[go: up one dir, main page]

MC1600A1 - Nouveaux derives de pyrimidone - Google Patents

Nouveaux derives de pyrimidone

Info

Publication number
MC1600A1
MC1600A1 MC841703A MC1703A MC1600A1 MC 1600 A1 MC1600 A1 MC 1600A1 MC 841703 A MC841703 A MC 841703A MC 1703 A MC1703 A MC 1703A MC 1600 A1 MC1600 A1 MC 1600A1
Authority
MC
Monaco
Prior art keywords
dimethoxy
group
methylene
tetrahydro
hydrogen
Prior art date
Application number
MC841703A
Other languages
English (en)
French (fr)
Inventor
Ado Kaiser
Frank Kienzle
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MC1600A1 publication Critical patent/MC1600A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60Three or more oxygen or sulfur atoms
    • C07D239/62Barbituric acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
MC841703A 1983-05-05 1984-05-02 Nouveaux derives de pyrimidone MC1600A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH244283 1983-05-05
CH139284 1984-03-20

Publications (1)

Publication Number Publication Date
MC1600A1 true MC1600A1 (fr) 1985-05-09

Family

ID=25687524

Family Applications (1)

Application Number Title Priority Date Filing Date
MC841703A MC1600A1 (fr) 1983-05-05 1984-05-02 Nouveaux derives de pyrimidone

Country Status (16)

Country Link
US (1) US4581172A (cs)
EP (1) EP0124893A3 (cs)
AU (1) AU2751084A (cs)
CA (1) CA1237429A (cs)
CS (1) CS243486B2 (cs)
DK (1) DK198784A (cs)
ES (1) ES532172A0 (cs)
FI (1) FI841619A7 (cs)
HU (1) HUT34025A (cs)
IL (1) IL71711A (cs)
MC (1) MC1600A1 (cs)
NO (1) NO841780L (cs)
NZ (1) NZ207981A (cs)
PH (1) PH19219A (cs)
PT (1) PT78549B (cs)
ZW (1) ZW6284A1 (cs)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3472678D1 (de) * 1983-07-18 1988-08-18 Beecham Group Plc Benzazepine and benzoxazepine derivatives
GB9707251D0 (en) * 1997-04-10 1997-05-28 Smithkline Beecham Plc Novel method and compounds
EP1165558B1 (en) * 1999-03-31 2003-09-24 Vernalis Limited Derivatives of pyrimido[6,1-a]isoquinolin-4-one
US7169907B2 (en) * 2002-03-01 2007-01-30 Roche Diagnostics Operations, Inc. Derivatives, immunogens, and antibodies for detecting ecstasy-class drugs
EP1641766A2 (en) * 2003-07-08 2006-04-05 Smithkline Beecham Corporation Novel chemical compounds
GB201502260D0 (en) 2015-02-11 2015-04-01 Verona Pharma Plc Salt of Pyrimido[6,1-A]Isoquinolin-4-one compound
WO2017016960A1 (en) * 2015-07-24 2017-02-02 F. Hoffmann-La Roche Ag Process for the preparation of (6s)-6-alkyl-10-alkoxy-9-(substituted alkoxy)-2-oxo-6,7-dihydrobenzo[a]quinolizine-3-carboxylic acid analogues
GB201613054D0 (en) 2016-07-28 2016-09-14 Verona Pharma Plc New compound and process
PL3822272T4 (pl) * 2018-07-13 2025-07-28 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Skondensowane związki tri-cykliczne jako podwójny inhibitor pde3/pde4
ES2995084T3 (en) * 2020-01-15 2025-02-05 Chia Tai Tianqing Pharmaceutical Group Co Ltd Pharmaceutical composition of tricyclic pde3/pde4 dual inhibitor compound
DK4092022T3 (da) * 2020-01-15 2025-12-01 Chia Tai Tianqing Pharmaceutical Group Co Ltd Kristal af pde3/pde4-dualhæmmer og anvendelse deraf

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2720085A1 (de) * 1977-05-05 1978-11-16 Hoechst Ag Pyrimido(6,1-a)isochinolin-2-on- derivate
NZ185900A (en) * 1976-12-10 1981-04-24 Hoechst Ag Pyrimido (6,1-a) isoquinolin-4-ones medicaments intermediate isoquinolines
FI64370C (fi) * 1977-05-05 1983-11-10 Hoechst Ag Foerfarande foer framstaellning av terapeutiskt anvaendbara pyimido-(6,1-a)isokinolin-2-imino-4-onderivat
DE2847693A1 (de) * 1978-11-03 1980-05-22 Hoechst Ag Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen
DE3135831A1 (de) * 1981-09-10 1983-04-28 Hoechst Ag, 6230 Frankfurt 9,10-substituierte 2-mesitylimino-3-alkyl-3,4,6,7-tetrahydro-2h-pyrimido(6,1-a)isochinolin-4-one, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
US4581172A (en) 1986-04-08
FI841619L (fi) 1984-11-06
DK198784D0 (da) 1984-04-17
AU2751084A (en) 1984-11-08
DK198784A (da) 1984-11-06
HUT34025A (en) 1985-01-28
PH19219A (en) 1986-02-12
ES8505369A1 (es) 1985-06-01
CS243486B2 (en) 1986-06-12
ZW6284A1 (en) 1985-10-30
FI841619A7 (fi) 1984-11-06
IL71711A (en) 1987-08-31
PT78549A (en) 1984-06-01
ES532172A0 (es) 1985-06-01
EP0124893A2 (de) 1984-11-14
FI841619A0 (fi) 1984-04-25
CS325584A2 (en) 1985-08-15
EP0124893A3 (de) 1987-11-11
NO841780L (no) 1984-11-06
IL71711A0 (en) 1984-09-30
PT78549B (en) 1986-09-15
NZ207981A (en) 1987-05-29
CA1237429A (en) 1988-05-31

Similar Documents

Publication Publication Date Title
EP0389352B1 (fr) Dérivés fluoro-4 benzoiques, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent
CZ99698A3 (cs) Heterocyklické deriváty s indolinovým, indolovým nebo tetrahydrochinolinovým cyklem a jejich farmaceutické použití
BE851310A (fr) Nouveaux derives de la tetrahydro-equinocandine b
FR2796644A1 (fr) Nouveaux derives de beta-carboline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PT86453B (pt) Processo para a preparacao de 6-benzoxazimil e 6-benzo-tiazimil-2,3,4,5-tetrahidro-piridazin-3-onas e de composicoes farmaceuticas que os contem
MC1600A1 (fr) Nouveaux derives de pyrimidone
EP0527081B1 (fr) Nouvelles pipérazinylalcoyl-3 dihydro-2,3 4H-benzoxazine-1,3 ones-4 substituées, leur préparation et leur application en thérapeutique
EP2880023A1 (fr) Derives de griseofulvine
MC1478A1 (fr) Nouveaux derives de l'imidazoquinazoline
EP0411912A2 (en) Coumarin derivatives, their preparation and their use in the treatment of cerebrovascular disorders
EP0463944B1 (fr) Acyl benzoxazolinones, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
EP0136198A1 (fr) Dérivés de triazolo pyrimidine, leur procédé de préparation et leur application thérapeutique en tant que toni-cardiaques
EP0495709A1 (fr) Nouveaux composés de structure aryltriazinique leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
MC1332A1 (fr) Nouveaux derives de quinazoline et preparations pharmaceutiques
FR2527608A1 (fr) Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments
MC1845A1 (fr) Derives de pyrimidine
MC1184A1 (fr) Derives d'oxadiazolopyrimidine
MC1410A1 (fr) Nouveaux derives de l'imidazoquinazoline
EP0718290B1 (en) Carboxyalkyl heterocyclic derivatives
EP1828125B1 (fr) Derives d'arylpiperazine et leur utilisation comme ligands selectifs du recepteur d3 de la dopamine
EP0536035A1 (fr) Dérivés de benzonaphtyridine-1,8 et compositions anti-microbiennes
BE898151A (fr) Nouveaux dérivés de la quinazoline, leur préparation et leur utilisation comme médicaments.
CA2346506C (fr) Derives d'aryl-{4-fluoro-4-[(2-pyridin-2-yl-ethylamino)-methyl]-piperidin-1-yl}-methanone comme agonistes du recepteur 5-ht1
EP0233804B1 (fr) Monoaryl-5 as triazinones-3 substituées en position 2, leur procédé de préparation et leur application en tant que medicaments
BE900003A (fr) Derives du spirosuccinimide utilisables comme medicaments.

Legal Events

Date Code Title Description
YP Annual fee paid