MX2009003283A - Nuevos derivados imidazolonas, su preparacion como medicamentos, composiciones farmaceuticas y uso como inhibidores de proteinas quinasas, principalmente cdc7. - Google Patents
Nuevos derivados imidazolonas, su preparacion como medicamentos, composiciones farmaceuticas y uso como inhibidores de proteinas quinasas, principalmente cdc7.Info
- Publication number
- MX2009003283A MX2009003283A MX2009003283A MX2009003283A MX2009003283A MX 2009003283 A MX2009003283 A MX 2009003283A MX 2009003283 A MX2009003283 A MX 2009003283A MX 2009003283 A MX2009003283 A MX 2009003283A MX 2009003283 A MX2009003283 A MX 2009003283A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- drugs
- protein kinase
- kinase inhibitors
- hal
- Prior art date
Links
- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 239000003909 protein kinase inhibitor Substances 0.000 title abstract 2
- WZELXJBMMZFDDU-UHFFFAOYSA-N Imidazol-2-one Chemical class O=C1N=CC=N1 WZELXJBMMZFDDU-UHFFFAOYSA-N 0.000 title 1
- 101150065030 cdc7 gene Proteins 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 3
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 2
- 102100034744 Cell division cycle 7-related protein kinase Human genes 0.000 abstract 1
- 101000945740 Homo sapiens Cell division cycle 7-related protein kinase Proteins 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La invención se refiere a productos de la fórmula (I) en la que: X-Y representa NH-C(S), N=C-NR7R8, N=C-SR, NC=R, o N=C-OR; R y R1 representan H, cicloalquilo, alquilo, heterocicloalquilo, arilo o heteroarilo, sustituidos opcionalmente; R2 representa H, Hal o alquilo; R3 representa H, Hal, OH, alquilo o alcoxi; R4 representa H, Hal, CN o alquilo; R5 representa esencialmente H, Hal, OH, NR7R8, cicloalquilo, alquilo, alcoxi, heterocicloalquilo, arilo o heteroarilo, sustituidos opcionalmente; R6 representa H, Hal, OH, NH2, NHalq, N(alq)2, alquilo o alcoxi; con R7 y R8 tales que uno representa H o alq sustituido opcionalmente; y el otro representa H, cicloalquilo, alquilo, heterocicloalquilo, heteroarilo o arilo, sustituidos opcionalmente; o R7 y R8 forman junto con N un radical cíclico, que contiene opcionalmente O, S o N sustituido opcionalmente; sus isómeros y sus sales, como medicamentos y esencialmente como inhibidores de quinasas, en particular de CDC7.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0608924A FR2907120B1 (fr) | 2006-10-12 | 2006-10-12 | Nouveaux derives imidazolones,leur preparation a titre de medicaments,compositions pharmaceutiques,utilisation comme inhibiteurs de proteines kinases notamment cdc7 |
| PCT/FR2007/001651 WO2008046982A2 (fr) | 2006-10-12 | 2007-10-10 | Nouveaux derives imidazolones, leur preparation a titre de medicaments, compositions pharmaceutiques, utilisation comme inhibiteurs de proteines kinases notamment cdc7 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009003283A true MX2009003283A (es) | 2009-04-08 |
Family
ID=37964098
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009003283A MX2009003283A (es) | 2006-10-12 | 2007-10-10 | Nuevos derivados imidazolonas, su preparacion como medicamentos, composiciones farmaceuticas y uso como inhibidores de proteinas quinasas, principalmente cdc7. |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US8314121B2 (es) |
| EP (1) | EP2094699B1 (es) |
| JP (1) | JP2010505922A (es) |
| KR (1) | KR101552361B1 (es) |
| CN (1) | CN101522678A (es) |
| AR (1) | AR063249A1 (es) |
| AT (1) | ATE517105T1 (es) |
| AU (1) | AU2007311833B2 (es) |
| BR (1) | BRPI0719790A2 (es) |
| CA (1) | CA2660166C (es) |
| CL (1) | CL2007002934A1 (es) |
| CO (1) | CO6160310A2 (es) |
| CY (1) | CY1112066T1 (es) |
| DK (1) | DK2094699T3 (es) |
| EA (1) | EA018496B1 (es) |
| ES (1) | ES2370049T3 (es) |
| FR (1) | FR2907120B1 (es) |
| HR (1) | HRP20110759T1 (es) |
| IL (1) | IL197452A (es) |
| MA (1) | MA30877B1 (es) |
| MX (1) | MX2009003283A (es) |
| NO (1) | NO20091486L (es) |
| PL (1) | PL2094699T3 (es) |
| PT (1) | PT2094699E (es) |
| RS (1) | RS51985B (es) |
| SI (1) | SI2094699T1 (es) |
| TW (1) | TW200821310A (es) |
| UY (1) | UY30642A1 (es) |
| WO (1) | WO2008046982A2 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010122979A1 (ja) | 2009-04-20 | 2010-10-28 | Ｓｂｉバイオテック株式会社 | チアゾリジノン誘導体 |
| JP2012533553A (ja) * | 2009-07-15 | 2012-12-27 | アボット・ラボラトリーズ | ピロロピリジン系キナーゼ阻害薬 |
| JP5802676B2 (ja) * | 2009-12-04 | 2015-10-28 | センワ バイオサイエンシズ インコーポレイテッド | Ｃｋ２阻害剤としてのピラゾロピリミジンおよび関連複素環化合物 |
| JP2013525354A (ja) * | 2010-04-19 | 2013-06-20 | アッヴィ・インコーポレイテッド | ピロロピリジン系キナーゼ阻害薬 |
| KR101964479B1 (ko) | 2011-03-31 | 2019-04-01 | 카나 바이오사이언스, 인코포레이션 | 신규 푸라논 유도체 |
| US9974795B2 (en) | 2014-01-31 | 2018-05-22 | Carna Biosciences, Inc. | Anticancer agent composition |
| GB201807147D0 (en) | 2018-05-01 | 2018-06-13 | Oncologica Uk Ltd | Therapeutic combination |
| CN114945569A (zh) * | 2019-12-26 | 2022-08-26 | 延世大学校产学协力团 | 吡咯烷衍生物，以及包含其的用于预防或治疗β-淀粉样蛋白或Tau蛋白相关疾病的药物组合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6335342B1 (en) | 2000-06-19 | 2002-01-01 | Pharmacia & Upjohn S.P.A. | Azaindole derivatives, process for their preparation, and their use as antitumor agents |
| EP1599475A2 (en) | 2003-03-06 | 2005-11-30 | Eisai Co., Ltd. | Jnk inhibitors |
| BRPI0413438A (pt) * | 2003-08-08 | 2006-10-17 | Pharmacia Italia Spa | derivados de pirimidilpirrol ativos como inibidores de cinase |
| MXPA06011328A (es) | 2004-04-02 | 2006-12-15 | Vertex Pharma | Azaindoles utiles como inhibidotes de roca y otras proteinas cinasas. |
| JP2008516903A (ja) * | 2004-10-14 | 2008-05-22 | エフ．ホフマン−ラ ロシュ アーゲー | 抗癌剤としての新規アザインドールチアゾリノン |
| US7371862B2 (en) * | 2005-11-11 | 2008-05-13 | Pfizer Italia S.R.L. | Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
-
2006
- 2006-10-12 FR FR0608924A patent/FR2907120B1/fr not_active Expired - Fee Related
-
2007
- 2007-10-10 MX MX2009003283A patent/MX2009003283A/es active IP Right Grant
- 2007-10-10 PL PL07858418T patent/PL2094699T3/pl unknown
- 2007-10-10 AU AU2007311833A patent/AU2007311833B2/en not_active Ceased
- 2007-10-10 HR HR20110759T patent/HRP20110759T1/hr unknown
- 2007-10-10 JP JP2009531874A patent/JP2010505922A/ja not_active Revoked
- 2007-10-10 CA CA2660166A patent/CA2660166C/fr not_active Expired - Fee Related
- 2007-10-10 BR BRPI0719790-0A2A patent/BRPI0719790A2/pt not_active IP Right Cessation
- 2007-10-10 CN CNA2007800378600A patent/CN101522678A/zh active Pending
- 2007-10-10 AT AT07858418T patent/ATE517105T1/de active
- 2007-10-10 KR KR1020097007392A patent/KR101552361B1/ko not_active Expired - Fee Related
- 2007-10-10 DK DK07858418.2T patent/DK2094699T3/da active
- 2007-10-10 EA EA200970364A patent/EA018496B1/ru not_active IP Right Cessation
- 2007-10-10 PT PT07858418T patent/PT2094699E/pt unknown
- 2007-10-10 RS RS20110456A patent/RS51985B/sr unknown
- 2007-10-10 EP EP07858418A patent/EP2094699B1/fr active Active
- 2007-10-10 WO PCT/FR2007/001651 patent/WO2008046982A2/fr not_active Ceased
- 2007-10-10 ES ES07858418T patent/ES2370049T3/es active Active
- 2007-10-10 SI SI200730750T patent/SI2094699T1/sl unknown
- 2007-10-11 CL CL200702934A patent/CL2007002934A1/es unknown
- 2007-10-11 AR ARP070104500A patent/AR063249A1/es unknown
- 2007-10-12 UY UY30642A patent/UY30642A1/es not_active Application Discontinuation
- 2007-10-12 TW TW096138357A patent/TW200821310A/zh unknown
-
2009
- 2009-03-05 IL IL197452A patent/IL197452A/en not_active IP Right Cessation
- 2009-03-31 US US12/415,391 patent/US8314121B2/en not_active Expired - Fee Related
- 2009-04-08 CO CO09036259A patent/CO6160310A2/es unknown
- 2009-04-16 NO NO20091486A patent/NO20091486L/no not_active Application Discontinuation
- 2009-05-08 MA MA31856A patent/MA30877B1/fr unknown
-
2011
- 2011-10-20 CY CY20111100996T patent/CY1112066T1/el unknown
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| Date | Code | Title | Description |
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| FG | Grant or registration |