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MX2007012782A - Metodos y acidos nucleicos para analisis de trastornos proliferativos celulares. - Google Patents

Metodos y acidos nucleicos para analisis de trastornos proliferativos celulares.

Info

Publication number
MX2007012782A
MX2007012782A MX2007012782A MX2007012782A MX2007012782A MX 2007012782 A MX2007012782 A MX 2007012782A MX 2007012782 A MX2007012782 A MX 2007012782A MX 2007012782 A MX2007012782 A MX 2007012782A MX 2007012782 A MX2007012782 A MX 2007012782A
Authority
MX
Mexico
Prior art keywords
proliferative disorders
detecting
nucleic acids
methods
analyses
Prior art date
Application number
MX2007012782A
Other languages
English (en)
Inventor
Juergen Distler
Thomas Hildmann
Ralf Lesche
Cathy Lofton-Day
Fabian Model
Matthias Schuster
Andrew Sledziewski
Xiaoling Song
Reimo Tetzner
Original Assignee
Epigenomics Ag
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36746665&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2007012782(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Epigenomics Ag filed Critical Epigenomics Ag
Publication of MX2007012782A publication Critical patent/MX2007012782A/es

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/57438Specifically defined cancers of liver, pancreas or kidney
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/154Methylation markers
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
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  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describen los aspectos de la invencion que proporcionan los metodos, acidos nucleicos y kits para detectar, o detectar y distinguir entre los trastornos proliferativos celulares de higado o para detectar, o para detectar y distinguir entre los trastornos proliferativos celulares colorrectales. Los aspectos particulares describen y proporcionan las secuencias genomicas, cuyos patrones de metilacion tienen una utilidad sustancial para la deteccion y diferenciacion mejoradas entre la clase de trastornos, de tal modo se permite la diagnosis y tratamiento mejorados de los pacientes.
MX2007012782A 2005-04-15 2006-04-17 Metodos y acidos nucleicos para analisis de trastornos proliferativos celulares. MX2007012782A (es)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US67224205P 2005-04-15 2005-04-15
US67699705P 2005-05-02 2005-05-02
US69752105P 2005-07-08 2005-07-08
US70486005P 2005-08-01 2005-08-01
US70931805P 2005-08-17 2005-08-17
US72360205P 2005-10-04 2005-10-04
US78740206P 2006-03-30 2006-03-30
PCT/US2006/014131 WO2006113466A2 (en) 2005-04-15 2006-04-17 Methods and nucleic acids for analyses of cellular proliferative disorders

Publications (1)

Publication Number Publication Date
MX2007012782A true MX2007012782A (es) 2008-03-14

Family

ID=36746665

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007012782A MX2007012782A (es) 2005-04-15 2006-04-17 Metodos y acidos nucleicos para analisis de trastornos proliferativos celulares.

Country Status (20)

Country Link
US (8) US7749702B2 (es)
EP (4) EP2045335B1 (es)
JP (2) JP5341506B2 (es)
KR (3) KR20080011287A (es)
CN (3) CN107663538B (es)
AT (1) ATE410524T1 (es)
AU (1) AU2006236620B2 (es)
BR (1) BRPI0607508B8 (es)
CA (1) CA2606296C (es)
DE (1) DE602006003012D1 (es)
DK (1) DK1721992T3 (es)
EA (1) EA013634B1 (es)
ES (2) ES2533767T3 (es)
IL (1) IL186556A (es)
MX (1) MX2007012782A (es)
PL (1) PL1721992T3 (es)
PT (1) PT1721992E (es)
SG (1) SG183708A1 (es)
SI (1) SI1721992T1 (es)
WO (1) WO2006113466A2 (es)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1668148B1 (en) 2003-09-04 2008-12-31 Human Genetic Signatures PTY Ltd. Nucleic acid detection assay
EP1828411B1 (en) 2004-12-03 2012-11-07 Human Genetic Signatures PTY Ltd Methods for simplifying microbial nucleic acids by chemical modification of cytosines
ES2533767T3 (es) * 2005-04-15 2015-04-15 Epigenomics Ag Métodos para el análisis de trastornos proliferativos celulares
WO2006125267A1 (en) * 2005-05-26 2006-11-30 Human Genetic Signatures Pty Ltd Isothermal strand displacement amplification using primers containing a non-regular base
US8343738B2 (en) 2005-09-14 2013-01-01 Human Genetic Signatures Pty. Ltd. Assay for screening for potential cervical cancer
EP2013360A2 (en) * 2006-04-17 2009-01-14 Epigenomics AG Methods and nucleic acids for the detection of colorectal cell proliferative disorders
US20080050738A1 (en) * 2006-05-31 2008-02-28 Human Genetic Signatures Pty Ltd. Detection of target nucleic acid
EP2634264B1 (en) * 2006-07-21 2016-09-14 Epigenomics AG Methods and nucleic acids related to the gene GLI3 for analyses of cellular proliferative disorders
CN101153336B (zh) 2006-09-27 2011-09-07 香港中文大学 检测dna甲基化程度的方法和试剂盒
US7662566B2 (en) * 2006-11-22 2010-02-16 Myriad Genetics, Inc. Gene copy number profiling
CA2676227A1 (en) * 2007-02-12 2008-08-21 The Johns Hopkins University Early detection and prognosis of colon cancers
WO2008113111A1 (en) * 2007-03-16 2008-09-25 Human Genetic Signatures Pty Ltd Assay for gene expression
WO2008122447A2 (en) * 2007-04-10 2008-10-16 Epigenomics Ag Dna methylation assay for the diagnosis or prognosis of medical conditions
PL2479289T3 (pl) * 2007-06-08 2016-10-31 Sposób analizy metylacji
FR2919061B1 (fr) * 2007-07-19 2009-10-02 Biomerieux Sa Procede de dosage de la plastine-i pour le diagnostic in vitro du cancer colorectal.
AU2008329549B2 (en) 2007-11-27 2013-08-22 Human Genetic Signatures Pty Ltd Enzymes for amplification and copying bisulphite modified nucleic acids
JP5694776B2 (ja) * 2007-12-11 2015-04-01 エピゲノミクス アーゲー 細胞増殖性障害の解析のための方法及び核酸
WO2009079703A1 (en) * 2007-12-20 2009-07-02 Human Genetic Signatures Pty Ltd Elimination of contaminants associated with nucleic acid amplification
TW200927925A (en) * 2007-12-27 2009-07-01 Agriculture And Food Agency Council Of Agriculture Specific Promoter Region Expresses in Actively Dividing Young Tissues and the Aging Tissues in Plants and its Application
US20110245087A1 (en) * 2008-03-18 2011-10-06 Gunter Weiss Method for optimizing and validating an assay for determining the presence or absence of a medical condition
US20110195070A1 (en) * 2008-10-09 2011-08-11 British Columbia Cancer Agency Branch Detection of granulosa-cell tumors
EP2309005B1 (en) * 2009-08-03 2015-03-04 Epigenomics AG Methods for preservation of genomic DNA sequence complexity
TWI434937B (zh) * 2009-10-28 2014-04-21 Univ Nat Chunghsing 具有廣泛性抗木瓜輪點病毒特性的基因轉殖木瓜品系18-2-4之核酸分子及其檢測方法及應用
GB201004147D0 (en) * 2010-03-12 2010-04-28 Dna Electronics Ltd Method and apparatus for sensing methylation
KR101747191B1 (ko) 2011-01-14 2017-06-14 에스케이하이닉스 주식회사 반도체 장치
GB201107466D0 (en) 2011-05-05 2011-06-15 Loktionov Alexandre Device and method for non-invasive collection of colorectal mucocellular layer and disease detection
US20130065228A1 (en) * 2011-06-01 2013-03-14 University Of Southern California Genome-scale analysis of aberrant dna methylation in colorectal cancer
FI20115709A0 (fi) * 2011-07-01 2011-07-01 Helsingin Yliopisto Menetelmä perinnöllisten syöpien diagnosointiin
CA2840149C (en) * 2011-07-08 2021-10-26 Epigenomics Ag Methods and nucleic acids for determining the prognosis of a cancer subject
SG11201400217WA (en) 2011-09-07 2014-03-28 Human Genetic Signatures Pty Molecular detection assay
US9546403B1 (en) 2011-12-14 2017-01-17 University Of Utah Research Foundation Substrate for methylated DNA testing
EP2828405B1 (en) * 2012-03-20 2017-06-28 Exact Sciences Corporation Marker panel for detecting cancer
SG11201501465SA (en) * 2012-08-31 2015-05-28 Nat Defense Medical Ct Method for screening cancer
US10706957B2 (en) 2012-09-20 2020-07-07 The Chinese University Of Hong Kong Non-invasive determination of methylome of tumor from plasma
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
KR101476769B1 (ko) * 2013-01-02 2014-12-26 대구대학교 산학협력단 leucine-richα-2 glyprotein를 함유하는 대장암 진행예측용 바이오마커 조성물 및 이를 포함하는 대장암 진단용 바이오키트
JP6369857B2 (ja) * 2013-05-29 2018-08-08 シスメックス株式会社 肝細胞癌に関する情報の取得方法、ならびに肝細胞癌に関する情報を取得するためのマーカーおよびキット
KR101527283B1 (ko) * 2013-08-13 2015-06-10 서울대학교산학협력단 당단백질의 탈당화 검출을 통한 암 마커 스크리닝 방법 및 간세포암 마커
KR101438519B1 (ko) * 2014-07-01 2014-09-17 대구대학교 산학협력단 complement factor B를 함유하는 대장암 진행예측용 바이오마커 조성물 및 이를 포함하는 대장암 진단용 바이오키트
WO2016000782A1 (en) 2014-07-03 2016-01-07 Aktiebolaget Electrolux Household appliance mixing arrangement
US10342238B2 (en) 2014-07-03 2019-07-09 Aktiebolaget Electrolux Household appliance mixing arrangement
US11062789B2 (en) 2014-07-18 2021-07-13 The Chinese University Of Hong Kong Methylation pattern analysis of tissues in a DNA mixture
CN104745575B (zh) * 2014-08-08 2019-03-12 博诚研究中心 用于检测细胞增殖性异常或疾病程度分级的基因组合物及其用途
CN107406874B (zh) * 2014-12-19 2021-03-26 表观基因组股份有限公司 用于检测CpG甲基化和诊断癌症的方法
EP3239302A4 (en) * 2014-12-26 2018-05-23 Peking University Method for detecting differentially methylated cpg islands associated with abnormal state of human body
CN115181802A (zh) * 2015-04-23 2022-10-14 博尔诚(北京)科技有限公司 一种检测Septin9基因甲基化的试剂盒及其应用
CN104830855A (zh) * 2015-05-21 2015-08-12 基因科技(上海)有限公司 一种检测sept9基因甲基化的探针及其应用
EP3452620B1 (en) * 2016-05-04 2025-11-05 Queen's University at Kingston Cell-free detection of methylated tumour dna
RU2630669C1 (ru) * 2016-07-21 2017-09-11 Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" (ФБУН ГНЦ ВБ "Вектор") Способ определения метилирования сайтов PuCGPy регуляторных областей генов-онкомаркеров колоректального рака методом GLAD-ПЦР-анализа и набор олигонуклеотидных праймеров и флуоресцентно-меченых зондов для осуществления указанного способа
US11566284B2 (en) 2016-08-10 2023-01-31 Grail, Llc Methods of preparing dual-indexed DNA libraries for bisulfite conversion sequencing
CN107723363A (zh) * 2016-08-11 2018-02-23 博尔诚(北京)科技有限公司 肿瘤标志物的组合检测方法及其应用
WO2018099418A1 (en) 2016-11-30 2018-06-07 The Chinese University Of Hong Kong Analysis of cell-free dna in urine and other samples
EP3360971A1 (en) * 2017-02-09 2018-08-15 Epiontis GmbH Improved method for epigenetic immune cell counting
US11965157B2 (en) 2017-04-19 2024-04-23 Singlera Genomics, Inc. Compositions and methods for library construction and sequence analysis
CN109609629A (zh) * 2017-09-30 2019-04-12 博尔诚(北京)科技有限公司 用于检测肝癌的组合物及其用途
US12027237B2 (en) 2018-03-13 2024-07-02 Grail, Llc Anomalous fragment detection and classification
WO2019195268A2 (en) 2018-04-02 2019-10-10 Grail, Inc. Methylation markers and targeted methylation probe panels
CN108866192B (zh) * 2018-07-26 2021-06-22 上海奕谱生物科技有限公司 基于甲基化修饰的肿瘤标记物stamp-ep1
CN108866191B (zh) * 2018-07-26 2021-07-09 上海奕谱生物科技有限公司 基于甲基化修饰的肿瘤标记物stamp-ep2
AU2019351130B2 (en) 2018-09-27 2025-10-23 GRAIL, Inc Methylation markers and targeted methylation probe panel
US12234514B2 (en) 2018-12-21 2025-02-25 Grail, Inc. Source of origin deconvolution based on methylation fragments in cell-free DNA samples
CN115786517A (zh) * 2019-02-14 2023-03-14 博尔诚(北京)科技有限公司 一种肠癌患癌、癌前筛查组合物及其用途
CN110211633B (zh) * 2019-05-06 2021-08-31 臻和精准医学检验实验室无锡有限公司 Mgmt基因启动子甲基化的检测方法、测序数据的处理方法及处理装置
CN112063712A (zh) * 2019-10-28 2020-12-11 北京康美天鸿生物科技有限公司 基于高分辨率熔解曲线检测septin9基因甲基化的特异引物对和试剂盒
WO2021122799A1 (en) * 2019-12-16 2021-06-24 Epigenomics Ag Methods for detecting colorectal cancer
KR102637032B1 (ko) * 2020-01-28 2024-02-15 주식회사 젠큐릭스 특정 유전자의 CpG 메틸화 변화를 이용한 방광암 진단용 조성물 및 이의 용도
WO2023017001A1 (en) 2021-08-09 2023-02-16 Epigenomics Ag Improved methods for detecting colorectal cancer
CN113584032B (zh) * 2021-08-20 2023-08-29 深圳市恩辑生物科技有限公司 一种迷你启动子pAPP及其应用
CN113862349A (zh) * 2021-10-26 2021-12-31 山东师范大学 一种肺纤维化诊断生物标志物
CN114783511B (zh) * 2022-02-25 2025-03-25 深圳市硬核酸生物科技有限公司 核酸分子溶液浓度推荐方法及装置、计算机设备
WO2024074558A1 (en) 2022-10-04 2024-04-11 Epigenomics Ag Improved methods for detecting cancer
WO2025019568A1 (en) * 2023-07-17 2025-01-23 The Penn State Research Foundation Improving immune cell-based therapies against solid tumors with optogenetically engineered septin proteins

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585481A (en) * 1987-09-21 1996-12-17 Gen-Probe Incorporated Linking reagents for nucleotide probes
US5457183A (en) 1989-03-06 1995-10-10 Board Of Regents, The University Of Texas System Hydroxylated texaphyrins
US5245022A (en) * 1990-08-03 1993-09-14 Sterling Drug, Inc. Exonuclease resistant terminally substituted oligonucleotides
US5565552A (en) * 1992-01-21 1996-10-15 Pharmacyclics, Inc. Method of expanded porphyrin-oligonucleotide conjugate synthesis
US5574142A (en) * 1992-12-15 1996-11-12 Microprobe Corporation Peptide linkers for improved oligonucleotide delivery
SE501439C2 (sv) 1993-06-22 1995-02-13 Pharmacia Lkb Biotech Sätt och anordning för analys av polynukleotidsekvenser
DE69417918T2 (de) 1993-11-30 2000-01-05 Mcgill University, Montreal Dna methyltransferase inhibierung
US5597696A (en) * 1994-07-18 1997-01-28 Becton Dickinson And Company Covalent cyanine dye oligonucleotide conjugates
US5514758A (en) 1994-09-30 1996-05-07 The Goodyear Tire & Rubber Company Process for making latex for high performance masking tape
US5871917A (en) 1996-05-31 1999-02-16 North Shore University Hospital Research Corp. Identification of differentially methylated and mutated nucleic acids
US5786146A (en) * 1996-06-03 1998-07-28 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US6017704A (en) * 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
JPH1090169A (ja) 1996-09-19 1998-04-10 Bunshi Bio Photonics Kenkyusho:Kk 顕微鏡装置
BR9712185A (pt) 1996-10-01 1999-08-31 Rappold Hoerbrand Gudrun Gene do crescimento humano e região de gene de baixa estatura.
AU7829398A (en) 1997-06-09 1998-12-30 University Of Southern California A cancer diagnostic method based upon dna methylation differences
DE19754482A1 (de) 1997-11-27 1999-07-01 Epigenomics Gmbh Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke
GB9726539D0 (en) 1997-12-16 1998-02-11 Univ Dundee Polypeptides, polynucleotides and uses thereof
GB9805918D0 (en) * 1998-03-19 1998-05-13 Nycomed Amersham Plc Sequencing by hybridisation
AUPP312998A0 (en) * 1998-04-23 1998-05-14 Commonwealth Scientific And Industrial Research Organisation Diagnostic assay
US7700324B1 (en) 1998-11-03 2010-04-20 The Johns Hopkins University School Of Medicine Methylated CpG island amplification (MCA)
US5958773A (en) * 1998-12-17 1999-09-28 Isis Pharmaceuticals Inc. Antisense modulation of AKT-1 expression
JP2000221136A (ja) 1999-01-29 2000-08-11 Jasco Corp 経時変化追跡方法および装置
US6331393B1 (en) 1999-05-14 2001-12-18 University Of Southern California Process for high-throughput DNA methylation analysis
US6783933B1 (en) * 1999-09-15 2004-08-31 The Johns Hopkins University School Of Medicine CACNA1G polynucleotide, polypeptide and methods of use therefor
AU1141301A (en) * 1999-10-19 2001-04-30 Universiteit Gent Identification of bpesc1, a novel gene disrupted by a balanced chromosomal translocation t(3;4)(q23;p15.2) in patient with bpes
JP3783826B2 (ja) 2000-01-17 2006-06-07 横河電機株式会社 バイオチップ読み取り装置
WO2005000087A2 (en) * 2003-06-03 2005-01-06 Chiron Corporation Gene products differentially expressed in cancerous colon cells and their methods of use ii
MXPA03001834A (es) * 2000-09-01 2003-08-01 Epigenomics Ag Metodo para determinar el grado de metilacion de determinadas citocinas en adn genomico en el contexto de secuencia 5'-cpg-3'.
US6756200B2 (en) * 2001-01-26 2004-06-29 The Johns Hopkins University School Of Medicine Aberrantly methylated genes as markers of breast malignancy
DE10112515B4 (de) 2001-03-09 2004-02-12 Epigenomics Ag Verfahren zum Nachweis von Cytosin-Methylierungsmustern mit hoher Sensitivität
US7473767B2 (en) * 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
EP1442129B1 (en) * 2001-10-18 2008-09-10 Lovelace Respiratory Research Institute Cancer monitoring by aberrant promotor methylation of the transcription factor genes pax5 alpha pax5 beta, novel loop helix loop protein, novel gene 2, and beta3 genes
WO2003042661A2 (en) * 2001-11-13 2003-05-22 Protein Design Labs, Inc. Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer
JP3448654B2 (ja) 2001-11-22 2003-09-22 北陸先端科学技術大学院大学長 バイオチップ、バイオチップアレイ、及びそれらを用いたスクリーニング方法
EP3098231A1 (en) 2001-11-30 2016-11-30 The John Hopkins University Methods for analyzing methylated cpg islands and gc rich regions
JP2003232725A (ja) 2002-02-12 2003-08-22 Japan Science & Technology Corp 表面プラズモン共鳴測定法を用いる化学反応解析センサ
DE10228917A1 (de) 2002-06-24 2004-01-22 Epigenomics Ag Vorrichtung zur Handhabung von Flüssigkeiten in einer Mehrzahl von Kanälen
JP4199609B2 (ja) 2002-07-12 2008-12-17 三菱化学株式会社 分析用チップ、分析用チップユニット及び分析装置ならびに分析用チップの作製方法
DK1525188T3 (da) 2002-07-16 2008-11-17 Inst Nat Sante Rech Med Hidtil ukendte derivater af 4,4-dithiobis-(3-aminobutan-1-sulfonater) og sammensætninger, der indeholder dem
DE10245779A1 (de) 2002-10-01 2004-04-29 Epigenomics Ag Verfahren und Nukleinsäuren für die verbesserte Behandlung von proliferativen Erkrankungen von Brustzellen
US20060024684A1 (en) 2002-10-01 2006-02-02 Epigenomics Ag Prognostic markers for prediction of treatment response and/or survival of breast cell proliferative disorder patients
JP4649331B2 (ja) 2002-10-01 2011-03-09 エピゲノミクス アーゲー 乳房細胞増殖障害の改良治療方法および核酸
DE10317955A1 (de) 2003-04-17 2004-11-25 Epigenomics Ag Verfahren und Nukleinsäuren für die verbesserte Behandlung von proliferativen Erkrankungen von Brustzellen
JP2004156911A (ja) 2002-11-01 2004-06-03 Osaka Industrial Promotion Organization 表面プラズモン蛍光顕微鏡、および表面プラズモンにより励起された蛍光を測定する方法
JP2004212204A (ja) 2002-12-27 2004-07-29 Olympus Corp 蛍光顕微鏡及び蛍光寿命の測定方法、並びに蛍光寿命の測定用プログラム
WO2004074441A2 (en) * 2003-02-19 2004-09-02 Government Of The United States Of America Represented By The Secretary Department Of Health And Human Services Amplification or overexpression of mll septin-like fusion (msf) and septin9 and methods related thereto
EP1636386B1 (en) 2003-06-23 2015-08-05 Epigenomics AG Methods and nucleic acids for analyses of colorectal cell proliferative disorders
US20040265833A1 (en) * 2003-06-23 2004-12-30 Cathy Lofton-Day Methods and nucleic acids for the analysis of colorectal cell proliferative disorders
CN102517389A (zh) 2003-10-09 2012-06-27 Epi基因组股份公司 改进的dna亚硫酸氢盐转化
DE10348407A1 (de) 2003-10-17 2005-05-19 Widschwendter, Martin, Prof. Prognostische und diagnostische Marker für Zell-proliferative Erkrankungen von Brustgeweben
AU2004286343A1 (en) 2003-11-03 2005-05-12 Genenews Inc. Liver cancer biomarkers
ES2801379T3 (es) 2003-12-01 2021-01-11 Epigenomics Ag Métodos y ácidos nucleicos para el análisis de la expresión génica asociada con el desarrollo de trastornos proliferativos de células de próstata
JP2005204651A (ja) 2003-12-11 2005-08-04 Epigenomics Ag 乳房細胞増殖障害の患者の治療応答及び/又は生存期間の予測のための予後診断マーカー
EP1561821B1 (en) 2003-12-11 2011-02-16 Epigenomics AG Prognostic markers for prediction of treatment response and/or survival of breast cell proliferative disorder patients
WO2005111232A2 (en) 2004-05-17 2005-11-24 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Silencing of tumor-suppressive genes by cpg-methylation in prostate cancer
DE102004029700A1 (de) 2004-06-15 2006-02-09 Epigenomics Ag Verfahren zur Quantifizierung methylierter DNA
WO2005123945A2 (en) 2004-06-21 2005-12-29 Epigenomics Ag Epigenetic markers for the treatment of breast cancer
EP2281902A1 (en) * 2004-07-18 2011-02-09 Epigenomics AG Epigenetic methods and nucleic acids for the detection of breast cell proliferative disorders
JP4192862B2 (ja) 2004-07-20 2008-12-10 ダイソー株式会社 ポリエーテル系共重合体の製造方法
BRPI0518734A2 (pt) 2004-11-30 2008-12-02 Veridex Llc prognàstico de cÂncer de pulmço
EP2284279A1 (en) * 2004-12-02 2011-02-16 Epigenomics AG Methods and nucleic acids for the analysis of gene expression associated with the prognosis of prostate cell proliferative disorders
ES2533767T3 (es) * 2005-04-15 2015-04-15 Epigenomics Ag Métodos para el análisis de trastornos proliferativos celulares
EP1904649A2 (en) 2005-07-18 2008-04-02 Epigenomics AG Compositions and methods for cancer diagnostics comprising pan-cancer markers
WO2007115213A2 (en) 2006-03-30 2007-10-11 Epigenomics Ag Methods and nucleic acids for analyses of cellular proliferative disorders
EP2013360A2 (en) 2006-04-17 2009-01-14 Epigenomics AG Methods and nucleic acids for the detection of colorectal cell proliferative disorders

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