patent/EP2218716B1/en
Priority to US12/746,666 priority patent/US9527828B2/en
Priority to ES08858085.7T priority patent/ES2605611T3/es
Priority to BRPI0820915A priority patent/BRPI0820915A8/pt
Application filed by Nissan Chemical Corp, Reprocell Inc filed Critical Nissan Chemical Corp
Priority to CN2008801196587A priority patent/CN101889007A/zh
Priority to JP2009544761A priority patent/JP5663169B2/ja
Priority to AU2008332303A priority patent/AU2008332303B2/en
Publication of WO2009072635A1 publication Critical patent/WO2009072635A1/ja
Priority to IL206185A priority patent/IL206185A0/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
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  • Developmental Biology & Embryology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

　各種の造血系疾患に対する治療方法として有用であり、遺伝子治療時の造血幹細胞への遺伝子導入効率の向上に有用である、造血幹細胞及び／又は造血前駆細胞の増幅剤を提供する。 　式（Ｉ）（式中のＸ、Ｙ、Ｚ、Ａｒ１、Ｒ１、Ｒ２、Ｒ３、Ｒ４、Ｒ５、Ｒ６及びＲ７は、本文中において定義される。）で表される化合物、該化合物の互変異性体若しくはその医薬的に許容され得る塩又はそれらの溶媒和物の存在下、造血幹細胞及び／又は造血前駆細胞を生体外で培養することを特徴とする造血幹細胞及び／又は造血前駆細胞の増幅方法。 （化１）
PCT/JP2008/072207 2007-12-06 2008-12-06 ヘテロ環化合物による造血幹細胞の増幅方法 Ceased WO2009072635A1 (ja)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AU2008332303A AU2008332303B2 (en) 2007-12-06 2008-12-06 Method for amplifying hematopoietic stem cells using heterocyclic compound
EP08858085.7A EP2218716B1 (en) 2007-12-06 2008-12-06 Method for amplifying hematopoietic stem cells using heterocyclic compound
US12/746,666 US9527828B2 (en) 2007-12-06 2008-12-06 Method for expanding hematopoietic stem cells using heterocyclic compound
ES08858085.7T ES2605611T3 (es) 2007-12-06 2008-12-06 Método para amplificar células madre hematopoyéticas utilizando un compuesto heterocíclico
BRPI0820915A BRPI0820915A8 (pt) 2007-12-06 2008-12-06 Método para expandir células-tronco hematopoéticas usando composto heterocíclico
CA2708050A CA2708050C (en) 2007-12-06 2008-12-06 Method for expanding hematopoietic stem cells using heterocyclic compound
CN2008801196587A CN101889007A (zh) 2007-12-06 2008-12-06 采用杂环化合物的造血干细胞的扩增方法
JP2009544761A JP5663169B2 (ja) 2007-12-06 2008-12-06 ヘテロ環化合物による造血幹細胞の増幅方法
IL206185A IL206185A0 (en) 2007-12-06 2010-06-03 Method for expanding hematopoietic stem cells using heterocyclic compound

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-316276 2007-12-06
JP2007316276 2007-12-06

Publications (1)

Publication Number Publication Date
WO2009072635A1 true WO2009072635A1 (ja) 2009-06-11

Family

ID=40717814

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/072207 Ceased WO2009072635A1 (ja) 2007-12-06 2008-12-06 ヘテロ環化合物による造血幹細胞の増幅方法

Country Status (10)

Country Link
US (1) US9527828B2 (ja)
EP (1) EP2218716B1 (ja)
JP (1) JP5663169B2 (ja)
CN (1) CN101889007A (ja)
AU (1) AU2008332303B2 (ja)
BR (1) BRPI0820915A8 (ja)
CA (1) CA2708050C (ja)
ES (1) ES2605611T3 (ja)
IL (1) IL206185A0 (ja)
WO (1) WO2009072635A1 (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010140685A1 (ja) * 2009-06-04 2010-12-09 日産化学工業株式会社 ヘテロ環化合物及び造血幹細胞の増幅剤
WO2012074068A1 (ja) * 2010-12-01 2012-06-07 日産化学工業株式会社 ピラゾール化合物による造血幹細胞の製造方法
WO2013051625A1 (ja) 2011-10-03 2013-04-11 日産化学工業株式会社 多能性幹細胞からの巨核球及び／又は血小板の製造方法
JP2016539659A (ja) * 2013-10-24 2016-12-22 オスペダーレ サン ラファエレ エス．アール．エル 方法

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CN103740644B (zh) * 2013-03-20 2016-08-17 深圳爱生再生医学科技有限公司 一种基于3d培养体系的扩增造血干细胞的方法
BR112022014327A2 (pt) * 2020-01-24 2022-09-13 Univ Tokyo Método de cultivo de células humanas, composição de meio de cultura para cultivar células humanas e células humanas
WO2021224395A1 (en) 2020-05-06 2021-11-11 Cellectis S.A. Methods for targeted insertion of exogenous sequences in cellular genomes
JP2023525510A (ja) 2020-05-06 2023-06-16 セレクティス ソシエテ アノニム 治療用タンパク質の送達のために細胞を遺伝子改変する方法
US11883436B2 (en) 2020-08-17 2024-01-30 The Board Of Trustees Of The University Of Illinois Method of preparing hematopoietic stem and progenitor cells for transplantation

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US20100266556A1 (en) 2010-10-21
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AU2008332303B2 (en) 2014-02-13
AU2008332303A1 (en) 2009-06-11
JPWO2009072635A1 (ja) 2011-04-28
EP2218716B1 (en) 2016-11-16
US9527828B2 (en) 2016-12-27
IL206185A0 (en) 2010-12-30

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