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PE20090216A1 - Compuestos triazolil aminopirimidina - Google Patents

Compuestos triazolil aminopirimidina

Info

Publication number
PE20090216A1
PE20090216A1 PE2008000798A PE2008000798A PE20090216A1 PE 20090216 A1 PE20090216 A1 PE 20090216A1 PE 2008000798 A PE2008000798 A PE 2008000798A PE 2008000798 A PE2008000798 A PE 2008000798A PE 20090216 A1 PE20090216 A1 PE 20090216A1
Authority
PE
Peru
Prior art keywords
amino
methyl
compounds
thiofen
pirrol
Prior art date
Application number
PE2008000798A
Other languages
English (en)
Inventor
Harold Burns Brooks
Joyce Z Crich
James Robert Henry
Delu Jiang
William Thomas Mcmillen
Jason Scott Sawyer
Melissa Kate Slater
Yan Wang
Hong Hu
Hong-Yu Li
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE20090216A1 publication Critical patent/PE20090216A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DE FORMULA I, EN EL QUE R1 ES HIDROXI, AMINO(ALQUILO C1-C4), (2-HIDROXI-2-METIL)-1-PROPILOXI, ENTRE OTROS; R2 ES H O AMINO, SIEMPRE QUE SI R2 ES AMINO, R1 Y R2 FORMAN UN ANILLO PIRROL FUSIONADO AL FENILO O SI R1 ES AMINO, R1 Y R2 PUEDEN FORMAR YA SEA UN ANILLO PIRROL O PIRIDINA FUSIONADO AL FENILO; R3 ES H, Cl O F; R4 ES H, METILO, Cl O F; R5 Y R6 SON H, HIDROXIMETILO O METILO. SON SELECCIONADOS: 2-(2-(2-(2-(2-(1H-1,2,3-TRIAZOL-1-IL)ETILAMINO)-5-FLUOROPIRIMIDIN-4-IL)BENZO[b]TIOFEN-7-IL)FENOXI)ETANOL, N-(2-(1H-1,2,3-TRIAZOL-1-IL)ETIL)-5-FLUORO-4-(7-(5-FLUORO-1H-INDOL-7-IL)BENZO[b]TIOFEN-2-IL)PIRIMIDIN-2-AMINA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCESO DE PREPARACION Y COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE P1K1 UTILES EN EL TRATAMIENTO DEL CANCER
PE2008000798A 2007-05-16 2008-05-07 Compuestos triazolil aminopirimidina PE20090216A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US93834707P 2007-05-16 2007-05-16

Publications (1)

Publication Number Publication Date
PE20090216A1 true PE20090216A1 (es) 2009-02-28

Family

ID=39951591

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000798A PE20090216A1 (es) 2007-05-16 2008-05-07 Compuestos triazolil aminopirimidina

Country Status (15)

Country Link
US (1) US8063035B2 (es)
EP (1) EP2155734A2 (es)
JP (1) JP5248600B2 (es)
KR (1) KR101131261B1 (es)
CN (1) CN101679395B (es)
AR (1) AR066473A1 (es)
AU (1) AU2008254319B2 (es)
BR (1) BRPI0811433A2 (es)
CA (1) CA2691997A1 (es)
CL (1) CL2008001323A1 (es)
EA (1) EA016781B1 (es)
MX (1) MX2009012228A (es)
PE (1) PE20090216A1 (es)
TW (1) TW200908981A (es)
WO (1) WO2008144223A2 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7964729B2 (en) 2006-08-28 2011-06-21 Massachusetts Institute Of Technology Sox-based kinase sensor
PT2125794E (pt) 2006-12-21 2011-01-10 Lilly Co Eli Compostos imidazolidinonilo aminopirimidina para o tratamento do cancro
CN101563342B (zh) 2006-12-21 2012-09-05 伊莱利利公司 用于治疗癌症的咪唑啉酮基氨基嘧啶化合物
US8440835B2 (en) 2007-02-26 2013-05-14 Massachusetts Institute Of Technology Environmentally sensitive fluorophores
EP2155734A2 (en) 2007-05-16 2010-02-24 Eli Lilly And Company Triazolyl aminopyrimidine compounds
US8114872B2 (en) 2007-05-16 2012-02-14 Eli Lilly And Company Triazolyl aminopyrimidine compounds
KR101123178B1 (ko) * 2009-04-09 2012-06-13 (주)에스메디 2-아릴벤조싸이오펜 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 퇴행성 뇌질환의 진단 또는 치료용 약학적 조성물
CN102597236A (zh) * 2009-08-25 2012-07-18 肿瘤疗法科学股份有限公司 癌症治疗和诊断的靶基因ercc6l
WO2011025546A1 (en) * 2009-08-31 2011-03-03 Massachusetts Institute Of Technology 1, 2, 3-triazole containing protein kinase sensors
UA119247C2 (uk) 2013-09-06 2019-05-27 РОЙВЕНТ САЙЕНСИЗ ҐмбГ Спіроциклічні сполуки як інгібітори триптофангідроксилази
US9611201B2 (en) * 2015-03-05 2017-04-04 Karos Pharmaceuticals, Inc. Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone
CN109415366B (zh) * 2016-06-23 2022-02-22 豪夫迈·罗氏有限公司 [1,2,3]三唑并[4,5-d]嘧啶衍生物
WO2020068600A1 (en) * 2018-09-24 2020-04-02 Rapt Therapeutics, Inc. Ubiquitin-specific-processing protease 7 (usp7) modulators and uses thereof
US20220324770A1 (en) * 2019-09-05 2022-10-13 The University Of Melbourne Nitrification inhibitors
CN112341428A (zh) * 2020-11-04 2021-02-09 菏泽鸿特药业有限公司 一种噻吩-2-乙胺的生产方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4929726A (en) * 1988-02-09 1990-05-29 Georgia State University Foundation, Inc. Novel diazines and their method of preparation
WO2004063192A1 (en) 2003-01-10 2004-07-29 Pharmacopeia Drug Discovery, Inc. Imidazolyl pyrimidine derivatives useful as il-8 receptor modulators
GB0308466D0 (en) 2003-04-11 2003-05-21 Novartis Ag Organic compounds
CA2534127A1 (en) * 2003-07-31 2005-02-10 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted benzothiophene compounds and uses thereof
JP4932735B2 (ja) 2004-12-17 2012-05-16 アムジエン・インコーポレーテツド アミノピリミジン化合物および使用方法
TW200800201A (en) 2005-11-18 2008-01-01 Lilly Co Eli Pyrimidinyl benzothiophene compounds
EP2001480A4 (en) 2006-03-31 2011-06-15 Abbott Lab Indazole CONNECTIONS
PT2125794E (pt) * 2006-12-21 2011-01-10 Lilly Co Eli Compostos imidazolidinonilo aminopirimidina para o tratamento do cancro
CN101563342B (zh) * 2006-12-21 2012-09-05 伊莱利利公司 用于治疗癌症的咪唑啉酮基氨基嘧啶化合物
EP2155734A2 (en) 2007-05-16 2010-02-24 Eli Lilly And Company Triazolyl aminopyrimidine compounds
US8114872B2 (en) * 2007-05-16 2012-02-14 Eli Lilly And Company Triazolyl aminopyrimidine compounds

Also Published As

Publication number Publication date
KR20090130242A (ko) 2009-12-21
JP5248600B2 (ja) 2013-07-31
US20100087431A1 (en) 2010-04-08
EP2155734A2 (en) 2010-02-24
US8063035B2 (en) 2011-11-22
AU2008254319B2 (en) 2012-04-19
WO2008144223A2 (en) 2008-11-27
AU2008254319A1 (en) 2008-11-27
CN101679395A (zh) 2010-03-24
EA016781B1 (ru) 2012-07-30
CA2691997A1 (en) 2008-11-27
CL2008001323A1 (es) 2009-05-29
EA200971068A1 (ru) 2010-04-30
KR101131261B1 (ko) 2012-04-24
BRPI0811433A2 (pt) 2016-03-22
CN101679395B (zh) 2012-06-13
WO2008144223A3 (en) 2009-02-05
AR066473A1 (es) 2009-08-19
MX2009012228A (es) 2009-12-01
JP2010527365A (ja) 2010-08-12
TW200908981A (en) 2009-03-01

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