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MX2009004019A - Compuestos heteroarilo, composiciones de los mismos, y uso de los mismos como inhibidores de proteina cinasa. - Google Patents

Compuestos heteroarilo, composiciones de los mismos, y uso de los mismos como inhibidores de proteina cinasa.

Info

Publication number
MX2009004019A
MX2009004019A MX2009004019A MX2009004019A MX2009004019A MX 2009004019 A MX2009004019 A MX 2009004019A MX 2009004019 A MX2009004019 A MX 2009004019A MX 2009004019 A MX2009004019 A MX 2009004019A MX 2009004019 A MX2009004019 A MX 2009004019A
Authority
MX
Mexico
Prior art keywords
compositions
sup
protein kinase
kinase inhibitors
heteroaryl compounds
Prior art date
Application number
MX2009004019A
Other languages
English (en)
Inventor
Ronald J Albers
Deborah Sue Mortensen
Maria Mercedes Mederos Delgado
John Joseph Sapienza
Branden G Lee
Dehua Huang
Kimberly Lyn Schwarz
Jason Simon Parnes
Jennifer R Riggs
Patrick William Papa
Original Assignee
Signal Pharm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Signal Pharm Llc filed Critical Signal Pharm Llc
Publication of MX2009004019A publication Critical patent/MX2009004019A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4

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  • Veterinary Medicine (AREA)
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Abstract

Se proporcionan en la presente Compuestos Heteroarilo que tienen la siguiente estructura: (I) en donde R1, R2, L, X, Y, Z, Q, A y B son como se definen en la presente, las composiciones comprenden una cantidad efectiva de un Compuesto Heteroarilo y métodos para tratar o prevenir cáncer, padecimientos inflamatorios, padecimientos inmunológicos, padecimientos metabólicos y padecimientos tratables o prevenibles por inhibición de una trayectoria de cinasa que comprende administrar una cantidad efectiva de un Compuesto Heteroarilo a un paciente en necesidad del mismo.
MX2009004019A 2006-10-19 2007-10-18 Compuestos heteroarilo, composiciones de los mismos, y uso de los mismos como inhibidores de proteina cinasa. MX2009004019A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85313506P 2006-10-19 2006-10-19
PCT/US2007/022375 WO2008051494A1 (en) 2006-10-19 2007-10-18 Heteroaryl compounds, compositions thereof, and use thereof as protein kinase inhibitors

Publications (1)

Publication Number Publication Date
MX2009004019A true MX2009004019A (es) 2009-06-19

Family

ID=39144905

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009004019A MX2009004019A (es) 2006-10-19 2007-10-18 Compuestos heteroarilo, composiciones de los mismos, y uso de los mismos como inhibidores de proteina cinasa.

Country Status (16)

Country Link
US (2) US7968556B2 (es)
EP (1) EP2078018B1 (es)
JP (1) JP5513119B2 (es)
KR (1) KR101451290B1 (es)
CN (1) CN101679432B (es)
AT (1) ATE549336T1 (es)
AU (1) AU2007309468B2 (es)
BR (1) BRPI0717773A2 (es)
CA (1) CA2666624C (es)
ES (1) ES2383370T3 (es)
IL (1) IL198116A (es)
MX (1) MX2009004019A (es)
NZ (1) NZ576279A (es)
RU (1) RU2474582C2 (es)
WO (1) WO2008051494A1 (es)
ZA (1) ZA200902384B (es)

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