[go: up one dir, main page]

MA47503A - Composés et méthodes pour le traitement de maladies inflammatoires chroniques de l'intestin avec manifestations extra-intestinales - Google Patents

Composés et méthodes pour le traitement de maladies inflammatoires chroniques de l'intestin avec manifestations extra-intestinales

Info

Publication number
MA47503A
MA47503A MA047503A MA47503A MA47503A MA 47503 A MA47503 A MA 47503A MA 047503 A MA047503 A MA 047503A MA 47503 A MA47503 A MA 47503A MA 47503 A MA47503 A MA 47503A
Authority
MA
Morocco
Prior art keywords
intestine
compounds
treatment
methods
inflammatory diseases
Prior art date
Application number
MA047503A
Other languages
English (en)
Inventor
Cheryl Geraldine Lassen
Original Assignee
Arena Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=61622673&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA47503(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Arena Pharm Inc filed Critical Arena Pharm Inc
Publication of MA47503A publication Critical patent/MA47503A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
MA047503A 2017-02-16 2018-02-16 Composés et méthodes pour le traitement de maladies inflammatoires chroniques de l'intestin avec manifestations extra-intestinales MA47503A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762459870P 2017-02-16 2017-02-16
US201762459881P 2017-02-16 2017-02-16

Publications (1)

Publication Number Publication Date
MA47503A true MA47503A (fr) 2021-04-21

Family

ID=61622673

Family Applications (1)

Application Number Title Priority Date Filing Date
MA047503A MA47503A (fr) 2017-02-16 2018-02-16 Composés et méthodes pour le traitement de maladies inflammatoires chroniques de l'intestin avec manifestations extra-intestinales

Country Status (11)

Country Link
US (2) US11478448B2 (fr)
EP (1) EP3582814B1 (fr)
JP (1) JP2020507610A (fr)
KR (1) KR20190113955A (fr)
CN (1) CN110545848A (fr)
AU (1) AU2018222747A1 (fr)
CA (1) CA3053416A1 (fr)
ES (1) ES2981521T3 (fr)
MA (1) MA47503A (fr)
MX (2) MX2019009843A (fr)
WO (1) WO2018151834A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201500639TA (en) 2010-01-27 2015-03-30 Arena Pharm Inc Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
CN116850181A (zh) 2015-01-06 2023-10-10 艾尼纳制药公司 治疗与s1p1受体有关的病症的方法
AU2016284162A1 (en) * 2015-06-22 2018-02-01 Arena Pharmaceuticals, Inc. Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid(Compound1) for use in SIP1 receptor-associated disorders
AU2018220521A1 (en) 2017-02-16 2019-09-05 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of primary biliary cholangitis
CA3053416A1 (fr) 2017-02-16 2018-08-23 Arena Pharmaceuticals, Inc. Composes et methodes pour le traitement de maladies inflammatoires chroniques de l'intestin avec manifestations extra-intestinales
WO2019236757A1 (fr) 2018-06-06 2019-12-12 Arena Pharmaceuticals, Inc. MÉTHODES DE TRAITEMENT DE TROUBLES ASSOCIÉS AU RÉCEPTEUR S1P1<sb />
US11555015B2 (en) * 2018-09-06 2023-01-17 Arena Pharmaceuticals, Inc. Compounds useful in the treatment of autoimmune and inflammatory disorders
US20210386706A1 (en) * 2018-10-03 2021-12-16 Arena Pharmaceuticals, Inc. Methods for the treatment of scleroderma
CA3156182A1 (fr) * 2019-10-01 2021-04-08 Arena Pharmaceuticals, Inc. Procedes de traitement d'etats lies au recepteur s1p1
WO2023135506A1 (fr) * 2022-01-13 2023-07-20 Arena Pharmaceuticals, Inc. Etrasimod destiné à être utilisé dans le traitement de troubles liés au récepteur s1p1 en association avec un traitement hormonal
KR20250102260A (ko) 2023-12-27 2025-07-07 가톨릭대학교 산학협력단 에타너셉트를 발현하는 줄기세포의 배양물을 유효성분으로 포함하는 염증성 장질환의 예방 또는 치료용 약학적 조성물

Family Cites Families (173)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL293572A (fr) 1962-06-07
DE2226703A1 (de) 1972-05-25 1973-12-13 Schering Ag Neue tetrahydrocarbazolderivate und verfahren zu ihrer herstellung
US4057559A (en) 1973-10-01 1977-11-08 American Home Products Corporation Carbazole acetic acid derivatives
US4476248A (en) 1983-02-28 1984-10-09 The Upjohn Company Crystallization of ibuprofen
US4810699A (en) 1987-02-20 1989-03-07 American Home Products Corporation Substituted 1,3,4,9-tetrahydropyrano[3,4,-b]indole-1-acetic acids, pharmaceutical compositions containing them, and methods for treating inflammatory conditions and for analgesic purposes using them
US4782076A (en) 1988-03-01 1988-11-01 American Home Products Corporation Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives, composition and use
PT95692A (pt) 1989-10-27 1991-09-13 American Home Prod Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase
US5221678A (en) 1990-07-26 1993-06-22 Merck Frosst Canada, Inc. (quinolin-2-ylmethoxy)tetrahydrocarbazoles as inhibitors of the biosynthesis of leukotrienes
US5998499A (en) 1994-03-25 1999-12-07 Dentsply G.M.B.H. Liquid crystalline (meth)acrylate compounds, composition and method
US5776967A (en) 1996-07-26 1998-07-07 American Home Products Corporation Pyranoindole inhibitors of COX--2
US5830911A (en) 1996-08-14 1998-11-03 American Home Products Corporation Pyranoindole and tetrahydrocarbazole inhibitors of COX-2
US6861448B2 (en) 1998-01-14 2005-03-01 Virtual Drug Development, Inc. NAD synthetase inhibitors and uses thereof
EE200100556A (et) 1999-04-28 2003-02-17 Aventis Pharma Deutschland Gmbh Diarüülhappe derivaat, seda sisaldav farmatseutiline kompositsioon ja ühendi kasutamine ravimite valmistamiseks
WO2001003739A1 (fr) 1999-07-12 2001-01-18 Ono Pharmaceutical Co., Ltd. Inhibiteurs de fibrose contenant comme ingredient actif l'agoniste du recepteur de sphingosine-1-phosphate ou la sphingosine-1-phosphate
US6410583B1 (en) 2000-07-25 2002-06-25 Merck Frosst Canada & Co. Cyclopentanoindoles, compositions containing such compounds and methods of treatment
AU2002223492A1 (en) 2000-11-14 2002-05-27 Neurosearch A/S Use of malaria parasite anion channel blockers for treating malaria
EP1383778B1 (fr) 2001-01-30 2009-10-21 University Of Virginia Patent Foundation Agonistes et antagonistes de recepteurs de sphingosine-1-phosphate
US7534547B2 (en) 2001-03-29 2009-05-19 Osaka Gas Company Limited Optically active compound and photosensitive resin composition
ES2316613T3 (es) 2001-05-10 2009-04-16 Ono Pharmaceutical Co., Ltd. Derivados de acido crboxilico y composiciones farmaceuticas que contienen los mismos como ingrediente activo.
CN1329372C (zh) 2001-09-27 2007-08-01 杏林制药株式会社 二芳基硫醚衍生物及其加成盐和免疫抑制剂
WO2003059346A1 (fr) 2002-01-18 2003-07-24 The Genetics Company Inc. Inhibiteurs de beta-secretase
WO2003062252A1 (fr) 2002-01-18 2003-07-31 Merck & Co., Inc. Agonistes du recepteur edg
CA2472680A1 (fr) 2002-01-18 2003-07-31 Merck & Co., Inc. Antagonistes selectifs du recepteur s1p1/edg1
AU2003218056A1 (en) 2002-03-01 2003-09-16 Merck & Co., Inc. Aminoalkylphosphonates and related compounds as edg receptor agonists
AU2003217764A1 (en) 2002-03-01 2003-09-16 Merck & Co., Inc. Aminoalkylphosphonates and related compounds as edg receptor agonists
JP2005533058A (ja) 2002-06-17 2005-11-04 メルク　エンド　カムパニー　インコーポレーテッド Ｅｄｇ受容体アゴニストとしての１−（（５−アリール−１，２，４−オキサジアゾール−３−イル）ベンジル）アゼチジン−３−カルボキシラートおよび１−（（５−アリール−１，２，４−オキサジアゾール−３−イル）ベンジル）ピロリジン−３−カルボキシラート
AU2003252478A1 (en) 2002-07-10 2004-02-02 Ono Pharmaceutical Co., Ltd. Ccr4 antagonist and medicinal use thereof
AU2003259296A1 (en) 2002-07-30 2004-02-16 University Of Virginia Patent Foundation Compounds active in spinigosine 1-phosphate signaling
CA2505322A1 (fr) 2002-11-08 2004-05-21 Takeda Pharmaceutical Company Limited Agent de controle de la fonction recepteur
CA2509218C (fr) 2002-12-20 2010-09-07 Merck & Co., Inc. 1-(amino)indanes et (1,2-dihydro-3-amino)-benzofuranes, benzothiophenes et indoles utilises en tant qu'agonistes du recepteur edg
GB0301259D0 (en) 2003-01-20 2003-02-19 Novartis Ag Organic compounds
EP1594508B1 (fr) 2003-02-11 2012-08-08 Irm Llc Nouveaux composes bicycliques et compositions associees
EP1602660B1 (fr) 2003-02-18 2011-04-06 Kyorin Pharmaceutical Co., Ltd. Derives d'acide aminophosphonique, leurs sels d'addition et des modulateurs de recepteurs s1p
MXPA05011597A (es) 2003-04-30 2005-12-15 Novartis Ag Derivados de aminopropanol como moduladores del receptor 1-fosfato de esfingosina.
WO2004099192A2 (fr) 2003-04-30 2004-11-18 The Institutes Of Pharmaceutical Discovery, Llc Acides carboxyliques substitues par des heterocycles
AU2004234066B2 (en) 2003-04-30 2008-02-21 Novartis Ag Amino-propanol derivatives as sphingosine-1-phosphate receptor modulator
CN1788008A (zh) 2003-05-15 2006-06-14 麦克公司 作为s1p受体激动剂的3－(2－氨基－1－氮杂环基)－5－芳基－1,2,4－噁二唑
WO2004104205A2 (fr) 2003-05-16 2004-12-02 Merck & Co., Inc. Preparation enzymatique d'esters d'indole chiraux
MY150088A (en) 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
AU2004240649A1 (en) 2003-05-19 2004-12-02 Irm, Llc Immunosuppressant compounds and compositions
TW200505442A (en) 2003-05-19 2005-02-16 Genomics Inst Of The Novartis Res Foundation Immunosuppressant compounds and compositions
AU2004249664A1 (en) 2003-05-19 2004-12-29 Irm Llc Immunosuppressant compounds and compositions
GB0313612D0 (en) 2003-06-12 2003-07-16 Novartis Ag Organic compounds
WO2005012221A1 (fr) 2003-08-04 2005-02-10 Ono Pharmaceutical Co., Ltd. Compose d'ether de diphenyle, sa methode de preparation et d'utilisation
BRPI0413151A (pt) 2003-08-28 2006-10-03 Novartis Ag derivados de amino propanol
CN1874991A (zh) 2003-08-29 2006-12-06 小野药品工业株式会社 能够结合s1p受体的化合物及其药物用途
WO2005023771A1 (fr) 2003-09-05 2005-03-17 Ono Pharmaceutical Co., Ltd. Antagoniste du recepteur de la chimiokine et son utilisation a des fins medicales
AU2004277947A1 (en) 2003-10-01 2005-04-14 Merck & Co., Inc. 3,5-aryl, heteroaryl or cycloalkyl substituted-1,2,4-oxadiazoles as S1P receptor agonists
WO2005041899A2 (fr) 2003-11-03 2005-05-12 University Of Virginia Patent Foundation Agonistes et antagonistes du recepteur de la sphingosine-1-phosphate pouvant etre pris par voie orale
WO2005044780A1 (fr) 2003-11-10 2005-05-19 Kyorin Pharmaceutical Co., Ltd. Derive d'acide aminocarboxylique, son sel d'addition et agent de regulation du recepteur s1p
WO2005058848A1 (fr) 2003-12-17 2005-06-30 Merck & Co., Inc. Carboxylates propanoiques 3,4-disusbstitues utilises en tant qu'agonistes du recepteur s1p (edg)
TW200521108A (en) 2003-12-19 2005-07-01 Ono Pharmaceutical Co Compounds having lysophosphatidic acid receptor(LPA)-antagonizing effect and their use
GB0329498D0 (en) 2003-12-19 2004-01-28 Novartis Ag Organic compounds
GB0401332D0 (en) 2004-01-21 2004-02-25 Novartis Ag Organic compounds
WO2005082841A1 (fr) 2004-02-24 2005-09-09 Irm Llc Composes et compositions d'immunosuppresseurs
TW200538433A (en) 2004-02-24 2005-12-01 Irm Llc Immunosuppressant compounds and compositiions
NZ549162A (en) 2004-02-24 2009-12-24 Sankyo Co Amino-pyrrol alcohol compounds
WO2005085214A1 (fr) 2004-03-05 2005-09-15 Banyu Pharmaceutical Co., Ltd Dérivé hétérocyclique à cinq éléments substitués par un diaryle
GB0405289D0 (en) 2004-03-09 2004-04-21 Novartis Ag Organic compounds
DE602005004393T2 (de) 2004-04-02 2009-01-08 Merck & Co., Inc. Verfahren zur asymmetrischen hydrierung, das sich für die herstellung von cycloalkanindolderivaten eignet
WO2005123677A1 (fr) 2004-06-16 2005-12-29 Actelion Pharmaceuticals Ltd Utilisation de derives de 1,1,2-trimethyl-1a,4,5,5a-tetrahydro-1h-4-aza-cyclopropa[a]pentalene a substitution 4-carbonyle comme agonistes du recepteur couple aux proteines g s1p1/edg1 et agents immunosuppresseurs
US8039674B2 (en) 2004-06-23 2011-10-18 Ono Pharmaceutical Co., Ltd. Compound having S1P receptor binding potency and use thereof
PT1772145E (pt) 2004-07-16 2011-05-27 Kyorin Seiyaku Kk Processo de utiliza??o eficaz de um medicamento e processo respeitante ? preven??o de efeitos secund?rios
JP2007284350A (ja) 2004-07-27 2007-11-01 Takeda Chem Ind Ltd 糖尿病治療剤
WO2006010379A1 (fr) 2004-07-29 2006-02-02 Actelion Pharmaceuticals Ltd. Nouveaux derives du thiophene utilises comme agents immunosupresseurs
TW200611687A (en) 2004-07-29 2006-04-16 Sankyo Co Pharmaceutical compositions used for immunosuppressant
WO2006013948A1 (fr) 2004-08-04 2006-02-09 Taisho Pharmaceutical Co., Ltd. Dérivé de traizol
US20060223866A1 (en) 2004-08-13 2006-10-05 Praecis Pharmaceuticals, Inc. Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity
EP1781595A1 (fr) 2004-08-13 2007-05-09 Praecis Pharmaceuticals Inc. Procedes et compositions servant a moduler l'activite du recepteur de la sphingosine-1-phosphate (s1p)
JP2008514611A (ja) 2004-09-23 2008-05-08 ワイス Ｃ型肝炎ウイルスによる感染を処置するためのカルバゾールおよびシクロペンタインドールの誘導体
CA2583947A1 (fr) 2004-10-12 2006-04-20 Forbes Medi-Tech (Research) Inc. Composes et methodes de traitement de la resistance insulinique et de la myocardiopathie
AU2005299851B2 (en) 2004-10-22 2011-03-17 Merck Sharp & Dohme Corp. 2-(aryl)azacyclylmethyl carboxylates, sulfonates, phosphonates, phosphinates and heterocycles as S1P receptor agonists
EP1650186B1 (fr) 2004-10-22 2008-06-04 Bioprojet Nouveaux derivés d'acides dicarboxyliques
WO2006055708A2 (fr) 2004-11-18 2006-05-26 The Institutes For Pharmaceutical Discovery, Llc Acides carboxyliques a substitution heterocyclique
EP1829863A4 (fr) 2004-11-26 2009-04-22 Takeda Pharmaceutical Derive d'acide arylalcanoique
MX2007006706A (es) 2004-12-06 2007-10-18 Univ Virginia Analogos de esfingosina 1-fosfato amida de arilo.
AU2005314938B2 (en) 2004-12-13 2011-06-09 Ono Pharmaceutical Co., Ltd. Aminocarboxylic acid derivative and medicinal use thereof
JP5798282B2 (ja) 2005-01-25 2015-10-21 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ メソゲン性化合物、液晶媒体および液晶ディスプレイ
EP1685841A1 (fr) 2005-01-31 2006-08-02 Bayer Health Care Aktiengesellschaft Prevention et traitement de troubles thromboemboliques
CA2596990A1 (fr) 2005-02-14 2006-08-24 University Of Virginia Patent Foundation Agonistes de sphingosine-1-phosphate comportant des cycloalcanes et heterocycles substitues par des groupes amino et phenyle
RU2404178C2 (ru) 2005-03-23 2010-11-20 Актелион Фармасьютиклз Лтд Новые производные тиофена в качестве агонистов рецептора сфингозин-1-фосфата-1
RU2007138878A (ru) 2005-03-23 2009-04-27 Актелион Фармасьютиклз Лтд (Ch) Новые производные тиофена в качестве агонистов рецептора сфингозин-1-фосфата-1
MX2007011670A (es) 2005-03-23 2007-11-15 Actelion Pharmaceuticals Ltd Derivados de benzo(c) tiofeno hidrogenados como inmunomoduladores.
WO2006131336A1 (fr) 2005-06-08 2006-12-14 Novartis Ag Oxadiazoles polycycliques ou soxazoles i et leur utilisation comme ligands recepteurs de s1p
RU2008101805A (ru) 2005-06-24 2009-07-27 Актелион Фармасьютиклз Лтд (Ch) Новые производные тиофена
TWI418350B (zh) 2005-06-24 2013-12-11 Sankyo Co 含有ｐｐａｒ調節劑之醫藥組成物的用途
US20070060573A1 (en) 2005-08-10 2007-03-15 Lars Wortmann Acyltryptophanols
CA2619101A1 (fr) 2005-08-23 2007-03-01 Irm Llc Composes immunosuppresseurs et compositions associees
JPWO2007037196A1 (ja) 2005-09-29 2009-04-09 山本化成株式会社 インドリン系化合物及びその製造方法
PL1932522T3 (pl) 2005-10-07 2012-09-28 Kyorin Seiyaku Kk Środek terapeutyczny do leczenia choroby wątroby zawierający jako składnik czynny pochodną 2-amino-1,3-propanodiolu
AR057894A1 (es) 2005-11-23 2007-12-26 Actelion Pharmaceuticals Ltd Derivados de tiofeno
JP2009520688A (ja) 2005-11-23 2009-05-28 エピックス デラウェア， インコーポレイテッド Ｓ１ｐ受容体調節化合物およびそれらの使用
TWI404706B (zh) 2006-01-11 2013-08-11 Actelion Pharmaceuticals Ltd 新穎噻吩衍生物
TW200736234A (en) 2006-01-17 2007-10-01 Astrazeneca Ab Chemical compounds
JP5063615B2 (ja) 2006-01-24 2012-10-31 アクテリオン ファーマシューティカルズ リミテッド 新規ピリジン誘導体
GB0601744D0 (en) 2006-01-27 2006-03-08 Novartis Ag Organic compounds
TWI389683B (zh) 2006-02-06 2013-03-21 Kyorin Seiyaku Kk A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient
TW200806611A (en) 2006-02-09 2008-02-01 Daiichi Seiyaku Co Novel amidopropionic acid derivatives and medicine containing the same
EP1987013A1 (fr) 2006-02-09 2008-11-05 University Of Virginia Patent Foundation Analogues de sphingosine 1-phosphate bicyclique
US20070191371A1 (en) 2006-02-14 2007-08-16 Kalypsys, Inc. Heterocyclic modulators of ppar
CN101460458A (zh) 2006-02-15 2009-06-17 阿勒根公司 具有1－磷酸－鞘氨醇(s1p)受体拮抗剂生物活性的带芳基或者杂芳基基团的吲哚－3－羧酸的酰胺、酯、硫代酰胺和硫羟酸酯化合物
KR20080102181A (ko) 2006-02-15 2008-11-24 알러간, 인코포레이티드 스핑고신-1-포스페이트 (에스1피) 수용체 길항제 생물학적 활성을 갖는 아릴 또는 헤테로아릴기를 포함하는 인돌-3-카르보실산 아미드, 에스테르, 티오아미드 및 티올 에스테르 화합물
AU2007217006A1 (en) 2006-02-21 2007-08-30 University Of Virginia Patent Foundation Phenyl-cycloalkyl and phenyl-heterocyclic derivatives as SIP receptor agonists
US7649098B2 (en) 2006-02-24 2010-01-19 Lexicon Pharmaceuticals, Inc. Imidazole-based compounds, compositions comprising them and methods of their use
EP2001844A2 (fr) 2006-03-14 2008-12-17 Amgen, Inc Derives bicycliques de l'acide carboxylique utiles dans le traitement de troubles metaboliques
EP2010524A2 (fr) 2006-03-21 2009-01-07 Epix Delaware, Inc. Composés modulant le récepteur de la sip
JP2007262009A (ja) 2006-03-29 2007-10-11 Dai Ichi Seiyaku Co Ltd ヘテロアリール低級カルボン酸誘導体
MX2008012738A (es) 2006-04-03 2009-02-06 Astellas Pharma Inc Heterocompuesto.
GB0607389D0 (en) 2006-04-12 2006-05-24 Novartis Ag Organic compounds
WO2007129473A1 (fr) 2006-05-09 2007-11-15 Daiichi Sankyo Company, Limited Dérivé arylique bicyclique
US20090324581A1 (en) 2006-05-09 2009-12-31 Daiichi Sankyo Company Limited Heteroarylamide lower carboxylic acid derivative
EP2258700A1 (fr) 2006-05-09 2010-12-08 Pfizer Products Inc. Dérivés d'acides aminés cycloalkyles et compositions pharmaceutiques les contenant
AR062156A1 (es) 2006-08-01 2008-10-22 Praecis Pharm Inc Compuestos agonistas y selectivos del receptor s1p-1
EP2046766A1 (fr) 2006-08-01 2009-04-15 Praecis Pharmaceuticals Incorporated Agonistes du récepteur du sphingosine - 1- phosphate (slp)
WO2008019090A2 (fr) 2006-08-04 2008-02-14 Praecis Pharmaceuticals Incorporated Composés chimiques
EP2058317B1 (fr) 2006-08-08 2013-10-16 Kyorin Pharmaceutical Co., Ltd. Dérivé d'ester de l'acide aminophosphorique et modulateur de récepteur s1p contenant le dit dérivé en tant que principe actif
WO2008024196A1 (fr) 2006-08-24 2008-02-28 Praecis Pharmaceuticals Incorporated Composés chimiques
JP2009269819A (ja) 2006-08-25 2009-11-19 Asahi Kasei Pharma Kk アミン化合物
KR101470659B1 (ko) 2006-09-07 2014-12-08 액테리온 파마슈티칼 리미티드 면역조절제로서 피리딘-4-일 유도체
TWI408139B (zh) 2006-09-07 2013-09-11 Actelion Pharmaceuticals Ltd 新穎噻吩衍生物
AU2007292347A1 (en) 2006-09-07 2008-03-13 Allergan, Inc. Heteroaromatic compounds having sphingosine-1-phosphate (S1P) receptor agonist and/or antagonist biological activity
WO2008028937A1 (fr) 2006-09-08 2008-03-13 Novartis Ag Dérivés du n-biaryl (hétéro) arylsulphonamide utilisables pour traiter des maladies induites par des interactions avec les lymphocytes
RU2442780C2 (ru) 2006-09-21 2012-02-20 Актелион Фармасьютиклз Лтд Фенильные производные и их применение в качестве иммуномодуляторов
JP2010513283A (ja) 2006-12-15 2010-04-30 アボット・ラボラトリーズ 新規なオキサジアゾール化合物
JO2701B1 (en) 2006-12-21 2013-03-03 جلاكسو جروب ليميتد Vehicles
GB0625648D0 (en) 2006-12-21 2007-01-31 Glaxo Group Ltd Compounds
CL2007003784A1 (es) 2006-12-21 2008-06-27 Abbott Lab Compuestos derivados de 1-amino-3-fenilciclopentano, que son agonistas o antagonistas de uno o mas receptores de la familia s1p; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar la esclerosis multiple, artritis reumato
WO2008089015A1 (fr) 2007-01-11 2008-07-24 Allergan, Inc. Composé amide d'acide indole-3-carboxylique 6-substitué ayant une activité biologique d'antagoniste du récepteur de sphingosine-1-phosphate (s1p)
WO2008091967A1 (fr) 2007-01-26 2008-07-31 Smithkline Beecham Corporation Composés chimiques
WO2008097819A2 (fr) 2007-02-05 2008-08-14 Smithkline Beecham Corporation Composés chimiques
DK2125797T3 (da) 2007-03-16 2014-02-10 Actelion Pharmaceuticals Ltd Aminopyridinderivater som s1p1/edg1-receptoragonister
JP5191497B2 (ja) 2007-03-21 2013-05-08 エピックス ファーマシューティカルズ，インコーポレイテッド Ｓ１ｐ受容体調節化合物およびその使用
BRPI0809472A2 (pt) 2007-04-19 2014-09-09 Glaxo Group Ltd Derivados indazol substituídos com oxadiazol para emprego como agonistas de esfingosina 1-fosfato (sip)
EP2014653A1 (fr) 2007-06-15 2009-01-14 Bioprojet Nouveaux dérivés d'acide dicarboxylique comme agonistes du recepteur S1P1
WO2009011850A2 (fr) 2007-07-16 2009-01-22 Abbott Laboratories Nouveaux composés thérapeutiques
WO2009019506A1 (fr) 2007-08-03 2009-02-12 Astrazeneca Ab Sulfonamides hétérocycliques ayant une activité antagoniste de edg-1
JP5508265B2 (ja) 2007-08-08 2014-05-28 メルク セローノ ソシエテ アノニム 多発性硬化症の治療のための、スフィンゴシン１−ホスフェート（ｓ１ｐ）受容体に結合する６−アミノ−ピリミジン−４−カルボキサミド誘導体及び関連化合物
TW200930368A (en) 2007-11-15 2009-07-16 Astrazeneca Ab Bis-(sulfonylamino) derivatives in therapy
WO2009073148A2 (fr) 2007-11-28 2009-06-11 Synta Pharmaceuticals Corp. Polymorphes de n-malonyl-bis(n'-méthyl-n'-thiobenzoylhydrazide)
ATE531711T1 (de) 2007-12-18 2011-11-15 Arena Pharm Inc Für die behandlung von autoimmunerkrankungen und entzündlichen erkrankungen geeignete tetrahydrocyclopentaäbüindol-3- ylcarbonsäurederivate
AU2009206733A1 (en) 2008-01-25 2009-07-30 Arena Pharmaceuticals, Inc. Dihydro- 1H- pyrrolo [1,2-a] indol-1-yl carboxylic derivatives which act as S1P1 agonists
AR070398A1 (es) 2008-02-22 2010-03-31 Gruenenthal Chemie Derivados sustituidos de indol
WO2009108924A2 (fr) 2008-02-28 2009-09-03 Solar Roofing Systems, Inc. Tuile photovoltaïque avec matériau anti-incendie
AR070842A1 (es) 2008-03-17 2010-05-05 Actelion Pharmaceuticals Ltd Regimen de dosificacion para un agonista de receptor selectivo de s1p1
PL2913326T3 (pl) 2008-05-14 2020-11-16 The Scripps Research Institute Nowe modulatory receptorów fosforanu sfingozyny
WO2009151626A1 (fr) 2008-06-13 2009-12-17 Arena Pharmaceuticals, Inc. Dérivés de l’acide (1, 2, 4-oxadiazol-3-yl)indolin-1-yl carboxylique substitué pouvant être utilisés comme agonistes de s1p1
WO2009151621A1 (fr) 2008-06-13 2009-12-17 Arena Pharmaceuticals, Inc. Dérivés de l’acide (1, 2, 4-oxadiazol-3-yl)indolin-1-yl carboxylique substitué utiles comme agonistes de s1p1
SI2326621T1 (sl) 2008-07-23 2016-10-28 Arena Pharmaceuticals, Inc. Substituirani derivati 1,2,3,4-tetrahidrociklopenta(b)indol-3-il)ocetne kisline, uporabni pri zdravljenju avtoimunskih in vnetnih motenj
NZ591001A (en) 2008-08-27 2012-11-30 Arena Pharm Inc Substituted tricyclic acid derivatives as s1p1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders
PT4098256T (pt) 2008-12-22 2025-04-10 Novartis Ag Regime de dosagem para um agonista do recetor de s1p
CN105213372A (zh) 2008-12-22 2016-01-06 诺华股份有限公司 S1p受体激动剂的给药方案
PE20120578A1 (es) 2009-02-10 2012-06-17 Abbott Lab Agonistas y antagonistas del receptor de s1p5, y metodos de uso de los mismos
WO2011005290A1 (fr) 2009-06-23 2011-01-13 Arena Pharmaceuticals, Inc. Dérivés d'oxadiazole disubstitués utiles dans le traitement de troubles auto-immuns et inflammatoires
WO2011005295A1 (fr) 2009-06-24 2011-01-13 Arena Pharmaceuticals, Inc. Modulateurs du récepteur sphingosine-1-phosphate (s1p) utiles pour le traitement de troubles associés à ceux-ci
EP2592071B1 (fr) 2009-10-29 2019-09-18 Bristol-Myers Squibb Company Composés hétérocycliques tricycliques
US8299059B2 (en) 2009-10-30 2012-10-30 Eli Lilly And Company Crystalline compound and a process for its preparation
MTP4285B (en) 2009-12-30 2011-07-04 Medichem Sa A 1-(1h-1,2,3-triazol-1-yl)butan-2-ol derivative for pharmaceutical use, and the use of a 1-(1h-1, 2, 4- triazol-1yl) butan-2-ol derivative with substially undefined crystal shap for preparing said 1-(1h-1, 2, 4-triazol-1-yl0 butan-2-ol derivative
SG10201500639TA (en) 2010-01-27 2015-03-30 Arena Pharm Inc Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
CN105503882B (zh) 2010-03-03 2019-07-05 艾尼纳制药公司 制备s1p1受体调节剂及其晶体形式的方法
US8747844B2 (en) 2010-07-30 2014-06-10 Saint Louis University Methods of treating pain
ES2772258T3 (es) 2011-02-07 2020-07-07 Biogen Ma Inc Agentes moduladores de S1P
AR089862A1 (es) 2012-02-03 2014-09-24 Teva Pharma USO DE LAQUINIMOD PARA EL TRATAMIENTO DE PACIENTES CON ENFERMEDAD DE CROHN EN QUIENES FRACASO UNA TERAPIA ANTI-FACTOR DE NECROSIS TUMORAL a (ANTI-TNFa) DE PRIMERA LINEA
US20160038506A1 (en) 2012-02-14 2016-02-11 Repros Therapeutics Inc. Selective Estrogen Receptor Modulators With Short Half-Lives and Uses Thereof
US8962888B2 (en) 2012-12-03 2015-02-24 Physical Sciences, Inc. Forming spherical crystal habit
JP5589110B1 (ja) 2013-03-08 2014-09-10 株式会社ポーラファルマ 晶癖を有する結晶及び該結晶を有効成分として含有する医薬組成物
CN116850181A (zh) * 2015-01-06 2023-10-10 艾尼纳制药公司 治疗与s1p1受体有关的病症的方法
AU2016284162A1 (en) 2015-06-22 2018-02-01 Arena Pharmaceuticals, Inc. Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid(Compound1) for use in SIP1 receptor-associated disorders
AU2018220521A1 (en) 2017-02-16 2019-09-05 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of primary biliary cholangitis
CA3053416A1 (fr) 2017-02-16 2018-08-23 Arena Pharmaceuticals, Inc. Composes et methodes pour le traitement de maladies inflammatoires chroniques de l'intestin avec manifestations extra-intestinales
WO2019236757A1 (fr) 2018-06-06 2019-12-12 Arena Pharmaceuticals, Inc. MÉTHODES DE TRAITEMENT DE TROUBLES ASSOCIÉS AU RÉCEPTEUR S1P1<sb />
US20210386706A1 (en) 2018-10-03 2021-12-16 Arena Pharmaceuticals, Inc. Methods for the treatment of scleroderma
CN113226307A (zh) 2018-11-30 2021-08-06 艾尼纳制药公司 治疗与s1p1受体有关的病况的方法
EP3908276B1 (fr) 2019-01-08 2025-06-11 Arena Pharmaceuticals, Inc. Méthodes pour le traitement de conditions liées au récepteur s1p1

Also Published As

Publication number Publication date
MX2019009843A (es) 2020-01-30
US11478448B2 (en) 2022-10-25
US12097182B2 (en) 2024-09-24
MX2022011834A (es) 2022-10-18
EP3582814A1 (fr) 2019-12-25
EP3582814B1 (fr) 2024-05-01
US20230092353A1 (en) 2023-03-23
AU2018222747A1 (en) 2019-09-05
ES2981521T3 (es) 2024-10-09
WO2018151834A1 (fr) 2018-08-23
US20200016121A1 (en) 2020-01-16
CA3053416A1 (fr) 2018-08-23
KR20190113955A (ko) 2019-10-08
CN110545848A (zh) 2019-12-06
JP2020507610A (ja) 2020-03-12

Similar Documents

Publication Publication Date Title
MA47503A (fr) Composés et méthodes pour le traitement de maladies inflammatoires chroniques de l&#39;intestin avec manifestations extra-intestinales
MA51200A (fr) Nouveaux composés et compositions pharmaceutiques associées pour le traitement de maladies
EP3390634A4 (fr) Compositions et méthodes pour le traitement de maladies oculaires
EP3452166A4 (fr) Stimulation intranasale pour le traitement de la maladie de la glande de meibomius et de la blépharite
EP3340982A4 (fr) Composés pour le traitement de troubles immunitaires et inflammatoires
IL262608A (en) Combination treatment of ocular inflammatory disorders and diseases
MA51203A (fr) Combinaison d&#39;un dérivé de 4-pyrimidinesulfamide avec un inhibiteur de sglt-2 pour le traitement de maladies liées à l&#39;endothéline
EP3448875A4 (fr) Compositions pour le traitement de maladies
MA45481A (fr) Utilisation d&#39;exosomes pour le traitement de maladies
EP3370748A4 (fr) Microbiote thérapeutique pour le traitement et/ou la prévention de l&#39;allergie alimentaire
EP3448398A4 (fr) Compositions et méthodes pour le traitement de troubles cutanés
EP3634442A4 (fr) Méthodes de traitement et de prévention de maladies
EP3658139A4 (fr) Méthodes de traitement de maladies hépatiques
MA52873A (fr) Nouveaux composés et compositions pharmaceutiques associées pour le traitement de maladies
EP3704108A4 (fr) Composés et compositions pour le traitement de troubles hématologiques
EP3661553A4 (fr) Méthodes et compositions pour le traitement des maladies à dépôts amyloïdes
EP3718561A4 (fr) Agent thérapeutique pour une maladie inflammatoire de l&#39;intestin
EP2967062A4 (fr) Déséthylhydroxychloroquine pour le traitement de maladies associées avec l&#39;inflammation
EP3655403A4 (fr) Composés affectant la production de pigments et leur utilisation pour le traitement de maladies bactériennes
MA51056A (fr) Compositions et méthodes pour le traitement d&#39;affections métaboliques
MA44126A (fr) Méthodes de traitement de maladies et troubles pulmonaires
EP3352749A4 (fr) Composés et compositions pour le traitement de troubles oculaires
EP3443962A4 (fr) Dérivé de quinoline pour le traitement du cancer de l&#39;estomac
EP3805216A4 (fr) Composés pour le traitement ou la prévention de maladies hépatiques
EP3370725A4 (fr) Dosage pédiatrique pour le traitement du cancer avec un inhibiteur d&#39;ezh2